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1. 发明授权

US4250765A Force transmitting arrangement 失效
标题翻译：力传动装置
公开(公告)号：US4250765A
公开(公告)日：1981-02-17
申请号：US4019
申请日：1979-01-17
申请人： Bernd Niklaus , Manfred Braun , Roland Maier
发明人： Bernd Niklaus , Manfred Braun , Roland Maier
IPC分类号： B62D5/02 , B62D5/04 , F16D13/08 , F16H35/00
CPC分类号： B62D5/0439 , B62D5/0403 , F16D13/08
摘要： A force transmitting arrangement, useable as force amplifier of drive arrangements, transmits the moment of a reversible electric motor, acting as a servo motor or as a drive motor, over a friction core and a looped spring cooperating therewith to an output shaft. The looped spring has a pair of outwardly bent ends, which at the outer sides thereof drive, while taking up a tension force, an output entrainment member connected to the output shaft, whereas an input entrainment member connected with a manually operated drive, for instance the steering wheel of a motor vehicle, is located between the outwardly bent ends of the looped spring.
摘要翻译：可用作驱动装置的力放大器的力传递装置将作为伺服电动机或作为驱动电动机的可逆电动机的力矩传递到摩擦芯和与其配合的环形弹簧到输出轴。环形弹簧具有一对向外弯曲的端部，其在其外侧驱动时同时承受张力，输出夹带构件连接到输出轴，而输入夹带构件与手动操作的驱动器连接，例如机动车辆的方向盘位于环形弹簧的向外弯曲的端部之间。

2. 发明授权

US08664232B2 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions 有权
标题翻译： 8- [3-氨基 - 哌啶-1-基] - 黄嘌呤，其制备及其作为药物组合物的用途
公开(公告)号：US08664232B2
公开(公告)日：2014-03-04
申请号：US13448495
申请日：2012-04-17
申请人： Frank Himmelsbach , Elke Langkopf , Matthias Eckhardt , Michael Mark , Roland Maier , Ralf R. H. Lotz , Mohammad Tadayyon
发明人： Frank Himmelsbach , Elke Langkopf , Matthias Eckhardt , Michael Mark , Roland Maier , Ralf R. H. Lotz , Mohammad Tadayyon
IPC分类号： A01N43/90 , C07D473/00
CPC分类号： C07D473/04 , C07D473/06 , C07D473/08 , C07D519/00
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译：本发明涉及通式为其中R1至R3如本文所定义的取代黄嘌呤，其互变异构体，立体异构体，混合物，其前药及其盐具有有价值的药理学性质，特别是对酶二肽肽酶-IV（DPP-IV）。

3. 发明授权

US07838529B2 Xanthine derivates, their preparation and their use in pharmaceutical compositions 有权
标题翻译：黄嘌呤衍生物，其制备及其在药物组合物中的应用
公开(公告)号：US07838529B2
公开(公告)日：2010-11-23
申请号：US12355011
申请日：2009-01-16
申请人： Frank Himmelsbach , Elke Langkopf , Matthias Eckhardt , Michael Mark , Roland Maier , Ralf Lotz
发明人： Frank Himmelsbach , Elke Langkopf , Matthias Eckhardt , Michael Mark , Roland Maier , Ralf Lotz
IPC分类号： C07D473/06 , A61K31/522 , A61P3/10 , A61P3/04
CPC分类号： C07D473/06 , C07D473/04
摘要： Compounds of formula (I) wherein R1 is a phenylcarbonylmethyl group wherein the phenyl moiety is substituted by R10 and R11 and R2 to R4 and R10 and R1l are defined as in the claims, or the prodrugs or salts thereof, particularly the physiologically acceptable salts thereof, pharmaceutical compositions containing these compounds, and methods of treating type II diabetes mellitus and obesity using these compounds.
摘要翻译：其中R 1是苯基部分被R 10和R 11以及R 2至R 4和R 10和R 11取代的苯基羰基甲基的式（I）化合物，如权利要求中所定义，或其前药或盐，特别是其生理上可接受的盐含有这些化合物的药物组合物，以及使用这些化合物治疗II型糖尿病和肥胖症的方法。

