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1. 发明授权

US09120818B2 Process and intermediates for preparing macrolactams 有权
标题翻译：制备马来酰胺的方法和中间体
公开(公告)号：US09120818B2
公开(公告)日：2015-09-01
申请号：US13993541
申请日：2011-12-13
申请人： Cheng Chen , Jongrock Kong , Guy Humphrey , Sarah Dolman , Hongmei Li , Matthew T. Tudge , Kelvin Yong , Bangping Xiang , Michael Zacuto
发明人： Cheng Chen , Jongrock Kong , Guy Humphrey , Sarah Dolman , Hongmei Li , Matthew T. Tudge , Kelvin Yong , Bangping Xiang , Michael Zacuto
IPC分类号： C07D207/02 , C07D403/12 , C07D498/16 , C07C271/22 , C07C271/24 , C07C309/80 , C07C309/85 , C07C311/51 , C07D207/16 , C07D498/18 , C07D209/44 , C07K5/062 , C07C271/56 , C07C311/47
CPC分类号： C07D498/16 , C07C271/22 , C07C271/24 , C07C271/56 , C07C309/80 , C07C309/85 , C07C311/47 , C07C311/51 , C07C2601/02 , C07D207/16 , C07D209/44 , C07D403/12 , C07D498/18 , C07K5/06034
摘要： The present invention relates to macrolactam compounds, intermediates useful in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing and modifying macrolactams. One use of the compounds and methods described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. An example of an HCV inhibitory compound that can be synthesized using the procedures described herein is Compound A and derivative thereof.
摘要翻译：本发明涉及大分子内酰胺化合物，可用于制备大内酰胺的中间体，制备中间体的方法以及制备和改性大环内酯的方法。本文所述的化合物和方法的一个用途是制备能够抑制HCV NS3蛋白酶活性的大环内酰胺化合物。可以使用本文所述方法合成的HCV抑制化合物的实例是化合物A及其衍生物。

2. 发明申请

US20130274463A1 PROCESS AND INTERMEDIATES FOR PREPARING MACROLACTAMS 有权
标题翻译：制备MACROLACTAMS的过程和中间件
公开(公告)号：US20130274463A1
公开(公告)日：2013-10-17
申请号：US13993541
申请日：2011-12-13
申请人： Cheng Chen , Jongrock Kong , Guy Humphrey , Sarah Dolman , Hongmei Li , Matthew T. Tudge , Kelvin Yong , Bangping Xiang , Michael Zacuto
发明人： Cheng Chen , Jongrock Kong , Guy Humphrey , Sarah Dolman , Hongmei Li , Matthew T. Tudge , Kelvin Yong , Bangping Xiang , Michael Zacuto
IPC分类号： C07D498/16 , C07D209/44 , C07C271/56 , C07C309/85 , C07C311/47 , C07D403/12 , C07C309/80
CPC分类号： C07D498/16 , C07C271/22 , C07C271/24 , C07C271/56 , C07C309/80 , C07C309/85 , C07C311/47 , C07C311/51 , C07C2601/02 , C07D207/16 , C07D209/44 , C07D403/12 , C07D498/18 , C07K5/06034
摘要： The present invention relates to macrolactam compounds, intermediates useful in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing and modifying macrolactams. One use of the compounds and methods described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. An example of an HCV inhibitory compound that can be synthesized using the procedures described herein is Compound A and derivative thereof.
摘要翻译：本发明涉及大分子内酰胺化合物，可用于制备大内酰胺的中间体，制备中间体的方法以及制备和改性大环内酯的方法。本文所述的化合物和方法的一个用途是制备能够抑制HCV NS3蛋白酶活性的大环内酰胺化合物。可以使用本文所述方法合成的HCV抑制化合物的实例是化合物A及其衍生物。

3. 发明申请

US20160311781A1 PROCESS FOR MAKING SUBSTITUTED QUINAZOLINE COMPOUNDS 有权
标题翻译：制备取代的喹啉腈化合物的方法
公开(公告)号：US20160311781A1
公开(公告)日：2016-10-27
申请号：US15102417
申请日：2014-12-08
申请人： Michael Luzung , Guy Humphrey , Bangping Xiang , Kevin M. Belyk , Stephen Mark Dalby , Wilfried Schwab , Burkhard Klenke , Tom Moody , Gareth Brown
发明人： Michael Luzung , Guy Humphrey , Bangping Xiang , Kevin M. Belyk , Stephen Mark Dalby , Wilfried Schwab , Burkhard Klenke , Tom Moody , Gareth Brown
IPC分类号： C07D239/84 , B01J31/02
CPC分类号： C07D239/84 , B01J31/0202 , B01J31/0232 , B01J31/0244 , B01J31/0271 , B01J2231/324 , C07D295/125
摘要： The present invention is directed to a process for making Substituted Quinazoline Compounds of formula (I): which are useful for the treatment and prophylaxis of HCMV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).

