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1. 发明授权

US07332128B2 Fiber-optic dissolution systems devices, and methods 失效
标题翻译：光纤溶解系统装置及方法
公开(公告)号：US07332128B2
公开(公告)日：2008-02-19
申请号：US10838907
申请日：2004-05-03
申请人： C. J. Anthony Fernando , James E. Swon , Henry Z. Hofer
发明人： C. J. Anthony Fernando , James E. Swon , Henry Z. Hofer
IPC分类号： G01N21/00
CPC分类号： G01N21/8507 , G01N13/00 , G01N21/253 , G01N33/15 , G01N2013/006 , G01N2021/8521 , G01N2021/8528 , Y10T436/117497 , Y10T436/2575
摘要： A dissolution system provides remote flow cells integrated into a manifold device. The manifold device communicates with liquid input and output lines associated with each flow cell, as well as fiber-optic input and output lines associated with each flow cell. Liquid samples are respectively drawn from dissolution vessels, optically-related measurements are taken, and the samples are thereafter returned their respective vessels. The manifold device can be adapted to receive probe-type instruments that incorporate the fiber-optics, wherein each probe-type instrument is associated with each flow cell. Alternatively, each corresponding pair of fiber-optic input and output lines are disposed in opposing, optically-aligned relation and probe-type instruments are not used. The gap between the ends of the opposing fiber-optic lines provides a light path across the corresponding flow cell. Calibration procedures using blank and/or standard media are performed using the same flow cells, with provisions made for bypassing the vessels in which the samples to be analyzed are held.
摘要翻译：溶解系统提供集成在歧管装置中的远程流动池。歧管装置与与每个流动池相关联的液体输入和输出线路以及与每个流动池相关联的光纤输入和输出线路通信。液体样品分别从溶解容器中抽出，进行光学相关测量，然后将样品返回其各自的容器。歧管装置可以适于接纳包含光纤的探针型仪器，其中每个探针型仪器与每个流动池相关联。或者，每个对应的一对光纤输入和输出线以相对的光学对准关系设置，并且不使用探针型仪器。相对的光纤线路的端部之间的间隙提供穿过相应的流动池的光路。使用空白和/或标准介质的校准程序使用相同的流动池进行，其中为绕过待分析样品的容器进行旁路。

2. 发明授权

US06764651B2 Fiber-optic dissolution systems, devices, and methods 失效
标题翻译：光纤溶解系统，装置和方法
公开(公告)号：US06764651B2
公开(公告)日：2004-07-20
申请号：US10014270
申请日：2001-11-07
申请人： C. J. Anthony Fernando , James E. Swon , Henry Z. Hofer
发明人： C. J. Anthony Fernando , James E. Swon , Henry Z. Hofer
IPC分类号： G01N2101
CPC分类号： G01N21/8507 , G01N13/00 , G01N21/253 , G01N33/15 , G01N2013/006 , G01N2021/8521 , G01N2021/8528 , Y10T436/117497 , Y10T436/2575
摘要： A dissolution system provides remote flow cells integrated into a manifold device. The manifold device communicates with liquid input and output lines associated with each flow cell, as well as fiber-optic input and output lines associated with each flow cell. Liquid samples are respectively drawn from dissolution vessels, optically-related measurements are taken, and the samples are thereafter returned their respective vessels. The manifold device can be adapted to receive probe-type instruments that incorporate the fiber-optics, wherein each probe-type instrument is associated with each flow cell. Alternatively, each corresponding pair of fiber-optic input and output lines are disposed in opposing, optically-aligned relation and probe-type instruments are not used. The gap between the ends of the opposing fiber-optic lines provides a light path across the corresponding flow cell. Calibration procedures using blank and/or standard media are performed using the same flow cells, with provisions made for bypassing the vessels in which the samples to be analyzed are held.
摘要翻译：溶解系统提供集成在歧管装置中的远程流动池。歧管装置与与每个流动池相关联的液体输入和输出线路以及与每个流动池相关联的光纤输入和输出线路通信。液体样品分别从溶解容器中抽出，进行光学相关测量，然后将样品返回其各自的容器。歧管装置可以适于接纳包含光纤的探针型仪器，其中每个探针型仪器与每个流动池相关联。或者，每个对应的一对光纤输入和输出线以相对的光学对准关系设置，并且不使用探针型仪器。相对的光纤线路的端部之间的间隙提供穿过相应的流动池的光路。使用空白和/或标准介质的校准程序使用相同的流动池进行，其中为绕过待分析样品的容器进行旁路。

