专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090118296A1 Heteroaromatic Compounds As Inhibitors Of Stearoyl-Coenzyme A Delta-9 Desaturase 审中-公开
标题翻译：杂芳族化合物作为硬脂酰辅酶A Delta-9去饱和酶的抑制剂
公开(公告)号：US20090118296A1
公开(公告)日：2009-05-07
申请号：US11988192
申请日：2006-07-18
申请人： Cameron Black , Denis Deschenes , Marc Gagnon , Nicolas Lachance , Yves LeBlanc , Serge Leger , Chun Sing Li , Renata M. Oballa
发明人： Cameron Black , Denis Deschenes , Marc Gagnon , Nicolas Lachance , Yves LeBlanc , Serge Leger , Chun Sing Li , Renata M. Oballa
IPC分类号： A61K31/501 , C07D417/14 , A61P3/00
CPC分类号： C07D413/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D417/14 , C07D471/04 , C07F9/65583
摘要： Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; lipid disorders; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and fatty liver disease.
摘要翻译：结构式（I）的杂芳族化合物是相对于其他已知的硬脂酰辅酶A去饱和酶的硬脂酰辅酶Aδ-9去饱和酶（SCD1）的选择性抑制剂。本发明的化合物可用于预防和治疗与脂质合成和代谢异常有关的病症，包括心血管疾病; 动脉粥样硬化脂质紊乱肥胖; 糖尿病; 神经系统疾病; 代谢综合征; 胰岛素抵抗; 和脂肪肝病。

2. 发明申请

US20100004245A1 AZACYCLOALKANE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE 审中-公开
标题翻译：作为硬脂酸苄酯的一种维生素A的脱乙酰壳多糖衍生物
公开(公告)号：US20100004245A1
公开(公告)日：2010-01-07
申请号：US12440835
申请日：2007-10-18
申请人： Renata M. Oballa , Denis Deschenes , Marc Gagnon , Yves Leblanc , David Powell , Yeeman K. Ramtohul
发明人： Renata M. Oballa , Denis Deschenes , Marc Gagnon , Yves Leblanc , David Powell , Yeeman K. Ramtohul
IPC分类号： A61K31/53 , C07D401/14 , C07D403/14 , C07D417/14 , C07D413/14 , A61K31/4545 , A61K31/501 , A61K31/506
CPC分类号： C07D413/14 , C07D401/14 , C07D417/14
摘要： Azacycloalkane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
摘要翻译：结构式（I）的Azacycalkalkane衍生物是相对于其它已知的硬脂酰辅酶A去饱和酶的硬脂酰辅酶Aδ-9去饱和酶（SCD1）的选择性抑制剂。本发明的化合物可用于预防和治疗与脂质合成和代谢异常有关的病症，包括心血管疾病，如动脉粥样硬化; 肥胖; 糖尿病; 神经系统疾病; 代谢综合征; 胰岛素抵抗; 和肝脂肪变性。

3. 发明授权

US07799787B2 Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase 失效
标题翻译：杂芳族化合物作为硬脂酰辅酶A-9去饱和酶的抑制剂
公开(公告)号：US07799787B2
公开(公告)日：2010-09-21
申请号：US12086023
申请日：2006-12-18
申请人： Denis Deschenes , Rejean Fortin , Chun Sing Li , Renata M. Oballa , Yeeman K. Ramtohul
发明人： Denis Deschenes , Rejean Fortin , Chun Sing Li , Renata M. Oballa , Yeeman K. Ramtohul
IPC分类号： C07D401/04 , A61K31/501 , A61P9/00 , A61P9/10 , A61P35/00 , A61P3/10 , A61P3/04 , A61P3/00 , A61P1/16
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D409/14 , C07D413/14 , C07D471/04
摘要： Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; lipid disorders; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; fatty liver disease and cancer.
摘要翻译：结构式（I）的杂芳族化合物是相对于其他已知的硬脂酰辅酶A去饱和酶的硬脂酰辅酶Aδ-9去饱和酶（SCD1）的选择性抑制剂。本发明的化合物可用于预防和治疗与脂质合成和代谢异常有关的病症，包括心血管疾病，如动脉粥样硬化; 脂质紊乱肥胖; 糖尿病; 神经系统疾病; 代谢综合征; 胰岛素抵抗; 脂肪肝病和癌症。