4. 发明授权

US07407955B2 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions 有权
标题翻译： 8- [3-氨基 - 哌啶-1-基] - 黄嘌呤，其制备及其作为药物组合物的用途
公开(公告)号：US07407955B2
公开(公告)日：2008-08-05
申请号：US10639036
申请日：2003-08-12
申请人： Frank Himmelsbach , Elke Langkopf , Matthias Eckhardt , Michael Mark , Roland Maier , Ralf R. H. Lotz , Mohammad Tadayyon
发明人： Frank Himmelsbach , Elke Langkopf , Matthias Eckhardt , Michael Mark , Roland Maier , Ralf R. H. Lotz , Mohammad Tadayyon
IPC分类号： C07D473/06 , A61K31/52 , A61P3/10 , A61P19/02 , A61P3/04 , C07D519/00
CPC分类号： C07D473/04 , C07D473/06 , C07D473/08 , C07D519/00
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R3 are defined as in claims 1 to 16, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译：本发明涉及以下通式的取代黄嘌呤：其中R 1至R 3定义如权利要求1至16中所定义，互变异构体，立体异构体，混合物，前体药物其具有有价值的药理学特性的盐，特别是对二肽基肽酶-IV（DPP-IV）的活性的抑制作用。

5. 发明申请

US20060247226A1 XANTHINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译： XANTHINE衍生物，其制备方法及其作为药物组合物的用途
公开(公告)号：US20060247226A1
公开(公告)日：2006-11-02
申请号：US11457030
申请日：2006-07-12
申请人： Frank Himmelsbach , Michael Mark , Matthias Eckhardt , Elke Langkopf , Roland Maier , Ralf Lotz
发明人： Frank Himmelsbach , Michael Mark , Matthias Eckhardt , Elke Langkopf , Roland Maier , Ralf Lotz
IPC分类号： A61K31/55
CPC分类号： C07D473/08 , C07D473/04 , C07D473/06 , C07D473/10 , C07D473/12
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R4 are defined as in claim 1, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译：本发明涉及以下通式的取代黄嘌呤：其中R 1至R 4定义如权利要求1，互变异构体及其立体异构体，其混合物，前药和其具有有价值的药理学特性的盐，特别是对二肽基肽酶-IV（DPP-IV）的活性的抑制作用。

6. 发明申请

US20050138959A1 Evaporator for a refrigeration device 审中-公开
标题翻译：蒸发器用于制冷装置
公开(公告)号：US20050138959A1
公开(公告)日：2005-06-30
申请号：US11017614
申请日：2004-12-20
申请人： Michael Howe , Hans Ihle , Helmut Konopa , Roland Maier , Michael Neumann
发明人： Michael Howe , Hans Ihle , Helmut Konopa , Roland Maier , Michael Neumann
IPC分类号： F25B39/02 , F25B47/00 , F28F13/18 , F25C1/14 , F28F19/02
CPC分类号： F25B39/02 , F25B47/006
摘要： The evaporator for a refrigeration device includes a hydrophobic coating on the surface thereof to inhibit the icing of the evaporator during operation and to reduce the generation of noises arising from relative displacements between the evaporator and the ice attached thereto. The evaporator is a lamellar evaporator and has a pipeline through which a refrigerant flows and a surface in thermally conductive contact with the pipeline. The surface is a heat-exchange surface and has a hydrophobic layer of oil thereon.
摘要翻译：用于制冷装置的蒸发器包括在其表面上的疏水涂层，以在操作期间抑制蒸发器的结冰并且减少由于蒸发器和附着在其上的冰之间的相对位移而产生的噪声。蒸发器是层状蒸发器，并且具有制冷剂流经的管道和与管道导热接触的表面。表面是热交换表面，并且在其上具有疏水层的油。

7. 发明申请

US20050020574A1 New substituted imidazo-pyridinones and imidazo-pyridazinones, the preparation thereof and their use as pharmaceutical compositions 有权
标题翻译：新的取代的咪唑并 - 吡啶酮和咪唑并哒嗪酮，其制备及其作为药物组合物的用途
公开(公告)号：US20050020574A1
公开(公告)日：2005-01-27
申请号：US10726214
申请日：2003-12-02
申请人： Norbert Hauel , Frank Himmelsbach , Elke Langkopf , Matthias Eckhardt , Roland Maier , Michael Mark , Mohammad Tadayyon , Iris Kauffmann-Hefner
发明人： Norbert Hauel , Frank Himmelsbach , Elke Langkopf , Matthias Eckhardt , Roland Maier , Michael Mark , Mohammad Tadayyon , Iris Kauffmann-Hefner
IPC分类号： C07D471/04 , C07D487/04 , C07D519/00 , C07D471/02 , A61K31/4745 , A61K31/503 , A61K31/55 , C07D487/02
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula wherein R1 to R4 are defined as in claim 1, the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译：本发明涉及通式的取代的咪唑并 - 吡啶酮和咪唑并哒嗪酮，其中R 1至R 4如权利要求1所定义，互变异构体，立体异构体，其混合物及其盐具有有价值的药理特性，特别是酶二肽肽酶-IV（DPP-IV）的活性的抑制作用。

