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1. 发明申请

US20080076145A1 Transgenic flies expressing tau and amyloid precursor fragment 审中-公开
标题翻译：表达tau和淀粉样前体片段的转基因蝇
公开(公告)号：US20080076145A1
公开(公告)日：2008-03-27
申请号：US11818413
申请日：2007-06-14
申请人： Christopher Cummings , Matthew Mahoney , Carol Singh
发明人： Christopher Cummings , Matthew Mahoney , Carol Singh
IPC分类号： A01K67/00 , C12N5/06 , C12Q1/20 , G01N33/00
CPC分类号： A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/0312 , C07K14/4711 , C12N15/8509 , C12N2830/002 , C12N2830/008
摘要： The present invention discloses a transgenic fly that expresses a carboxy terminal fragment of the human amyloid-β precursor protein (APP) and a double transgenic fly that expresses both the fragment of APP and tau protein. The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.
摘要翻译：本发明公开了表达人淀粉样蛋白-β前体蛋白（APP）的羧基末端片段和表达APP和tau蛋白片段的双转基因飞蝇的转基因飞行物。本发明的转基因苍蝇提供了神经变性疾病如阿尔茨海默氏病的模型。本发明进一步公开了用于鉴定遗传修饰剂的方法，以及用于鉴定使用转基因苍蝇治疗神经变性疾病的治疗化合物的筛选方法。

2. 发明申请

US20050137220A1 Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors 审中-公开
标题翻译： β-咔啉化合物及其类似物作为丝裂原活化蛋白激酶活化蛋白激酶-2抑制剂
公开(公告)号：US20050137220A1
公开(公告)日：2005-06-23
申请号：US10895187
申请日：2004-07-20
申请人： David Anderson , Ingrid Buchler , Shridhar Hegde , Matthew Mahoney , Marvin Meyers , David Reitz , John Trujillo , William Vernier , Kun Wu
发明人： David Anderson , Ingrid Buchler , Shridhar Hegde , Matthew Mahoney , Marvin Meyers , David Reitz , John Trujillo , William Vernier , Kun Wu
IPC分类号： A61K20060101 , A61K31/40 , A61K31/403 , A61K31/407 , A61K31/4745 , A61K31/55 , C07D209/82 , C07D209/94 , C07D471/02 , C07D471/14
CPC分类号： A61K31/40 , C07D471/04 , C07D471/14 , C07D471/18 , Y02A50/475
摘要： A method is described for inhibiting mitogen activated protein kinase-activated protein kinase-2 in a subject in need of such inhibition, where the method involves administering to the subject a beta-carboline MK-2 inhibiting compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：描述了一种在需要这种抑制的受试者中抑制丝裂原活化蛋白激酶活化蛋白激酶-2的方法，其中该方法涉及向受试者施用β-咔啉MK-2抑制化合物或其药学上可接受的盐。

3. 发明申请

US20090289819A1 EFFICIENT DATA COMPRESSION & DECOMPRESSION OF NUMERIC SEQUENCES 有权
标题翻译：有效的数据压缩和解码数字序列
公开(公告)号：US20090289819A1
公开(公告)日：2009-11-26
申请号：US12470469
申请日：2009-05-21
申请人： Matthew Mahoney
发明人： Matthew Mahoney
IPC分类号： H03M7/34
CPC分类号： H03M7/24 , H03M7/4006
摘要： Embodiments described herein relate to compression and decompression of data consisting of a one dimensional time series of floating point numbers. A compressor may comprise a lossless stage and in some embodiments a lossy stage in addition to the lossless stage. The lossy stage quantizes the data by discarding some of the least significant bits as specified by the user. The lossless stage uses a context mixing algorithm with two bit-wise predictive models whose predictions are combined and fed to an arithmetic coder. One model is a direct context model using the most significant bits of prior numeric samples as context. The other model is the output of an adaptive filter, in which the approximate predicted numeric value is used as context to model the actual value. A corresponding decompressor uses the same lossless model with the arithmetic coder replaced by an arithmetic decoder.
摘要翻译：本文描述的实施例涉及由一维时间序列的浮点数组成的数据的压缩和解压缩。压缩机可以包括无损阶段，并且在一些实施例中，除了无损阶段之外还包括有损阶段。有损阶段通过丢弃由用户指定的一些最低有效位来量化数据。无损阶段使用具有两个逐位预测模型的上下文混合算法，其预测被组合并被馈送到算术编码器。一个模型是使用现有数字样本的最高有效位作为上下文的直接上下文模型。另一个模型是自适应滤波器的输出，其中将近似预测数值用作对实际值进行建模的上下文。对应的解压缩器使用与算术解码器替换的算术编码器相同的无损模型。

