专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20130131284A1 POLYHEDRAL OLIGOMERIC SILSESQUIOXANE (POSS)-LINKED LIGANDS 有权
标题翻译：聚合物低聚硅氧烷（POSS）
公开(公告)号：US20130131284A1
公开(公告)日：2013-05-23
申请号：US13582010
申请日：2011-02-28
申请人： Cengiz Azap , Dorit Wolf , Hendrikus Cornelis Louis Abbenhuis , Gijsbert Gerritsen , Karol Grela , Jos B.M. Wilting , Kinga Leszczynska , Justyna Czaban , Anna Wojtasiewicz
发明人： Cengiz Azap , Dorit Wolf , Hendrikus Cornelis Louis Abbenhuis , Gijsbert Gerritsen , Karol Grela , Jos B.M. Wilting , Kinga Leszczynska , Justyna Czaban , Anna Wojtasiewicz
IPC分类号： C08G77/398 , C08G77/388 , C08G77/395
CPC分类号： C08G77/398 , C07F7/21 , C08G77/388 , C08G77/395
摘要： Polyhedral oligomeric silsesquioxanes (POSS) linked ligand of the general formula (I) L[(R1a)n-1(SiO1,5)nR2a]k[(R1b)n-1SiO1,5)nR2b]l[(R1c)n-1SiO1,5)nR2c]m (I) in which (R1a,b,c)n-1(SiO1,5)n is a polyhedral oligomeric silsesquioxanes (POSS) with n=4, 6, 8, 10, 12, 14, 16 or 18 and R1a, R1b, R1c is each independently selected from the group consisting of same or different branched or linear C1-C20 alkyl chains, cyclo alkyl, C1-C20 alkoxy, aryl, aryloxy, heteroaryl and arylalkyl groups, k, l, m is 0 or 1 provided that k+l+m≧1, R2a, R2b, R2c is a spacer that binds the polyhedral oligomeric silsesquioxane (POSS) to the ligand L and ligand L is an uncharged electron donor.
摘要翻译：通式（I）L [（R1a）n-1（SiO1,5）nR2a] k [（R1b）n-1SiO1,5）nR2b] l [（R1c）n-1（SiO1））的多面体低聚倍半硅氧烷（POSS）连接的配体 1SiO1,5）nR2c] m（I）其中（R1a，b，c）n-1（SiO1,5）n是具有n = 4,6,8,10,12,14的多面体低聚倍半硅氧烷（POSS），16或18，并且R 1a，R 1b，R 1c各自独立地选自相同或不同的支链或直链C 1 -C 20烷基链，环烷基，C 1 -C 20烷氧基，芳基，芳氧基，杂芳基和芳基烷基，k， l，m为0或1，条件是k + 1 + m> = 1，R2a，R2b，R2c是将多面体低聚倍半硅氧烷（POSS）与配体L结合的间隔基，配体L是不带电子的电子给体。