8. 发明授权

US06346545B1 Urethanes, thio and dithio analogues and their use as inhibitors of cholesterol biosynthesis 有权
标题翻译：聚氨酯，硫代和二硫代类似物及其作为胆固醇生物合成抑制剂的用途
公开(公告)号：US06346545B1
公开(公告)日：2002-02-12
申请号：US09275318
申请日：1999-03-24
申请人： Roland Maier , Rudolf Hurnaus , Michael Mark , Bernhard Eisele , Peter Mueller , Gebhard Adelgoss , Gebhard Schilcher
发明人： Roland Maier , Rudolf Hurnaus , Michael Mark , Bernhard Eisele , Peter Mueller , Gebhard Adelgoss , Gebhard Schilcher
IPC分类号： A61K3127
CPC分类号： C07D295/135 , C07C271/24 , C07C271/56 , C07C333/06 , C07C333/24 , C07C2601/14 , Y02P20/55
摘要： The present invention relates to urethanes and the thio and dithio analogues thereof of general formula wherein m, n, A, X, Y and R1 to R8 are defined as in claim 1, the enantiomers, diastereomers and the salts thereof, particularly the physiologically acceptable acid addition salts thereof which have valuable properties, particularly an inhibitory effect on cholesterol biosynthesis, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
摘要翻译：本发明涉及聚氨酯，其一般形式的n，A，X，Y和R 1至R 8的硫代和二硫类似物如权利要求1中所定义，其对映异构体，非对映异构体及其盐，特别是生理上可接受的酸加成其具有有价值的性质，特别是对胆固醇生物合成的抑制作用，含有这些化合物的药物组合物，其用途和制备方法。

9. 发明授权

US4370327A Cephalosporins and pharmaceutical compositions 失效
标题翻译：头孢菌素和药物组合物
公开(公告)号：US4370327A
公开(公告)日：1983-01-25
申请号：US237066
申请日：1981-02-23
申请人： Bernd Wetzel , Eberhard Woitun , Wolfgang Reuter , Roland Maier , Uwe Lechner , Hanns Goeth
发明人： Bernd Wetzel , Eberhard Woitun , Wolfgang Reuter , Roland Maier , Uwe Lechner , Hanns Goeth
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D277/20 , C07D501/20 , C07D501/24 , C07D501/57 , C07D501/22 , C07D501/36 , C07D501/46
CPC分类号： C07D277/587 , Y02P20/55
摘要： The invention is directed to cephalosporins of the formula ##STR1## and the tautomers thereof, and, when E is a hydrogen atom, the pharmacologically acceptable salts thereof with inorganic or organic bases.
摘要翻译：本发明涉及式IMA的头孢菌素及其互变异构体，并且当E是氢原子时，其药理上可接受的盐与无机或有机碱形成。