4. 发明申请

US20090088431A1 Heteroaromatic Compounds as Inhibitors of Stearoyl-Coenzyme a Delta-9 Desaturase 失效
标题翻译：杂芳族化合物作为硬脂酰辅酶Delta-9去饱和酶的抑制剂
公开(公告)号：US20090088431A1
公开(公告)日：2009-04-02
申请号：US12086023
申请日：2006-12-18
申请人： Denis Deschenes , Rejean Fortin , Chun Sing Li , Renata M. Oballa , Yeeman K. Ramtohul
发明人： Denis Deschenes , Rejean Fortin , Chun Sing Li , Renata M. Oballa , Yeeman K. Ramtohul
IPC分类号： A61K31/5377 , C07D403/02 , A61K31/501 , A61P3/04 , A61P1/16 , A61P3/10 , C07D413/14
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D409/14 , C07D413/14 , C07D471/04
摘要： Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; lipid disorders; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; fatty liver disease and cancer.
摘要翻译：结构式（I）的杂芳族化合物是相对于其他已知的硬脂酰辅酶A去饱和酶的硬脂酰辅酶Aδ-9去饱和酶（SCD1）的选择性抑制剂。本发明的化合物可用于预防和治疗与脂质合成和代谢异常有关的病症，包括心血管疾病，如动脉粥样硬化; 脂质紊乱肥胖; 糖尿病; 神经系统疾病; 代谢综合征; 胰岛素抵抗; 脂肪肝病和癌症。

5. 发明申请

US20100152208A1 BICYCLIC HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE 审中-公开
标题翻译：作为硬脂酸苄酯A DELTA-9去饱和酶抑制剂的双相异构化合物
公开(公告)号：US20100152208A1
公开(公告)日：2010-06-17
申请号：US12600484
申请日：2008-05-22
申请人： Serge Leger , Denis Deschenes , Rejean Fortin , Elise Isabel , David Powell
发明人： Serge Leger , Denis Deschenes , Rejean Fortin , Elise Isabel , David Powell
IPC分类号： A61K31/519 , C07D513/04 , A61P3/10 , A61P3/06 , A61P9/10
CPC分类号： C07D513/04
摘要： Bicyclic heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis. Formula (I).
摘要翻译：结构式I的双环杂芳族化合物是硬脂酰辅酶A-9去饱和酶（SCD）的抑制剂。本发明的化合物可用于预防和治疗与脂质合成和代谢异常有关的病症，包括心血管疾病，如动脉粥样硬化; 肥胖; 2型糖尿病; 胰岛素抵抗; 高血糖症代谢综合征; 神经系统疾病; 癌症; 和肝脂肪变性。式（I）。

6. 发明授权

US07482456B2 8-(3-Biaryl)phenylquinoline phosphodiesterase-4 inhibitors 失效
标题翻译： 8-（3-二芳基）苯基喹啉磷酸二酯酶-4抑制剂
公开(公告)号：US07482456B2
公开(公告)日：2009-01-27
申请号：US10554176
申请日：2004-04-27
申请人： Daniel Dube , Laurence Dube , Michel Gallant , Patrick Lacombe , Denis Deschenes , Dwight Macdonald
发明人： Daniel Dube , Laurence Dube , Michel Gallant , Patrick Lacombe , Denis Deschenes , Dwight Macdonald
IPC分类号： C07D215/38
CPC分类号： C07D401/10 , C07D215/12 , C07D215/14 , C07D401/14 , C07D409/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/04 , C07D513/04
摘要： Novel substituted 8-phenylquinolines represented by Formula (I), wherein the phenyl group at the 8-position contains an aryl or heteroaryl substituent in the meta position, are PDE4 inhibitors.
摘要翻译：由式（I）表示的新型取代的8-苯基喹啉，其中8位上的苯基在间位含有芳基或杂芳基取代基是PDE4抑制剂。

