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1. 发明申请

US20060134062A1 Polymeric boronic acid derivatives as lipase inhibitors 审中-公开
标题翻译：聚合硼酸衍生物作为脂肪酶抑制剂
公开(公告)号：US20060134062A1
公开(公告)日：2006-06-22
申请号：US10535639
申请日：2003-11-19
申请人： Chad Huval , Xinhua Li , Stephen Holmes-Farley , Pradeep Dhal
发明人： Chad Huval , Xinhua Li , Stephen Holmes-Farley , Pradeep Dhal
IPC分类号： A61K31/785
CPC分类号： C08F230/06 , A61K31/69 , A61K45/06 , C08F30/06 , C08F220/56 , C08F220/60 , C08F226/10 , C08F265/00 , C08F289/00 , C08F290/06 , C08F290/14 , C08F291/00 , C08F293/005 , C08F297/00 , C08F297/02 , C08F2438/02
摘要： Human obesity is a health problem affecting a significant proportion of the American population. Numerous methods of treating obesity have been developed, but all have serious drawbacks. The present invention discloses a novel class of polymers with either a sulfur atom or an electron withdrawing group between a polymer backbone and a pendant aryl boronic acid group. Polymers having such an electron withdrawing group have been found to be particularly effective in inhibiting lipase in vitro and in vivo. Methods of treating obesity and reducing absorption of fat are also disclosed.
摘要翻译：人类肥胖是影响美国人口相当大比例的健康问题。已经开发出许多治疗肥胖症的方法，但都具有严重的缺点。本发明公开了一种新型聚合物，其在聚合物主链和芳基硼酸基团之间具有硫原子或吸电子基团。已经发现具有这种吸电子基团的聚合物在体外和体内特别有效地抑制脂肪酶。还公开了治疗肥胖和减少脂肪吸收的方法。

2. 发明申请

US20060128664A1 Aryl boronic acids for treating obesity 有权
公开(公告)号：US20060128664A1
公开(公告)日：2006-06-15
申请号：US11343598
申请日：2006-01-31
申请人： Stephen Holmes-Farley , W. Mandeville , Pradeep Dhal , Chad Huval , Xinhua Li
发明人： Stephen Holmes-Farley , W. Mandeville , Pradeep Dhal , Chad Huval , Xinhua Li
IPC分类号： A61K31/69 , C07F5/02
CPC分类号： C07F5/025 , A61K31/74 , A61K31/785
摘要： Disclosed is a phenyl boronic acid compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aryl group. Z and Z′ are independently —O—. —NH— or —S—. X is an electron withdrawing group. R is a substituted or unsubstituted straight chained hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups and Y is —H, an amine, —[NH—(CH2)q]r—NH2, halogen, —CF3, thiol, ammonium, alcohol, —COOH, —SO3H, —OSO3H or phosphonium group covalently bonded to the terminal position of R. Each —NH— in —[NH—(CH2)q]r—NH2 is optionally N-alkylated or N,N-dialkylated and —NH2 in —[NH—CH2)q]r—NH2 is optionally N-alkylated, N,N-dialkylated or N,N,N-trialkylated. q is an integer from 2 to about 10 and r is an integer from 1 to about 5. R1 and R1′ are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or, taken together, are a C2-C5 substituted or unsubstituted alkylene group optionally comprising an amine linking group [—N+(R1a)—]. Each R1 is Structural Formula (I) is preferably —H. R1a is —H, alkyl, substituted alkyl phenyl or substituted phenyl. Also disclosed is a method of treating obesity in a subject by administering an effective amount of a compound represented by Structural Formula (I) and a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier or diluent.

3. 发明申请

US20060128663A1 Aryl boronate functionalized polymers for treating obesity 审中-公开
公开(公告)号：US20060128663A1
公开(公告)日：2006-06-15
申请号：US11342129
申请日：2006-01-27
申请人： Stephen Holmes-Farley , W. Mandeville , Pradeep Dhal , Chad Huval , Xinhua Li , Steven Polomoscanik
发明人： Stephen Holmes-Farley , W. Mandeville , Pradeep Dhal , Chad Huval , Xinhua Li , Steven Polomoscanik
IPC分类号： A61K31/69 , C08G79/08 , A01N55/08
CPC分类号： C08F8/42 , A61K31/74 , A61K31/785 , A61K47/58 , C08F8/44 , C08G65/331 , C08G73/0206 , C08G79/08 , C08F20/60 , C08F26/02
摘要： Disclosed are polymers comprising one or more phenyl boronate ester, boronamide or boronate thioester groups. The phenyl boronate ester, boronamide and boronate thioester groups are represented by one of the following structural formulas: Ar in Structural Formulas (I) and (II) is substituted or unsubstituted; and each Z is —O—, —NH— or —S— and is independently selected. Pharmaceutically acceptable salts of the polymer are also included. The aryl boronate ester, boronamide or boronate thioester can be cleaved to release the corresponding aryl boronic acid. Also disclosed are pharmaceutical compositions comprising the polymers of the present invention and a pharmaceutically acceptable carrier or diluent; and methods of treating a subject for obesity with the polymers of the present invention.

