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1. 发明申请

US20210171577A1 COMBINATORIAL ANTIBIOTIC DERIVATIVES BASED ON SUPRAMOLECULAR STRUCTURES 有权
公开(公告)号：US20210171577A1
公开(公告)日：2021-06-10
申请号：US16771762
申请日：2017-06-16
申请人： Boris Farber , Sof'ya Farber , ARTUR VIKTOROVICH MARTYNOV
发明人： Boris Farber , Sof'ya Farber , ARTUR VIKTOROVICH MARTYNOV
IPC分类号： C07K7/62 , C07H15/234 , C07C235/82 , C07K7/28
摘要： Field of application: The invention relates to combinatorial chemistry, pharmacy and cosmetology, allows to synthesize new combinatorial libraries of derivatives of antibiotics for use in pharmacy, cosmetology and pharmacy.
Technical result: modified combinatorial derivatives of antibiotics with antimicrobial and antifungal activity against multiresistant and pan drug resistance strains of microorganisms and fungi. Means have a wide spectrum of action, and the supramolecular and combinatorial structure of their tens and hundreds of derivatives eliminates the resistance of microorganisms.

2. 发明授权

US11053608B2 Combinatorial derivatives of RNA oligonucleotides 有权
公开(公告)号：US11053608B2
公开(公告)日：2021-07-06
申请号：US16771364
申请日：2017-06-16
申请人： Boris Farber , Sof'ya Farber , Artur Viktorovich Martynov
发明人： Boris Farber , Sof'ya Farber , Artur Viktorovich Martynov
IPC分类号： C40B40/06
摘要： Field of application: This invention relates to the chemistry of nucleotides and allows to synthesize new combinatorial libraries of supramolecular oligonucleotides for use in medical fields, cosmetology and pharmaceutical industry. This invention also can be applied for the creation of means used in the body rejuvenation, treating human diseases such as cancer, trophic ulcers, creating new herbicides and pesticides.
The essence of the invention Combinatorial derivatives of RNA oligonucleotides, wherein for their production, covalent modification of the initial RNA oligonucleotides is carried out by simultaneous combinatorial carboxylation and formylation of the exocyclic amino groups of adenine, guanine, cytosine and the ribose alcohol residue in the reaction with the maximum number of different synthesis derivatives, and as a result of synthesis, a combinatorial mixture of derivatives of each oligonucleotide is formed and then use the resulting combinatorial mixture as a whole without fragmentation to create biologically active compositions.

3. 发明公开

US20230190756A1 PHARMACEUTICAL FORMULATION FOR THE ELIMINATION OF CAUSATIVE AGENTS OF HERPESVIRAL INFECTIONS FROM THE TISSUES OF A MACROORGANISM 审中-公开
公开(公告)号：US20230190756A1
公开(公告)日：2023-06-22
申请号：US16893903
申请日：2017-12-08
申请人： Boris Farber , Sof'ya Farber , ARTUR VIKTOROVICH MARTYNOV
发明人： Boris Farber , Sof'ya Farber , ARTUR VIKTOROVICH MARTYNOV
IPC分类号： A61K31/522 , A61K31/353 , A61K31/47 , A61K47/12 , A61P31/22 , C40B40/04
CPC分类号： A61K31/522 , A61K31/353 , A61K31/47 , A61K47/12 , A61P31/22 , C40B40/04
摘要： A pharmaceutical composition is proposed for the elimination of the causative agents of herpes virus infections from macroorganism tissues, including histone deacetylase inhibitors, acyclovir derivatives, epigallocatechin gallate and glycyrrhizin, characterized in that it additionally contains a supramolecular structure of a combination of gator epigalocatechin gallate and galactate epigalocatechol at least two covalent modifying agents.
Also, the composition may include such substances as chorlecalciferol, toll receptor activators acridonoacetic acid, tilorone, zymosan, imidazoquinoline, imiquimod. As modifiers of the structures of epigalocatechin gallate and glycyrrhizin can be used: succinic anhydride, acetic anhydride, propionic anhydride, butane anhydride, acetic-propionic anhydride, acetic-buttanic anhydride, glutaric anhydride, phthalic anhydride, citric anhydride, citric anhydride citric anhydride, isolimonic anhydride, acetyl chloride, acetyl fluoride, propionyl chloride, butyroyl chloride, ethoxyoxalyl monochloride, monochloroacetic acid.

