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1. 发明申请

US20070260595A1 FUZZY STRING MATCHING USING TREE DATA STRUCTURE 审中-公开
标题翻译：使用树数据结构的FUZZY STRING MATCHING
公开(公告)号：US20070260595A1
公开(公告)日：2007-11-08
申请号：US11381182
申请日：2006-05-02
申请人： Bryan Beatty , Nikolai Faaland , Duncan Lawler , Elizabeth Wood , David Horne
发明人： Bryan Beatty , Nikolai Faaland , Duncan Lawler , Elizabeth Wood , David Horne
IPC分类号： G06F17/30
CPC分类号： G06F16/903 , G06F16/322 , G06F16/907
摘要： The subject disclosure pertains to systems and methods for performing fuzzy searches of a tree data structure. A search request can include a search term or terms and search conditions. The tree is traversed in response to the search request and nodes of the tree are examined using a function or set of rules to generate a score. The score reflects the probability that the current node is a match to the search term and can be used to determine the search results to be returned. Due to the organization of the tree, if the score indicates that the current node is not a possible match, child nodes of the current node will not be possible matches. Therefore, the traversal of the current node and its children can be terminated.
摘要翻译：本发明涉及用于执行树状数据结构的模糊搜索的系统和方法。搜索请求可以包括搜索条件或条款和搜索条件。响应于搜索请求遍历树，并使用函数或一组规则来检查树的节点以生成分数。分数反映当前节点与搜索项匹配的概率，并可用于确定要返回的搜索结果。由于树的组织，如果分数表示当前节点不是可能的匹配，则当前节点的子节点将不可能匹配。因此，可以终止当前节点及其子节点的遍历。

2. 发明申请

US20070258623A1 Controlling and customizing access to spatial information 有权
标题翻译：控制和定制对空间信息的访问
公开(公告)号：US20070258623A1
公开(公告)日：2007-11-08
申请号：US11393442
申请日：2006-03-30
申请人： Timothy McGrath , Leonard Smith , David Horne , Duncan Lawler
发明人： Timothy McGrath , Leonard Smith , David Horne , Duncan Lawler
IPC分类号： G06K9/00
CPC分类号： G06F17/3087
摘要： A spatial data handling and map generation system comprises a receiver component that receives a request for information associated with a geographic region and data associated with an initiator of the request. A mapping component renders a representation of the geographic region, the representation is customized according to a role assigned to the initiator of the request, the role is assigned based at least in part upon the received data.
摘要翻译：空间数据处理和地图生成系统包括：接收器组件，其接收与地理区域相关联的信息的请求以及与请求的发起者相关联的数据。映射组件呈现地理区域的表示，根据分配给请求的发起者的角色对表示进行定制，至少部分地基于所接收的数据分配角色。

3. 发明授权

US09648589B2 Multiple radio devices for implementing dynamic band access background 有权
公开(公告)号：US09648589B2
公开(公告)日：2017-05-09
申请号：US13996682
申请日：2012-06-06
申请人： Geoff Weaver , Carlos Cordeiro , Srikathyayani Srikanteswara , Bahareh Sadeghi , Reza Arefi , David Horne , Takashi Shono
发明人： Geoff Weaver , Carlos Cordeiro , Srikathyayani Srikanteswara , Bahareh Sadeghi , Reza Arefi , David Horne , Takashi Shono
IPC分类号： H04W72/00 , H04L29/06 , H04W4/00 , H04W72/04 , H04W16/14 , H04W4/24 , H04W24/08 , H04W28/16 , H04L12/24 , H04W16/10 , H04W72/12 , H04W76/02 , H04W74/00 , H04W88/06
CPC分类号： H04W72/04 , H04L41/0896 , H04W4/24 , H04W16/10 , H04W16/14 , H04W24/08 , H04W28/16 , H04W72/0486 , H04W72/0493 , H04W72/1257 , H04W74/002 , H04W76/10 , H04W88/06
摘要： A system and method are provided to implement dynamic spectrum access with individual multi-mode devices that incorporate multiple radios in a single device. A multi-mode device is configured to make use of the incremental spectrum by maintaining a data communication link via a base station that is operated by a primary operator to support communications in the primary operator's exclusively-licensed spectrum. This data communication link is maintained by a first radio, the data communication link being used to support a first level of data communication as well as to signal an availability of additional spectrum to the multi-mode device. The multi-mode device may request access to additional spectrum. A second radio may facilitate access to received additional spectrum with the multi-radio multi-mode device.

