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1. 发明申请

US20130045180A9 VACCINES, IMMUNOTHERAPEUTICS AND METHODS FOR USING THE SAME 审中-公开
标题翻译：疫苗，免疫球蛋白及其使用方法
公开(公告)号：US20130045180A9
公开(公告)日：2013-02-21
申请号：US13360389
申请日：2012-01-27
申请人： David B. Weiner , Jong J. Kim , Jeong-Im Sin
发明人： David B. Weiner , Jong J. Kim , Jeong-Im Sin
IPC分类号： A61K38/20 , A61K39/00 , A61K39/245 , A61K39/21 , A61K38/19 , C07K16/24 , C07K16/28 , C07K16/40 , C07K16/18 , A61K39/395 , A61P37/06 , A61P37/04 , A61P31/18 , A61P35/00 , A61P31/22 , A61P31/00 , C12N15/63
CPC分类号： A61K39/39 , A61K39/12 , A61K39/21 , A61K39/245 , A61K2039/53 , A61K2039/545 , A61K2039/555 , A61K2039/55522 , A61K2039/55527 , C07K14/523 , C07K14/5421 , C07K2319/00 , C12N2710/16634 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234
摘要： Improved vaccines which include a nucleotide sequence that encodes immunomodulating protein operably linked to regulatory elements are disclosed. The improved vaccines include DNA vaccines, recombinant vaccines for delivering foreign antigen and live attenuated vaccines. Methods of immunizing individuals are disclosed. Compositions for and methods of treating individuals with autoimmune diseases are disclosed.
摘要翻译：公开了包括编码与调控元件可操作地连接的免疫调节蛋白的核苷酸序列的改进的疫苗。改进的疫苗包括DNA疫苗，用于递送外源抗原和减毒活疫苗的重组疫苗。公开了免疫个体的方法。公开了治疗患有自身免疫性疾病的个体的组合物和方法。

2. 发明申请

US20120195852A1 VACCINES, IMMUNOTHERAPEUTICS AND METHODS FOR USING THE SAME 审中-公开
标题翻译：疫苗，免疫球蛋白及其使用方法
公开(公告)号：US20120195852A1
公开(公告)日：2012-08-02
申请号：US13360389
申请日：2012-01-27
申请人： David B. Weiner , Jong J. Kim , Jeong-Im Sin
发明人： David B. Weiner , Jong J. Kim , Jeong-Im Sin
IPC分类号： A61K38/20 , A61K39/00 , A61K39/245 , A61K39/21 , A61K38/19 , C07K16/24 , C07K16/28 , C07K16/40 , C07K16/18 , A61K39/395 , A61P37/06 , A61P37/04 , A61P31/18 , A61P35/00 , A61P31/22 , A61P31/00 , C12N15/63
CPC分类号： A61K39/39 , A61K39/12 , A61K39/21 , A61K39/245 , A61K2039/53 , A61K2039/545 , A61K2039/555 , A61K2039/55522 , A61K2039/55527 , C07K14/523 , C07K14/5421 , C07K2319/00 , C12N2710/16634 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234
摘要： Improved vaccines which include a nucleotide sequence that encodes immunomodulating protein operably linked to regulatory elements are disclosed. The improved vaccines include DNA vaccines, recombinant vaccines for delivering foreign antigen and live attenuated vaccines. Methods of immunizing individuals are disclosed. Compositions for and methods of treating individuals with autoimmune diseases are disclosed.
摘要翻译：公开了包括编码与调控元件可操作地连接的免疫调节蛋白的核苷酸序列的改进的疫苗。改进的疫苗包括DNA疫苗，用于递送外源抗原和活减毒疫苗的重组疫苗。公开了免疫个体的方法。公开了治疗患有自身免疫性疾病的个体的组合物和方法。

3. 发明授权

US08119395B1 Vaccines, immunotherapeutics and methods for using the same 有权
标题翻译：疫苗，免疫治疗剂及其使用方法
公开(公告)号：US08119395B1
公开(公告)日：2012-02-21
申请号：US09622452
申请日：1999-02-26
申请人： David B. Weiner , Jong J. Kim , Jeong-Im Sin
发明人： David B. Weiner , Jong J. Kim , Jeong-Im Sin
IPC分类号： C12N15/85 , A61K48/00 , C12N15/33
CPC分类号： A61K39/39 , A61K39/12 , A61K39/21 , A61K39/245 , A61K2039/53 , A61K2039/545 , A61K2039/555 , A61K2039/55522 , A61K2039/55527 , C07K14/523 , C07K14/5421 , C07K2319/00 , C12N2710/16634 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234
摘要： Improved vaccines which include a nucleotide sequence that encodes immunomodulating protein operably linked to regulatory elements are disclosed. The improved vaccines include DNA vaccines, recombinant vaccines for delivering foreign antigen and live attenuated vaccines. Methods of immunizing individuals are disclosed. Compositions for and methods of treating individuals with autoimmune diseases are disclosed.
摘要翻译：公开了包括编码与调控元件可操作地连接的免疫调节蛋白的核苷酸序列的改进的疫苗。改进的疫苗包括DNA疫苗，用于递送外源抗原和活减毒疫苗的重组疫苗。公开了免疫个体的方法。公开了治疗患有自身免疫性疾病的个体的组合物和方法。