4. 发明授权

US09890128B2 Process for making substituted quinazoline compounds 有权
公开(公告)号：US09890128B2
公开(公告)日：2018-02-13
申请号：US15102417
申请日：2014-12-08
申请人： Michael Luzung , Guy Humphrey , Bangping Xiang , Kevin M. Belyk , Stephen Mark Dalby , Wilfried Schwab , Burkhard Klenke , Tom Moody , Gareth Brown
发明人： Michael Luzung , Guy Humphrey , Bangping Xiang , Kevin M. Belyk , Stephen Mark Dalby , Wilfried Schwab , Burkhard Klenke , Tom Moody , Gareth Brown
IPC分类号： C07D239/84 , B01J31/02 , C07D295/125
CPC分类号： C07D239/84 , B01J31/0202 , B01J31/0232 , B01J31/0244 , B01J31/0271 , B01J2231/324 , C07D295/125
摘要： The present invention is directed to a process for making Substituted Quinazoline Compounds of formula (I): which are useful for the treatment and prophylaxis of HCMV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).

5. 发明申请

US20130331597A1 AMIDATION PROCESS 审中-公开
标题翻译：氨化过程
公开(公告)号：US20130331597A1
公开(公告)日：2013-12-12
申请号：US14000950
申请日：2012-02-27
申请人： Guy Humphrey , Kelvin Yong
发明人： Guy Humphrey , Kelvin Yong
IPC分类号： C07C315/04
CPC分类号： C07C315/04 , C07C253/30 , C07C2601/02 , C07C255/46
摘要： This invention describes an amidation process whereby perfluorinated amino acids can be activated and treated with an amine in the presence of a coupling agent and a pyridine derivative to yield amides, without loss of optical purity.
摘要翻译：本发明描述了一种酰胺化方法，其中全氟化氨基酸可以在偶联剂和吡啶衍生物的存在下用胺活化和处理以产生酰胺，而不损失光学纯度。

6. 发明申请

US20060025089A1 Stable process induced correction bias circuitry for receivers on single-ended applications 失效
标题翻译：用于单端应用的接收器的稳定过程感应校正偏置电路
公开(公告)号：US20060025089A1
公开(公告)日：2006-02-02
申请号：US10902559
申请日：2004-07-29
申请人： Manuel Salcido , Gilbert Yoh , Guy Humphrey , Salvador Salcido
发明人： Manuel Salcido , Gilbert Yoh , Guy Humphrey , Salvador Salcido
IPC分类号： H04Q7/20
CPC分类号： H04L25/0276 , H04L25/0296
摘要： A second single-ended receiver having a first stage for receiving an input signal and outputting a pair of corresponding output signals, and a second stage for receiving the pair of output signals and outputting a corresponding single output signal. First and second pull-down transistors are coupled to first and second inputs to the first stage. A bias circuit electrically biases the first stage, second stage, and first and second pull-down transistors, and a power supply provides power to those components.
摘要翻译：第二单端接收机，具有用于接收输入信号并输出一对相应输出信号的第一级，以及用于接收一对输出信号并输出相应的单输出信号的第二级。第一和第二下拉晶体管耦合到第一和第二输入到第一级。偏置电路电偏置第一级，第二级以及第一和第二下拉式晶体管，并且电源为这些部件提供电力。

7. 发明申请

US20140243519A1 METHODS AND INTERMEDIATES FOR PREPARING MACROLACTAMS 有权
标题翻译：用于制备微波炉的方法和中间件
公开(公告)号：US20140243519A1
公开(公告)日：2014-08-28
申请号：US14239391
申请日：2012-08-16
申请人： Nobuyoshi Yasuda , Jeffrey T. Kuethe , Guy Humphrey , Gregory L. Beutner , Yong-Li Zhong , Edward Cleator , Carl Baxter
发明人： Nobuyoshi Yasuda , Jeffrey T. Kuethe , Guy Humphrey , Gregory L. Beutner , Yong-Li Zhong , Edward Cleator , Carl Baxter
IPC分类号： C07D498/16 , C07D403/12 , C07C269/04 , C07C271/34 , C07C69/013 , C07C67/14 , C07C35/04 , C07C69/12
CPC分类号： C07C35/04 , A61K38/00 , C07C67/14 , C07C69/013 , C07C69/12 , C07C269/04 , C07C271/34 , C07D403/12 , C07D498/16 , C07K5/0808 , C07K5/126
摘要： The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applica
摘要翻译：本发明包括可用作制备大内酰胺的中间体的化合物，制备中间体的方法和制备大新戊酰胺的方法。本文描述的方法和中间体的一个用途是制备能够抑制HCV NS3蛋白酶活性的大环内酰胺化合物。 HCV NS3抑制化合物具有治疗和研究应用

