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1. 发明申请

US20050288347A1 Certain triazole-based compounds, compositions, and uses thereof 审中-公开
标题翻译：某些三唑类化合物，组合物及其用途
公开(公告)号：US20050288347A1
公开(公告)日：2005-12-29
申请号：US11090956
申请日：2005-03-25
申请人： Carl Hodge , John Dickson , Ioana Popa-Burke , Jose Mendoza
发明人： Carl Hodge , John Dickson , Ioana Popa-Burke , Jose Mendoza
IPC分类号： A61K31/4196 , C07D249/08 , C07D249/12 , C07D249/14 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D417/06 , C07D417/12 , C07D417/14 , C07D495/04
CPC分类号： C07D249/12 , C07D249/14 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D417/06 , C07D417/12 , C07D417/14 , C07D495/04
摘要： Thiotriazole-based chemical entities exhibiting ATP-utilizing enzyme inhibitory activity, methods of using such chemical entities, and compositions comprising such chemical entities, are described.
摘要翻译：描述了表现出ATP利用酶抑制活性的基于硫代三唑的化学实体，使用这些化学实体的方法，以及包含这些化学实体的组合物。

2. 发明申请

US20080015193A1 Certain azoles exhibiting ATP-utilizing enzyme inhibitory activity, compositions, and uses thereof 审中-公开
标题翻译：表现出ATP-利用酶抑制活性的某些唑类，组合物及其用途
公开(公告)号：US20080015193A1
公开(公告)日：2008-01-17
申请号：US11818914
申请日：2007-06-15
申请人： Jose Mendoza , John Dickson , Carl Hodge
发明人： Jose Mendoza , John Dickson , Carl Hodge
IPC分类号： A61K31/5377 , A61K31/4184 , A61K31/4192 , A61K31/42 , A61K31/428 , A61P1/00 , A61P19/02 , A61P3/10 , A61P35/00 , C07D277/62 , C07D263/02 , C07D249/18 , C07D241/36 , C07D237/02 , C07D235/04 , C07D215/00 , C07D213/00 , A61P43/00 , C07D295/00 , A61P31/00 , A61P25/00 , A61P11/00 , A61K31/4427 , A61K31/47 , A61K31/498 , A61K31/501
CPC分类号： C07D263/32 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： Certain oxazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.
摘要翻译：公开了具有ATP利用酶抑制活性的某些基于恶唑的化合物，使用显示ATP利用酶抑制活性的化合物的方法，以及包含表现出ATP利用酶抑制活性的化合物的组合物。

3. 发明申请

US20060052416A1 2-Amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof 有权
标题翻译：具有ATP利用酶抑制活性的2-酰氨基 - 噻唑类化合物及其组合物及其用途
公开(公告)号：US20060052416A1
公开(公告)日：2006-03-09
申请号：US11202927
申请日：2005-08-11
申请人： John Dickson , Carl Hodge , Jose Mendoza , Ke Chen
发明人： John Dickson , Carl Hodge , Jose Mendoza , Ke Chen
IPC分类号： A61K31/4709 , A61K31/4439 , A61K31/426 , C07D417/02
CPC分类号： C07D417/04 , C07D277/46 , C07D417/12 , C07D417/14
摘要： 2-Amido-4-substituted-aryl-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.
摘要翻译：公开了具有ATP利用酶抑制活性的2-酰氨基-4-取代 - 芳基 - 噻唑基化合物，使用显示出ATP-利用酶抑制活性的化合物的方法，以及包含显示出ATP-利用酶抑制活性的化合物的组合物。

4. 发明申请

US20060009460A1 Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof 失效
标题翻译：显示ATP利用酶抑制活性的喹啉和异喹啉类化合物及其组合物及其用途
公开(公告)号：US20060009460A1
公开(公告)日：2006-01-12
申请号：US11145562
申请日：2005-06-03
申请人： John Dickson , Kevin Williams , Carl Hodge
发明人： John Dickson , Kevin Williams , Carl Hodge
IPC分类号： A61K31/501 , A61K31/496 , C07D43/14
CPC分类号： A61K31/4709 , A61K31/4725 , A61K31/496 , C07D401/10 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.
摘要翻译：公开了具有ATP利用酶抑制活性的喹啉和异喹啉基化合物，使用显示出ATP利用酶抑制活性的化合物的方法，以及包含显示出ATP-利用酶抑制活性的化合物的组合物。