3. 发明授权

US07407631B2 Apparatus and method for agitating a sample during in vitro testing 有权
标题翻译：在体外测试中搅拌样品的装置和方法
公开(公告)号：US07407631B2
公开(公告)日：2008-08-05
申请号：US10829640
申请日：2004-04-22
申请人： James E. Swon , C. J. Anthony Fernando
发明人： James E. Swon , C. J. Anthony Fernando
IPC分类号： B01L9/00
CPC分类号： B01F11/0082 , B01F13/0818 , B01L99/00
摘要： In an apparatus and method for agitating a sample during dissolution or other in vitro testing, a movable component is disposed in a container for reciprocating or rotating a sample carrier such as a dosage form or stent through a medium in the container. The apparatus can include a closure member to seal the container for substantially preventing loss of contents during movement of the sample carrier. The movable component can be actuated by a driving source in a non-contacting manner. The movable component can include a magnet drivable by a source external to the container. The container can include first and second container sections having different volumes, in which case actuation of the movable component causes agitation of the sample carrier through a medium contained in one of the container sections. The container can include a hole at or near the bottom for filling the container, using instruments, and the like.
摘要翻译：在用于在溶解或其它体外测试期间搅拌样品的装置和方法中，可移动部件设置在用于通过容器中的介质往复或旋转样品载体（例如剂型或支架）的容器中。该装置可以包括封闭构件以密封容器，用于在样品载体移动期间基本上防止内容物的损失。可移动部件可以以非接触的方式由驱动源致动。可移动部件可以包括可由容器外部的源驱动的磁体。容器可以包括具有不同体积的第一和第二容器部分，在这种情况下，活动部件的致动引起样品载体通过容纳在其中一个容器部分中的介质的搅动。容器可以在底部或附近包括用于填充容器的孔，使用仪器等。

4. 发明授权

US06962674B2 Dissolution test apparatus 有权
标题翻译：溶解试验装置
公开(公告)号：US06962674B2
公开(公告)日：2005-11-08
申请号：US09795819
申请日：2001-02-28
申请人： Stephen D. Dean , James E. Swon , C. J. Anthony Fernando , Paul Shoytush
发明人： Stephen D. Dean , James E. Swon , C. J. Anthony Fernando , Paul Shoytush
IPC分类号： G01N13/00 , G01N33/15 , G01N33/48 , B01F7/08 , B01F13/08 , B01F15/00 , G01N33/00
CPC分类号： G01N33/15 , G01N13/00 , G01N2013/006
摘要： A dissolution test apparatus comprises a spindle head assembly interconnected between first and second lateral support members. The lateral support members are translatable along a first axis, and the spindle head assembly is translatable along a second axis, such that the spindle head assembly is movable from a front, operative position at which test procedures are effected, to a rear position at which access to the dissolution test apparatus is enhanced. The spindle head assembly includes a dosage delivery mechanism including an actuatable dosage unit-retaining member. A front portion of the dissolution test apparatus has a tapered width to accommodate a triangular or trapezoidal array of test vessels, resulting in high visibility of the vessels.
摘要翻译：溶解测试装置包括在第一和第二横向支撑构件之间互连的主轴头组件。横向支撑构件可沿着第一轴线平移，并且主轴头组件可沿着第二轴线平移，使得主轴头组件可从执行测试程序的前部操作位置移动到后部位置增加了溶解试验装置的使用。主轴头组件包括剂量递送机构，其包括可致动剂量单位保持构件。溶出测试装置的前部具有锥形宽度以容纳测试容器的三角形或梯形阵列，导致容器的高可见性。

