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1. 发明授权

US08124832B2 Method for producing cloned dog 有权
标题翻译：生产克隆狗的方法
公开(公告)号：US08124832B2
公开(公告)日：2012-02-28
申请号：US11762077
申请日：2007-06-13
申请人： Byeong Chun Lee , Sung Keun Kang , Dae Yong Kim , Min Kyu Kim , Goo Jang , Hyun Ju Oh , M. Shamim Hossein , Fibrianto Yuda , Hye Jin Kim , So Gun Hong , Jung Eun Park , Joung Joo Kim
发明人： Byeong Chun Lee , Sung Keun Kang , Dae Yong Kim , Min Kyu Kim , Goo Jang , Hyun Ju Oh , M. Shamim Hossein , Fibrianto Yuda , Hye Jin Kim , So Gun Hong , Jung Eun Park , Joung Joo Kim
IPC分类号： A01K67/027 , C12N15/00
CPC分类号： C12N15/873 , A01K67/027 , A01K2227/00 , A61D19/04
摘要： Provided is a method for producing a cloned dog by enucleating an oocyte of a dog to produce an enucleated oocyte, transferring a somatic cell of the dog into the enucleated oocyte, carrying out electrofusion under optimized conditions to produce a nuclear transfer embryo, and transferring the nuclear transfer embryo into its surrogate mother.
摘要翻译：本发明提供了通过将狗的卵母细胞去核以产生去核卵母细胞，将狗的体细胞转移到去核卵母细胞中，在优化条件下进行电融合以产生核转移胚，并转移核转移胚胎成为其代孕母亲。

2. 发明申请

US20080295191A1 METHOD FOR PRODUCING CLONED DOG 有权
标题翻译：生产克隆狗的方法
公开(公告)号：US20080295191A1
公开(公告)日：2008-11-27
申请号：US11762077
申请日：2007-06-13
申请人： Byeong Chun Lee , Sung Keun Kang , Dae Yong Kim , Min Kyu Kim , Goo Jang , Hyun Ju Oh , M. Shamim Hossein , Fibrianto Yuda , Hye Jin Kim , So Gun Hong , Jung Eun Park , Joung Joo Kim
发明人： Byeong Chun Lee , Sung Keun Kang , Dae Yong Kim , Min Kyu Kim , Goo Jang , Hyun Ju Oh , M. Shamim Hossein , Fibrianto Yuda , Hye Jin Kim , So Gun Hong , Jung Eun Park , Joung Joo Kim
IPC分类号： A01K67/027 , C12N15/89
CPC分类号： C12N15/873 , A01K67/027 , A01K2227/00 , A61D19/04
摘要： Provided is a method for producing a cloned dog by enucleating an oocyte of a dog to produce an enucleated oocyte, transferring a somatic cell of the dog into the enucleated oocyte, carrying out electrofusion under optimized conditions to produce a nuclear transfer embryo, and transferring the nuclear transfer embryo into its surrogate mother.The method has the effect of producing a cloned dog with high efficiency, and thus can contribute to the development of studies in veterinary medicine, anthropology and medical science, such as the propagation of superior species, xenotransplantation and diseased animal models. In addition, the present invention has the effect of exactly researching production properties of the cloned dog by producing a female cloned dog for the first time, rather than the conventional male cloned dog.
摘要翻译：本发明提供了通过将狗的卵母细胞去核以产生去核卵母细胞，将狗的体细胞转移到去核卵母细胞中，在优化条件下进行电融合以产生核转移胚，并转移核转移胚胎成为其代孕母亲。该方法具有高效生产克隆狗的作用，有助于兽医，人类学，医学等研究的发展，如优良种的繁殖，异种移植和病态动物模型。此外，本发明具有通过首次生产雌性克隆狗而不是常规的雄性克隆狗来正确研究克隆狗的生产性质的效果。