10. 发明授权

US4364944A Cephalosporins 失效
标题翻译：头孢菌素
公开(公告)号：US4364944A
公开(公告)日：1982-12-21
申请号：US323382
申请日：1981-11-20
申请人： Bernd Wetzel , Eberhard Woitun , Wolfgang Reuter , Roland Maier , Uwe Lechner , Hanns Goeth
发明人： Bernd Wetzel , Eberhard Woitun , Wolfgang Reuter , Roland Maier , Uwe Lechner , Hanns Goeth
IPC分类号： C07D501/06 , A61K20060101 , A61K31/545 , A61K31/546 , C07D20060101 , C07D501/00 , C07D501/20 , C07D501/22 , C07D501/24 , C07D501/34 , C07D501/36 , C07D501/46 , C07D501/56 , C07D501/57
CPC分类号： C07D501/20 , Y02P20/55
摘要： Compounds of the formula ##STR1## wherein Y is hydrogen or methoxy;A is ##STR2## or, when Y is methoxy, also phenyl, 4-hydroxy-phenyl, 2-thienyl, 3-thienyl of 3,4-dihydroxy-phenyl;A' is hydrogen, --COCH.sub.2 Cl, --COCH.sub.2 Br, --COOCH.sub.2 CCL.sub.3, formyl or trityl;D is hydrogen, acetoxy, aminocarbonyloxy, pyridinium, 4-aminocarbonyl-pyridinium or -S-Het, where Het is 3-methyl-1,2,4-thiadiazol-5-yl, 1,2,4-thiadiazol-5-yl, 1,3,4-thiadiazol-5-yl, 2-methyl-1,3,4-thiadiazol-5-yl, 4H-5,6-dioxo-1,2,4-triazine-3-yl, 4-methyl-5,6-dioxo-1,2,4-triazin-3-yl, 1-vinyl-tetrazol-5-yl, 1-allyl-tetrazol-5-yl or ##STR3## n is 1, 2 or 3; R.sub.1 is hydroxyl, amino, dimethylamino, acetylamino, aminocarbonyl, aminocarbonylamino, aminosulfonyl, aminosulfonylamino, methylcarbonyl, methylsulfonylamino, cyano, hydroxysulfonylamino, methylsulfonyl, methylsulfinyl, a carboxylic acid group or a sulfonic acid group; or--(CH.sub.2).sub.n R.sub.1 is alkyl of 1 to 4 carbon atoms or 2,3-dihydroxy-propyl;R.sub.2 is unsubstituted or monosubstituted 3-pyridyl, 5-pyrimidinyl, 2-thienyl, 2-furyl-methyl, 2-thienyl-methyl, 2-imidazolyl-methyl, 2-thiazolyl-methyl, 3-pyridyl-methyl or 5-pyrimidinyl-methyl, where the substituent is chlorine, methyl, acetylamino, hydroxyl, methylsulfinyl, methylsulfonyl, aminocarbonyl or aminosulfonyl; andE is hydrogen or a carboxyl-protective group which is easily removable in vitro or in vivo;and, E is hydrogen, non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases; the compounds as well as their salts are useful as antibiotics.
摘要翻译：其中Y是氢或甲氧基的式“IMAGE”的化合物; A是，或者当Y是甲氧基时，3,4-二羟基 - 苯基的苯基，4-羟基 - 苯基，2-噻吩基，3-噻吩基; A'是氢，-COCH 2 Cl，-COCH 2 Br，-COOCH 2 CCl 3，甲酰基或三苯甲基; D是氢，乙酰氧基，氨基羰氧基，吡啶鎓，4-氨基羰基 - 吡啶鎓或-S-Het，其中Het是3-甲基-1,2,4-噻二唑-5-基，1,2,4-噻二唑-5-基， 1,3,4-噻二唑-5-基，2-甲基-1,3,4-噻二唑-5-基，4H-5,6-二氧代-1,2,4-三嗪-3-基， 4-甲基-5,6-二氧代-1,2,4-三嗪-3-基，1-乙烯基 - 四唑-5-基，1-烯丙基 - 四唑-5-基或n为1,2 或3; R1是羟基，氨基，二甲基氨基，乙酰基氨基，氨基羰基，氨基羰基氨基，氨基磺酰基，氨基磺酰基氨基，甲基羰基，甲基磺酰基氨基，氰基，羟基磺酰基氨基，甲基磺酰基，甲基亚磺酰基，羧酸基或磺酸基团。或 - （CH 2）n R 1是1至4个碳原子的烷基或2,3-二羟基 - 丙基; R2是未取代的或单取代的3-吡啶基，5-嘧啶基，2-噻吩基，2-呋喃基 - 甲基，2-噻吩基 - 甲基，2-咪唑基 - 甲基，2-噻唑基 - 甲基，3-吡啶基 - 甲基或5-嘧啶基甲基，其中取代基是氯，甲基，乙酰氨基，羟基，甲基亚磺酰基，甲基磺酰基，氨基羰基或氨基磺酰基; E是氢或羧基保护基，其在体外或体内容易除去; 和E是氢，与无机或有机碱形成的无毒的药理学上可接受的盐; 化合物及其盐可用作抗生素。

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