5. 发明授权

US06611334B1 Sample analysis system with fiber optics and related method 失效
标题翻译：具有光纤及相关方法的样品分析系统
公开(公告)号：US06611334B1
公开(公告)日：2003-08-26
申请号：US10077675
申请日：2002-02-14
申请人： C. J. Anthony Fernando , James E. Swon
发明人： C. J. Anthony Fernando , James E. Swon
IPC分类号： G01N2100
CPC分类号： G01N21/59
摘要： A sample analysis system comprises a plurality of media containers, a plurality of sample test sites, a plurality of media sampling lines, a plurality of optical source lines, a plurality of optical return lines, and an optical input selection device. Each media sampling line is adapted for transferring a quantity of media from a corresponding one of the media containers to a corresponding one of the sample test sites. Each optical source line has an optical source line input end and an optical source line output end. Each optical source line output end communicates with a corresponding one of the sample test sites. Each optical return line has an optical return line input end and an optical return line output end. Each optical return line input end communicates with a corresponding one of the sample test sites. The optical input selection device is rotatable about a first axis, and comprises a first internal optical fiber having a first input end and a first output end. The first input end is disposed collinearly with the first axis. The first output end is disposed at a radially offset distance from the first axis and is alignable with a selected one of the optical source line input ends.
摘要翻译：样品分析系统包括多个介质容器，多个样品测试点，多个介质采样管线，多个光源管线，多个光学返回管线和光学输入选择装置。每个介质采样管线适于将一定量的介质从相应的一个介质容器转移到相应的一个样品测试位置。每个光源线具有光源线输入端和光源线输出端。每个光源线输出端与对应的一个样本测试点通信。每个光学返回线具有光学返回线输入端和光学返回线输出端。每个光学返回线输入端与相应的一个样本测试点通信。光输入选择装置可围绕第一轴线旋转，并且包括具有第一输入端和第一输出端的第一内部光纤。第一输入端与第一轴线共线设置。第一输出端设置在距离第一轴线的径向偏移距离处，并且与所选择的一个光源线路输入端对准。

6. 发明授权

US06727480B2 Waterless vessel heating system and method 有权
标题翻译：无水容器加热系统及方法
公开(公告)号：US06727480B2
公开(公告)日：2004-04-27
申请号：US09911103
申请日：2001-07-23
申请人： C. J. Anthony Fernando , James E. Swon , Michael F. Haw
发明人： C. J. Anthony Fernando , James E. Swon , Michael F. Haw
IPC分类号： H05B336
CPC分类号： H05B1/025 , B01F1/00 , B01F1/0011 , B01F2215/0037 , B01J19/0013 , B01J2219/00011 , B01J2219/00038 , B01J2219/00063 , B01J2219/00135 , B01J2219/002 , B01J2219/00213 , B01J2219/00238 , B01L7/00 , B01L2300/1805 , G01N13/00 , G01N33/15 , G01N2013/006 , H05B3/00 , H05B3/34 , H05B3/54 , H05B2203/005 , H05B2203/014 , H05B2203/017 , H05B2203/037
摘要： A dissolution testing system comprises a vessel plate on which a plurality of vessels are mounted. Each vessel includes a lateral wall having an outer surface around which a plurality of flexible heater elements are attached. Each heater element includes a transparent surface area, a heat conductive element extending along the transparent surface area, a temperature sensing element extending along the transparent surface area, and an electrical contact element connected to the heat conductive element and the temperature sensing element. The heater element can have more than one heating zone, with at least one of the heating zones being selectively energizable. The transparent heater element allows unobstructed view into the interior of its vessel, and reduces the time required to achieve a stabilized set point temperature in the vessel. A heater control system communicates with each heat conductive element and each temperature sensing element through a corresponding one of the electrical contact elements. The heater control system permits each vessel to be controlled independently of the other vessels.
摘要翻译：溶解测试系统包括其上安装有多个容器的容器板。每个容器包括具有外表面的侧壁，多个柔性加热器元件围绕该外表面附接。每个加热器元件包括透明表面区域，沿着透明表面区域延伸的导热元件，沿着透明表面区域延伸的温度感测元件以及连接到导热元件和温度检测元件的电接触元件。加热器元件可以具有多于一个加热区，其中至少一个加热区可选择性地通电。透明加热器元件允许在其容器的内部看不到障碍物，并且减少在容器中达到稳定的设定点温度所需的时间。加热器控制系统通过相应的一个电接触元件与每个导热元件和每个温度感测元件连通。加热器控制系统允许每个容器独立于其他容器进行控制。