3. 发明申请

US20100293626A1 METHODS FOR IMPROVEMENT OF BIRTH RATES IN CANIDAE ON SOMATIC CELL NUCLEAR TRANSFER 审中-公开
标题翻译：改善角膜细胞核转移中生殖系统发生率的方法
公开(公告)号：US20100293626A1
公开(公告)日：2010-11-18
申请号：US12517567
申请日：2008-11-19
申请人： Byeong Chun Lee , Min Kyu Kim , Goo Jang , Hyun Ju Oh , So Gun Hong , Jung Eun Park , Jung Taek Kang
发明人： Byeong Chun Lee , Min Kyu Kim , Goo Jang , Hyun Ju Oh , So Gun Hong , Jung Eun Park , Jung Taek Kang
IPC分类号： C12N15/06
CPC分类号： C12N5/16 , A01K67/0273 , A01K2227/10 , C12N15/877 , C12N2501/405 , C12N2517/10
摘要： The present invention relates to a method for increasing the efficiency of offspring production in producing animals belonging to the family Canidae (canines) by somatic cell nuclear transfer. More specifically, relates to a method for increasing the efficiency of production of cloned canines by a method for cloning canines comprising enucleating the oocyte of a canine to prepare an enucleated oocyte, fusing a nuclear donor cell with the enucleated oocyte to prepare a nuclear transfer embryo and transferring the nuclear transfer embryo into the oviduct of a surrogate mother, wherein the nuclear donor cell is cultured in a medium containing a specific cell cycle synchronization-inducing substance such as roscovitine in the preparation thereof. The method enables to clone canines with high efficiency, and thus can contribute to the development of studies in the fields of veterinary medicine, anthropology and medical science such as the propagation of superior canines, the conservation of rare or nearly extinct canines, xenotransplantation and disease animal models.
摘要翻译：本发明涉及通过体细胞核转移提高属于犬科（犬科）的动物的后代生产效率的方法。更具体地，涉及通过克隆犬的方法来提高克隆犬的生产效率的方法，包括将犬的卵母细胞去核以制备去核卵母细胞，将核供体细胞与去核卵母细胞融合以制备核转移胚并将核转移胚胎转移到替代母体的输卵管中，其中在其制备中，在含有特定细胞周期同步诱导物质如roscovitine的培养基中培养核供体细胞。该方法能够高效地克隆犬科动物，从而有助于兽医，人类学和医学领域的研究发展，如高等犬传播，保护罕见或几乎灭绝的犬，异种移植和疾病动物模型。

4. 发明申请

US20110076693A1 METHOD FOR DETECTION AND QUANTIFICATION OF PLK1 EXPRESSION AND ACTIVITY 审中-公开
标题翻译： PLK1表达和活性的检测和定量方法
公开(公告)号：US20110076693A1
公开(公告)日：2011-03-31
申请号：US12992887
申请日：2009-05-15
申请人： Kyung S. Lee , Jung Eun Park
发明人： Kyung S. Lee , Jung Eun Park
IPC分类号： G01N33/573 , C07K14/00 , C07K7/06 , C07K7/08 , C12Q1/48 , G01N33/53
CPC分类号： C07K14/00 , C07K17/00 , C12N9/1229 , C12Q1/485 , G01N33/57484 , G01N2500/04 , G01N2800/56
摘要： Isolated peptide substrates of Plk1 and nucleic acids encoding these peptides are disclosed. The peptides include two to ten repeats of the amino acid sequence set forth as X1X2AX3X4X5PLHSTX6X7X8X9X10X11X12 (SEQ ID NO: 1), in which within each repeat X1, X2, X6, X7, X8, X9, X10, X11, and X12 are each independently any amino acid or no amino acid, and X3 and X4 are each independently any amino acid. Methods of using these peptides to detect Plk1 activity in a sample are also disclosed. In some examples, the method includes contacting a sample with a disclosed peptide substrate of Plk1 in the presence of adenosine triphosphate, or an analog thereof, for a period of time sufficient for Plk1 to phosphorylate the PBIPtide. The presence and/or amount of the phosphorylated and/or the unphosphorylated peptide is detected, thereby detecting and/or quantitating Plk1 kinase activity in the sample.
摘要翻译：公开了Plk1的分离的肽底物和编码这些肽的核酸。肽包括X1X2AX3X4X5PLHSTX6X7X8X9X10X11X12（SEQ ID NO：1）所示的氨基酸序列的2至10个重复，其中每个重复X1，X2，X6，X7，X8，X9，X10，X11和X12各自独立地任何氨基酸或不含氨基酸，X3和X4各自独立地为任何氨基酸。还公开了使用这些肽检测样品中Plk1活性的方法。在一些实例中，该方法包括在三磷酸腺苷或其类似物的存在下将样品与公开的Plk1肽底物接触足以使Plk1磷酸化PBIPtide的时间。检测磷酸化和/或未磷酸化肽的存在和/或量，从而检测和/或定量样品中的Plk1激酶活性。

5. 发明授权

US10650196B2 Communication assistive device and communication assistive method outputting an audible sentence based on touch screen image selections comprising postpositions 有权
公开(公告)号：US10650196B2
公开(公告)日：2020-05-12
申请号：US15750544
申请日：2016-08-16
申请人： Jung Eun Park
发明人： Jung Eun Park
IPC分类号： G06F3/16 , G10L13/033 , G06F3/0488 , G06Q10/06 , G06F40/51 , G09B19/04 , H04M1/725 , G06F3/0481 , G10L15/18 , G10L13/00
摘要： A communication assistive device and a communication assistive method for people with language disorder are provided. The communication assistive method comprises the steps of: receiving user touch screen input selecting one of images representing sentence components displayed on a screen, the sentence components such as words and postpositions constituting a sentence to be outputted; combining the received sentence components to generate a sentence; and outputting the generated sentence by voice, wherein input for at least one of the sentence components is performed by selection of an image coding a shape or meaning of a character, wherein a widget is created for the generated sentence.

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