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1. 发明授权

US08653141B2 HIV protease inhibiting compounds 有权
标题翻译： HIV蛋白酶抑制化合物
公开(公告)号：US08653141B2
公开(公告)日：2014-02-18
申请号：US13451370
申请日：2012-04-19
申请人： Charles A. Flentge , Hui-Ju Chen , David A. DeGoey , William J. Flosi , David J. Grampovnik , Peggy P. Huang , Dale J. Kempf , Larry L. Klein , Allan C. Krueger , Darold L. Madigan , John T. Randolph , Minghua Sun , Ming C. Yeung , Chen Zhao
发明人： Charles A. Flentge , Hui-Ju Chen , David A. DeGoey , William J. Flosi , David J. Grampovnik , Peggy P. Huang , Dale J. Kempf , Larry L. Klein , Allan C. Krueger , Darold L. Madigan , John T. Randolph , Minghua Sun , Ming C. Yeung , Chen Zhao
IPC分类号： A61K31/18 , C07D307/00
CPC分类号： C07D417/12 , C07C311/18 , C07C311/29 , C07C311/41 , C07C311/47 , C07C317/18 , C07D209/14 , C07D213/30 , C07D213/40 , C07D233/36 , C07D233/64 , C07D233/72 , C07D277/24 , C07D277/28 , C07D307/14 , C07D307/20 , C07D307/52 , C07D333/20 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/10 , C07D409/06 , C07D409/10 , C07D417/06 , C07D417/10 , C07D471/04 , C07D493/04
摘要： A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
摘要翻译：公开了式的化合物作为HIV蛋白酶抑制剂。还公开了用于抑制HIV感染的方法和组合物。

2. 发明授权

US08592467B2 Benzothiazole cyclobutyl amine derivatives 有权
公开(公告)号：US08592467B2
公开(公告)日：2013-11-26
申请号：US12489269
申请日：2009-06-22
申请人： Marlon D. Cowart , Minghua Sun , Chen Zhao , Guo Zhu Zheng
发明人： Marlon D. Cowart , Minghua Sun , Chen Zhao , Guo Zhu Zheng
IPC分类号： A61K31/428 , C07D277/62
CPC分类号： C07D277/64 , C07D417/04 , C07D417/08 , C07D417/12 , C07D487/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

3. 发明授权

US08568892B2 Coated articles 有权
标题翻译：涂层文章
公开(公告)号：US08568892B2
公开(公告)日：2013-10-29
申请号：US12740235
申请日：2008-10-29
申请人： Chen Zhao , David Volsin , Cornell Chappell, Jr.
发明人： Chen Zhao , David Volsin , Cornell Chappell, Jr.
IPC分类号： B32B23/00 , B32B23/08 , B32B23/18 , B32B27/06 , B32B27/08 , B32B27/18 , B32B27/20 , B32B27/34 , B32B27/36
CPC分类号： C09D101/284 , C08J7/047 , C08J2367/02 , C08J2401/28 , C08L61/28 , C08L63/00 , C08L71/00 , C08L79/00 , C08L83/00 , Y10T428/31511 , Y10T428/31634 , Y10T428/31725 , Y10T428/31736 , Y10T428/31786 , Y10T428/3179 , Y10T428/31971 , C08L2666/22 , C08L2666/14 , C08L2666/20 , C08L2666/16
摘要： A coated article includes a substrate having on its surface a coating that includes a polymer selected from the group consisting of hydroxypropylcellulose, poly(2-ethyl-2-oxazoline) and mixtures of these, a surfactant, colloidal silica, and a crosslinker selected from the group consisting of water-soluble titanium salts and water-soluble or water-dispersible organic crosslinkers. The coating may be formed by applying a dispersion of the coating composition in a diluent to the substrate and subsequently drying the coated substrate to evaporate the diluent.
摘要翻译：涂覆制品包括其表面上具有包括选自羟丙基纤维素，聚（2-乙基-2-恶唑啉）及其混合物，表面活性剂，胶态二氧化硅和交联剂的聚合物的涂层的基材，所述交联剂选自该组由水溶性钛盐和水溶性或水分散性有机交联剂组成。涂层可以通过将涂料组合物的分散体施加到稀释剂中而形成，然后干燥涂覆的基材以蒸发稀释剂。