4. 发明申请

US20050107336A1 Aryl boronic acids for treating obesity 有权
公开(公告)号：US20050107336A1
公开(公告)日：2005-05-19
申请号：US11027643
申请日：2004-12-30
申请人： Stephen Holmes-Farley , W. Mandeville , Pradeep Dhal , Chad Huval , Xinhua Li
发明人： Stephen Holmes-Farley , W. Mandeville , Pradeep Dhal , Chad Huval , Xinhua Li
IPC分类号： A61K31/69 , A61K31/74 , A61K31/785 , A61P3/04 , A61P3/06 , C07F5/02
CPC分类号： C07F5/025 , A61K31/74 , A61K31/785
摘要： Disclosed is a phenyl boronic acid compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aryl group. Z and Z′ are independently —O—. —NH— or —S—. X is an electron withdrawing group. R is a substituted or unsubstituted straight chained hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups and Y is —H, an amine, —[NH—(CH2)q]r—NH2, halogen, —CF3, thiol, ammonium, alcohol, —COOH, —SO3H, —OSO3H or phosphonium group covalently bonded to the terminal position of R. Each —NH— in —[NH—(CH2)q]r—NH2 is optionally N-alkylated or N,N-dialkylated and —NH2 in —[NH—(CH2)q]r—NH2 is optionally N-alkylated, N,N-dialkylated or N,N,N-trialkylated. q is an integer from 2 to about 10 and r is an integer from 1 to about 5. R1 and R1′ are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or, taken together, are a C2-C5 substituted or unsubstituted alkylene group optionally comprising an amine linking group [—N+(R1a)—]. Each R1 is Structural Formula (I) is preferably —H. R1a is —H, alkyl, substituted alkyl, phenyl or substituted phenyl. Also disclosed is a method of treating obesity in a subject by administering an effective amount of a compound represented by Structural Formula (I) and a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier or diluent.

5. 发明申请

US20120000162A1 SINGLE KNIFE CAPPING MACHINE 审中-公开
标题翻译：单刀切割机
公开(公告)号：US20120000162A1
公开(公告)日：2012-01-05
申请号：US12998455
申请日：2008-12-30
申请人： Xinhua Li , Niansheng Yang , Shen Liu , Jianyong Liu , Zhimin Duan , Yue Tang
发明人： Xinhua Li , Niansheng Yang , Shen Liu , Jianyong Liu , Zhimin Duan , Yue Tang
IPC分类号： B65B7/28
CPC分类号： B67B3/18
摘要： A capping machine, comprising a depressing member, a cap pressing device connected to the depressing member, a supporting device, a transmission device, a first driving wheel, a second driving wheel, and an actuating wheel, wherein the first driving wheel is rotatably connected to the depressing member, wherein the depressing member comprises a driver member, while the cap pressing device comprises a driver ring, wherein the driver member is received in the driver ring, wherein the depressing member is engaged with the first driving wheel such that the first driving wheel is arranged to drive the depressing member and the cap pressing device in a vertical direction, wherein the depressing member is driven to rotate by the transmission device, while the supporting device is also rotatably connected to the transmission device so as to rotate with the depressing member in a synchronized manner.
摘要翻译：一种封盖机，包括按压构件，连接到按压构件的盖按压装置，支撑装置，传动装置，第一驱动轮，第二驱动轮和致动轮，其中第一驱动轮可旋转地连接到所述按压部件，其中所述按压部件包括驱动部件，同时所述盖按压装置包括驱动器环，其中所述驱动器部件被容纳在所述驱动器环中，其中所述按压部件与所述第一驱动轮接合，使得所述第一驱动轮被布置成沿垂直方向驱动按压构件和盖按压装置，其中按压构件由传动装置驱动旋转，同时支撑装置也可旋转地连接到传动装置，以便与按压构件以同步的方式。

