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1. 发明授权

US06554795B2 Balloon catheter and method of manufacture 失效
标题翻译：球囊导管及制造方法
公开(公告)号：US06554795B2
公开(公告)日：2003-04-29
申请号：US09026225
申请日：1998-02-19
申请人： Celso J. Bagaoisan , Ketan P. Muni , Hung V. Ha , Sivette Lam , Gholam-Reza Zadno-Azizi , Mukund R. Patel
发明人： Celso J. Bagaoisan , Ketan P. Muni , Hung V. Ha , Sivette Lam , Gholam-Reza Zadno-Azizi , Mukund R. Patel
IPC分类号： A61M2900
CPC分类号： A61M25/1029 , A61M25/0009 , A61M25/1034 , B29C55/04
摘要： Disclosed herein is a compliant catheter balloon with an improved elastic response and reduced longitudinal expansion, and a method of forming the same. The balloon comprises a SEBS block copolymer, which is longitudinally pre-stretched during the balloon manufacture process. In order to control the working length of a balloon on a catheter, at least one adhesive stop is provided on the catheter which prevents adhesive from wicking into the working length of the balloon. Preferably, a pair of thermoset tubings with an outer diameter size close to the size of the inner diameter of the balloon are inserted on the distal portion of the catheter. After the proper placement of the balloon, the adhesive is applied at the balloon's proximal and distal ends. As the adhesive wicks to the balloon, the thermoset tubings will eventually stop the adhesive to prevent further wicking of adhesive into the balloon's working length. In another aspect of the present invention, there is provided a method of manufacturing a balloon catheter to improve centering of the balloon on the catheter. After a balloon tubing is stretched, the stretched tubing is clamped to a fixture and stabilized at about 100° C. for 15 minutes. This stabilization step ensures that a balloon mounted on a catheter will inflate in a uniform manner.
摘要翻译：本文公开了一种具有改进的弹性响应和减小的纵向膨胀的柔顺导管气囊及其形成方法。气球包含SEBS嵌段共聚物，其在球囊制造过程中被纵向预拉伸。为了控制导管上的气球的工作长度，在导管上提供至少一个粘合阻挡件，其防止粘合剂吸入气球的工作长度。优选地，具有接近球囊内径尺寸的外径尺寸的一对热固管插入导管的远端部分。在适当放置气囊之后，将粘合剂施加在气囊的近端和远端。当粘合剂吸入气球时，热固性管将最终停止粘合剂，以防止粘合剂进一步吸入气囊的工作长度。在本发明的另一方面，提供一种制造球囊导管以改善球囊在导管上的对中的方法。在气囊管被拉伸之后，将拉伸的管道夹紧到夹具上并在约100℃下稳定15分钟。该稳定步骤确保安装在导管上的气囊将以均匀的方式充气。

