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1. 发明申请

US20050256098A1 CGRP receptor antagonists 有权
公开(公告)号：US20050256098A1
公开(公告)日：2005-11-17
申请号：US11152537
申请日：2005-06-14
申请人： Christopher Burgey , Zhengwu Deng , Diem Nguyen , Daniel Paone , Anthony Shaw , Theresa Williams
发明人： Christopher Burgey , Zhengwu Deng , Diem Nguyen , Daniel Paone , Anthony Shaw , Theresa Williams
IPC分类号： A61K31/4188 , A61K31/55 , A61K31/553 , A61K31/554 , A61P25/06 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/00 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention is directed to compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

2. 发明申请

US20070225272A1 CGRP receptor antagonists 有权
标题翻译： CGRP受体拮抗剂
公开(公告)号：US20070225272A1
公开(公告)日：2007-09-27
申请号：US11724066
申请日：2007-03-14
申请人： Christopher Burgey , Zhengwu Deng , Diem Nguyen , Daniel Paone , Anthony Shaw , Theresa Williams
发明人： Christopher Burgey , Zhengwu Deng , Diem Nguyen , Daniel Paone , Anthony Shaw , Theresa Williams
IPC分类号： A61K31/55 , C07D401/14
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention is directed to compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译：本发明涉及式I化合物和式II化合物：其中R 1，R 2，R 3，R 3， A，B，G，J，Q，T，U，V，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防 CGRP涉及，如头痛，偏头痛和丛集性头痛。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

3. 发明申请

US20060194783A1 Cgrp receptor antagonists 有权
标题翻译： Cgrp受体拮抗剂
公开(公告)号：US20060194783A1
公开(公告)日：2006-08-31
申请号：US10551830
申请日：2004-04-09
申请人： Christopher Burgey , Daniel Paone , Anthony Shaw , Theresa Williams
发明人： Christopher Burgey , Daniel Paone , Anthony Shaw , Theresa Williams
IPC分类号： A61K31/554 , A61K31/55 , A61K31/553 , C07D417/14 , C07D413/14 , C07D403/14
CPC分类号： C07D401/14 , C07D413/14
摘要： The present invention is directed to compounds of Formula I and Formula II: (where variables R1, R2, R3, R4, R6, A, B, G, J, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译：本发明涉及用作CGRP拮抗剂的式I和式II化合物（其中变量R1，R2，R3，R4，R6，A，B，G，J，W，X和Y如本文所定义）受体，并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

4. 发明申请

US20070287696A1 Cgrp Receptor Antagonists 有权
标题翻译： Cgrp受体拮抗剂
公开(公告)号：US20070287696A1
公开(公告)日：2007-12-13
申请号：US10587121
申请日：2005-01-25
申请人： Christopher Burgey , Daniel Paone , Anthony Shaw , Craig Stump , Theresa Williams
发明人： Christopher Burgey , Daniel Paone , Anthony Shaw , Craig Stump , Theresa Williams
IPC分类号： A61K31/551 , A61K31/454 , A61K31/553 , A61K31/554 , A61P25/00 , A61P25/06 , C07D243/08 , C07D267/10 , C07D401/14
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14
摘要： Compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, D, G, J, Q, T, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, pharmaceutical compositions comprising these compounds, use of these compounds and compositions to prevent or treat diseases involving CGRP.
摘要翻译：式I化合物和式II化合物（其中R 1，R 2，R 3，R 4，R 4， >，A，B，D，G，J，Q，T，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病，药物组合物包括这些化合物，使用这些化合物和组合物来预防或治疗涉及CGRP的疾病。

5. 发明申请

US20070287697A1 Cgrp Receptor Antagonists 有权
标题翻译： Cgrp受体拮抗剂
公开(公告)号：US20070287697A1
公开(公告)日：2007-12-13
申请号：US11665520
申请日：2005-10-12
申请人： Daniel Paone , Anthony Shaw , Craig Potteiger
发明人： Daniel Paone , Anthony Shaw , Craig Potteiger
IPC分类号： A61K31/55 , A61K31/44 , A61K31/445 , A61K31/551 , A61P43/00 , C07D213/00 , C07D237/26 , C07D241/36 , C07D267/02 , C07D243/06 , C07D239/70 , C07D223/02 , C07D211/00 , A61K31/553 , A61K31/4985 , A61K31/519
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： Compounds of Formula (I) and Formula (II) (where variables R1, R2, R4, A, B, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译：式（I）和式（II）化合物（其中R 1，R 2，R 4，A，B，W， X，Y和Z如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

6. 发明申请

US20070269259A9 Mesh sponge with pocket 审中-公开
标题翻译：口袋海绵
公开(公告)号：US20070269259A9
公开(公告)日：2007-11-22
申请号：US11483112
申请日：2006-07-07
申请人： Anthony Shaw
发明人： Anthony Shaw
IPC分类号： A47K7/02
CPC分类号： A47K7/03 , A47K7/02
摘要： A mesh sponge is formed as a batting of multiple layers of a tubular mesh material defining a pocket. The pocket may house a cleaning aid article, for example, a bar of soap or a structural form. Liquid soap may be used in conjunction with the mesh sponge and structural form, which provides a solid feel to the user. The pocket in the mesh sponge may house a bladder that is filled with liquid soap. The bladder may be porous or contain one or more valved openings to facilitate the excretion or dispensing of the liquid soap upon squeezing of the bladder by a user.
摘要翻译：形成网状海绵作为限定袋的多层管状网状材料的棉条。口袋可以容纳清洁助剂物品，例如一条肥皂或结构形式。液体皂可以与网状海绵和结构形式结合使用，这为使用者提供了坚实的感觉。网状海绵中的口袋可容纳充满液体肥皂的膀胱。膀胱可以是多孔的或包含一个或多个阀门开口，以便于在用户挤压膀胱时排出或分配液体肥皂。