5. 发明申请

US20070287706A1 Certain substituted quinolones, compositions, and uses thereof 审中-公开
标题翻译：某些取代的喹诺酮类，组合物及其用途
公开(公告)号：US20070287706A1
公开(公告)日：2007-12-13
申请号：US11803140
申请日：2007-05-10
申请人： John Dickson , Ke Chen , Carl Hodge
发明人： John Dickson , Ke Chen , Carl Hodge
IPC分类号： A61K31/47 , A61K31/538 , A61P11/06 , A61P17/06 , A61P19/02 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P3/04 , A61P3/10 , A61P31/04 , A61P31/10 , A61P31/12 , A61P35/00 , A61P35/02 , A61P9/00 , C07D215/227 , C07D265/36
CPC分类号： C07D215/227 , C07D215/22
摘要： Certain quinolone-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.
摘要翻译：公开了一些具有ATP利用酶抑制活性的喹诺酮类化合物，使用表现出ATP-利用酶抑制活性的化合物的方法，以及包含表现出ATP-利用酶抑制活性的化合物的组合物。

6. 发明授权

US4364265A Method and apparatus for obtaining an efficiently running internal combustion engine 失效
标题翻译：用于获得有效运行的内燃机的方法和装置
公开(公告)号：US4364265A
公开(公告)日：1982-12-21
申请号：US314762
申请日：1981-10-26
申请人： John Dickson
发明人： John Dickson
IPC分类号： F02D41/14 , F02P5/145 , G01M15/00
CPC分类号： F02D41/1406 , F02P5/1455 , Y02T10/46
摘要： A method of providing an efficiently running internal combustion engine including the steps of operating an engine at a constant rpm while increasing the torque load on the engine, measuring the torque value at predetermined intervals of the torque load to obtain a brake mean effective pressure for each of the intervals, and measuring the fuel consumption at the predetermined intervals. The common log of the brake mean effective pressure is plotted against the common log of the fuel consumption for each interval to obtain a straight line curve (10) which extends linearly with a constant first slope to a D-point coordinate (16) after which it continues at a different second slope. A straight line extension (20) is plotted having the first slope and extending upwardly from the D-point coordinate (16). The instant invention is characterized by controlling at least one of the fuel inputs to the engine and the spark timing so that the plot of the common log of the brake mean effective pressure against the common log of the value of the fuel consumption for the constant rpm falls on the straight line extension (20).The instant invention further provides an internal combustion engine assembly including an engine, a fuel input mechanism for supplying fuel to the engine, and a spark-generating mechanism for igniting the fuel within the engine. The assembly is characterized by a control mechanism for controlling at least one of the fuel input mechanisms and the timing of the spark-generating mechanism at predetermined values which result in the substantially straight line plot of the common log of the brake mean effective pressure against the common log of the fuel consumption of the assembly extending linearly with a constant slope at the operating rpm.
摘要翻译：一种提供有效运行的内燃机的方法，包括以增加发动机的转矩负荷以恒定转速操作发动机的步骤，以扭矩负荷的预定间隔测量转矩值，以获得每个转矩负载的制动平均有效压力并且以预定间隔测量燃料消耗。将制动器平均有效压力的公共对数相对于每个间隔的燃料消耗的公共对数绘制，以获得以恒定的第一斜率线性地延伸到D点坐标（16）的直线曲线（10），之后它继续在不同的第二斜坡。绘制了具有第一斜率并从D点坐标（16）向上延伸的直线延伸部（20）。本发明的特征在于控制发动机的燃料输入和火花正时中的至少一个，使得制动器的公共对数的曲线图表示有效压力相对于恒定rpm的燃料消耗值的公共对数落在直线延伸部（20）上。本发明还提供了一种内燃机组件，其包括发动机，用于向发动机供应燃料的燃料输入机构和用于点燃发动机内的燃料的火花发生机构。该组件的特征在于用于将燃料输入机构中的至少一个和火花发生机构的定时控制在预定值的控制机构，该预定值导致制动器的公用对数的基本直线图表示相对于组件的燃料消耗的常见对数在运转转速下以恒定的斜率线性延伸。

7. 发明申请

US20110283615A1 Seedling growing container 审中-公开
标题翻译：幼苗生长容器
公开(公告)号：US20110283615A1
公开(公告)日：2011-11-24
申请号：US12801071
申请日：2010-05-20
申请人： John Dickson
发明人： John Dickson
IPC分类号： A01G9/02
CPC分类号： A01G9/028
摘要： A seedling growing container having a plurality of partitions removably mounted therein. The partitions are constructed and arranged to provide a plurality of trough-like configured cells containing seedlings and growing material. A humidity dome is also removably mounted on said container.
摘要翻译：一种具有可移除地安装在其中的多个隔板的幼苗生长容器。分隔件被构造和布置成提供包含幼苗和生长材料的多个槽状配置的细胞。湿度圆顶也可拆卸地安装在所述容器上。