4. 发明授权

US08722698B2 Berbamine derivatives 有权
标题翻译：伯胺衍生物
公开(公告)号：US08722698B2
公开(公告)日：2014-05-13
申请号：US12783535
申请日：2010-05-19
申请人： David Horne , Jun Xie , Angela L. Perkins Harki , Richard Jove , Sangkil Nam , Wendong Huang , Rongzhen Xu
发明人： David Horne , Jun Xie , Angela L. Perkins Harki , Richard Jove , Sangkil Nam , Wendong Huang , Rongzhen Xu
IPC分类号： C07D491/18 , A61K31/4745
CPC分类号： C07D491/147 , A61K31/4745
摘要： The invention provides novel berbamine derivatives, and compositions or pharmaceutical compositions thereof. These berbamine derivatives have shown higher potency in killing cancer/tumor cells comparing to berbamine, and can be used in cancer/tumor treatments.
摘要翻译：本发明提供新颖的柏柏胺衍生物及其组合物或药物组合物。与berbamine相比，这些berbamine衍生物在杀死癌症/肿瘤细胞方面表现出较高的效力，可用于癌症/肿瘤治疗。

5. 发明申请

US20120302815A1 MULTI-VALENT POLY-UBL CHAIN INHIBITORS AND METHODS OF USE 有权
标题翻译：多功能多环链抑制剂及其使用方法
公开(公告)号：US20120302815A1
公开(公告)日：2012-11-29
申请号：US13401642
申请日：2012-02-21
申请人： Yuan Chen , David Horne , Yi-Jia Li , Yuelong Ma , Angela L. Perkins-Harki , Yang Su
发明人： Yuan Chen , David Horne , Yi-Jia Li , Yuelong Ma , Angela L. Perkins-Harki , Yang Su
IPC分类号： C07F1/12 , A61L2/08 , A61M37/00 , C12N5/09
CPC分类号： A61K38/00 , A61K41/0038 , A61K47/6923 , B82Y5/00 , C07D233/64 , C07K5/06034 , C07K5/06043 , C07K5/06052
摘要： A composition used to develop a reagent for investigating Ubl-modifications in cellular functions and in the treatment of cancer is provided. The composition comprises gold nanoparticle (AuNP)-ligand conjugates that include at least two components: gold nanoparticles (AuNPs) and modified ubiquitin- or ubiquitin-like interacting motif (UIM or ULIM) mimetics. In one embodiment, the modified ULM mimetic is a modified SUMO interaction motif (SIM) mimetic. According to the embodiments described herein, the compound inhibits ubiquitin- or ubiquitin-like protein (Ubl)-mediated protein-protein interactions and sensitizes cells to ionizing radiation. The modified UIM and ULIM mimetics may be conjugated to the AuNP such that each AuNP is conjugated to a plurality of modified UIM or ULIM mimetics. The modified ULIM mimetics may be conjugated to the AuNP via a thiol group.
摘要翻译：提供了用于开发用于研究细胞功能和治疗癌症中的Ubl修饰的试剂的组合物。该组合物包含金纳米颗粒（AuNP） - 偶联物，其包含至少两个组分：金纳米颗粒（AuNP）和修饰的泛素或泛素样相互作用基序（UIM或ULIM）模拟物。在一个实施方案中，修饰的ULM模拟物是修饰的SUMO相互作用基序（SIM）模拟物。根据本文所述的实施方案，化合物抑制泛素或泛素样蛋白（Ubl）介导的蛋白质 - 蛋白质相互作用并使细胞对电离辐射敏感。修饰的UIM和ULIM模拟物可以与AuNP缀合，使得每个AuNP与多个修饰的UIM或ULIM模拟物缀合。修饰的ULIM模拟物可以通过硫醇基团与AuNP缀合。