8. 发明申请

US20140200343A1 PROCESS AND INTERMEDIATES FOR PREPARING MACROLACTAMS 有权
标题翻译：制备MACROLACTAMS的过程和中间件
公开(公告)号：US20140200343A1
公开(公告)日：2014-07-17
申请号：US14239393
申请日：2012-08-16
申请人： Feng Xu , Guy Humphrey , Tao Pei , Zhiguo Jake Song , Tao Wang , Laura Artino
发明人： Feng Xu , Guy Humphrey , Tao Pei , Zhiguo Jake Song , Tao Wang , Laura Artino
IPC分类号： C07D498/16 , C07D403/12
CPC分类号： C07C35/04 , A61K38/00 , C07C67/14 , C07C69/013 , C07C69/12 , C07C269/04 , C07C271/34 , C07D403/12 , C07D498/16 , C07K5/0808 , C07K5/126
摘要： The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams from the intermediates. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applications.
摘要翻译：本发明包括可用作制备大新戊酰胺的中间体的化合物，制备中间体的方法和从中间体制备大环内酯的方法。本文描述的方法和中间体的一个用途是制备能够抑制HCV NS3蛋白酶活性的大环内酰胺化合物。 HCV NS3抑制化合物具有治疗和研究应用。

9. 发明申请

US20050242830A1 Hybrid binary/thermometer code for controlled-voltage integrated circuit output drivers 有权
标题翻译：用于控制电压集成电路输出驱动器的混合二进制/温度计代码
公开(公告)号：US20050242830A1
公开(公告)日：2005-11-03
申请号：US10835906
申请日：2004-04-30
申请人： Guy Humphrey , David Linam
发明人： Guy Humphrey , David Linam
IPC分类号： H03K19/00 , H03K19/003
CPC分类号： H03K19/0005
摘要： A hybrid binary/thermometer code is employed to adjust the output impedance of a variable impedance output driver circuit having an impedance network comprising a plurality of impedance legs each programmably electrically connectable according to the hybrid binary/thermometer code in parallel between a voltage source and the signal pad. The plurality of impedance legs are partitioned into one or more set pairs of binary stepped impedance legs and corresponding thermometer stepped impedance legs. A binary set of calibration signals in the hybrid binary/thermometer code steps a given set of binary stepped impedance legs according to a binary code and a thermometer set of calibration signals in the hybrid binary/thermometer code steps the corresponding set of thermometer stepped impedance legs according to a thermometer code once per full count iteration of the binary set of calibration signals.
摘要翻译：采用混合二进制/温度计代码来调整具有阻抗网络的可变阻抗输出驱动器电路的输出阻抗，该阻抗网络包括多个阻抗支路，每个阻抗支路可根据混合二进制/温度计代码在电压源和信号垫。多个阻抗腿分成一组或多组二进制步进阻抗腿和对应的温度计步进阻抗腿。混合二进制/温度计代码中的一组二进制校准信号根据二进制码和二进制/温度计代码中的温度计校准信号组合，给出一组给定的二进制步进阻抗支路，步进相应的温度计步进阻抗腿组根据温度计代码，每次完全计数二进制集合的校准信号。

10. 发明申请

US20050222428A1 Asymmetric hydrogenation process 失效
标题翻译：不对称加氢工艺
公开(公告)号：US20050222428A1
公开(公告)日：2005-10-06
申请号：US11097565
申请日：2005-04-01
申请人： David Tellers , Guy Humphrey
发明人： David Tellers , Guy Humphrey
IPC分类号： C07B53/00 , C07D209/30 , C07D209/80 , C07D209/82 , C07D209/94
CPC分类号： C07D209/80 , C07B53/00 , C07D209/94
摘要： The present invention provides an asymmetric hydrogenation process for the preparation of chiral cycloalkanoindole DP receptor antagonists in high enantiomeric excess.
摘要翻译：本发明提供了用于制备高对映体过量的手性环烷基吲哚DP受体拮抗剂的不对称氢化方法。

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