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1. 发明授权

US06495713B2 Synthesis of ketosulfone esters 失效
标题翻译：酮砜酯的合成
公开(公告)号：US06495713B2
公开(公告)日：2002-12-17
申请号：US10052088
申请日：2002-01-17
申请人： Cheng Yi Chen , Weirong Chen , Paul O'Shea , Lushi Tan , Richard Tillyer , Feng Xu , Philippe Dagneau
发明人： Cheng Yi Chen , Weirong Chen , Paul O'Shea , Lushi Tan , Richard Tillyer , Feng Xu , Philippe Dagneau
IPC分类号： C07C6966
CPC分类号： C07C315/02 , C07C319/20 , C07C317/24 , C07C323/22
摘要： This invention encompasses a process for making a compound of Formula A These compounds are intermediates useful in the preparation of certain non-steroidal anti-inflammnatory agents.
摘要翻译：本发明包括制备式的化合物的方法。该化合物是可用于制备某些非甾体抗炎剂的中间体。

2. 发明申请

US20170233382A1 PROCESSES FOR THE PREPARATION OF A BACE INHIBITOR 审中-公开
公开(公告)号：US20170233382A1
公开(公告)日：2017-08-17
申请号：US15503035
申请日：2015-08-10
申请人： Steven P. MILLER , Carmela MOLINARO , David THAISRIVONGS , Feng XU , Richard DESMOND , Hongming LI , Qinghao CHEN , Andrew STAMFORD , Zhiguo Jake SONG , Lushi TAN , Merck Sharp & Dohme Corp.
发明人： Steven P. Miller , Carmela Molinaro , David Thaisrivongs , Feng Xu , Richard Desmond , Hongming Li , Qinghao Chen , Andrew W. Stamford , Zhiguo Jake Song , Lushi Tan
IPC分类号： C07D417/12 , C07C313/06 , C07C311/33 , C07D213/81
CPC分类号： C07D417/12 , C07C303/40 , C07C311/33 , C07C311/35 , C07C313/06 , C07D213/81
摘要： This invention provides processes for the preparation of verubecestat (Compound of Formula (I)), a potent inhibitor of BACE-1 and BACE-2. In addition, the invention provides certain synthetic intermediates which are useful, among other things, for the preparation of the Compound of Formula (I).

3. 发明申请

US20050119343A1 Dihydroxy open-acid salt of simvastatin 审中-公开
标题翻译：辛伐他汀二羟基开酸盐
公开(公告)号：US20050119343A1
公开(公告)日：2005-06-02
申请号：US10981866
申请日：2004-11-05
申请人： Richard Tillyer , Paul Reider , Edward Grabowski , Feng Xu , Robert Wenslow , Jose Vega , Richard Varsolona
发明人： Richard Tillyer , Paul Reider , Edward Grabowski , Feng Xu , Robert Wenslow , Jose Vega , Richard Varsolona
IPC分类号： A61K9/52 , A61K9/00 , A61K9/28 , A61K31/22 , A61K31/366 , A61P3/06 , A61P9/10 , A61P43/00 , C07C67/28 , C07C67/52 , C07C67/56 , C07C69/30 , C07D309/30 , A61K31/225 , C07C69/66
CPC分类号： A61K31/366 , A61K9/0004 , A61K31/22 , C07C69/30 , C07C2602/28 , C07D309/30
摘要： The instant invention provides methods and pharmaceutical compositions for inhibiting HMG-CoA reductase, as well as for treating and/or reducing the risk for diseases and conditions affected by inhibition of HMG-CoA reductase, comprising orally administering a therapeutically effective amount of a crystalline hydrated form of the calcium salt of dihydroxy open acid simvastatin to a patient in need of such treatment. Methods for making the calcium salt of dihydroxy open acid simvastatin are also provided.
摘要翻译：本发明提供用于抑制HMG-CoA还原酶的方法和药物组合物，以及用于治疗和/或降低受HMG-CoA还原酶抑制影响的疾病和病症的风险，包括口服施用治疗有效量的水合形式的二羟基开酸辛伐他汀的钙盐对需要这种治疗的患者。还提供了制备二羟基开酸辛伐他汀钙盐的方法。

4. 发明授权

US5856492A Efficient synthesis of a chiral mediator 失效
标题翻译：有效合成手性介体
公开(公告)号：US5856492A
公开(公告)日：1999-01-05
申请号：US2853
申请日：1998-01-05
申请人： Cheng Yi Chen , Feng Xu , Richard D. Tillyer , Dalian Zhao
发明人： Cheng Yi Chen , Feng Xu , Richard D. Tillyer , Dalian Zhao
IPC分类号： C07D209/44 , C07D221/14 , C07D295/084 , C07D295/096 , C07D211/20 , C07D207/12
CPC分类号： C07D221/14 , C07D209/44 , C07D295/092 , C07D295/096 , C07B2200/07
摘要： An efficient method for the quantitative preparation and isolation of a compound of formula I ##STR1## or its enantiomer, a chiral mediator used in enantioselective synthesis.
摘要翻译：用于定量制备和分离式I化合物或其对映异构体的有效方法，其用于对映选择性合成中的手性介质。