7. 发明申请

US20070158278A1 Sand filter cleaning apparatus and method thereof 审中-公开
标题翻译：砂过滤器清洁装置及其方法
公开(公告)号：US20070158278A1
公开(公告)日：2007-07-12
申请号：US11327513
申请日：2006-01-09
申请人： Denis Deschenes
发明人： Denis Deschenes
IPC分类号： B01D24/46
CPC分类号： B01D24/105 , B01D24/4631
摘要： An apparatus for cleaning and/or sterilizing sand filter is provided. The apparatus comprises at least one sand filter but preferably a plurality. The apparatus comprises a clean water pipe circuit and a backwash water pipe circuit. Preferably connected to the backwash water pipe circuit is a cleaning and/or sterilizing means provider. On a regular basis and/or when it is detected that the efficiency of the filter has decreased below a certain threshold, cleaning and/or sterilizing means are added to the backwash water in order to remove unwanted particles, bacteria, oils and/or greases, metal deposits and the like that previous simple backwashes failed to remove. A method for using the apparatus thereof is also provided.
摘要翻译：提供了一种用于清洗和/或消毒砂滤器的设备。该装置包括至少一个砂滤器，但优选多个。该装置包括清水管回路和反冲洗水管回路。优选地连接到反洗水管回路是清洁和/或消毒装置提供者。和/或当检测到过滤器的效率已经降低到某一阈值以下时，清洗和/或灭菌装置被添加到回洗水中，以便去除不需要的颗粒，细菌，油和/或油脂，金属沉积物等，以前的简单反冲洗不能去除。还提供了一种使用该装置的方法。

8. 发明申请

US20060223850A1 8-(3-Biaryl)phenylquinoline phosphodiesterase-4 inhibitors 失效
公开(公告)号：US20060223850A1
公开(公告)日：2006-10-05
申请号：US10554176
申请日：2004-04-27
申请人： Daniel Dube , Laurence Dube , Michel Gallant , Patrick Lacombe , Denis Deschenes , Dwight Macdonald
发明人： Daniel Dube , Laurence Dube , Michel Gallant , Patrick Lacombe , Denis Deschenes , Dwight Macdonald
IPC分类号： A61K31/4709 , C07D401/02 , C07D417/02 , C07D413/02
CPC分类号： C07D401/10 , C07D215/12 , C07D215/14 , C07D401/14 , C07D409/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/04 , C07D513/04
摘要： Novel substituted 8-phenylquinolines represented by Formula (I), wherein the phenyl group at the 8-position contains an aryl or heteroaryl substituent in the meta position, are PDE4 inhibitors.

