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1. 发明授权

US4604208A Liquid filtration using an anionic microporous membrane 失效
标题翻译：使用阴离子微孔膜进行液体过滤
公开(公告)号：US4604208A
公开(公告)日：1986-08-05
申请号：US566764
申请日：1983-12-29
申请人： Chaokang Chu , Joseph V. Fiore , Rodney A. Knight , Paul J. Marinaccio , Asit Roy
发明人： Chaokang Chu , Joseph V. Fiore , Rodney A. Knight , Paul J. Marinaccio , Asit Roy
IPC分类号： B01D65/00 , B01D67/00 , B01D71/56 , B01D13/00
CPC分类号： B01D67/0093 , B01D61/147 , B01D63/06 , B01D71/56 , B01D2323/30
摘要： A novel hydrophilic anionic charge modified microporous filter membrane is provided comprising an organic polymeric microporous filter membrane having a micro-structure throughout the membrane and a modifying amount of an anionic charge modifying agent bound to substantially all of the membrane micro-structure without substantial pore size reduction or pore blockage.The invention is further directed to a process for anionically charge modifying an organic polymeric microporous filter membrane by applying to the membrane the charge modifying agent, preferably, by contacting the membrane with a solution of the charge modifying agent.The anionic modified microporous membrane of this invention may be used for the filtration of fluids, particularly parenteral or biological liquids contaminated with charged particulates, and for plasmapheresis, particularly in the form of hollow fiber tubes. The membrane has low extractables and is sanitizable or sterilizable.
摘要翻译：提供了一种新颖的亲水性阴离子电荷改性微孔过滤膜，其包括在整个膜上具有微观结构的有机聚合物微孔过滤膜和修饰量的阴离子电荷改性剂与基本上所有的膜微结构结合而没有实质的孔径减少或堵塞孔隙。本发明进一步涉及一种通过将膜与电荷改性剂的溶液接触来向膜施加电荷改性剂进行阴离子电荷改性有机聚合物微孔过滤膜的方法。本发明的阴离子改性微孔膜可用于过滤流体，特别是被带电粒子污染的肠外或生物液体，以及血浆去除术，特别是中空纤维管的形式。膜具有低可提取物，可消毒或消毒。

2. 发明授权

US4915839A Process for surface modifying a microporous membrane 失效
标题翻译：用于表面改性微孔膜的方法
公开(公告)号：US4915839A
公开(公告)日：1990-04-10
申请号：US292324
申请日：1988-12-30
申请人： Paul J. Marinaccio , Rodney A. Knight , Joseph V. Fiore
发明人： Paul J. Marinaccio , Rodney A. Knight , Joseph V. Fiore
IPC分类号： B01D39/14 , B01D39/16 , B01D67/00
CPC分类号： B01D39/1623 , B01D39/14 , B01D67/0011 , B01D2325/36
摘要： A process for surface modifying skinless hydrophilic microporous membrane having an internal microstructure throughout said membrane and a surface modifying amount of surface modifying agent bound thereto without substantial pore reduction of pore blockage involves the steps of providing a dope solution of a membrane forming polymer in a solvent system comprising a mixture of at least one solvent and one non-solvent for the polymer, and a membrane surface modifying agent, and combining said dope solution with sufficient additional non-solvent for the polymer to precipitate said membrane from said dope solution.
摘要翻译：用于表面改性的表面改性无孔亲水性微孔膜，其具有整个所述膜的内部微观结构，并且表面改性量与其结合的表面改性剂无明显孔隙减少的堵塞作用包括以下步骤：将成膜聚合物的掺杂溶液该系统包括用于聚合物的至少一种溶剂和一种非溶剂的混合物，以及膜表面改性剂，并将所述掺杂溶液与足够的另外的非溶剂组合以用于聚合物以从所述掺杂溶液沉淀所述膜。

