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1. 发明授权

US09896696B2 Compositions and methods for modifying genomes 有权
公开(公告)号：US09896696B2
公开(公告)日：2018-02-20
申请号：US15432109
申请日：2017-02-14
申请人： BENSON HILL BIOSYSTEMS, INC.
发明人： Matthew Begemann , Benjamin Neil Gray
IPC分类号： C12N15/82 , C12N9/22 , C12N15/62 , C12N15/10
CPC分类号： C12N15/8274 , C12N9/22 , C12N15/102 , C12N15/62 , C12N15/8202 , C12N15/8213
摘要： Compositions and methods for modifying genomic DNA sequences are provided. The methods produce double-stranded breaks (DSBs) at pre-determined target sites in a genomic DNA sequence, resulting in mutation, insertion, and/or deletion of DNA sequences at the target site(s) in a genome. Compositions comprise DNA constructs comprising nucleotide sequences that encode a Cpf1 or Csm1 protein operably linked to a promoter that is operable in the cells of interest. The DNA constructs can be used to direct the modification of genomic DNA at pre-determined genomic loci. Methods to use these DNA constructs to modify genomic DNA sequences are described herein. Additionally, compositions and methods for modulating the expression of genes are provided. Compositions comprise DNA constructs comprising a promoter that is operable in the cells of interest operably linked to nucleotide sequences that encode a mutated Cpf1 or Csm1 protein with an abolished ability to produce DSBs, optionally linked to a domain that regulates transcriptional activity. The methods can be used to up- or down-regulate the expression of genes at predetermined genomic loci.

2. 发明申请

US20170233756A1 COMPOSITIONS AND METHODS FOR MODIFYING GENOMES 有权
公开(公告)号：US20170233756A1
公开(公告)日：2017-08-17
申请号：US15432109
申请日：2017-02-14
申请人： BENSON HILL BIOSYSTEMS, INC.
发明人： Matthew Begemann , Benjamin Neil Gray
IPC分类号： C12N15/82 , C12N9/22 , C12N15/62
CPC分类号： C12N15/8274 , C12N9/22 , C12N15/102 , C12N15/62 , C12N15/8202 , C12N15/8213
摘要： Compositions and methods for modifying genomic DNA sequences are provided. The methods produce double-stranded breaks (DSBs) at pre-determined target sites in a genomic DNA sequence, resulting in mutation, insertion, and/or deletion of DNA sequences at the target site(s) in a genome. Compositions comprise DNA constructs comprising nucleotide sequences that encode a Cpf1 or Csm1 protein operably linked to a promoter that is operable in the cells of interest. The DNA constructs can be used to direct the modification of genomic DNA at pre-determined genomic loci. Methods to use these DNA constructs to modify genomic DNA sequences are described herein. Additionally, compositions and methods for modulating the expression of genes are provided. Compositions comprise DNA constructs comprising a promoter that is operable in the cells of interest operably linked to nucleotide sequences that encode a mutated Cpf1 or Csm1 protein with an abolished ability to produce DSBs, optionally linked to a domain that regulates transcriptional activity. The methods can be used to up- or down-regulate the expression of genes at predetermined genomic loci.

3. 发明授权

US11371053B2 Increasing plant growth and yield by expression of an m-type thioredoxin 有权
公开(公告)号：US11371053B2
公开(公告)日：2022-06-28
申请号：US16311905
申请日：2017-06-28
申请人： Benson Hill Biosystems, Inc.
发明人： Benjamin Neil Gray , Henry D. Priest
IPC分类号： C12N15/82 , C07K14/415
摘要： Compositions and methods for improving plant growth are provided herein. Disclosed herein are polypeptides encompassing m-type thioredoxin proteins, and polynucleotides encoding m-type thioredoxin proteins, wherein the thioredoxin protein-encoding sequence is expressed from mesophyll-preferred promoters. Also provided herein are expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants.

4. 发明授权

US10837023B2 Compositions and methods for modifying genomes 有权
公开(公告)号：US10837023B2
公开(公告)日：2020-11-17
申请号：US16393062
申请日：2019-04-24
申请人： BENSON HILL BIOSYSTEMS, INC.
发明人： Matthew Begemann , Benjamin Neil Gray
IPC分类号： C12N15/82 , C12N9/22 , C12N15/10 , C07K14/415
CPC分类号： C12N15/82 , C12N9/22 , C12N15/102 , C12N15/825 , C12N15/8213 , C12N15/8269 , C07K14/415 , C07K2319/00
摘要： Compositions and methods for modifying genomic DNA sequences are provided. The methods produce double-stranded breaks (DSBs) at pre-determined target sites in a genomic DNA sequence, resulting in mutation, insertion, and/or deletion of DNA sequences at the target site(s) in a genome. Compositions comprise DNA constructs comprising nucleotide sequences that encode a Cms1 protein operably linked to a promoter that is operable in the cells of interest. The DNA constructs can be used to direct the modification of genomic DNA at pre-determined genomic loci. Methods to use these DNA constructs to modify genomic DNA sequences are described herein. Additionally, compositions and methods for modulating the expression of genes are provided. Compositions comprise DNA constructs comprising a promoter that is operable in the cells of interest operably linked to nucleotide sequences that encode a mutated Cms1 protein with an abolished ability to produce DSBs, optionally linked to a domain that regulates transcriptional activity. The methods can be used to up- or down-regulate the expression of genes at predetermined genomic loci.

5. 发明申请

US20200149058A1 INCREASING PLANT GROWTH AND YIELD BY USING A PHENYLALANINE AMMONIA LYASE SEQUENCE 审中-公开
公开(公告)号：US20200149058A1
公开(公告)日：2020-05-14
申请号：US16308993
申请日：2017-06-12
申请人： BENSON HILL BIOSYSTEMS, INC.
发明人： Benjamin Neil Gray , Henry D. Priest
IPC分类号： C12N15/82 , C07K14/415
摘要： Compositions and methods for improving plant growth are provided herein. Polynucleotides encoding phenylalanine ammonia lyase (PAL) proteins, polypeptides encompassing PAL proteins, and expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants are also provided.