5. 发明授权

US09353391B2 Compositions comprising a polypeptide having cellulolytic enhancing activity and a nitrogen-containing compound and uses thereof 有权
标题翻译：包含具有纤维素分解增强活性的多肽的组合物和含氮化合物及其用途
公开(公告)号：US09353391B2
公开(公告)日：2016-05-31
申请号：US13816153
申请日：2011-08-05
申请人： Jason Quinlan , Feng Xu , Matthew Sweeney
发明人： Jason Quinlan , Feng Xu , Matthew Sweeney
IPC分类号： C12N9/42 , C12P19/14 , C12P7/10 , C12P19/02 , C12N9/24 , C12N9/96 , C12P7/14 , B01J31/06
CPC分类号： C12P19/14 , B01J31/06 , C12N9/2402 , C12N9/2437 , C12N9/2445 , C12N9/96 , C12P7/10 , C12P7/14 , C12P19/02 , C12P2203/00 , C12Y302/01021 , Y02E50/16 , Y02P20/52
摘要： The present invention relates to compositions comprising: a polypeptide having cellulolytic enhancing activity and a nitrogen-containing compound. The present invention also relates to methods of using the compositions.
摘要翻译：本发明涉及包含：具有纤维素分解增强活性的多肽和含氮化合物的组合物。本发明还涉及使用该组合物的方法。

6. 发明授权

US09125265B2 Light-emitting device control circuit 有权
标题翻译：发光装置控制电路
公开(公告)号：US09125265B2
公开(公告)日：2015-09-01
申请号：US13569945
申请日：2012-08-08
申请人： Hiroyuki Kojima , Noriaki Okada , Kazuhiko Saito , Shuhei Kawai , Feng Xu
发明人： Hiroyuki Kojima , Noriaki Okada , Kazuhiko Saito , Shuhei Kawai , Feng Xu
IPC分类号： H05B33/08 , H05B37/02
CPC分类号： H05B33/0818 , H05B33/0851
摘要： In a control circuit for a light-emitting device, a reference voltage generation circuit detects a full-wave rectified voltage and generates a first voltage as well as generating a second voltage by converting the rectified voltage into a DC voltage. A voltage corresponding to a difference between the first voltage and the second voltage or a voltage corresponding to a ratio of the first voltage to the second voltage is generated as a reference voltage by a subtraction circuit or by a division circuit, respectively. As a result, a change in amplitude of the reference voltage can be suppressed when amplitude of the rectified voltage is varied due to a variation in an AC input voltage supplied from an AC power supply.
摘要翻译：在发光装置的控制电路中，参考电压产生电路检测全波整流电压，并通过将整流电压转换成直流电压来产生第一电压以及产生第二电压。相应于第一电压和第二电压之间的差的电压或对应于第一电压与第二电压的比率的电压分别由减法电路或分频电路产生作为参考电压。结果，由于由交流电源供给的交流输入电压的变化，整流电压的振幅变化，可以抑制基准电压的振幅的变化。

7. 发明授权

US08760626B2 Focus detection apparatus for projection lithography system 失效
标题翻译：投影光刻系统的焦点检测装置
公开(公告)号：US08760626B2
公开(公告)日：2014-06-24
申请号：US13464321
申请日：2012-05-04
申请人： Jinlong Li , Song Hu , Lixin Zhao , Feng Xu , Lanlan Li , Zhuang Sheng
发明人： Jinlong Li , Song Hu , Lixin Zhao , Feng Xu , Lanlan Li , Zhuang Sheng
IPC分类号： G03B27/52 , G03B27/70 , G03F9/00
CPC分类号： G03F9/7026 , G03F9/7061
摘要： Disclosed is a focus detection apparatus for a projection lithography system. The apparatus includes: a laser; a focus optical unit configured to focusing the emitted laser beam; a force detection unit configured to reflect the focused laser beam at the backside; a position detection unit configured to detect variations in position of a light spot formed by the reflected laser beam, and output a strength signal indicating the strength of the interaction force between the force detection unit and the object; a differential amplifier configured to output a Z-direction differential signal based on the strength signal and a reference signal; a Z-direction feedback control unit configured to perform feedback control; and a scan signal generator configured to output a signal for controlling the movement of the stage in the XY plane. The focus detection apparatus has high precision, efficiency and process applicability.
摘要翻译：公开了一种用于投影光刻系统的焦点检测装置。该装置包括：激光器; 被配置为聚焦所发射的激光束的聚焦光学单元; 力检测单元，被配置为将聚焦的激光束反射到背面; 位置检测单元，被配置为检测由所述反射的激光束形成的光点的位置的变化，并且输出表示所述力检测单元与所述物体之间的相互作用力的强度的强度信号; 差分放大器，被配置为基于强度信号和参考信号输出Z方向差分信号; 配置为执行反馈控制的Z方向反馈控制单元; 以及扫描信号发生器，被配置为输出用于控制所述载物台在XY平面中的运动的信号。焦点检测装置具有高精度，高效率和工艺适用性。