3. 发明授权

US4384957A Molecular separation column and use thereof 失效
标题翻译：分子分离柱及其用途
公开(公告)号：US4384957A
公开(公告)日：1983-05-24
申请号：US287609
申请日：1981-07-28
申请人： Alvin L. Crowder, III , Nils L. Dailey , Joseph V. Fiore , Kenneth C. Hou , Paul J. Marinaccio , Eugene A. Ostreicher
发明人： Alvin L. Crowder, III , Nils L. Dailey , Joseph V. Fiore , Kenneth C. Hou , Paul J. Marinaccio , Eugene A. Ostreicher
IPC分类号： B01J20/281 , B01D15/08 , B01J20/28 , G01N30/52 , G01N30/56 , G01N30/88
CPC分类号： B01J20/282 , B01D15/22 , B01J20/28004 , B01J20/28028 , B01J20/28033 , B01J20/28052 , G01N30/56 , B01J2220/54 , G01N2030/527
摘要： A molecular separation chromotography column for effecting the differential distribution, between two phases, of the components of a sample flowing therethrough. The column contains a substantially homogeneous solid stationary phase which comprises a porous matrix of fiber having particulate immobilized therein, wherein at least one of said fiber or particulate is effective for molecular separation. The column is characterized by a reduced pressure drop, increased axial dispersion, more uniform peak shapes and better separations at high sample loading.
摘要翻译：分子分离色谱柱，用于实现两相之间的样品流动过程中的分量的差分分布。该柱包含基本上均匀的固体固定相，其包含其中固定有颗粒的纤维的多孔基质，其中所述纤维或颗粒中的至少一种对分子分离是有效的。该柱的特征在于降低的压降，增加的轴向分散，更均匀的峰形和在高样品加载时更好的分离。

4. 发明授权

US4673504A Charge modified microporous membrane 失效
标题翻译：电荷改性微孔膜
公开(公告)号：US4673504A
公开(公告)日：1987-06-16
申请号：US649561
申请日：1984-09-11
申请人： Eugene A. Ostreicher , Rodney A. Knight , Joseph V. Fiore , George T. Emond , Kenneth C. Hou
发明人： Eugene A. Ostreicher , Rodney A. Knight , Joseph V. Fiore , George T. Emond , Kenneth C. Hou
IPC分类号： A61L2/00 , A61L2/02 , B01D67/00 , B01D71/56 , B01D13/00
CPC分类号： B01D67/0093 , A61L2/0017 , A61L2/022 , B01D67/0011 , B01D71/56 , B01D2323/12 , B01D2323/30 , B01D2325/36
摘要： A cationic charge modified microporous membrane comprising a hydrophilic organic polymeric microporous membrane and a cationic charge modifying agent bonded to substantially all of the wetted surfaces of the membrane, the charge modifying agent being an epichlorohydrin modified polyamide having tertiary amine or quaternary ammonium groups. A secondary charge modifying agent may be employed selected from: (i) aliphatic polyamines having at least one primary amine or at least two secondary amines; and (ii) aliphatic amines having at least one secondary amine and a carboxyl or hydroxyl substituent. Processes for producing and using the membrane are also described.
摘要翻译：一种阳离子电荷改性微孔膜，其包含亲水性有机聚合物微孔膜和与膜的基本上所有润湿表面结合的阳离子电荷改性剂，电荷改性剂是具有叔胺或季铵基团的表氯醇改性聚酰胺。可以使用次要电荷改性剂，其选自：（i）具有至少一个伯胺或至少两个仲胺的脂族多胺; 和（ii）具有至少一个仲胺和羧基或羟基取代基的脂族胺。还描述了用于生产和使用膜的方法。

5. 发明授权

US4708803A Liquid filtration using hydrophilic cationic isotropic microporous nylon membrane 失效
标题翻译：使用亲水阳离子各向同性微孔尼龙膜进行液体过滤
公开(公告)号：US4708803A
公开(公告)日：1987-11-24
申请号：US648401
申请日：1984-09-06
申请人： Eugene A. Ostreicher , Rodney A. Knight , Joseph V. Fiore , George T. Emond , Kenneth C. Hou
发明人： Eugene A. Ostreicher , Rodney A. Knight , Joseph V. Fiore , George T. Emond , Kenneth C. Hou
IPC分类号： A61L2/00 , A61L2/02 , B01D67/00 , B01D71/56 , B01D13/00
CPC分类号： B01D67/0093 , A61L2/0017 , A61L2/022 , B01D67/0011 , B01D71/56 , B01D2323/08 , B01D2323/12 , B01D2323/30 , B01D2323/36 , B01D2325/16
摘要： A cationic charge modified microporous membrane comprising a hydrophilic organic polymeric microporous membrane and a cationic charge modifying agent bonded to substantially all of the wetted surfaces of the membrane, the charge modifying agent being an epichlorohydrin modified polyamide having tertiary amine or quaternary ammonium groups. A secondary charge modifying agent may be employed selected from: (i) aliphatic polyamines having at least one primary amine or at least two secondary amines; and (ii) aliphatic amines having at least one secondary amine and a carboxyl or hydroxyl substituent. Processes for producing and using the membrane are also described.
摘要翻译：一种阳离子电荷改性微孔膜，其包含亲水性有机聚合物微孔膜和与膜的基本上所有润湿表面结合的阳离子电荷改性剂，电荷改性剂是具有叔胺或季铵基团的表氯醇改性聚酰胺。可以使用次要电荷改性剂，其选自：（i）具有至少一个伯胺或至少两个仲胺的脂族多胺; 和（ii）具有至少一个仲胺和羧基或羟基取代基的脂族胺。还描述了用于生产和使用膜的方法。