7. 发明授权

US06661512B2 Sample analysis system with fiber optics and related method 失效
公开(公告)号：US06661512B2
公开(公告)日：2003-12-09
申请号：US10076316
申请日：2002-02-13
申请人： C. J. Anthony Fernando , James E. Swon
发明人： C. J. Anthony Fernando , James E. Swon
IPC分类号： G01J342
CPC分类号： G01N21/253
摘要： A sample measurement and analysis system comprises a fiber-optic channel selecting apparatus, a plurality of optical source lines, a plurality of optical return lines, a plurality of sample test sites, and an optical receiving device. The selecting apparatus comprises an optical input selection device, an optical output selection device, and a controller element. The optical input selection device defines a first optical path running between a first input end and a first output end. The first output end is rotatable to a plurality of first index positions defined along a first circular path. The optical output selection device defines a second optical path running between a second input end and a second output end. The second input end is rotatable to a plurality of second index positions defined along a second circular path. The controller element communicates with the optical input selection device and the optical output selection device for selectively aligning the first optical path with the first index positions and the second optical path with the second index positions.

8. 发明授权

US06562301B1 Vessel centering system and method 有权
标题翻译：船舶定心系统及方法
公开(公告)号：US06562301B1
公开(公告)日：2003-05-13
申请号：US09697963
申请日：2000-10-27
申请人： Stephen D. Dean , C. J. Anthony Fernando , James E. Swon
发明人： Stephen D. Dean , C. J. Anthony Fernando , James E. Swon
IPC分类号： B01L302
CPC分类号： B01L3/5082 , B01F7/1605 , B01L9/06 , G01N13/00 , G01N33/15 , G01N2013/006
摘要： A vessel centering system comprises a vessel, an annular, spacer member, a fastening element, and an elastometric component. The vessel includes an outer surface and a vessel groove formed on a circumference of the vessel outer surface. The spacer member is fitted in the vessel groove and extends outwardly with respect to the vessel. The first and second lateral end surfaces define a spacing therebetween. The spacer member includes a tangential bore and an annular groove. The tangential bore extends along a line generally tangential to a curvature of the spacer member. The fastening element, which could be a screw, is disposed in the tangential bore in engagement with the ring member and extends across the ring spacing. The elastometric component, which could be a gasket or O-ring, is disposed in the annular groove. A plurality of biased bearings can be provided instead of the elastometric component. When the vessel is installed in the aperture of a vessel plate, concentricity between the inner surfaces of the vessel and a shaft extending into the vessel is easily obtained.
摘要翻译：容器对中系统包括容器，环形隔离构件，紧固元件和弹性组件。容器包括形成在容器外表面的圆周上的外表面和容器凹槽。间隔件装配在容器槽中并相对于容器向外延伸。第一和第二侧端表面之间限定了间隔。间隔件包括切向孔和环形槽。切向孔沿着与间隔件的曲率大致相切的线延伸。可以是螺钉的紧固元件设置在与环构件接合的切向孔中，并且跨越环间隔延伸。可以是垫圈或O形环的弹性组件设置在环形槽中。可以提供多个偏置的轴承来代替弹性组件。当容器安装在容器板的孔中时，容器的内表面和延伸到容器中的轴之间的同心度容易获得。