4. 发明授权

US08436005B2 Macrocyclic pyrimidine derivatives 有权
标题翻译：大环嘧啶衍生物
公开(公告)号：US08436005B2
公开(公告)日：2013-05-07
申请号：US12413168
申请日：2009-03-27
申请人： Huaqing Liu , Irene Drizin , John R. Koenig , Marlon D. Cowart , Chen Zhao , Brian D. Wakefield , Lawrence A. Black , Robert J. Altenbach
发明人： Huaqing Liu , Irene Drizin , John R. Koenig , Marlon D. Cowart , Chen Zhao , Brian D. Wakefield , Lawrence A. Black , Robert J. Altenbach
IPC分类号： C07D403/04 , C07D401/04 , A61K31/517
CPC分类号： C07D401/04 , C07D239/70 , C07D239/84 , C07D239/88 , C07D401/12 , C07D403/04 , C07D403/12 , C07D453/02 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10
摘要： Macrocyclic pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions, and disorders using such compounds and compositions are described herein.
摘要翻译：本文描述了大环嘧啶化合物，包含这些化合物的组合物，制备化合物的方法，以及使用这些化合物和组合物治疗和预防疾病，病症和病症进展的方法。

5. 发明授权

US08153813B2 Benzothiazole and benzooxazole derivatives and methods of use 有权
标题翻译：苯并噻唑和苯并恶唑衍生物及其使用方法
公开(公告)号：US08153813B2
公开(公告)日：2012-04-10
申请号：US12337433
申请日：2008-12-17
申请人： Lawrence A. Black , Marlon D. Cowart , Gregory A. Gfesser , Brian D. Wakefield , Robert J. Altenbach , Huaqing Liu , Chen Zhao , Gin C. Hsieh
发明人： Lawrence A. Black , Marlon D. Cowart , Gregory A. Gfesser , Brian D. Wakefield , Robert J. Altenbach , Huaqing Liu , Chen Zhao , Gin C. Hsieh
IPC分类号： A61K31/454 , A61K31/4545 , C07D417/04 , C07D417/14
CPC分类号： C07D417/14 , C07D413/04 , C07D417/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.
摘要翻译：式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。还公开了式（I）化合物的药物组合物，使用这些化合物和组合物的方法及其制备方法。

6. 发明申请

US20100222358A1 OCTAHYDRO-PYRROLO[3,4-B]PYRROLE DERIVATIVES 有权
标题翻译： OCTAHYDRO-PYRROLO [3,4-B]吡咯烷酮衍生物
公开(公告)号：US20100222358A1
公开(公告)日：2010-09-02
申请号：US12715660
申请日：2010-03-02
申请人： Marlon D. Cowart , Chen Zhao , Minghua Sun , Lawrence A. Black , Guo Zhu Zheng , Robert J. Gregg , Geoff G.Z. Zhang , Ahmad Y. Sheikh , Xiaochun Lou , Rodger F. Henry , David M. Barnes , Lawrence Kolaczkowski , Anthony R. Haight , Sou-Jen Chang , Steven J. Wittenberger , Michael G. Fickes
发明人： Marlon D. Cowart , Chen Zhao , Minghua Sun , Lawrence A. Black , Guo Zhu Zheng , Robert J. Gregg , Geoff G.Z. Zhang , Ahmad Y. Sheikh , Xiaochun Lou , Rodger F. Henry , David M. Barnes , Lawrence Kolaczkowski , Anthony R. Haight , Sou-Jen Chang , Steven J. Wittenberger , Michael G. Fickes
IPC分类号： A61K31/501 , A61K31/407 , C07D487/04 , A61K31/47 , C07D215/00 , A61K31/4439 , C07D401/14 , A61K31/428 , C07D417/14 , A61K31/4164 , C07D233/00 , C07D403/14 , A61K31/506 , A61K31/497 , A61P3/04 , A61P5/00 , A61P11/06 , A61P25/00 , A61P29/00 , A61P37/08 , A61P1/02
CPC分类号： C07D487/04
摘要： Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.
摘要翻译：八氢吡咯并[3,4-b]吡咯衍生物可用于治疗组胺-3受体配体预防或改善的病症或病症。八氢吡咯并[3,4-b]吡咯化合物，使用这些化合物的方法，制备它们的组合物和制备这些化合物的方法在本文中公开。

7. 发明申请

US20090163464A1 BENZOTHIAZOLE AND BENZOOXAZOLE DERIVATIVES AND METHODS OF USE 有权
标题翻译：苯并噻唑和苯并噻唑衍生物及其使用方法
公开(公告)号：US20090163464A1
公开(公告)日：2009-06-25
申请号：US12337433
申请日：2008-12-17
申请人： Lawrence A. Black , Marlon D. Cowart , Gregory A. Gfesser , Brian D. Wakefield , Robert J. Altenbach , Huaqing Liu , Chen Zhao , Gin C. Hsieh
发明人： Lawrence A. Black , Marlon D. Cowart , Gregory A. Gfesser , Brian D. Wakefield , Robert J. Altenbach , Huaqing Liu , Chen Zhao , Gin C. Hsieh
IPC分类号： A61K31/397 , C07D417/14 , A61P25/00
CPC分类号： C07D417/14 , C07D413/04 , C07D417/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.
摘要翻译：式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。还公开了式（I）化合物的药物组合物，使用这些化合物和组合物的方法，以及制备该化合物的方法。

