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1. 发明授权

US10100316B2 Aptamers comprising CPG motifs 有权
公开(公告)号：US10100316B2
公开(公告)日：2018-10-16
申请号：US10829504
申请日：2004-04-21
申请人： David Epstein , Dilara Grate , Martin Stanton , John L. Diener , Charles Wilson , Thomas Greene McCauley , Errol Desouza
发明人： David Epstein , Dilara Grate , Martin Stanton , John L. Diener , Charles Wilson , Thomas Greene McCauley , Errol Desouza
IPC分类号： C12N15/115 , C12N15/117
摘要： Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.

2. 发明授权

US07125660B2 Nucleic acid sensor molecules and methods of using same 失效
标题翻译：核酸传感器分子及其使用方法
公开(公告)号：US07125660B2
公开(公告)日：2006-10-24
申请号：US10215982
申请日：2002-08-09
申请人： Martin Stanton , David Epstein , Nobuko Hamaguchi , Markus Kurz , Tony Keefe , Charles Wilson , Dilara Grate , Kristin A. Marshall , Thomas G. McCauley , Jeffrey C. Kurz
发明人： Martin Stanton , David Epstein , Nobuko Hamaguchi , Markus Kurz , Tony Keefe , Charles Wilson , Dilara Grate , Kristin A. Marshall , Thomas G. McCauley , Jeffrey C. Kurz
IPC分类号： C12Q1/00 , C12Q1/68 , C07H19/00
CPC分类号： B82Y30/00 , B01J2219/00385 , B01J2219/00479 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00653 , B01J2219/00662 , B01J2219/00691 , B01J2219/00722 , C07H21/02 , C07H21/04 , C12Q1/485 , C12Q1/6816 , C12Q1/6825 , C40B40/06 , C40B60/14 , C12Q2565/101 , C12Q2525/179 , C12Q2521/337 , C12Q2521/501
摘要： Methods for engineering a nucleic acid sensor molecule are provided. Biosensors comprise a plurality of nucleic acid sensor molecules labeled with a first signaling moiety and a second signaling moiety. The nucleic acid sensor molecules recognizes target molecules which do not naturally bind to DNA. Binding of a target molecule to the sensor molecules triggers a change in the proximity of the signaling moieties which leads to a change in the optical properties of the nucleic acid sensor molecules on the biosensor. Reagents and systems for performing the method are also provided. The method is useful in diagnostic applications and drug optimization.
摘要翻译：提供了设计核酸传感器分子的方法。生物传感器包含用第一信号传导部分和第二信号传导部分标记的多个核酸传感器分子。核酸传感器分子识别不天然结合DNA的靶分子。靶分子与传感器分子的结合触发信号部分的接近度的变化，导致生物传感器上的核酸传感器分子的光学性质的变化。还提供了用于执行该方法的试剂和系统。该方法可用于诊断应用和药物优化。

3. 发明申请

US20050124565A1 Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics 审中-公开
公开(公告)号：US20050124565A1
公开(公告)日：2005-06-09
申请号：US10873853
申请日：2004-06-21
申请人： John Diener , David Epstein , Alicia Ferguson , Dilara Grate , Anthony Keefe , Thomas McCauley , Jeffrey Preiss , Martin Stanton , Charles Wilson
发明人： John Diener , David Epstein , Alicia Ferguson , Dilara Grate , Anthony Keefe , Thomas McCauley , Jeffrey Preiss , Martin Stanton , Charles Wilson
IPC分类号： A61K48/00 , C07H21/04 , C12N15/85
CPC分类号： A61K48/00 , C07H21/04 , C12N15/85
摘要： Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.