6. 发明授权

US4711793A Process for charge modifying a microphorous membrane 失效
标题翻译：电荷改性微孔膜的方法
公开(公告)号：US4711793A
公开(公告)日：1987-12-08
申请号：US651749
申请日：1984-09-18
申请人： Eugene A. Ostreicher , Rodney A. Knight , Joseph V. Fiore , George T. Emond , Kenneth C. Hou
发明人： Eugene A. Ostreicher , Rodney A. Knight , Joseph V. Fiore , George T. Emond , Kenneth C. Hou
IPC分类号： A61L2/00 , A61L2/02 , B01D67/00 , B01D71/56 , B05D5/00
CPC分类号： B01D67/0093 , A61L2/0017 , A61L2/022 , B01D67/0011 , B01D69/12 , B01D71/56 , B01D2323/08 , B01D2323/12 , B01D2323/30 , B01D2325/36
摘要： A process is provided for for cationically charge modifying a microporous filter membrane, wherein the membrane is a substantially symmetrical isotropic, hydrophilic, organic polymeric microporous filter membrane, preferably nylon, having a microstructure throughout the membrane. The process comprises bonding a primary charge modifying amount of a water soluble cationic charge modifying agent to substantially all of the membrane microstructure, without substantial pore size reduction or pore blockage. The charge modifying agent is a reaction product of a polyamine with epichlorohydrin, the reactive product having (i) tertiary amine or quaternary ammonium groups, and (ii) epoxide groups along a polyamine chain, the epoxide groups capable of bonding to the microstructure of the membrane.
摘要翻译：提供了一种用于阳离子电荷改性微孔过滤膜的方法，其中所述膜是基本上对称的各向同性，亲水的有机聚合物微孔过滤膜，优选尼龙，其在整个膜上具有微结构。该方法包括将主要电荷改性量的水溶性阳离子电荷改性剂结合到基本上所有的膜微结构，而没有显着的孔径减小或孔堵塞。电荷改性剂是多胺与表氯醇的反应产物，反应产物具有（i）叔胺或季铵基团，和（ii）沿着多胺链的环氧基团，能够键合至膜。

7. 发明授权

US4473474A Charge modified microporous membrane, process for charge modifying said membrane and process for filtration of fluid 失效
标题翻译：电荷改性微孔膜，用于对所述膜进行电荷改性的方法和用于过滤流体的方法
公开(公告)号：US4473474A
公开(公告)日：1984-09-25
申请号：US314307
申请日：1981-10-23
申请人： Eugene A. Ostreicher , Rodney A. Knight , Joseph V. Fiore , George T. Emond , Kenneth C. Hou
发明人： Eugene A. Ostreicher , Rodney A. Knight , Joseph V. Fiore , George T. Emond , Kenneth C. Hou
IPC分类号： A61L2/00 , A61L2/02 , B01D67/00 , B01D71/56 , B01D13/00
CPC分类号： B01D71/56 , A61L2/0005 , A61L2/02 , B01D67/0011 , B01D67/0093 , B01D2323/08 , B01D2323/12 , B01D2323/30 , B01D2325/36
摘要： A cationic charge modified microporous membrane, process for producing said membrane and use thereof are provided. The membrane comprises a hydrophilic organic polymeric microporous membrane and a charge modifying amount of a primary cationic charge modifying agent bonded to substantially all of the wetted surfaces of the membrane. The primary charge modifying agent if a water soluble organic polymer having a molecular weight greater than about 1000 wherein each monomer thereof has at least one epoxide group capable of bonding to the surface of the membrane and at least one tertiary amine or quaternary ammonium group. Preferably, a portion of the epoxy groups on the organic polymer are bonded to a secondary charge modifying agent selected from the group consisting of:(i) aliphatic amines having at least one primary amine or at least two secondary amines; and(ii) aliphatic amines having at least one secondary amine and a carboxyl or hydroxyl substituent.The charge modified microporous membrane of this invention may be used for the filtration of fluids, particularly parenteral or biological liquids. The membrane has low extractables and is sanitizable or sterilizable.
摘要翻译：提供了一种阳离子电荷改性微孔膜，用于制备所述膜的方法及其用途。膜包括亲水性有机聚合物微孔膜和电荷改性量的基本上阳离子电荷改性剂，其结合到膜的基本上所有的润湿表面。如果分子量大于约1000的水溶性有机聚合物，其主要电荷调节剂，其中每个单体具有至少一个能与膜表面结合的环氧基团和至少一个叔胺或季铵基团。优选地，有机聚合物上的一部分环氧基团与二次电荷调节剂结合，所述次级电荷改性剂选自：（i）具有至少一个伯胺或至少两个仲胺的脂族胺; 和（ii）具有至少一个仲胺和羧基或羟基取代基的脂族胺。本发明的电荷改性微孔膜可用于过滤流体，特别是肠外或生物液体。膜具有低可提取物，可消毒或消毒。