8. 发明申请

US20080113982A1 AZACYCLOSTEROID HISTAMINE-3 RECEPTOR LIGANDS 审中-公开
标题翻译： AZACYCLOSTEROID组胺3受体配体
公开(公告)号：US20080113982A1
公开(公告)日：2008-05-15
申请号：US12014566
申请日：2008-01-15
申请人： Chen Zhao , Minghua Sun , Marlon Cowart , Youssef Bennani
发明人： Chen Zhao , Minghua Sun , Marlon Cowart , Youssef Bennani
IPC分类号： A61K31/5377 , A61K31/403 , A61K31/427 , A61P3/08 , A61P25/28 , A61P9/00
CPC分类号： C07J71/00
摘要： Azacyclosteroid histamine-3 receptor ligands, pharmaceutical compositions comprising such compounds, and methods for using such compounds and compositions are described herein.
摘要翻译：氮杂环绕组胺胺受体配体，包含这些化合物的药物组合物和使用这些化合物和组合物的方法在本文中描述。

9. 发明申请

US20070232612A1 Octahydro-pyrrolo[3,4-b]pyrrole Derivatives 有权
标题翻译：八氢吡咯并[3,4-b]吡咯衍生物
公开(公告)号：US20070232612A1
公开(公告)日：2007-10-04
申请号：US11674518
申请日：2007-02-13
申请人： Marlon Cowart , Chen Zhao , Minghua Sun , Lawrence Black , Guo Zheng , Robert Gregg , Geoff Zhang , Ahmand Sheikh , Xiaochun Lou , Rodger Henry , David Barnes , Lawrence Kolaczkowski , Anthony Haight , Sou-Jen Chang , Steven Wittenberger , Michael Fickes
发明人： Marlon Cowart , Chen Zhao , Minghua Sun , Lawrence Black , Guo Zheng , Robert Gregg , Geoff Zhang , Ahmand Sheikh , Xiaochun Lou , Rodger Henry , David Barnes , Lawrence Kolaczkowski , Anthony Haight , Sou-Jen Chang , Steven Wittenberger , Michael Fickes
IPC分类号： A61K31/506 , A61K31/501 , A61K31/496 , A61K31/4439 , A61K31/407 , C07D487/02 , A61K31/416
CPC分类号： C07D487/04
摘要： Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands, Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.
摘要翻译：八氢 - 吡咯并[3,4-b]吡咯衍生物可用于治疗组胺-3受体配体，八氢吡咯并[3,4-b]吡咯化合物，使用这些化合物的方法，组合物制备这些化合物的方法和方法。

10. 发明申请

US20050010897A1 Program generating apparatus 审中-公开
标题翻译：程序生成装置
公开(公告)号：US20050010897A1
公开(公告)日：2005-01-13
申请号：US10880523
申请日：2004-07-01
申请人： Hajime Ogawa , Taketo Heishi , Shuichi Takayama , Chen Zhao
发明人： Hajime Ogawa , Taketo Heishi , Shuichi Takayama , Chen Zhao
IPC分类号： G06F11/28 , G06F9/44
CPC分类号： G06F8/30 , G06F8/43 , G06F8/51
摘要： A test program generating apparatus for a compiler comprising: a conditional expression generating unit operable to receive a description of a control structure of a program and generate a plurality of conditional expressions to be inserted into insert parts of the conditional expressions of the control structure using a linear programming method, the plurality of conditional expressions allowing a control flow of the program to pass through all paths in the control structure; an initial value generating unit operable to generate initial values of variables, for each of all the paths, which are included in the plurality of conditional expressions for allowing the control flow of the program to pass through all the paths in the control structure; and a test program generating unit operable to generate a test program based on the control structure, the conditional expressions and the initial values.
摘要翻译：一种用于编译器的测试程序生成装置，包括：条件表达式生成单元，用于接收对程序的控制结构的描述，并生成多个条件表达式，以使用以下操作插入到控制结构的条件表达式的插入部分中所述多个条件表达式允许所述程序的控制流程通过所述控制结构中的所有路径; 初始值生成单元，用于针对包含在所述多个条件表达式中的每个所述路径生成用于允许所述程序的控制流通过所述控制结构中的所有路径的变量的初始值; 以及测试程序生成单元，其可操作以基于所述控制结构，所述条件表达式和所述初始值生成测试程序。

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