4. 发明申请

US20090053138A1 Stabilized Aptamers to Platelet Derived Growth Factor and their Use as Oncology Therapeutics 审中-公开
标题翻译：稳定的血小板衍生生长因子及其作为肿瘤学治疗的用途
公开(公告)号：US20090053138A1
公开(公告)日：2009-02-26
申请号：US11666954
申请日：2005-11-02
申请人： Jeffrey Preiss , Charles Wilson , Martin Stanton , John Diener , David Epstein , Dilara McCauley , Thomas McCauley
发明人： Jeffrey Preiss , Charles Wilson , Martin Stanton , John Diener , David Epstein , Dilara McCauley , Thomas McCauley
IPC分类号： A61K49/00 , C07H21/04 , A61P35/00 , A61K31/711
CPC分类号： C12N15/115 , A61K31/711 , A61K47/549 , A61K47/60 , C07H21/04 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/351 , C12N2310/3521
摘要： Materials and methods are provided for producing and using aptamers as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and/or VEGF receptor or any combination thereof with affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.
摘要翻译：提供材料和方法用于生产和使用适配体作为能够以亲和力和特异性结合PDGF，PDGF同种型，PDGF受体，VEGF和/或VEGF受体或其任何组合的肿瘤学治疗剂。本发明的组合物特别可用于实体瘤治疗，并且可以单独使用或与已知的细胞毒剂组合用于治疗实体瘤。还公开了具有一个或多个CpG基序嵌入其中或附着于其上的适体。

5. 发明申请

US20090274272A1 METHODS AND APPARATUS FOR OBTAINING LOW-DOSE IMAGING 有权
标题翻译：用于获取低剂量成像的方法和装置
公开(公告)号：US20090274272A1
公开(公告)日：2009-11-05
申请号：US12497074
申请日：2009-07-02
申请人： Martin Stanton , Alexander Stewart , Edward Bullard
发明人： Martin Stanton , Alexander Stewart , Edward Bullard
IPC分类号： G01N23/04 , G01N23/201 , G06K9/00
CPC分类号： A61B6/482 , A61B6/02 , A61B6/405 , A61B6/4233 , A61B6/4291 , A61B6/466 , A61B6/502 , A61B6/5258 , A61B6/542 , G01N23/04 , G01N2223/423
摘要： In one aspect, A method of imaging an object of interest positioned in an exposure area is provided. The method comprises obtaining projection data of the object by providing radiation to the exposure area and detecting at least some of the radiation exiting the object to form the projection data, performing a first reconstruction of the projection data to form at least one bootstrap image, obtaining first data based on information provided by the at least one bootstrap image, and performing a second reconstruction of the projection data based, at least in part, on the first data to form at least one second image.
摘要翻译：在一个方面，提供了一种对曝光区域中的感兴趣物体进行成像的方法。该方法包括：通过向曝光区域提供辐射并检测离开物体的至少一些辐射以形成投影数据，执行投影数据的第一重建以形成至少一个自举图像，获得物体的投影数据，获得基于由所述至少一个自举图像提供的信息的第一数据，以及至少部分地基于第一数据执行投影数据的第二重建以形成至少一个第二图像。

6. 发明申请

US20050105679A1 Tomosynthesis imaging system and method 有权
标题翻译：系统合成成像系统及方法
公开(公告)号：US20050105679A1
公开(公告)日：2005-05-19
申请号：US10776690
申请日：2004-02-11
申请人： Tao Wu , Alex Stewart , Martin Stanton , Walter Phillips , Daniel Kopans , Richard Moore
发明人： Tao Wu , Alex Stewart , Martin Stanton , Walter Phillips , Daniel Kopans , Richard Moore
IPC分类号： A61B6/00 , A61B6/03 , G01N23/04 , G06T11/00 , G21K1/12 , G01N23/00 , H05G1/60
CPC分类号： G06T11/006 , A61B6/025 , A61B6/502 , A61B6/583 , G01N23/04 , G06T2211/424 , G06T2211/436
摘要： A system for three-dimensional tomosynthesis imaging of a target element is provided having an image acquisition element and a processor. The image acquisition element obtains a plurality of images of the target element from a plurality of angles and includes a radiation source that is positionable at a plurality of angles with respect to the target element and a radiation detector. The radiation detector is positioned so as to detect radiation emitted by the radiation source passing through the target element and determine a plurality of attenuation values for radiation passing through the target element to establish a radiation absorbance projection image of the target element for a particular radiation source angle. The processor is configured to apply an iterative reconstruction algorithm to the radiation absorbance projection images of the target element obtained from a plurality of radiation source angles to generate a three-dimensional reconstruction of the target element. The system can gain further accuracy where the iterative reconstruction algorithm is applied using cone-beam forward projection and back projection.
摘要翻译：提供了具有图像采集元件和处理器的目标元件的三维断层合成成像系统。图像采集元件从多个角度获得目标元件的多个图像，并且包括可相对于目标元件以多个角度定位的辐射源和放射线检测器。放射线检测器被定位成检测通过目标元件的辐射源发射的辐射，并确定用于通过目标元件的辐射的多个衰减值，以建立用于特定辐射源的目标元件的辐射吸收投影图像角度。处理器被配置为对从多个辐射源角度获得的目标元件的辐射吸收投影图像应用迭代重建算法，以产生目标元素的三维重建。在使用锥束前向投影和反投影应用迭代重建算法的情况下，系统可以获得进一步的准确性。