4. 发明授权

US11229622B2 Cosmetological and pharmaceutical composition based on combinatorial quercetin derivative 有权
公开(公告)号：US11229622B2
公开(公告)日：2022-01-25
申请号：US16771355
申请日：2017-06-16
申请人： Boris Farber , Sof'ya Farber , Artur Viktorovich Martynov
发明人： Boris Farber , Sof'ya Farber , Artur Viktorovich Martynov
IPC分类号： A61K31/353 , A61P17/02 , A61K8/02 , A61K8/49 , A61K8/67 , A61K9/127 , A61K9/51 , A61K31/593 , A61K47/24 , A61Q19/08 , C04B40/04 , C40B40/04
摘要： The basis to develop a cosmetic and pharmaceutical composition based on a combinatorial derivative of quercetin in the form of nanoparticles (liposomes) for the treatment of atherosclerosis and its complications, as well as hypertension, for rejuvenating the body and healing wounds.
The problem is solved by obtaining a cosmetic and pharmaceutical composition based on a combinatorial quercetin derivative, characterized in that the modified combinatorial quercetin derivative is represented as a combinatorial library (mixture) of quercetin derivatives obtained by simultaneous combinatorial modification of quercetin with at least two alkylating and acylating modifiers in the combinatorial reaction synthesis to obtain the maximum number of different derivatives of quercetin, and as biologically active substances, a whole combinatorial mixture of quercetin derivatives is used without separation into individual components to create cosmetic and pharmaceutical compositions.

5. 发明申请

US20210361696A1 BIOLOGICALLY ACTIVE COMBINATORIAL POLYSACCHARIDE DERIVATIVES 有权
公开(公告)号：US20210361696A1
公开(公告)日：2021-11-25
申请号：US16771573
申请日：2017-06-16
申请人： Boris Farber , Sof'ya Farber , ARTUR VIKTOROVICH MARTYNOV
发明人： Boris Farber , Sof'ya Farber , ARTUR VIKTOROVICH MARTYNOV
IPC分类号： A61K31/727 , A61K31/717 , A61K31/722 , A61K31/718 , A61P37/02 , A61P31/12 , A61P17/02 , A61P7/04
摘要： The invention related to organic and bioorganic combinatorial chemistry, namely, to new combinatorial libraries of polysaccharide derivatives and supramolecular structures based on them, which, when used without separation into separate components, have high biological activity.
The essence is a combinatorial library and a supramolecular structure based on it from biologically active derivatives of polysaccharides, as well as pharmaceutical compositions based on them with a hemostatic, wound healing, antiviral and immunomodulating action, containing as an active substance an undivided whole combinatorial mixture of substituted glucopyranose polymer derivatives, obtained simultaneous combinatorial modification of a polysaccharide with at least two covalent modifier in the synthesis, a combinatorial mixture with the maximum number of combinations of modified polysaccharide derivatives is formed, and as a biologically active substance, a whole combinatorial mixture of polysaccharide derivatives in the form of a supramolecular structure without separation into individual components is used to obtain a pharmaceutical composition.

6. 发明申请

US20210085774A1 VACCINES WITH ENHANCED IMMUNOGENICITY, LOW ALLERGENICITY AND REACTOGENICITY 有权
公开(公告)号：US20210085774A1
公开(公告)日：2021-03-25
申请号：US16954835
申请日：2018-05-04
申请人： Boris Farber , Sof'ya Farber , ARTUR VIKTOROVICH MARTYNOV
发明人： Boris Farber , Sof'ya Farber , ARTUR VIKTOROVICH MARTYNOV
IPC分类号： A61K39/104 , A61K39/17 , A61K39/39
摘要： Field of application: the invention relates to veterinary medicine and, in particular, to vaccinology and pharmacy, and is intended for the prevention and treatment of infectious and other diseases of humans and animals, where low allergenic low reactogenic vaccination is used. The essence of the invention: developed vaccines with increased immunogenicity, low allergenicity and reactogenicity, containing antigen/toxin and adjuvant, wherein that they contain vaccine antigen/toxin inactivated by electromagnetic radiation in the ultraviolet and visible regions of the spectrum in the presence of a solution of photosensitizer and salts of divalent metals, and then covalently modified according to the residues of amino groups and hydroxyls groups of antigen/toxin available for modification, at least two modifying agents at the same time in terms of 0.01-10.0% of the mass concentration of the antigen/toxin protein, and as an adjuvant it contains hydrosol hydroxide ferric chloride.

7. 发明申请

US20210071317A1 COMBINATORIAL DERIVATIVES OF RNA OLIGONUCLEOTIDES 有权
公开(公告)号：US20210071317A1
公开(公告)日：2021-03-11
申请号：US16771364
申请日：2017-06-16
申请人： Boris Farber , Sof'ya Farber , ARTUR VIKTOROVICH MARTYNOV
发明人： Boris Farber , Sof'ya Farber , ARTUR VIKTOROVICH MARTYNOV
IPC分类号： C40B40/06
摘要： Field of application: This invention relates to the chemistry of nucleotides and allows to synthesize new combinatorial libraries of supramolecular oligonucleotides for use in medical fields, cosmetology and pharmaceutical industry. This invention also can be applied for the creation of means used in the body rejuvenation, treating human diseases such as cancer, trophic ulcers, creating new herbicides and pesticides.
The essence of the invention Combinatorial derivatives of RNA oligonucleotides, wherein for their production, covalent modification of the initial RNA oligonucleotides is carried out by simultaneous combinatorial carboxylation and formylation of the exocyclic amino groups of adenine, guanine, cytosine and the ribose alcohol residue in the reaction with the maximum number of different synthesis derivatives, and as a result of synthesis, a combinatorial mixture of derivatives of each oligonucleotide is formed and then use the resulting combinatorial mixture as a whole without fragmentation to create biologically active compositions.