6. 发明申请

US20190071688A1 COMPOSITIONS AND METHODS FOR MODIFYING GENOMES 审中-公开
公开(公告)号：US20190071688A1
公开(公告)日：2019-03-07
申请号：US16135724
申请日：2018-09-19
申请人： BENSON HILL BIOSYSTEMS, INC.
发明人： Matthew Begemann , Benjamin Neil Gray
IPC分类号： C12N15/82 , C12N9/22 , C12N15/10 , C12N15/62
摘要： Compositions and methods for modifying genomic DNA sequences are provided. The methods produce double-stranded breaks (DSBs) at pre-determined target sites in a genomic DNA sequence, resulting in mutation, insertion, and/or deletion of DNA sequences at the target site(s) in a genome. Compositions comprise DNA constructs comprising nucleotide sequences that encode a Cpf1 or Csm1 protein operably linked to a promoter that is operable in the cells of interest. The DNA constructs can be used to direct the modification of genomic DNA at pre-determined genomic loci. Methods to use these DNA constructs to modify genomic DNA sequences are described herein. Additionally, compositions and methods for modulating the expression of genes are provided. Compositions comprise DNA constructs comprising a promoter that is operable in the cells of interest operably linked to nucleotide sequences that encode a mutated Cpf1 or Csm1 protein with an abolished ability to produce DSBs, optionally linked to a domain that regulates transcriptional activity. The methods can be used to up- or down-regulate the expression of genes at predetermined genomic loci.

7. 发明申请

US20200032286A1 METHODS FOR INCREASING PLANT GROWTH AND YIELD BY USING AN ICTB SEQUENCE 审中-公开
公开(公告)号：US20200032286A1
公开(公告)日：2020-01-30
申请号：US16589923
申请日：2019-10-01
申请人： BENSON HILL BIOSYSTEMS, INC.
发明人： Benjamin Neil Gray , Matthew Begemann
IPC分类号： C12N15/82 , C07K14/195
摘要： Compositions and methods for increasing plant growth for higher crop yield are provided. The methods involve the expression of at least one ictB coding sequence in a C4 plant of interest. Further provided are methods for expressing at least one ictB coding sequence and increasing the expression of at least one additional coding sequence of interest selected from CO2 assimilating sequences, such as those sequences involved in the Calvin Benson cycle, starch synthesis pathway, and C4 carbon shuttle in the plant. C4 plants expressing an ictB sequence are encompassed by the invention. Additionally, plants expressing an ictB sequence and those plants showing increased expression of a sequence of interest are encompassed by the invention. The expression of ictB in the C4 plant and the co-expression of ictB with this additional gene or genes results in yield gains.

8. 发明授权

US10316324B2 Compositions and methods for modifying genomes 有权
公开(公告)号：US10316324B2
公开(公告)日：2019-06-11
申请号：US16058718
申请日：2018-08-08
申请人： BENSON HILL BIOSYSTEMS, INC.
发明人： Matthew Begemann , Benjamin Neil Gray
IPC分类号： C12N15/82 , C07K14/415
摘要： Compositions and methods for modifying genomic DNA sequences are provided. The methods produce double-stranded breaks (DSBs) at pre-determined target sites in a genomic DNA sequence, resulting in mutation, insertion, and/or deletion of DNA sequences at the target site(s) in a genome. Compositions comprise DNA constructs comprising nucleotide sequences that encode a Cms1 protein operably linked to a promoter that is operable in the cells of interest. The DNA constructs can be used to direct the modification of genomic DNA at pre-determined genomic loci. Methods to use these DNA constructs to modify genomic DNA sequences are described herein. Additionally, compositions and methods for modulating the expression of genes are provided. Compositions comprise DNA constructs comprising a promoter that is operable in the cells of interest operably linked to nucleotide sequences that encode a mutated Cms1 protein with an abolished ability to produce DSBs, optionally linked to a domain that regulates transcriptional activity. The methods can be used to up- or down-regulate the expression of genes at predetermined genomic loci.

9. 发明授权

US11008583B2 Increasing plant growth and yield by using an ADP-glucose pyrophosphorylase sequence 有权
公开(公告)号：US11008583B2
公开(公告)日：2021-05-18
申请号：US16311377
申请日：2017-06-14
申请人： BENSON HILL BIOSYSTEMS, INC.
发明人： Benjamin Neil Gray
IPC分类号： C12N15/82 , C12N9/12
摘要： Compositions and methods for improving plant growth are provided herein. Polynucleotides encoding ADP-glucose pyrophosphorylase small subunit (AGPaseSS) proteins, polypeptides encompassing AGPaseSS proteins, and expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants are also provided.

10. 发明申请

US20190233839A1 INCREASING PLANT GROWTH AND YIELD BY USING A PSAN SEQUENCE 审中-公开
公开(公告)号：US20190233839A1
公开(公告)日：2019-08-01
申请号：US16311389
申请日：2017-06-14
申请人： Benson Hill Biosystems. Inc.
发明人： Benjamin Neil Gray , Henry D. Priest
IPC分类号： C12N15/82 , C07K14/415
CPC分类号： C12N15/8261 , C07K14/415 , C12N15/8223 , C12N15/8269 , Y02A40/146
摘要： Compositions and methods for improving plant growth are provided herein. Polynucleotides encoding photosystem I reaction center subunit N (PSAN) proteins, polypeptides encompassing PSAN proteins, and expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants are also provided.

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