7. 发明授权

US08071734B2 Nucleic acid-based detection 有权
标题翻译：基于核酸的检测
公开(公告)号：US08071734B2
公开(公告)日：2011-12-06
申请号：US11645362
申请日：2006-12-22
申请人： Martin Stanton , Pieter Wensink , Alexander Stewart
发明人： Martin Stanton , Pieter Wensink , Alexander Stewart
IPC分类号： C07H21/04
CPC分类号： G01N21/6428 , B01J19/0046 , B01J2219/00387 , B01J2219/005 , B01J2219/00529 , B01J2219/00576 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01J2219/0072 , C40B30/04 , C40B40/06 , C40B60/12 , C40B70/00 , G01N21/6458 , G01N21/648
摘要： The invention relates to compositions, systems, and methods for simultaneously detecting the presence and quantity of one or more different compounds in a sample using aptamer beacons. Aptamer beacons are oligonucleotides that have a binding region that can bind to a non-nucleotide target molecule, such as a protein, a steroid, or an inorganic molecule. New aptamer beacons having binding regions configured to bind to different target molecules can be used in solution-based and solid, array-based systems. The aptamer beacons can be attached to solid supports, e.g., at different predetermined points in two-dimensional arrays. The invention includes devices, methods, and computer software for carrying out the methods.
摘要翻译：本发明涉及用于使用适配子信标同时检测样品中一种或多种不同化合物的存在和量的组合物，系统和方法。适配器信标是具有可结合非核苷酸靶分子如蛋白质，类固醇或无机分子的结合区的寡核苷酸。具有配置成结合不同靶分子的结合区域的新适配子信标可用于基于溶液和固体的基于阵列的体系。适配器信标可以连接到固体支持物，例如在二维阵列中的不同预定点处。本发明包括用于执行方法的装置，方法和计算机软件。

8. 发明申请

US20090262893A1 METHODS AND APPARATUS FOR OBTAINING LOW-DOSE IMAGING 审中-公开
标题翻译：用于获取低剂量成像的方法和装置
公开(公告)号：US20090262893A1
公开(公告)日：2009-10-22
申请号：US12463491
申请日：2009-05-11
申请人： Alexander Stewart , Martin Stanton , Edward Bullard
发明人： Alexander Stewart , Martin Stanton , Edward Bullard
IPC分类号： G01N23/04
CPC分类号： A61B6/482 , A61B6/02 , A61B6/4035 , A61B6/405 , A61B6/4085 , A61B6/4233 , A61B6/4291 , A61B6/466 , A61B6/502 , A61B6/542 , A61B6/583 , G01N23/046 , G01N2223/419 , G01N2223/423 , G01N2223/612
摘要： In one aspect, a method of obtaining projection data of an object from a plurality of view angles with respect to the object is provided. The method comprises acts of providing radiation, at each of the plurality of view angles, to an exposure area in which the object is positioned, controlling a radiation energy of the radiation provided at each of the plurality of view angles such that the respective radiation energy is different for at least two of the plurality of view angles, and detecting at least some of the radiation passing through the exposure area at each of the plurality of view angles to obtain the projection data.
摘要翻译：一方面，提供从多个视角相对于物体获取物体的投影数据的方法。该方法包括在多个视角中的每一个处将辐射提供给物体所在的曝光区域的动作，控制在多个视角中的每一个处提供的辐射的辐射能量，使得相应的辐射能量对于多个视角中的至少两个视角不同，并且在多个视角中的每一个处检测通过曝光区域的至少一些辐射，以获得投影数据。