2. 发明授权

US09029483B2 Polyhedral oligomeric silsesquioxane (POSS)-linked ligands 有权
标题翻译：多面体低聚倍半硅氧烷（POSS）连接的配体
公开(公告)号：US09029483B2
公开(公告)日：2015-05-12
申请号：US13582010
申请日：2011-02-28
申请人： Cengiz Azap , Dorit Wolf , Hendrikus Cornelis Louis Abbenhuis , Gijsbert Gerritsen , Karol Grela , Jos B. M. Wilting , Kinga Leszczynska , Justyna Czaban , Anna Wojtasiewicz
发明人： Cengiz Azap , Dorit Wolf , Hendrikus Cornelis Louis Abbenhuis , Gijsbert Gerritsen , Karol Grela , Jos B. M. Wilting , Kinga Leszczynska , Justyna Czaban , Anna Wojtasiewicz
IPC分类号： C08G77/398 , C08G77/388 , C08G77/395 , C07F7/21
CPC分类号： C08G77/398 , C07F7/21 , C08G77/388 , C08G77/395
摘要： Polyhedral oligomeric silsesquioxanes (POSS) linked ligand of the general formula (I) L[(R1a)n-1(SiO1,5)nR2a]k[(R1b)n-1SiO1,5)nR2b]l[(R1c)n-1SiO1,5)nR2c]m (I) in which (R1a,b,c)n-1(SiO1,5)n is a polyhedral oligomeric silsesquioxanes (POSS) with n=4, 6, 8, 10, 12, 14, 16 or 18 and R1a, R1b, R1c is each independently selected from the group consisting of same or different branched or linear C1-C20 alkyl chains, cyclo alkyl, C1-C20 alkoxy, aryl, aryloxy, heteroaryl and arylalkyl groups, k, l, m is 0 or 1 provided that k+l+m≧1, R2a, R2b, R2c is a spacer that binds the polyhedral oligomeric silsesquioxane (POSS) to the ligand L and ligand L is an uncharged electron donor.
摘要翻译：通式（I）L [（R1a）n-1（SiO1,5）nR2a] k [（R1b）n-1SiO1,5）nR2b] l [（R1c）n-1（SiO1））的多面体低聚倍半硅氧烷（POSS） 1SiO1,5）nR2c] m（I）其中（R1a，b，c）n-1（SiO1,5）n是具有n = 4,6,8,10,12,14的多面体低聚倍半硅氧烷（POSS），16或18，并且R 1a，R 1b，R 1c各自独立地选自相同或不同的支链或直链C 1 -C 20烷基链，环烷基，C 1 -C 20烷氧基，芳基，芳氧基，杂芳基和芳基烷基，k， l，m为0或1，条件是k + 1 +m≥1，R2a，R2b，R2c是将多面体低聚倍半硅氧烷（POSS）与配体L结合的间隔物，配体L是不带电子的电子给体。

3. 发明授权

US07829746B2 Process for the preparation of calcipotriol 有权
标题翻译：卡泊三醇的制备方法
公开(公告)号：US07829746B2
公开(公告)日：2010-11-09
申请号：US12685256
申请日：2010-01-11
申请人： Andrzej Kutner , Michal Chodynski , Kinga Leszczynska , Wieslaw Szelejewski , Hanna Fitak
发明人： Andrzej Kutner , Michal Chodynski , Kinga Leszczynska , Wieslaw Szelejewski , Hanna Fitak
IPC分类号： C07C35/00
CPC分类号： C07C401/00 , C07C2601/02 , Y02P20/55
摘要： A process for the preparation of calcipotriol at least including: (a) reacting a C-22 phenylsulfonyl derivative of cholecalciferol of Formula 2, wherein R1 and R2 are the same or different and represent hydroxyl protecting groups, with a silyl derivative of alfa-hydroxy aldehyde of Formula 3, wherein R3 represents silyl group of formula Si(R4)(R5)(R6), where R4-R6 are the same or different and represent C1-6 alkyl or phenyl groups, in the presence of a strong organic base in an aprotic solvent, followed by reductive desulfonation of the obtained diastereomeric mixture of alfa-hydroxysulfones with sodium amalgam, removal of the hydroxyl protecting groups, and purification of the product. The process leads to the formation of calcipotriol containing less than 0.3% of the (22Z)-isomer. The obtained calcipotriol is free of mercury traces.
摘要翻译：一种制备卡泊三醇的方法，至少包括：（a）使式2的胆钙化甾醇的C-22苯基磺酰基衍生物与其中R 1和R 2相同或不同并代表羟基保护基，与α-羟基的甲硅烷基衍生物醛，其中R 3表示式Si（R 4）（R 5）（R 6）的甲硅烷基，其中R 4 -R 6相同或不同，表示C 1-6烷基或苯基，在强有机碱存在下在非质子溶剂中，然后将所得到的α-羟基磺酰胺与汞齐汞合物的非对映异构体混合物还原脱磺化，除去羟基保护基团并纯化产物。该方法导致含有小于0.3％的（22Z）异构体的卡泊三醇的形成。得到的卡泊三醇没有汞痕迹。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式