8. 发明授权

US4002178A Foams and sponge sheet for cigar manufacture 失效
标题翻译：泡沫和海绵片用于雪茄制造
公开(公告)号：US4002178A
公开(公告)日：1977-01-11
申请号：US518446
申请日：1974-10-29
申请人： Joseph V. Fiore , T. Kenneth Kelly , William J. Nellen
发明人： Joseph V. Fiore , T. Kenneth Kelly , William J. Nellen
IPC分类号： A24B15/14 , A24D1/02 , A24B3/14
CPC分类号： A24B15/14
摘要： Cigar tobacco sheet of low density, smoking articles prepared therewith, and foamed intermediates therefor. Fine-bubble stable foams, wherein at least 80% of the bubbles are less than about 100 microns in normalized dimension are formed in a high shear system utilizing tobacco particles of generally smaller than 100-120 mesh. The foam is cast and dried to form reconstituted cigar tobacco sheet, utilized preferably for wrapper and/or binder in cigars, characterized especially by excellent taste.
摘要翻译：低密度的雪茄烟草片，其制备的吸烟制品及其发泡中间体。微气泡稳定的泡沫，其中至少80％的气泡在标准化尺寸上小于约100微米，在高剪切系统中形成，其利用通常小于100-120目的烟草颗粒。泡沫被铸造并干燥以形成重组的烟草烟草片，其优选用于雪茄中的包装物和/或粘合剂，其特征在于特征在于极好的味道。

9. 发明授权

US4176668A Novel reconstituted tobacco sheets and process 失效
标题翻译：新型重组烟草片和工艺
公开(公告)号：US4176668A
公开(公告)日：1979-12-04
申请号：US793232
申请日：1977-05-02
申请人： Joseph V. Fiore , John M. Slanski
发明人： Joseph V. Fiore , John M. Slanski
IPC分类号： A24B15/14 , A24B3/00 , A24B3/14
CPC分类号： A24B15/287 , A24B15/14 , A24B15/186
摘要： Reconstituted tobacco sheet coated with a hydrophobic coating containing a spectrophotometrically-determinable metal cation, including the process of making such products and the process of monitoring the coating process to assure even distribution of coating on tobacco sheet.
摘要翻译：涂覆有含有分光光度学可测定的金属阳离子的疏水涂层的重组烟草片，包括制备这种产品的过程以及监测涂布过程的过程，以确保涂料在烟草片上的均匀分布。

10. 发明授权

US4144895A Solvent extraction process 失效
标题翻译：溶剂萃取工艺
公开(公告)号：US4144895A
公开(公告)日：1979-03-20
申请号：US556080
申请日：1975-03-06
申请人： Joseph V. Fiore
发明人： Joseph V. Fiore
IPC分类号： A24B1/04 , A24B3/18 , A24B15/18 , A24B15/24 , A24B15/26 , B01D11/02 , A24B15/02
CPC分类号： A24B15/26 , A24B15/24
摘要： Processes for the selective removal of lipid constituents from elements of the tobacco plant comprising treating said elements in a solvolysis system consisting essentially of a mixture constituted by a major proportion of a hydrocarbon fat solvent and a minor proportion of a lower alkanol, whereby residual lipid level as determined by Soxhlet extraction is substantially reduced; and smoking compositions incorporating the processed tobacco material.
摘要翻译：用于从烟草植物的元件中选择性除去脂质成分的方法，包括在溶剂分解系统中处理所述元素，所述溶剂分解系统基本上由主要部分烃脂溶剂和少量低级链烷醇构成的混合物组成，由此残留的脂质含量如索格利特萃取法所确定的那样大大降低; 和加入烟草材料的吸烟组合物。

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