2. 发明授权

US06398773B1 Aspiration system and method 失效
标题翻译：吸气系统和方法
公开(公告)号：US06398773B1
公开(公告)日：2002-06-04
申请号：US09591733
申请日：2000-06-12
申请人： Celso J. Bagaoisan , Hung V. Ha , Mukund R. Patel , Sivette Lam , Mir Imran
发明人： Celso J. Bagaoisan , Hung V. Ha , Mukund R. Patel , Sivette Lam , Mir Imran
IPC分类号： A61M3100
CPC分类号： A61M25/0009 , A61B17/22 , A61B18/245 , A61B2017/22067 , A61B2017/22084 , A61B2017/320716 , A61B2217/005 , A61M25/0029 , A61M25/005 , A61M25/0053 , A61M25/0054 , A61M25/0075 , A61M25/09 , A61M25/09033 , A61M25/10 , A61M25/1011 , A61M25/10184 , A61M25/104 , A61M2025/0018 , A61M2025/0034 , A61M2025/0037 , A61M2025/0183 , A61M2025/09008 , A61M2025/09175 , A61M2025/09183 , A61M2025/1015 , A61M2025/1052 , A61M2025/1079 , A61M2025/109 , A61M2025/1093
摘要： Aspiration catheters and methods for the treatment of an occlusion in a blood vessel. These catheters and methods are especially useful in the removal of occlusions from saphenous vein grafts, the coronary and carotid arteries, arteries above the aortic arch and even smaller vessels. The catheters of the present invention are provided in either over-the-wire or in single operator form. Radiopaque markers are preferably incorporated into distal ends of the catheters, and visual markers are incorporated into the proximal end of the catheters, to facilitate their positioning within the body. The catheters are provided with varying flexibility along the length of the shaft, such that they are soft and flexible enough to be navigated through the vasculature of a patient without causing damage, but are stiff enough to sustain the axial push required to position the catheter properly and to sustain the aspiration pressures. Support mandrels and support sheaths may also be added to impart additional strength to the length of the catheter.
摘要翻译：吸入导管和用于治疗血管闭塞的方法。这些导管和方法特别适用于去除隐静脉移植物，冠状动脉和颈动脉，主动脉弓上方的动脉甚至更小的血管的闭塞。本发明的导管以线上或单个操作者形式提供。不透射线标记物优选并入导管的远端，并且将视觉标记物结合到导管的近端中，以便于它们在体内定位。导管沿着轴的长度设置有不同的柔性，使得它们柔软且足够灵活，以便穿过患者的脉管系统而不造成损伤，但足够坚硬以维持正确定位导管所需的轴向推动并维持吸引压力。还可以添加支撑心轴和支撑护套以对导管的长度赋予额外的强度。

3. 发明授权

US6152909A Aspiration system and method 失效
公开(公告)号：US6152909A
公开(公告)日：2000-11-28
申请号：US26013
申请日：1998-02-19
申请人： Celso J. Bagaoisan , Hung V. Ha , Mukund R. Patel , Sivette Lam , Mir Imran
发明人： Celso J. Bagaoisan , Hung V. Ha , Mukund R. Patel , Sivette Lam , Mir Imran
IPC分类号： A61B17/22 , A61B18/24 , A61F2/958 , A61M1/00 , A61M25/00 , A61M29/02
CPC分类号： A61M25/0009 , A61B17/22 , A61B18/245 , A61M25/0053 , A61M25/0054 , A61M25/0075 , A61M25/09 , A61M25/09033 , A61M25/1011 , A61M25/1018 , A61M25/10184 , A61M25/104 , A61B2017/22067 , A61B2017/22084 , A61B2017/320716 , A61B2217/005 , A61M2025/0018 , A61M2025/0034 , A61M2025/0037 , A61M2025/0183 , A61M2025/09008 , A61M2025/09175 , A61M2025/09183 , A61M2025/1015 , A61M2025/1052 , A61M2025/1079 , A61M2025/109 , A61M2025/1093 , A61M25/0029 , A61M25/005 , A61M25/10
摘要： Aspiration catheters and methods for the treatment of an occlusion in a blood vessel. These catheters and methods are especially useful in the removal of occlusions from saphenous vein grafts, the coronary and carotid arteries, arteries above the aortic arch and even smaller vessels. The catheters of the present invention are provided in either over-the-wire or in single operator form. Radiopaque markers are preferably incorporated into distal ends of the catheters, and visual markers are incorporated into the proximal end of the catheters, to facilitate their positioning within the body. The catheters are provided with varying flexibility along the length of the shaft, such that they are soft and flexible enough to be navigated through the vasculature of a patient without causing damage, but are stiff enough to sustain the axial push required to position the catheter properly and to sustain the aspiration pressures. Support mandrels and support sheaths may also be added to impart additional strength to the length of the catheter.