7. 发明授权

US07022527B2 Method for the simultaneous and direct determination of serum cholesterol in high and low density lipoproteins using infrared spectroscopy 有权
标题翻译：使用红外光谱法同时直接测定高密度脂蛋白和低密度脂蛋白的血清胆固醇的方法
公开(公告)号：US07022527B2
公开(公告)日：2006-04-04
申请号：US10485413
申请日：2002-09-11
申请人： Kan-Zhi Liu , Anthony Shaw , Henry H. Mantsch
发明人： Kan-Zhi Liu , Anthony Shaw , Henry H. Mantsch
IPC分类号： G01N33/92
CPC分类号： G01N33/491 , G01N21/35 , G01N21/359 , G01N33/92 , G01N2201/1293
摘要： A method of simultaneously determining the concentrations of cardiovascular risk markers selected from the group consisting of High Density Lipoprotein cholesterol (HDL-C), Low Density Lipoprotein cholesterol (LDL-C), total cholesterol, triglycerides and oxidized LDL using infra-red and/or near infrared light is described.
摘要翻译：选自高密度脂蛋白胆固醇（HDL-C），低密度脂蛋白胆固醇（LDL-C），总胆固醇，甘油三酯和氧化低密度脂蛋白的心血管风险标志物浓度的方法，其使用红外和/ 或近红外光。

8. 发明授权

US06398238B1 Steering control mechanism for kick scooter 失效
标题翻译：脚踏车的转向控制机构
公开(公告)号：US06398238B1
公开(公告)日：2002-06-04
申请号：US09865556
申请日：2001-05-29
申请人： Anthony Shaw
发明人： Anthony Shaw
IPC分类号： A63C1700
CPC分类号： B62K3/002
摘要： A steering control mechanism formed of a base, two steering bars, an intermediate block, and two links, and installed in a kick scooter to function as two parallel four-bar linkages for controlling the steering direction of the front wheels of the kick scooter.
摘要翻译：一种由基座，两个转向杆，中间块和两个连杆组成的转向控制机构，并安装在脚踏踏板车中，用作两个平行的四杆连杆，用于控制脚踏踏板车前轮的转向方向。

9. 发明申请

US20070215809A1 MICROFLUIDIC PRECONDITIONING OF (BIO)FLUIDS FOR REAGENT-FREE INFRARED CLINICAL ANALYSIS AND DIAGNOSTICS 有权
标题翻译：用于无菌红细胞临床分析和诊断的（生物）流体的微流感预处理
公开(公告)号：US20070215809A1
公开(公告)日：2007-09-20
申请号：US11568937
申请日：2005-05-05
申请人： Colin Mansfield , Anthony Shaw
发明人： Colin Mansfield , Anthony Shaw
IPC分类号： G01N21/35
CPC分类号： G01N21/35 , G01N21/03 , G01N2001/4016 , G01N2001/4072
摘要： A number of reagent-free infrared spectroscopic diagnostic and analytical methods have been established previously, making use of dry biofluid films. For example, this approach has successfully measured high concentration analytes of serum and urine. However, a number of low concentration diagnostically relevant analytes presently elude detection by infrared spectroscopy. This is due in part to their relatively low concentration and in part to spectral interference by other strongly absorbing constituents. The applicability of the technique would be broadened substantially if it were possible to separate and concentrate, lower concentration analytes, e.g. serum creatinine and urine proteins, from the obscuring presence of relatively high concentration compounds. The invention disclosed achieves this is through microfluidic sample preconditioning based upon laminar fluid diffusion interfaces. Preferential separation of certain low concentration serum and urine analytes of clinical interest that presently lie just below the threshold of detection by infrared spectroscopy is provided.
摘要翻译：以前已经建立了许多无试剂的红外光谱诊断和分析方法，利用干生物流体膜。例如，这种方法已成功测量血清和尿液的高浓度分析物。然而，许多低浓度诊断相关分析物目前排除通过红外光谱检测。这部分归因于它们的相对低的浓度，部分是由于其它强吸收组分的光谱干扰。如果可以分离和浓缩，降低浓度的分析物，例如，可以将该技术的适用性显着扩大。血清肌酐和尿蛋白，来自相对高浓度化合物的模糊存在。所公开的发明通过基于层流扩散界面的微流体样品预处理来实现。提供目前正在低于通过红外光谱法检测阈值的临床兴趣的某些低浓度血清和尿液分析物的优先分离。

10. 发明申请

US20070065224A1 Mesh sponge with pocket 审中-公开
公开(公告)号：US20070065224A1
公开(公告)日：2007-03-22
申请号：US11483112
申请日：2006-07-07
申请人： Anthony Shaw
发明人： Anthony Shaw
IPC分类号： A47K7/02
CPC分类号： A47K7/03 , A47K7/02
摘要： A mesh sponge is formed as a batting of multiple layers of a tubular mesh material defining a pocket. The pocket may house a cleaning aid article, for example, a bar of soap or a structural form. Liquid soap may be used in conjunction with the mesh sponge and structural form, which provides a solid feel to the user. The pocket in the mesh sponge may house a bladder that is filled with liquid soap. The bladder may be porous or contain one or more valved openings to facilitate the excretion or dispensing of the liquid soap upon squeezing of the bladder by a user.

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