6. 发明授权

US07041280B2 Aryl boronate functionalized polymers for treating obesity 有权
公开(公告)号：US07041280B2
公开(公告)日：2006-05-09
申请号：US10187316
申请日：2002-06-27
申请人： Stephen Randall Holmes-Farley , W. Harry Mandeville, III , Pradeep K. Dhal , Chad Cori Huval , Xinhua Li , Steven Craig Polomoscanik
发明人： Stephen Randall Holmes-Farley , W. Harry Mandeville, III , Pradeep K. Dhal , Chad Cori Huval , Xinhua Li , Steven Craig Polomoscanik
IPC分类号： A61K31/80
CPC分类号： C08F8/42 , A61K31/74 , A61K31/785 , A61K47/58 , C08F8/44 , C08G65/331 , C08G73/0206 , C08G79/08 , C08F20/60 , C08F26/02
摘要： Disclosed are polymers comprising one or more phenyl boronate ester, boronamide or boronate thioester groups. The phenyl boronate ester, boronamide and boronate thioester groups are represented by one of the following structural formulas: Ar in Structural Formulas (I) and (II) is substituted or unsubstituted; and each Z is —O—, —NH— or —S— and is independently selected. Pharmaceutically acceptable salts of the polymer are also included. The aryl boronate ester, boronamide or boronate thioester can be cleaved to release the corresponding aryl boronic acid.Also disclosed are pharmaceutical compositions comprising the polymers of the present invention and a pharmaceutically acceptable carrier or diluent; and methods of treating a subject for obesity with the polymers of the present invention.

7. 发明授权

US06858592B2 Aryl boronic acids for treating obesity 有权
标题翻译：用于治疗肥胖症的芳基硼酸
公开(公告)号：US06858592B2
公开(公告)日：2005-02-22
申请号：US10187397
申请日：2002-06-27
申请人： Stephen Randall Holmes-Farley , W. Harry Mandeville, III , Pradeep K. Dhal , Chad Cori Huval , Xinhua Li
发明人： Stephen Randall Holmes-Farley , W. Harry Mandeville, III , Pradeep K. Dhal , Chad Cori Huval , Xinhua Li
IPC分类号： A61K31/69 , A61K31/74 , A61K31/785 , A61P3/04 , A61P3/06 , C07F5/02
CPC分类号： C07F5/025 , A61K31/74 , A61K31/785
摘要： Disclosed is a phenyl boronic acid compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aryl group. Z and Z′ are independently —O—. —NH— or —S—. X is an electron withdrawing group. R is a substituted or unsubstituted straight chained hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups and Y is —H, an amine, —[NH—(CH2)q]r—NH2, halogen, —CF3, thiol ammonium, alcohol, —COOH, —SO3H, —OSO3H or phosphonium group covalently bonded to the terminal position of R. Each —NH— in —[NH—(CH2)q]r—NH2 is optionally N-alkylated or N,N-dialkylated and —NH2 in —[NH—(CH2)q]r—NH2 is optionally N-alkylated, N,N-dialkylated or N,N,N-trialkylated. q is an integer from 2 to about 10 and r is an integer from 1 to about 5. R1 and R1′ are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or, taken together, are a C2-C5 substituted or unsubstituted alkylene group optionally comprising an amine linking group [—N+(R1a)—]. Each R1 is Structural Formula (I) is preferably —H. R1a is —H, alkyl, substituted alkyl, phenyl or substituted phenyl. Also disclosed is a method of treating obesity in a subject by administering an effective amount of a compound represented by Structural Formula (I) and a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier or diluent.
摘要翻译：公开了由结构式（I）表示的苯基硼酸化合物：Ar是取代或未取代的芳基.Z和Z'独立地是-O-。 -NH-或-S-X是吸电子基团.R是任选地包含一个或多个胺，铵，醚，硫醚或亚苯基连接基团的取代或未取代的直链烃基，Y是-H，胺， - [NH-（CH 2）q] r -NH 2，卤素，-CF 3，硫醇铵，醇，-COOH，-SO 3 H，-OSO 3 H或共价键合到R的末端的鏻基团。 NH-（CH 2）q] r -NH 2任选被N-烷基化或N，N-二烷基化，-NH 2在 - [NH-（CH 2）q] r -NH 2中任选地N-烷基化，N，N-二烷基化或N ，N，N-三烷基化.q为2至约10的整数，r为1至约5.R1的整数，R1'独立地为-H，脂族基团，取代的脂族基团，芳基或取代的芳基，或者一起是任选地包含胺连接基团[-N +（R 1a） - ] - 的C 2 -C 5取代或未取代的亚烷基。每个R1是结构式（I）优选-HR 1a是-H，烷基，取代的烷基，苯基或取代的苯基。还公开了通过给予有效量的由结构式（I）和包含该化合物和药学上可接受的载体或稀释剂的药物组合物。