4. 发明授权

US06849068B1 Aspiration catheter 失效
标题翻译：吸气导管
公开(公告)号：US06849068B1
公开(公告)日：2005-02-01
申请号：US09454522
申请日：1999-12-06
申请人： Celso J. Bagaoisan , Hung V. Ha , Mukund R. Patel , Sivette Lam
发明人： Celso J. Bagaoisan , Hung V. Ha , Mukund R. Patel , Sivette Lam
IPC分类号： A61F2/958 , A61M25/00
CPC分类号： A61M25/1011 , A61M2025/1015 , A61M2025/1052 , A61M2025/109 , A61M2025/1093
摘要： Aspiration catheters suitable for use in the treatment of an occlusion in a blood vessel are disclosed. These catheters are especially useful in the removal of occlusions from saphenous vein grafts, the coronary and carotid arteries, arteries above the aortic arch and even smaller vessels. The catheters of the present invention are provided in either over-the-wire or in single operator form. Radiopaque markers are preferably incorporated into distal ends of the catheters to facilitate their positioning within the body. The catheters are provided with varying flexibility along the length of the shaft, such that they are soft and flexible enough to be navigated through the vasculature of a patient without causing damage, but are stiff enough to sustain the axial push required to position the catheter properly and to sustain the aspiration pressures.
摘要翻译：公开了适合用于治疗血管闭塞的吸引导管。这些导管特别适用于从隐静脉移植物，冠状动脉和颈动脉，主动脉弓上方的动脉以及更小的血管中去除闭塞。本发明的导管以线上或单个操作者形式提供。不透射线标记物优选并入导管的远端，以便于它们在体内的定位。导管沿着轴的长度设置有不同的柔性，使得它们柔软且足够灵活，以便穿过患者的脉管系统而不造成损伤，但足够坚硬以维持正确定位导管所需的轴向推动并维持吸引压力。

5. 发明授权

US06605074B2 Method for containing and removing occlusions in the carotid arteries 失效
公开(公告)号：US06605074B2
公开(公告)日：2003-08-12
申请号：US10246077
申请日：2002-09-16
申请人： Gholam-Reza Zadno-Azizi , Mukund R. Patel , Ketan P. Muni , Celso J. Bagaoisan , Hung V. Ha
发明人： Gholam-Reza Zadno-Azizi , Mukund R. Patel , Ketan P. Muni , Celso J. Bagaoisan , Hung V. Ha
IPC分类号： A61M3100
CPC分类号： A61M25/008 , A61B17/22 , A61B2017/22067 , A61B2017/22084 , A61B2217/005 , A61M25/0071 , A61M25/1011 , A61M2025/0081 , A61M2025/0183 , A61M2025/1052 , A61M2210/0693
摘要： A method for the treatment of a stenosis or an occlusion in a blood vessel is disclosed in which a main catheter is first delivered to a site proximal to the occlusion. The main catheter may include an occlusive device at its distal end. An inner catheter or elongate member (e.g., a guidewire) having an occlusive device at its distal end is delivered to the site of the occlusion, and the occlusive device is activated at a site distal to the occlusion. A therapy catheter is then introduced to treat the occlusion. Next, a catheter is delivered just proximal to the occlusive device, and this catheter is used to aspirate and/or irrigate the area removing particles and debris. The aspiration and irrigation steps are preferably repeated until the particles and debris are removed. Perfusion may be performed by using a perfusion-filter distal of the lesion to be treated or a hypotube which extends beyond the occlusive device attached to the guidewire. The present invention provides for a minimally invasive procedure which can be performed quickly and efficiently, with reduced risks to the patient.