9. 发明授权

US07570732B2 Methods and apparatus for obtaining low-dose imaging 有权
标题翻译：获得低剂量成像的方法和装置
公开(公告)号：US07570732B2
公开(公告)日：2009-08-04
申请号：US11603876
申请日：2006-11-22
申请人： Martin Stanton , Alexander Stewart , Edward Bullard
发明人： Martin Stanton , Alexander Stewart , Edward Bullard
IPC分类号： G01N23/04
CPC分类号： A61B6/482 , A61B6/02 , A61B6/405 , A61B6/4233 , A61B6/4291 , A61B6/466 , A61B6/502 , A61B6/5258 , A61B6/542 , G01N23/04 , G01N2223/423
摘要： In one aspect, A method of imaging an object of interest positioned in an exposure area is provided. The method comprises obtaining projection data of the object by providing radiation to the exposure area and detecting at least some of the radiation exiting the object to form the projection data, performing a first reconstruction of the projection data to form at least one bootstrap image, obtaining first data based on information provided by the at least one bootstrap image, and performing a second reconstruction of the projection data based, at least in part, on the first data to form at least one second image.
摘要翻译：在一个方面，提供了一种对曝光区域中的感兴趣物体进行成像的方法。该方法包括：通过向曝光区域提供辐射并检测离开物体的至少一些辐射以形成投影数据，执行投影数据的第一重建以形成至少一个自举图像，获得物体的投影数据，获得基于由所述至少一个自举图像提供的信息的第一数据，以及至少部分地基于第一数据执行投影数据的第二重建以形成至少一个第二图像。

10. 发明申请

US20080020939A1 Nucleic acid-based detection 有权
标题翻译：基于核酸的检测
公开(公告)号：US20080020939A1
公开(公告)日：2008-01-24
申请号：US11645362
申请日：2006-12-22
申请人： Martin Stanton , Pieter Wensink , Alexander Stewart
发明人： Martin Stanton , Pieter Wensink , Alexander Stewart
IPC分类号： C40B30/04 , C40B30/02 , C40B60/12 , C40B70/00
CPC分类号： G01N21/6428 , B01J19/0046 , B01J2219/00387 , B01J2219/005 , B01J2219/00529 , B01J2219/00576 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01J2219/0072 , C40B30/04 , C40B40/06 , C40B60/12 , C40B70/00 , G01N21/6458 , G01N21/648
摘要： The invention relates to compositions, systems, and methods for simultaneously detecting the presence and quantity of one or more different compounds in a sample using aptamer beacons. Aptamer beacons are oligonucleotides that have a binding region that can bind to a non-nucleotide target molecule, such as a protein, a steroid, or an inorganic molecule. New aptamer beacons having binding regions configured to bind to different target molecules can be used in solution-based and solid, array-based systems. The aptamer beacons can be attached to solid supports, e.g., at different predetermined points in two-dimensional arrays. The invention includes devices, methods, and computer software for carrying out the methods.
摘要翻译：本发明涉及用于使用适配子信标同时检测样品中一种或多种不同化合物的存在和量的组合物，系统和方法。适配器信标是具有可结合非核苷酸靶分子如蛋白质，类固醇或无机分子的结合区的寡核苷酸。具有配置成结合不同靶分子的结合区域的新适配子信标可用于基于溶液和固体的基于阵列的体系。适配器信标可以连接到固体支持物，例如在二维阵列中的不同预定点处。本发明包括用于执行方法的装置，方法和计算机软件。

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