8. 发明申请

US20140163240A1 PROCESS FOR THE SYNTHESIS OF (+) AND (-)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE 有权
标题翻译：合成（+）和（ - ） - 1-（3,4-二氯苯基）-3-亚甲基[[3.1.0] HEXANE
公开(公告)号：US20140163240A1
公开(公告)日：2014-06-12
申请号：US13945605
申请日：2013-07-18
申请人： Jerry A. Murry , Edwin G. Corley , Feng Xu , Bryon Simmons
发明人： Jerry A. Murry , Edwin G. Corley , Feng Xu , Bryon Simmons
IPC分类号： C07D209/52 , C07C215/38 , C07C211/29 , C07C255/46
CPC分类号： C07C255/46 , C07C211/29 , C07C215/20 , C07C215/38 , C07C2601/02 , C07D209/52
摘要： The present invention is concerned with novel processes for the preparation of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and (−)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof. These compounds have pharmaceutical utility and are known to be useful for treating e.g., depression, anxiety disorders, eating disorders and urinary incontinence.
摘要翻译：本发明涉及制备（+） - 1-（3,4-二氯苯基）-3-氮杂双环[3.1.0]己烷或其药学上可接受的盐的新方法，和（ - ） - 1- 3,4-二氯苯基）-3-氮杂双环[3.1.0]己烷或其药学上可接受的盐。这些化合物具有药物效用并且已知可用于治疗例如抑郁症，焦虑障碍，进食障碍和尿失禁。

9. 发明授权

US08724899B2 Method of processing an image and corresponding device 有权
标题翻译：处理图像和相应设备的方法
公开(公告)号：US08724899B2
公开(公告)日：2014-05-13
申请号：US13578003
申请日：2010-02-11
申请人： Debing Liu , Zhibo Chen , Xiaodong Gu , Feng Xu
发明人： Debing Liu , Zhibo Chen , Xiaodong Gu , Feng Xu
IPC分类号： G06K9/34
CPC分类号： G06T7/40 , G06T2207/10004 , G06T2207/10016 , G06T2207/20021 , G06T2207/30168 , H04N19/117 , H04N19/159 , H04N19/176 , H04N19/86 , H04N19/865
摘要： A method for processing an image divided into blocks of pixels is disclosed. The method comprises the steps of: detecting, for each block, a largest sub-block whose pixels have an equal luminance value; identifying, for each block, if the detected largest sub-block is or is not a natural texture; determining, for each block, a block blockiness level on the basis of the number of pixels within the detected largest sub-block and on the basis of the identification step; and processing the image on the basis of the block blockiness levels.
摘要翻译：公开了一种用于处理被划分成像素块的图像的方法。该方法包括以下步骤：针对每个块检测其像素具有相等亮度值的最大子块; 识别每个块，如果检测到的最大子块是或不是自然纹理; 基于所检测的最大子块内的像素数量，并基于所述识别步骤，为每个块确定块块级别; 并且基于块阻塞级别处理图像。

10. 发明申请

US20130236933A1 Methods for Producing a Fermentation Product from Lignocellulose-Containing Material 审中-公开
标题翻译：从含木素纤维素材料生产发酵产品的方法
公开(公告)号：US20130236933A1
公开(公告)日：2013-09-12
申请号：US13884027
申请日：2011-12-09
申请人： Hongzhi Huang , Yun Wang , Haiyu Ren , Ye Chen , Feng Xu
发明人： Hongzhi Huang , Yun Wang , Haiyu Ren , Ye Chen , Feng Xu
IPC分类号： C08B1/00 , C12P19/14 , C12P7/14
CPC分类号： C08B1/003 , C08H8/00 , C10L1/023 , C12P7/10 , C12P7/14 , C12P19/02 , C12P19/14 , C12P2201/00 , C12P2203/00 , C13K1/02 , C13K13/002 , C13K13/007 , Y02E50/16
摘要： The present invention provides a method for producing a fermentation product from lignocellulose-containing material, a method for converting lignocellulose-containing material into a hydrolyzate comprising mono- and oligo-saccharides, and a method for treating lignocellulose-containing material, all of which comprise the step of mixing an acid pre-treated lignocellulose-containing material and an alkaline pre-treated lignocellulose-containing material. The present invention further provides a fermentation product made according to the method for producing a fermentation product.
摘要翻译：本发明提供了一种用于从含木素纤维素的材料生产发酵产物的方法，将含木素纤维素的材料转化为包含单糖和寡糖的水解产物的方法，以及用于处理含木素纤维素的材料的方法，所述方法包括混合酸预处理的含木素纤维素的材料和碱性预处理的含木素纤维素的材料的步骤。本发明还提供根据发酵产物的制造方法制造的发酵产物。

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