6. 发明授权

US06270477B1 Catheter for emboli containment 失效
标题翻译：导管栓塞栓塞
公开(公告)号：US06270477B1
公开(公告)日：2001-08-07
申请号：US08813023
申请日：1997-03-06
申请人： Celso J. Bagaoisan , Hung V. Ha , Mukund R. Patel , Gholam-Reza Zadno-Azizi
发明人： Celso J. Bagaoisan , Hung V. Ha , Mukund R. Patel , Gholam-Reza Zadno-Azizi
IPC分类号： A61M2900
CPC分类号： A61M25/0009 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61B17/12172 , A61B17/22 , A61B2017/12127 , A61B2017/22055 , A61B2017/22067 , A61B2017/22084 , A61B2017/320716 , A61B2217/005 , A61M25/0012 , A61M25/0026 , A61M25/0029 , A61M25/0032 , A61M25/0053 , A61M25/0054 , A61M25/0068 , A61M25/007 , A61M25/0075 , A61M25/10 , A61M25/1011 , A61M25/1018 , A61M25/1027 , A61M25/104 , A61M2025/0018 , A61M2025/0034 , A61M2025/0036 , A61M2025/0037 , A61M2025/0081 , A61M2025/0183 , A61M2025/0681 , A61M2025/1015 , A61M2025/1031 , A61M2025/1045 , A61M2025/1052 , A61M2025/1079 , A61M2025/109 , A61M2025/1093 , B29C55/04
摘要： Disclosed herein is a catheter for use in an emboli containment system. In one embodiment, the catheter has a tubular body with a metallic braid construction. Two lumen extend through the tubular body, the lumen being in a side-by-side configuration. One of the lumen functions as an inflation lumen, and is in fluid communication with an inflatable balloon mounted on the distal end of the catheter. The second lumen is adapted to receive other therapeutic catheters which comprise the emboli containment system.
摘要翻译：本文公开了一种用于栓塞收容系统的导管。在一个实施例中，导管具有带有金属编织结构的管状体。两个内腔延伸穿过管状体，内腔处于并排构型。管腔中的一个作为充气腔起作用，并且与安装在导管的远端上的可充气气囊流体连通。第二腔适于接收包括栓塞容纳系统的其它治疗导管。

7. 发明授权

US06312407B1 Occlusion of a vessel 失效
标题翻译：阻塞血管
公开(公告)号：US06312407B1
公开(公告)日：2001-11-06
申请号：US09026106
申请日：1998-02-19
申请人： Gholam-Reza Zadno-Azizi , Celso J. Bagaoisan , Mukund R. Patel , Ketan P. Muni
发明人： Gholam-Reza Zadno-Azizi , Celso J. Bagaoisan , Mukund R. Patel , Ketan P. Muni
IPC分类号： A61M2900
CPC分类号： A61B17/12022 , A61B17/12036 , A61B17/12109 , A61B17/12168 , A61B17/12172 , A61B17/22 , A61B2017/1205 , A61B2017/22067 , A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0065 , A61F2230/0069 , A61F2230/0076 , A61F2230/008 , A61F2230/0091 , A61M25/0009 , A61M25/0026 , A61M25/0054 , A61M25/0075 , A61M25/09 , A61M25/09033 , A61M25/10 , A61M25/1011 , A61M25/10182 , A61M29/02 , A61M2025/0018 , A61M2025/0079 , A61M2025/09008 , A61M2025/09116 , A61M2025/09125 , A61M2025/09175 , A61M2025/1015 , A61M2025/1045 , A61M2025/1052 , A61M2025/1079 , A61M2025/1081 , A61M2025/1093
摘要： A device for occluding a vessel employs one of a number of different expansion members joined to one or more elongate members. The expansion member may include a braid, one or more coils, ribs, a ribbon-like structure, a slotted tube, or a filter-like mesh. If the expansion member is enclosed by a suitable membrane, the device seals with the vessel wall to partially or completely occlude the vessel. A perforated membrane may be used to permit the perfusion of blood. The expansion member may be self-expanding, or it may be expanded by engaging it with one of the elongate members. Alternatively, the expansion member may be expanded by heating it.
摘要翻译：用于封闭容器的装置采用与一个或多个细长构件连接的多个不同的膨胀构件中的一个。膨胀构件可以包括编织物，一个或多个线圈，肋，带状结构，开槽管或过滤器状网。如果膨胀构件被合适的膜封闭，则装置与容器壁密封以部分地或完全地封闭容器。穿孔膜可用于允许血液灌注。膨胀构件可以是自膨胀的，或者可以通过使其与细长构件之一接合而膨胀。或者，可以通过加热来膨胀膨胀构件。