4. 发明授权

US07569218B2 Compositions for and methods of using herpes simplex virus glycoprotein D to suppress immune responses 有权
标题翻译：使用单纯疱疹病毒糖蛋白D的组合物和方法来抑制免疫应答
公开(公告)号：US07569218B2
公开(公告)日：2009-08-04
申请号：US10333802
申请日：2001-07-27
申请人： David B. Weiner , Jeong-Im Sin
发明人： David B. Weiner , Jeong-Im Sin
IPC分类号： A61K48/00
CPC分类号： A61K48/00 , A61K38/162 , A61K39/385 , A61K2039/53 , A61K2039/6075 , C07K14/005 , C12N2710/10343 , C12N2710/16622
摘要： Methods of delivering a desired polypeptide to an individual are disclosed. The methods comprise administering to the individual an immunogenic vector comprising a nucleic acid encoding the desired polypeptide operably linked to regulatory elements in combination with one or more of gD protein, a function fragment of gD protein, a nucleic acid encoding gD protein operably linked to regulatory elements, or a nucleic acid encoding a functional fragment of gD protein operably linked to regulatory elements. Compositions comprising an immunogenic vector that comprises a nucleic acid encoding the desired polypeptide operably linked to regulatory elements; and one or more of gD protein, a function fragment of gD protein, a nucleic acid encoding gD protein operably linked to regulatory elements, or a nucleic acid encoding a functional fragment of gD protein operably linked to regulatory elements are disclosed. Methods for inhibiting an undesirable immune response in an individual are disclosed.
摘要翻译：公开了将期望的多肽递送给个体的方法。所述方法包括向个体施用免疫原性载体，其包含编码所需多肽的核酸，其与调节元件结合使用，所述多核苷酸可与gD蛋白，gD蛋白的功能片段，编码可调控的元件或编码与调节元件可操作地连接的gD蛋白的功能性片段的核酸。包含免疫原性载体的组合物，其包含编码可操作地连接到调节元件的所需多肽的核酸; 并且公开了一种或多种gD蛋白，gD蛋白的功能片段，编码与调控元件可操作地连接的gD蛋白的核酸，或编码与调节元件可操作地连接的gD蛋白的功能性片段的核酸。公开了抑制个体中不期望的免疫应答的方法。

5. 发明申请

US20080219953A1 Cosmid dna constructs and methods of making and using same 有权
标题翻译：粘粒dna构建及其制作和使用方法
公开(公告)号：US20080219953A1
公开(公告)日：2008-09-11
申请号：US10168694
申请日：2000-12-22
申请人： David B. Weiner , Jeong-Im Sin , Donghui Zhang
发明人： David B. Weiner , Jeong-Im Sin , Donghui Zhang
IPC分类号： A61K48/00 , A61K31/445 , C12N15/86
CPC分类号： A61K39/00 , A61K39/12 , A61K39/245 , A61K48/00 , A61K2039/53 , A61K2039/54 , C12N2710/16634
摘要： Methods of inducing immune responses in individuals against a pathogen are disclosed. Methods of treating individuals susceptible to or suffering from a disease associated with a genetic defect which results in the non-production or under production of a protein or the production of a non-functioning or partially functioning protein are disclosed. Methods of delivering a protein to an individual are disclosed. Pharmaceutical compositions that comprise cosmids are disclosed.
摘要翻译：公开了在针对病原体的个体中诱导免疫应答的方法。公开了治疗导致非生产或正在产生蛋白质或产生不起作用或部分功能的蛋白质的遗传缺陷相关疾病或患有疾病的个体的方法。公开了向个体递送蛋白质的方法。公开了包含粘粒的药物组合物。

6. 发明授权

US08529884B2 Cosmid DNA constructs and methods of making and using same 有权
标题翻译：粘粒DNA构建体及其制备和使用方法
公开(公告)号：US08529884B2
公开(公告)日：2013-09-10
申请号：US10168694
申请日：2000-12-22
申请人： David B. Weiner , Jeong-Im Sin , Donghui Zhang
发明人： David B. Weiner , Jeong-Im Sin , Donghui Zhang
IPC分类号： A01N63/00 , A01N43/04
CPC分类号： A61K39/00 , A61K39/12 , A61K39/245 , A61K48/00 , A61K2039/53 , A61K2039/54 , C12N2710/16634
摘要： Methods of inducing immune responses in individuals against a pathogen are disclosed. Methods of treating individuals susceptible to or suffering from a disease associated with a genetic defect which results in the non-production or under production of a protein or the production of a non-functioning or partially functioning protein are disclosed. Methods of delivering a protein to an individual are disclosed. Pharmaceutical compositions that comprise cosmids are disclosed.
摘要翻译：公开了在针对病原体的个体中诱导免疫应答的方法。公开了治疗导致非生产或正在产生蛋白质或产生不起作用或部分功能的蛋白质的遗传缺陷相关疾病或患有疾病的个体的方法。公开了向个体递送蛋白质的方法。公开了包含粘粒的药物组合物。

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