8. 发明申请

US20080053183A1 METHODS AND SYSTEMS FOR REDUCING TENSILE RESIDUAL STRESSES IN COMPRESSED TUBING AND METAL TUBING PRODUCTS PRODUCED FROM SAME 有权
标题翻译：压缩管道和金属管材产品中减少拉伸残余应力的方法和系统
公开(公告)号：US20080053183A1
公开(公告)日：2008-03-06
申请号：US11847967
申请日：2007-08-30
申请人： John Dickson , Dan Gadbery , Duane Bendzinski
发明人： John Dickson , Dan Gadbery , Duane Bendzinski
IPC分类号： B21D41/00
CPC分类号： B21C5/00 , B21C37/16 , B21C37/30 , B21K1/063 , B21K1/12 , B21K21/12
摘要： Methods and systems for reducing the stress state of compressed ends of compressed tubes are disclosed. The methods and systems may provide a reduced tensile residual stress state, or even a compressive residual stress state. Tube products produced from the same are also provided.
摘要翻译：公开了用于减小压缩管的压缩端的应力状态的方法和系统。所述方法和系统可以提供减小的拉伸残余应力状态，或甚至压缩残余应力状态。还提供了从其生产的管材。

9. 发明申请

US20070072688A1 Driveshaft system 审中-公开
标题翻译：驱动轴系统
公开(公告)号：US20070072688A1
公开(公告)日：2007-03-29
申请号：US11485173
申请日：2006-07-12
申请人： John Dickson , Duane Bendzinski , Douglas Larsen
发明人： John Dickson , Duane Bendzinski , Douglas Larsen
IPC分类号： F16C3/00
CPC分类号： F16C3/02 , F16F15/10 , Y10T464/50
摘要： The present invention provides a dampening system including a driveline including a tubular driveshaft; and at least one attenuator positioned at frequency nodes within the tubular driveshaft, the attenuator including a dampening material disposed about a perimeter of a rigid carrier corresponding to an interior surface of the tubular driveshaft, the rigid carrier uniformly distributing the high frequency dampening material about the interior surface of the tubular driveshaft. The present invention also provides a method for uniformly distributing an expandable material about the interior surface of a tubular driveshaft.
摘要翻译：本发明提供一种包括包括管状驱动轴的传动系统的阻尼系统; 以及位于所述管状驱动轴内的频率节点处的至少一个衰减器，所述衰减器包括围绕对应于所述管状驱动轴的内表面的刚性载体的周边设置的阻尼材料，所述刚性载体均匀地分布所述高频阻尼材料管状驱动轴的内表面。本发明还提供了一种用于在管状驱动轴的内表面均匀分布可膨胀材料的方法。

10. 发明申请

US20050004151A1 Trisubstituted heteroaromatic compounds as calcium sensing receptor modulators 有权
标题翻译：三取代杂芳族化合物作为钙敏感受体调节剂
公开(公告)号：US20050004151A1
公开(公告)日：2005-01-06
申请号：US10854484
申请日：2004-05-26
申请人： Wu Yang , John Dickson , Christopher Cooper , Dharmpal Dodd , Zheming Ruan , Dora Schnur
发明人： Wu Yang , John Dickson , Christopher Cooper , Dharmpal Dodd , Zheming Ruan , Dora Schnur
IPC分类号： A61K31/4418 , A61K31/444 , A61K31/505 , A61K31/506 , C07D20060101 , C07D213/36 , C07D239/42 , C07D401/04 , C07D403/04 , C07D405/12 , C07D405/14 , C07
CPC分类号： C07D239/42 , C07D401/04 , C07D403/04 , C07D405/12 , C07D405/14
摘要： Trisubstituted heteroaromatic compounds having the structure are provided, wherein X is C or N; A and B are each independently CH or N, with the proviso that A and B cannot both be CH; R1 is Ar-L-; R2 is hydrogen or alkyl; or R1 and R2 can be joined together to form a 4- to 7-membered cycloheteroalkyl ring; R3 to R8, Ar and L are as defined herein. A method for using these compounds to treat diseases associated with abnormal bone or mineral homeostasis is also provided.
摘要翻译：提供具有该结构的三取代杂芳族化合物，其中X为C或N; A和B各自独立地为CH或N，条件是A和B不能都是CH; R 1是Ar-L-; R 2是氢或烷基; 或R 1和R 2可以连接在一起形成4-至7-元环杂烷基环; R 3至R 8中，Ar和L如本文所定义。还提供了使用这些化合物治疗与异常骨或矿物质内稳态相关疾病的方法。

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