4. 发明申请

US20050101623A1 Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors 审中-公开
标题翻译： β-咔啉化合物及其类似物作为丝裂原活化蛋白激酶活化蛋白激酶-2抑制剂
公开(公告)号：US20050101623A1
公开(公告)日：2005-05-12
申请号：US10894594
申请日：2004-07-20
申请人： Marvin Meyers , David Anderson , Shridhar Hegde , John Trujillo , David Reitz , Matthew Mahoney , William Vernier , Ingrid Buchler , Kun Wu
发明人： Marvin Meyers , David Anderson , Shridhar Hegde , John Trujillo , David Reitz , Matthew Mahoney , William Vernier , Ingrid Buchler , Kun Wu
IPC分类号： A61K20060101 , A61K31/40 , A61K31/403 , A61K31/407 , A61K31/4745 , A61K31/55 , C07D209/82 , C07D209/94 , C07D471/02 , C07D471/14
CPC分类号： A61K31/40 , C07D471/04 , C07D471/14 , C07D471/18 , Y02A50/475
摘要： The present invention provides novel bridged beta-carboline compounds that are capable of inhibiting mitogen activated protein kinase-activated protein kinase-2 and analogues thereof and pharmaceutical compositions and kits that include these compounds.
摘要翻译：本发明提供能够抑制丝裂原活化蛋白激酶活化蛋白激酶-2及其类似物的新型桥连β-咔啉化合物和包括这些化合物的药物组合物和试剂盒。

5. 发明申请

US20050043313A1 Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade 审中-公开
公开(公告)号：US20050043313A1
公开(公告)日：2005-02-24
申请号：US10940693
申请日：2004-09-14
申请人： Michael South , Brenda Case , Thomas Dice , Ricky Fenton , Gary Franklin , Michael Hayes , Horng-Chih Huang , Wei Huang , Darin Jones , Carrie Kusturin , Richard Lindmark , Scott Long , William Neumann , David Reitz , John Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Matthew Mahoney , John Parlow , Melvin Rueppel
发明人： Michael South , Brenda Case , Thomas Dice , Ricky Fenton , Gary Franklin , Michael Hayes , Horng-Chih Huang , Wei Huang , Darin Jones , Carrie Kusturin , Richard Lindmark , Scott Long , William Neumann , David Reitz , John Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Matthew Mahoney , John Parlow , Melvin Rueppel
IPC分类号： A61K38/00 , C07D241/20 , C07D401/12 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/06 , C07K5/078 , A61K31/4965 , A61K31/497 , C07D43/02
CPC分类号： C07D401/12 , A61K38/00 , C04B35/632 , C07D241/20 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/06139 , C07K5/06191
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.