9. 发明授权

US06303909B1 Waterless vessel heating system and method 有权
标题翻译：无水容器加热系统及方法
公开(公告)号：US06303909B1
公开(公告)日：2001-10-16
申请号：US09603305
申请日：2000-06-23
申请人： C. J. Anthony Fernando , James E. Swon , Michael F. Haw
发明人： C. J. Anthony Fernando , James E. Swon , Michael F. Haw
IPC分类号： H05B336
CPC分类号： G01N13/00 , B01F1/00 , B01F1/0011 , B01F2215/0037 , B01J19/0013 , B01J2219/00011 , B01J2219/00038 , B01J2219/00063 , B01J2219/00135 , B01J2219/002 , B01J2219/00213 , B01J2219/00238 , B01L7/00 , B01L2300/1805 , G01N33/15 , G01N2013/006 , H05B3/00 , H05B3/34 , H05B3/54 , H05B2203/005 , H05B2203/014 , H05B2203/017 , H05B2203/037
摘要： A dissolution testing system comprises a vessel plate on which a plurality of vessels are mounted. Each vessel includes a lateral wall having an outer surface around which a plurality of flexible heater elements are attached. Each heater element includes a transparent surface area, a heat conductive element extending along the transparent surface area, a temperature sensing element extending along the transparent surface area, and an electrical contact element connected to the heat conductive element and the temperature sensing element. The transparent heater element allows unobstructed view into the interior of its vessel, and reduces the time required to achieve a stabilized set point temperature in the vessel. A heater control system communicates with each heat conductive element and each temperature sensing element through a corresponding one of the electrical contact elements. The heater control system permits each vessel to be controlled independently of the other vessels.
摘要翻译：溶解测试系统包括其上安装有多个容器的容器板。每个容器包括具有外表面的侧壁，多个柔性加热器元件围绕该外表面附接。每个加热器元件包括透明表面区域，沿着透明表面区域延伸的导热元件，沿着透明表面区域延伸的温度感测元件以及连接到导热元件和温度检测元件的电接触元件。透明加热器元件允许在其容器的内部看不到障碍物，并且减少在容器中达到稳定的设定点温度所需的时间。加热器控制系统通过相应的一个电接触元件与每个导热元件和每个温度感测元件连通。加热器控制系统允许每个容器独立于其他容器进行控制。

10. 发明授权

US07151869B2 Fiber-optic channel selecting apparatus 失效
公开(公告)号：US07151869B2
公开(公告)日：2006-12-19
申请号：US11157254
申请日：2005-06-21
申请人： C. J. Anthony Fernando , James E. Swon
发明人： C. J. Anthony Fernando , James E. Swon
IPC分类号： G02B6/26 , G01N1/10 , G02B6/00
CPC分类号： G02B6/3504 , G01N21/255 , G01N21/31 , G02B6/3548 , G02B6/3558 , G02B6/3574 , G02B6/3582
摘要： An apparatus for selectively coupling fiber optic lines comprises an optical input selection device, an optical output selection device, and a rotatable coupling mechanism interconnecting the optical input selection device and the optical output selection device. The optical input selection device is rotatable about a first central axis, and comprises a first input end and a first output end. The first input end is disposed collinearly with the first central axis, and the first output end is disposed at a radially offset distance from the first central axis. The optical output selection device is rotatable about a second central axis, and comprises a second input end and a second output end. The second input end is disposed at a radially offset distance from the second central axis, and the second output end is disposed collinearly with the second central axis. Rotation of the coupling mechanism causes rotation of the first output end and the second input end.

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