8. 发明授权

US5375657A Chain long-stroke oil-well pumping unit 失效
标题翻译：链长行程油井抽油机
公开(公告)号：US5375657A
公开(公告)日：1994-12-27
申请号：US85939
申请日：1993-07-06
申请人： Chaoying Shi , Kaili Song , Xinhua Li , Guanggi Gao , Juanhuan Yang , Quingkun Zeng
发明人： Chaoying Shi , Kaili Song , Xinhua Li , Guanggi Gao , Juanhuan Yang , Quingkun Zeng
IPC分类号： E21B43/12 , F04B47/02 , E21B43/00
CPC分类号： E21B43/126 , F04B47/026
摘要： The invention relates to oil recovery equipment improved from existing chain oil-well pumping units. Double suspending cables, double balance flexible cables and a counterweight structure without inertial load are used in the invention. There are guide buffer devices and a buffer eccentric regulation shaft coupling in the apparatus according to the invention. Consequently, the load distribution and the stressed condition are more reasonable, the structure is simplified and reliable, and power is obviously economized. The invention has the striking strong points mentioned above in recovering condensed oil, high-condensed oil and bathhypelagic oil.
摘要翻译：本发明涉及从现有连续油井抽油机改进的油回收设备。在本发明中使用双悬挂电缆，双平衡柔性电缆和没有惯性负载的配重结构。在根据本发明的设备中有引导缓冲装置和缓冲偏心调节轴联接器。因此，负载分布和应力状况更为合理，结构简单可靠，功率明显节省。本发明在回收浓缩油，高浓缩油和浴前油中具有突出的优点。

9. 发明授权

US11111782B2 System and method for oilfield management 有权
公开(公告)号：US11111782B2
公开(公告)日：2021-09-07
申请号：US16870275
申请日：2020-05-08
申请人： Xinhua Li
发明人： Xinhua Li , Haifeng Tian , Binghui Li
IPC分类号： E21B47/13 , G06Q10/06 , G06Q10/08 , G06Q50/02
摘要： The present invention relates to an oilfield management system. The oilfield management system comprises: one or more devices for measuring working conditions of oil wells, the one or more devices for measuring working conditions of oil wells are installed on one or more oil wells respectively for measuring working conditions of the one or more oil wells, the working conditions of oil wells at least comprise indicator diagrams of oil wells; one or more remote transmission units, each of the remote transmission units receives the working conditions measured by one or more of the devices for measuring working conditions of oil wells; and server, which determines running status of the one or more oil wells according to the working conditions of oil wells from the one or more remote transmission units; maintenance staff or administrators manage the one or more oil wells according to the running status of the one or more oil wells. The present invention can collect indicator diagrams of an oil well on a regular basis, detect ON/OFF status of an oil well in real time, and realize the calculation of liquid production capacity via indicator diagrams and efficient and elaborate management of working conditions of oil wells.

10. 发明授权

US10000717B2 Lubricating oil compositions containing encapsulated microscale particles 有权
公开(公告)号：US10000717B2
公开(公告)日：2018-06-19
申请号：US14978000
申请日：2015-12-22
申请人： Michael White , Xinhua Li , Joseph McLellan , Olivier Schueller , Patrick Reust , Alan M. Schilowitz , David J. Baillargeon
发明人： Michael White , Xinhua Li , Joseph McLellan , Olivier Schueller , Patrick Reust , Alan M. Schilowitz , David J. Baillargeon
IPC分类号： C10M113/16 , C10M125/10 , C10M125/26 , C10M129/40 , C10M137/12 , C10M133/06 , C10M137/10 , C10M169/04 , C10M141/02 , C10M141/06 , C10M141/10 , C10M103/06
CPC分类号： C10M125/26 , C10M103/06 , C10M125/10 , C10M129/40 , C10M133/06 , C10M137/10 , C10M137/12 , C10M141/02 , C10M141/06 , C10M141/10 , C10M169/04 , C10M2201/062 , C10M2201/14 , C10M2205/0285 , C10M2207/125 , C10M2207/126 , C10M2207/16 , C10M2207/262 , C10M2215/04 , C10M2219/046 , C10M2223/045 , C10M2223/06 , C10N2210/02 , C10N2230/06 , C10N2230/40 , C10N2230/42 , C10N2230/43 , C10N2230/50 , C10N2230/70 , C10N2240/10 , C10N2250/16
摘要： A method for improving wear control in an engine or other mechanical component lubricated with a lubricating oil by using as the lubricating oil a formulated oil. The formulated oil has a composition including a lubricating oil base stock as a major component, and encapsulated microscale particles, as a minor component. The minor component contains no sulfur or phosphorus. The encapsulated microscale particles include an encapsulating material and a core material encapsulated by the encapsulating material. The core material includes at least one metal salt selected from a metal oxide, metal hydroxide, metal carbonate, or mixtures thereof. The encapsulating material is derived from a carboxylic acid selected from an aliphatic carboxylic acid, a cycloaliphatic carboxylic acid, an aromatic carboxylic acid, and mixtures thereof. The lubricating oils are useful in internal combustion engines.

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