6. 发明申请

US20080033004A1 SYNTHESIS OF GROSSULARINES-1 AND ANALOGS THEREOF AND METHOD OF USE 有权
标题翻译： GRASSULARINES-1及其类似物的合成及其使用方法
公开(公告)号：US20080033004A1
公开(公告)日：2008-02-07
申请号：US11742383
申请日：2007-04-30
申请人： David Horne , Richard Jove , Sangkil Nam , Kenichi Yakushijin
发明人： David Horne , Richard Jove , Sangkil Nam , Kenichi Yakushijin
IPC分类号： A61K31/437 , A61P35/00 , C07D471/14 , C07D471/22
CPC分类号： C07D471/14
摘要： In one embodiment of the present invention, a synthesis of grossularine-1 and N,N-didesmethylgrossularine-1 2 and analogs thereof based on a novel oxidative dimerization-electrocyclization sequence of 2-amino-4-(3-indolyl)imidazoles derived from oxotryptamine 3 is described.
摘要翻译：在本发明的一个实施方案中，基于由2-氨基-4-（3-吲哚基）咪唑衍生的新的氧化二聚化 - 电循环序列，合成粗略1和N，N-二甲基十八烷基-1,2及其类似物描述了氧杂色胺3。

7. 发明申请

US20050051646A1 Plastic recycling system and process 审中-公开
标题翻译：塑料回收系统和工艺
公开(公告)号：US20050051646A1
公开(公告)日：2005-03-10
申请号：US10769439
申请日：2004-01-30
申请人： David Horne
发明人： David Horne
IPC分类号： B02C18/14 , B29B17/00 , B29B17/04 , B29C47/00 , B29C47/38 , B29C47/52 , B02C19/12
CPC分类号： B29B17/0412 , B02C18/144 , B02C18/148 , B29B17/0036 , B29B2017/0021 , B29B2017/046 , B29B2017/048 , B29C48/00 , B29C48/0022 , B29C48/03 , B29C48/04 , B29C48/395 , B29C48/46 , B29C48/53 , B29C2793/009 , Y02W30/62 , Y02W30/625
摘要： The present invention provides a plastic recycling system, including a first granulator for reducing plastic waste to a first particle size. The system also includes a second granulator for reducing plastic waste to a second particle size. A frictional melting stricture is provided which melts the first particles and the second particles via use of a rotating plate.
摘要翻译：本发明提供一种塑料回收系统，其包括用于将塑料废物减少至第一粒度的第一造粒机。该系统还包括用于将塑料废物减少至第二颗粒尺寸的第二造粒机。提供摩擦熔融的狭缝，其通过使用旋转板熔化第一颗粒和第二颗粒。

8. 发明授权

US4753287A Circuit board installation 失效
标题翻译：电路板安装
公开(公告)号：US4753287A
公开(公告)日：1988-06-28
申请号：US111265
申请日：1987-10-22
申请人： David Horne
发明人： David Horne
IPC分类号： H01L23/40 , H01L23/433 , H05K7/20 , B22D23/06
CPC分类号： H01L23/4338 , H01L23/4006 , H05K7/20445 , H01L2023/4056 , H01L2023/4062 , H01L2023/4068 , H01L2924/0002
摘要： A thermally conductive module for locally extracting heat from an individual electrical component of a circuit board installation comprises a tubular metal housing of high thermal conductivity closed at one end and having at that end a screw-threaded stud for securing the housing to and in thermal contact with a thermal conductor. A spring-loaded metal piston of high thermal conductivity is slidably mounted in the bore of and protrudes from the housing and has a throughbore extending through and opening into the exposed end face of the piston. A grease-like medium of high thermal conductivity is contained in the closed bore of the housing. When the housing is secured in thermal contact with a thermal conductor and the exposed end face of the piston is brought into thermal contact with an electrical component from which heat is to be extracted, the piston is urged against the action of its associated coil spring and grease-like medium exudes from the throughbore and flows between the exposed end face of the piston and the electrical component to provide an effective thermal contact therebetween.
摘要翻译：用于从电路板装置的单个电气部件局部提取热量的导热模块包括在一端封闭的具有高导热性的管状金属壳体，并且在该端部具有螺纹螺柱，用于将壳体固定并接触热接触带有导热体。具有高导热性的弹簧加载的金属活塞可滑动地安装在壳体的孔中并从壳体突出，并且具有延伸穿过活塞的暴露端面的通孔。具有高导热性的油脂状介质包含在壳体的闭孔中。当壳体被固定成与热导体热接触时，并且活塞的暴露的端面与要从其中提取热量的电气部件热接触时，活塞被推动以抵抗其相关的螺旋弹簧的作用，润滑脂状介质从通孔渗出并在活塞的暴露端面和电气部件之间流动，从而在它们之间提供有效的热接触。