9. 发明授权

US07153968B2 8-(biaryl)quinoline PDE4 inhibitors 失效
标题翻译： 8-（联芳）喹啉PDE4抑制剂
公开(公告)号：US07153968B2
公开(公告)日：2006-12-26
申请号：US10517416
申请日：2003-06-23
申请人： Daniel Dube , Michel Gallant , Patrick Lacombe , Denis Deschenes , Laurence Dube , Yves Girard , Dwight Macdonald
发明人： Daniel Dube , Michel Gallant , Patrick Lacombe , Denis Deschenes , Laurence Dube , Yves Girard , Dwight Macdonald
IPC分类号： C07D219/08 , C07D215/12 , A61K31/47
CPC分类号： C07D215/04 , C07D215/06 , C07D215/12 , C07D215/14 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D405/10 , C07D407/10 , C07D409/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/12 , C07D471/04 , C07F7/0812 , C07F9/60
摘要： 8-(biaryl) quinolines wherein the bi-aryl group at the 8-position is in a meta relationship to the quinoline group, are PDE4 inhibitors useful in the treatment of asthma, chronic bronchitis, chronic obstructive pulmonary disease, eosinophilic granuloma, psoriasis and other benign or malignant proliferative skin diseases, endotoxic shock, laminitis in horses, colic in horses, septic shock, ulcerative colitis, Crohn's disease, reperfusion injury of the myocardium and brain, inflammatory arthritis, chronic glomerulonephritis, atopic dermatitis, urticaria, adult respiratory distress syndrome, chronic obstructive pulmonary disease in animals, diabetes insipidus, allergic rhinitis, allergic conjunctivitis, vernal conjunctivitis, arterial restenosis, ortherosclerosis, atherosclerosis, neurogenic inflammation, pain, cough, rheumatoid arthritis, ankylosing spondylitis, transplant rejection, graft versus host disease, hypersecretion of gastric acid, bacterial, fungal induced sepsis, viral induced sepsis, fungal induced septic shock, viral induced septic shock, inflammation-mediated chronic tissue degeneration, cytokine-mediated chronic tissue degeneration, osteoarthritis, cancer, cachexia, muscle wasting, depression, memory impairment, tumour growth, or cancerous invasion of normal tissues. In another aspect, the present invention is directed to a method of enhancing cognition in a healthy subject comprising administering a safe cognition enhancing amount of phosphodiesterase-4 inhibitor. In particular, this invention is directed to a method of enhancing memory, learning, retention, recall, awareness and judgement in health subjects comprising administering a safe and cognition enhancing amount of a phosphodiesterase-4 inhibitor.
摘要翻译： 8-（联芳）喹啉，其中8-位上的双芳基与喹啉基团呈元间关系，是可用于治疗哮喘，慢性支气管炎，慢性阻塞性肺疾病，嗜酸性肉芽肿，银屑病的PDE4抑制剂其他良性或恶性增殖性皮肤疾病，内毒素性休克，马匹中的扁桃体炎，马蹄痛，败血性休克，溃疡性结肠炎，克罗恩病，心肌和脑的再灌注损伤，炎症性关节炎，慢性肾小球肾炎，特应性皮炎，荨麻疹，成人呼吸窘迫综合征，动物慢性阻塞性肺病，尿崩症，过敏性鼻炎，过敏性结膜炎，春季结膜炎，动脉再狭窄或动脉粥样硬化，动脉粥样硬化，神经源性炎症，疼痛，咳嗽，类风湿关节炎，强直性脊柱炎，移植排斥反应，移植物抗宿主病，分泌过多的胃酸，细菌，真菌诱导的败血症，病毒诱导 d败血症，真菌诱发的败血症休克，病毒诱导的败血性休克，炎症介导的慢性组织变性，细胞因子介导的慢性组织变性，骨关节炎，癌症，恶病质，肌肉消瘦，抑郁，记忆障碍，肿瘤生长或正常组织的癌性侵袭。另一方面，本发明涉及一种增强健康受试者认知的方法，其包括施用安全认知增加量的磷酸二酯酶-4抑制剂。特别地，本发明涉及一种在健康受试者中增强记忆，学习，保留，召回，意识和判断的方法，包括施用安全和认知增加量的磷酸二酯酶-4抑制剂。

10. 发明申请

US20050245513A1 Hetero-bridge substituted 8-arylquinoline pde4 inhibitors 失效
标题翻译：异桥桥取代的8-芳基喹啉pde4抑制剂
公开(公告)号：US20050245513A1
公开(公告)日：2005-11-03
申请号：US10508261
申请日：2003-03-17
申请人： Michel Gallant , Denis Deschenes , Daniel Dube , Laurence Dube , Patrick Lacombe , Dwight MacDonald
发明人： Michel Gallant , Denis Deschenes , Daniel Dube , Laurence Dube , Patrick Lacombe , Dwight MacDonald
IPC分类号： A61K31/4709 , A61K31/5377 , A61P11/00 , A61P25/00 , C07D215/04 , C07D215/12 , C07D215/14 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/02 , C07D413/12 , C07D417/02 , C07D417/12 , C07D487/04 , C07D43/02
CPC分类号： C07D215/04 , C07D215/12 , C07D215/14 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D487/04
摘要： 8-arylquinolines wherein the aryl group at the 8-position contains a meta one or two atom bridge to a phenyl, 5 or 6 member heteroaryl or fused bicyclic heteroaryl group, and wherein at least one of the bridge atoms is not carbon, are PDE4 inhibitors.
摘要翻译： 8-芳基喹啉，其中8-位上的芳基含有与苯基，5或6元杂芳基或稠合双环杂芳基相连的一个或两个原子桥，并且其中至少一个桥原子不是碳，是PDE4 抑制剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式