6. 发明授权

US07864083B2 Efficient data compression and decompression of numeric sequences 有权
标题翻译：数字序列的高效数据压缩和解压缩
公开(公告)号：US07864083B2
公开(公告)日：2011-01-04
申请号：US12470469
申请日：2009-05-21
申请人： Matthew Mahoney
发明人： Matthew Mahoney
IPC分类号： H03M7/30
CPC分类号： H03M7/24 , H03M7/4006
摘要： Embodiments described herein relate to compression and decompression of data consisting of a one dimensional time series of floating point numbers. A compressor may comprise a lossless stage and in some embodiments a lossy stage in addition to the lossless stage. The lossy stage quantizes the data by discarding some of the least significant bits as specified by the user. The lossless stage uses a context mixing algorithm with two bit-wise predictive models whose predictions are combined and fed to an arithmetic coder. One model is a direct context model using the most significant bits of prior numeric samples as context. The other model is the output of an adaptive filter, in which the approximate predicted numeric value is used as context to model the actual value. A corresponding decompressor uses the same lossless model with the arithmetic coder replaced by an arithmetic decoder.
摘要翻译：本文描述的实施例涉及由一维时间序列的浮点数组成的数据的压缩和解压缩。压缩机可以包括无损阶段，并且在一些实施例中，除了无损阶段之外还包括有损阶段。有损阶段通过丢弃由用户指定的一些最低有效位来量化数据。无损阶段使用具有两个逐位预测模型的上下文混合算法，其预测被组合并被馈送到算术编码器。一个模型是使用现有数字样本的最高有效位作为上下文的直接上下文模型。另一个模型是自适应滤波器的输出，其中将近似预测数值用作对实际值进行建模的上下文。对应的解压缩器使用与算术解码器替换的算术编码器相同的无损模型。

7. 发明申请

US20050143371A1 Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors 审中-公开
标题翻译： β-咔啉化合物及其类似物作为丝裂原活化蛋白激酶活化蛋白激酶-2抑制剂
公开(公告)号：US20050143371A1
公开(公告)日：2005-06-30
申请号：US10894567
申请日：2004-07-20
申请人： Marvin Meyers , David Reitz , David Anderson , Shridhar Hegde , Matthew Mahoney
发明人： Marvin Meyers , David Reitz , David Anderson , Shridhar Hegde , Matthew Mahoney
IPC分类号： A61K20060101 , A61K31/40 , A61K31/403 , A61K31/407 , A61K31/4745 , A61K31/55 , C07D209/82 , C07D209/94 , C07D471/02 , C07D471/14
CPC分类号： A61K31/40 , C07D471/04 , C07D471/14 , C07D471/18 , Y02A50/475
摘要： The present invention provides novel compounds that are capable of inhibiting mitogen activated protein kinase-activated protein kinase-2 and analogues thereof and pharmaceutical compositions and kits that include these compounds.
摘要翻译：本发明提供能够抑制丝裂原活化蛋白激酶活化蛋白激酶-2及其类似物的新型化合物和包括这些化合物的药物组合物和试剂盒。

8. 发明授权

US06664255B1 Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade 失效
标题翻译：用于选择性抑制凝血级联的取代的多环芳基和杂芳基吡嗪酮
公开(公告)号：US06664255B1
公开(公告)日：2003-12-16
申请号：US09574752
申请日：2000-05-18
申请人： Michael South , John J. Parlow , Darin E. Jones , Brenda Case , Tom Dice , Richard Lindmark , Michael J. Hayes , Melvin L. Rueppel , Horng-Chih Huang , Wei Huang , Scott A. Long , Matthew Mahoney , William L. Neumann , David Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Rick Fenton , Gary W. Franklin , Carrie Kusturin
发明人： Michael South , John J. Parlow , Darin E. Jones , Brenda Case , Tom Dice , Richard Lindmark , Michael J. Hayes , Melvin L. Rueppel , Horng-Chih Huang , Wei Huang , Scott A. Long , Matthew Mahoney , William L. Neumann , David Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Rick Fenton , Gary W. Franklin , Carrie Kusturin
IPC分类号： C07D24120
CPC分类号： C07D417/12 , A61K38/00 , C07D241/20 , C07D401/12 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07K5/06139 , C07K5/06191
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
摘要翻译：本发明涉及可用作凝血级联丝氨酸蛋白酶抑制剂的取代的多环芳基和杂芳基吡嗪酮化合物，以及用于治疗和预防各种血栓形成病症（包括冠状动脉和脑血管疾病）的抗凝血治疗的化合物，组合物和方法。

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