9. 发明授权

US09045750B2 Humanized lewis-Y specific antibody-based delivery of dicer substrate siRNA (D-siRNA) against STAT3 有权
标题翻译：针对STAT3的人源化的基于路易斯威氏Y特异性抗体的dicer底物siRNA（D-siRNA）递送
公开(公告)号：US09045750B2
公开(公告)日：2015-06-02
申请号：US13424267
申请日：2012-03-19
申请人： Yuelong Ma , David Horne , Hua Yu
发明人： Yuelong Ma , David Horne , Hua Yu
IPC分类号： C07H21/04 , A61K39/00 , A61K39/38 , C12N15/11 , C07K1/107 , A61K47/48 , C12N15/87 , C12N15/113
CPC分类号： C12N15/111 , A61K47/6849 , C07K1/1077 , C12N15/113 , C12N15/87 , C12N2310/14 , C12N2310/3513 , C12N2320/32
摘要： According to some embodiments, methods for covalently or non-covalently conjugating an antibody (e.g., hu3S193 or other humanized antibody) or functional fragment thereof with an siRNA molecule (e.g., anti-STAT3 siRNA) is provided. Such methods may include (1) modifying an antibody or functional fragment thereof with a linker to provide a linker-modified antibody, combining a target siRNA with a disulfide containing aldehyde linker to provide a linker-modified target siRNA and combining the linker-modified target siRNA with linker-modified antibody to form an antibody-siRNA complex; or (2) modifying an antibody or functional fragment thereof with a (Arginine)9 peptide to form an antibody-9R complex and associating an siRNA molecule with the antibody-9R complex to form an electrostatic antibody-9R:siRNA complex. In another embodiment, an antibody-siRNA conjugate may be used in methods for suppressing or silencing STAT3 protein expression in a cancer cell.
摘要翻译：根据一些实施方案，提供了将抗体（例如，hu3S193或其他人源化抗体）或其功能片段与siRNA分子（例如抗STAT3 siRNA）共价或非共价缀合的方法。这样的方法可以包括（1）用接头修饰抗体或其功能片段以提供接头修饰的抗体，将靶siRNA与含二硫键的醛连接体组合以提供接头修饰的靶siRNA并将接头修饰的靶具有接头修饰抗体的siRNA以形成抗体-siRNA复合物; 或（2）用（精氨酸）9肽修饰抗体或其功能片段以形成抗体-9R复合物，并将siRNA分子与抗体-9R复合物缔合，形成静电抗体-9R：siRNA复合物。在另一个实施方案中，抗体-siRNA缀合物可用于抑制或沉默癌细胞中STAT3蛋白表达的方法。

10. 发明授权

US07729409B2 Codebook indexing to achieve high bit densities in a direct-sequence CDMA spread spectrum communication system 失效
标题翻译：代码簿索引以在直接序列CDMA扩频通信系统中实现高比特密度
公开(公告)号：US07729409B2
公开(公告)日：2010-06-01
申请号：US11929366
申请日：2007-10-30
申请人： David Horne
发明人： David Horne
IPC分类号： H04B1/02
CPC分类号： H04J13/18 , H04B1/707 , H04J13/0022
摘要： Apparatuses for achieving high bit densities in a direct-sequence CDMA spread spectrum communication system are disclosed. A table of orthogonal pseudo-noise codes is stored. This table is then partitioned into multiple codebook. Then, the codebook is assigned to a user. The pseudo-noise code contained within the codebooks are used to spread information signal. Information signal for a first user is spread by a pseudo-noise code contained within the codebook assigned to the first user. Multiple bits of information signal may be sent at a time by using the location of the pseudo-noise code within the codebook such that the value of the information signal corresponds the location of the pseudo-noise code within the codebook. The information signal is then despread by using the same pseudo-noise code.
摘要翻译：公开了用于在直接序列CDMA扩展频谱通信系统中实现高比特密度的装置。存储正交伪噪声码表。然后将该表分成多个码本。然后，将码本分配给用户。码本中包含的伪噪声码用于扩展信息信号。用于第一用户的信息信号由包含在分配给第一用户的码本内的伪噪声码扩展。可以通过使用码本内的伪噪声码的位置来一次发送信息信号的多个比特，使得信息信号的值对应于码本内的伪噪声码的位置。然后通过使用相同的伪噪声码对信息信号进行解扩。

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