8. 发明授权

US06994689B1 Occlusion of a vessel 失效
标题翻译：阻塞血管
公开(公告)号：US06994689B1
公开(公告)日：2006-02-07
申请号：US09636278
申请日：2000-08-10
申请人： Gholam-Reza Zadno-Azizi , Celso J. Bagaoisan , Mukund R. Patel , Ketan P. Muni
发明人： Gholam-Reza Zadno-Azizi , Celso J. Bagaoisan , Mukund R. Patel , Ketan P. Muni
IPC分类号： A61M29/00 , A61M31/00 , A61M5/00
CPC分类号： A61B17/12109 , A61B17/12022 , A61B17/1204 , A61B17/12172 , A61B2017/1205 , A61F2/013 , A61F2002/016 , A61F2002/018 , A61F2002/30095 , A61F2210/0023 , A61F2230/0065 , A61F2230/0069 , A61F2230/0076 , A61F2230/008 , A61F2230/0091
摘要： A device for occluding a vessel employs one of a number of different expansion members joined to one or more elongate members. The expansion member may include a braid, one or more coils, ribs, a ribbon-like structure, a slotted tube, or a filter-like mesh. If the expansion member is enclosed by a suitable membrane, the device seals with the vessel wall to partially or completely occlude the vessel. A perforated membrane may be used to permit the perfusion of blood. The expansion member may be self-expanding, or it may be expanded by engaging it with one of the elongate members. Alternatively, the expansion member may be expanded by heating it.
摘要翻译：用于封闭容器的装置采用与一个或多个细长构件连接的多个不同的膨胀构件中的一个。膨胀构件可以包括编织物，一个或多个线圈，肋，带状结构，开槽管或过滤器状网。如果膨胀构件被合适的膜封闭，则装置与容器壁密封以部分地或完全地封闭容器。穿孔膜可用于允许血液灌注。膨胀构件可以是自膨胀的，或者可以通过使其与细长构件之一接合而膨胀。或者，可以通过加热来膨胀膨胀构件。

9. 发明授权

US06790204B2 Method for containing and removing occlusions in the carotid arteries 失效
标题翻译：颈动脉内容纳和去除闭塞的方法
公开(公告)号：US06790204B2
公开(公告)日：2004-09-14
申请号：US10419912
申请日：2003-04-15
申请人： Gholam-Reza Zadno-Azizi , Mukund R. Patel , Ketan P. Muni , Celso J. Bagaosian , Hung V. Ha
发明人： Gholam-Reza Zadno-Azizi , Mukund R. Patel , Ketan P. Muni , Celso J. Bagaosian , Hung V. Ha
IPC分类号： A61M3100
CPC分类号： A61M25/008 , A61B17/22 , A61B2017/22067 , A61B2017/22084 , A61B2217/005 , A61M25/0071 , A61M25/1011 , A61M2025/0081 , A61M2025/0183 , A61M2025/1052 , A61M2210/0693
摘要： A method for the treatment of a stenosis or an occlusion in a blood vessel is disclosed in which a main catheter is first delivered to a site proximal to the occlusion. The main catheter may include an occlusive device at its distal end. An inner catheter or elongate member (e.g., a guidewire) having an occlusive device at its distal end is delivered to the site of the occlusion, and the occlusive device is activated at a site distal to the occlusion. A therapy catheter is then introduced to treat the occlusion. Next, a catheter is delivered just proximal to the occlusive device, and this catheter is used to aspirate and/or irrigate the area removing particles and debris. The aspiration and irrigation steps are preferably repeated until the particles and debris are removed. Perfusion may be performed by using a perfusion-filter distal of the lesion to be treated or a hypotube which extends beyond the occlusive device attached to the guidewire. The present invention provides for a minimally invasive procedure which can be performed quickly and efficiently, with reduced risks to the patient.
摘要翻译：公开了一种用于治疗血管狭窄或闭塞的方法，其中主导管首先被输送到接近闭塞的部位。主导管可以在其远端处包括闭塞装置。在其远端具有闭塞装置的内导管或细长构件（例如，导丝）被输送到闭塞部位，并且闭塞装置在远端闭塞位置被激活。然后引入治疗导管以治疗闭塞。接下来，将导管刚好靠近闭塞装置输送，并且该导管用于抽吸和/或冲洗除去颗粒和碎屑的区域。优选重复抽吸和冲洗步骤，直到除去颗粒和碎屑。灌注可以通过使用待治疗的病变的远侧的灌注过滤器或延伸超过连接到导丝线的闭塞装置的海波管来进行。本发明提供了可以快速有效地执行并降低患者风险的微创手术。

