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    • 5. 发明授权
    • Universally adjustable telescopic spectacle assembly for use with
implanted intraocular lenses and associated methods
    • 通用可调伸缩眼镜组件,用于植入人工晶状体及相关方法
    • US4863468A
    • 1989-09-05
    • US128921
    • 1987-12-04
    • Richard E. FeinbloomDavid B. Soll
    • Richard E. FeinbloomDavid B. Soll
    • A61F2/16G02C7/02
    • G02C7/02A61F2/16A61F2/1651
    • A universally adjustable telescopic spectacle assembly for use with an implanted intraocular lens employs an objective lens which has positioned in front of the objective lens a cylindrical lens to provide cylindrical correction to the handicapped user. The telescopic assembly employs universal motion in that the assembly can be moved with respect to a spectacle frame so that one is able to shift the objective lens axis about a central point while further having the capability of moving the objective lens in a spiral motion away from or towards the eye of the user and further having means for providing a pivotal joint mechanism to permit maximum oblique adjustment of the entire telescopic assembly as related to the optical or central axis of the objective lens. In this manner any change in conditions of vision or a misalignment of the intraocular lens as inserted during surgery can be compensated for by the universal adjustable telescopic assembly as disclosed.
    • 与植入式眼内透镜一起使用的普遍可调节的伸缩眼镜组件采用位于物镜前方的柱面透镜的物镜,以向残疾用户提供圆柱形校正。 伸缩组件采用通用运动,因为组件可以相对于眼镜架移动,使得能够使物镜轴线绕中心点移动,同时还具有将物镜以螺旋运动远离的能力 或朝向使用者的眼睛,并且还具有用于提供枢转关节机构以允许与物镜的光学或中心轴相关的整个伸缩组件的最大倾斜调节的装置。 以这种方式,可以通过如所公开的通用可调式伸缩组件来补偿在手术期间插入的眼内晶状体的视力条件或者未对准的任何变化。
    • 8. 发明申请
    • Ophthalmic composition
    • 眼科成分
    • US20100105643A1
    • 2010-04-29
    • US12589341
    • 2009-10-22
    • David B. Soll
    • David B. Soll
    • A61K31/57A61P27/02
    • B82Y5/00A61K9/0048A61K9/14A61K31/57A61K45/06A61K47/40A61K47/6951A61K2300/00
    • It has now been found that tetrahydrocortisol alone, when in solution or in the form of nanoparticles, or a combination of compounds where each affects intraocular pressure by a different mechanism of action is especially valuable for the treatment of elevated intraocular pressure and glaucoma, especially in the resistant patient. With such a combination, each compound may be present at a reduced concentration, even to a sub-therapeutic level (i.e., as little as 25% to 50% of the usual therapeutically active dose), thus decreasing or eliminating troublesome side effects while the combined effect on reducing intraocular pressure remains in the therapeutically useful range.
    • 现在已经发现,当以溶液或纳米颗粒的形式单独使用四氢皮质醇或其中各种通过不同作用机制影响眼内压的化合物的组合对于治疗眼内压升高和青光眼尤其有用,特别是在 耐药患者。 通过这样的组合,每种化合物可以以降低的浓度,甚至达到亚治疗水平(即,通常治疗活性剂量的少至25%至50%)存在,从而减少或消除麻烦的副作用,同时 对降低眼内压的联合作用保持在治疗上有用的范围。
    • 9. 发明授权
    • Protection of human and animal cells
    • 保护人体和动物细胞
    • US5498606A
    • 1996-03-12
    • US109206
    • 1993-08-19
    • David B. SollSol E. Harrison
    • David B. SollSol E. Harrison
    • A61K31/70A61K31/715
    • A61K31/70A61K31/715
    • The cells of the coverings and linings of internal human and animal tissues, organs and body cavities subject to trauma, such as surgery, may be protected against exfoliation or destruction by the topical application or injection of effective amounts of chondroitin sulfate prior to or during the trauma. Preferably, the chondroitin sulfate is used in physiological solutions in concentrations of about 40 to 55 weight percent, and may be used as a surgical irrigating solution. Intraarticular injection of such chondroitin sulfate solutions into human and animal joints having degenerative joint conditions protects the joint cells, reduces aseptic inflammation and/or prevents further degeneration of cartilage tissue. Solutions for preserving human and animal cells and tissues in vitro for later in vivo use have extended storage life when chondroitin sulfate is added to such storage solutions in effective amounts such as about 1 to 20 weight percent of the storage solution.
    • 内部人体和动物组织,受创伤的器官和体腔(例如外科手术)的覆盖物和衬里的细胞可以被保护以免受局部施用或在注射有效量的硫酸软骨素之前的剥落或破坏 外伤。 优选地,硫酸软骨素在浓度为约40至55重量%的生理溶液中使用,并且可以用作手术灌洗溶液。 将这种硫酸软骨素溶液注射到具有退行性关节病症的人和动物关节中保护关节细胞,减少无菌性炎症和/或防止软骨组织进一步退化。 用于在体外保存人体和动物细胞和组织以用于后续体内使用的解决方案将硫酸软骨素添加到有效量例如约1至20重量%的储存溶液的这种储存溶液中具有延长的储存寿命。