8. 发明申请

US20220395555A1 Derivatives of antibiotics 有权
公开(公告)号：US20220395555A1
公开(公告)日：2022-12-15
申请号：US17890503
申请日：2022-08-18
申请人： Boris Farber , Sof'ya Farber , ARTUR VIKTOROVICH MARTYNOV
发明人： Boris Farber , Sof'ya Farber , ARTUR VIKTOROVICH MARTYNOV
IPC分类号： A61K38/12 , A61K31/7036 , A61K31/65 , A61K31/40 , A61K31/7048
摘要： Field of application: The invention relates to chemistry, pharmacy and cosmetology, allows to synthesize of supramolecular structure on base antibiotics derivatives for use in pharmacy, cosmetology and pharmacy.
The essence of the invention: a new derivatives of antibiotics based on supramolecular structures and a method for their preparation, characterized in that the supramolecular structures are obtained by combinatorial synthesis of an antibiotic from one source molecule with two or more groups available in the reaction for covalent modification, at least with two different modifiers simultaneously, this creates a mixture of modified derivatives of the original molecule, with a maximum variety of derivatives with forming new supramolecular structure, and as biologically active substances to create pharmaceutical compositions use such supramolecular structure without separation into individual components, and in the reaction a combinatorial mixture of modified derivatives of the original molecule is formed antibiotic, the maximum number of combinations.
Technical result: modified combinatorial derivatives of antibiotics with antimicrobial and antifungal activity against multiresistant and pan drug resistance strains of microorganisms and fungi. Means have a wide spectrum of action, and the supramolecular and combinatorial structure of their tens and hundreds of derivatives eliminates the resistance of microorganisms.

9. 发明授权

US11446338B2 Food, cosmetic and pharmaceutical formulation with an immunomodulatory and protective anti-viral effect 有权
公开(公告)号：US11446338B2
公开(公告)日：2022-09-20
申请号：US16954854
申请日：2018-05-04
申请人： Boris Farber , Sof'ya Farber
发明人： Boris Farber , Sof'ya Farber , Artur Viktorovich Martynov
IPC分类号： A61K35/742 , A61K45/06 , A61K31/196 , A61K31/205 , A61K36/064 , A61K36/484 , A61K36/28 , A61K35/748 , A61K36/48 , A61K31/714 , A61K31/525 , A61K31/51 , A61K31/519 , A61K31/7048 , A61K31/198 , A61K31/145 , A61K36/66 , A61K31/472 , A61K8/99 , A61K8/44 , A61K8/9789 , A61K8/9728 , A61K8/67 , A61K8/60 , A61K8/46 , A61K8/49 , A61Q11/00 , A23L33/135 , A23L33/105 , A23L33/175 , A23L33/15 , A23L33/00
摘要： Field of application: the invention relates to biotechnology, can be used in the food industry, medicine and cosmetology in the prevention and/or treatment of diseases associated with immunodeficiencies and respiratory viral infections.
The proposed food, cosmetic and pharmaceutical composition with an immunomodulating and protective antiviral effect additionally has the ability to completely prevent infection by a number of viruses, including influenza, rotavirus and coronavirus, as well as stimulate the immune system more than individual probiotics.

10. 发明授权

US11213579B2 Vaccines with enhanced immunogenicity, low allergenicity and reactogenicity 有权
公开(公告)号：US11213579B2
公开(公告)日：2022-01-04
申请号：US16954835
申请日：2018-05-04
申请人： Boris Farber , Sof'ya Farber , Artur Viktorovich Martynov
发明人： Boris Farber , Sof'ya Farber , Artur Viktorovich Martynov
IPC分类号： A61K39/104 , A61K39/17 , A61K39/39 , A61K39/00
摘要： Field of application: the invention relates to veterinary medicine and, in particular, to vaccinology and pharmacy, and is intended for the prevention and treatment of infectious and other diseases of humans and animals, where low allergenic low reactogenic vaccination is used. The essence of the invention: developed vaccines with increased immunogenicity, low allergenicity and reactogenicity, containing antigen/toxin and adjuvant, wherein that they contain vaccine antigen/toxin inactivated by electromagnetic radiation in the ultraviolet and visible regions of the spectrum in the presence of a solution of photosensitizer and salts of divalent metals, and then covalently modified according to the residues of amino groups and hydroxyls groups of antigen/toxin available for modification, at least two modifying agents at the same time in terms of 0.01-10.0% of the mass concentration of the antigen/toxin protein, and as an adjuvant it contains hydrosol hydroxide ferric chloride.

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