10. 发明申请

US20130206579A1 SELECTIVE DEHYDROHALOGENATION OF TERTIARY HALOGENATED HYDROCARBONS AND REMOVAL OF TERTIARY HALOGENATED HYDROCARBON IMPURITIES FROM A HALOGENATED HYDROCARBON PRODUCT 审中-公开
标题翻译：选择性脱氢氢化氢化石油烃，并从氢化氢产物中去除苛性氢化烃类污染物
公开(公告)号：US20130206579A1
公开(公告)日：2013-08-15
申请号：US13837276
申请日：2013-03-15
申请人： Michael L. Trippeer , Timothy C. Frank , Patrick H. Au-Yeung , Jason L. Bronkema , Robin K. Johnston , Mukund R. Patel , Bruce S. Holden , Terrence McCabe , Daniel A. Hickman
发明人： Michael L. Trippeer , Timothy C. Frank , Patrick H. Au-Yeung , Jason L. Bronkema , Robin K. Johnston , Mukund R. Patel , Bruce S. Holden , Terrence McCabe , Daniel A. Hickman
IPC分类号： C07C17/395
CPC分类号： C07C17/395 , B01D3/00 , B01D3/009 , B01D3/34 , C07B2200/09 , C07C17/383 , C07C21/073
摘要： A process for converting a tertiary halogenated hydrocarbons in a tertiary halogenated hydrocarbon-containing stream to a corresponding unhalogenated or less-halogenated unsaturated hydrocarbon product with the release of hydrogen halide involves contacting the tertiary halogenated hydrocarbon with a sorbent-type dehydrohalogenation catalyst in a reaction zone and optionally passing a stripping gas through the reaction zone to remove vapor phase reaction products from the reaction zone. A process for removing a tertiary chlorinated hydrocarbon impurity from 1,3-dichloro-1-propene involves contacting a mixture containing the 1,3-dichloro-1-propene and the tertiary chlorinated hydrocarbon impurity with a dehydrochlorination catalyst effective to catalyze a conversion of the tertiary chlorinated hydrocarbon impurity to a corresponding unchlorinated or less-chlorinated unsaturated hydrocarbon and hydrogen chloride and distilling the 1,3-dichloro-1-propene to produce a purified cis-1,3-dichloro-1-propene fraction and a purified trans-1,3-dichloro-1-propene fraction.
摘要翻译：在含卤代烃的物流中将叔卤代烃转化为相应的未卤化或低卤化的不饱和烃产物的方法，其中卤化氢的释放包括使叔卤代烃与吸附剂型脱卤化氢催化剂在反应区并且可选地使汽提气体通过反应区以从反应区除去气相反应产物。从1,3-二氯-1-丙烯中除去叔氯化烃杂质的方法包括将含有1,3-二氯-1-丙烯和叔氯化烃杂质的混合物与脱氯化氢催化剂接触，该催化剂有效催化转化率叔氯化烃杂质转化成相应的未氯化或较少氯化的不饱和烃和氯化氢并蒸馏1,3-二氯-1-丙烯以产生纯化的顺式-1,3-二氯-1-丙烯馏分和纯化的反式 -1,3-二氯-1-丙烯馏分。

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