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1. 发明申请

US20050176729A1 Indole derivatives useful for the treatment of CNS disorders 失效
标题翻译：可用于治疗CNS疾病的吲哚衍生物
公开(公告)号：US20050176729A1
公开(公告)日：2005-08-11
申请号：US11073497
申请日：2005-03-03
申请人： Benny Bang-Andersen , Jakob Felding , Jan Kehler , Kim Andersen
发明人： Benny Bang-Andersen , Jakob Felding , Jan Kehler , Kim Andersen
IPC分类号： A61K31/4709 , A61K31/4725 , A61K31/538 , A61P25/06 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , C07D401/14 , C07D413/14 , A61K31/496 , C07D43/14
CPC分类号： C07D401/14 , C07D413/14
摘要： The present invention relates to dopamine D4 ligands having the general formula I wherein R1-R10, W, X, Y1-Y4, and n are as described herein. The compounds of the invention are potent dopamine D4 receptor ligands.
摘要翻译：本发明涉及具有通式I的多巴胺D 4配体，其中R 1，R 2，R 10，W，X，Y， 1 4，n如本文所述。本发明的化合物是有效的多巴胺D 4 S受体配体。

2. 发明授权

US07276508B2 Indole derivatives useful for the treatment of CNS disorders 失效
标题翻译：可用于治疗CNS疾病的吲哚衍生物
公开(公告)号：US07276508B2
公开(公告)日：2007-10-02
申请号：US11073497
申请日：2005-03-03
申请人： Benny Bang-Andersen , Jakob Felding , Jan Kehler , Kim Andersen
发明人： Benny Bang-Andersen , Jakob Felding , Jan Kehler , Kim Andersen
IPC分类号： A61K31/496 , C07D401/12
CPC分类号： C07D401/14 , C07D413/14
摘要： The present invention relates to dopamine D4 ligands having the general formula I wherein R1-R10, W, X, Y1-Y4, and n are as described herein. The compounds of the invention are potent dopamine D4 receptor ligands.
摘要翻译：本发明涉及具有通式I的多巴胺D 4配体，其中R 1，R 2，R 10，W，X，Y， 1 4，n如本文所述。本发明的化合物是有效的多巴胺D 4 S受体配体。

3. 发明授权

US06890916B2 Indole derivatives useful for the treatment of CNS disorders 失效
公开(公告)号：US06890916B2
公开(公告)日：2005-05-10
申请号：US10315927
申请日：2002-12-09
申请人： Benny Bang-Andersen , Jakob Felding , Jan Kehler , Kim Andersen
发明人： Benny Bang-Andersen , Jakob Felding , Jan Kehler , Kim Andersen
IPC分类号： A61K31/4709 , A61K31/4725 , A61K31/538 , A61P25/06 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , C07D401/14 , C07D413/14 , A61K31/33 , A61K31/445 , A61K31/47 , C07D215/00 , C07D401/00
CPC分类号： C07D401/14 , C07D413/14
摘要： The present invention relates to dopamine D4 ligands having the general formula I wherein R1—R10, W, X, Y1—Y4, and n are as described herein. The compounds of the invention are potent dopamine D4 receptor ligands.

4. 发明授权

US07223765B2 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives 失效
标题翻译： 4-苯基-1-哌嗪基，哌啶基和四氢吡啶基衍生物
公开(公告)号：US07223765B2
公开(公告)日：2007-05-29
申请号：US11377772
申请日：2006-03-15
申请人： Benny Bang-Andersen , Jan Kehler , Jakob Felding
发明人： Benny Bang-Andersen , Jan Kehler , Jakob Felding
IPC分类号： A61K31/496 , C07D403/06 , C07D403/12
CPC分类号： C07D215/227 , C07D209/08 , C07D209/30 , C07D217/06 , C07D295/073
摘要： The present invention relates to substituted 4-phenyl-1-piperazinyl derivatives having the formula I wherein W is C, CH or N, and the dotted line emanating from W indicates a bond when W is C and no bond when W is N or CH; X is CH2, O, S, CO, CS, SO or SO2; and Q is a group of formula wherein Z is a chain of 3 to 4 chain members; wherein the chain members are selected from C, CH, CH2, CO, N and NH, provided that only one of the chain members may be N or NH, and said chain optionally containing one or two double bonds; provided that X is not O or S when the group Q is attached via an N atom; and any of its enantiomers and acid addition salts thereof. These compounds have high affinity for D4 receptors.
摘要翻译：本发明涉及具有式I的取代的4-苯基-1-哌嗪基衍生物，其中W是C，CH或N，当W是C时，由W发出的虚线表示键，当W是N或CH时，没有键 ; X是CH 2，O，S，CO，CS，SO或SO 2; Q为下式的基团，其中Z为3至4个链成员的链; 其中链成员选自C，CH，CH 2，CO，N和NH，条件是链中只有一个可以是N或NH，并且所述链任选地含有一个或两个双债券条件是当基团Q经由N原子连接时，X不为O或S; 及其任何对映异构体及其酸加成盐。这些化合物对D 4 S受体具有高亲和力。

5. 发明申请

US20060148815A1 4-Phenyl-1-piperazinyl, -piperidinyl and-tetrahydropyridyl derivatives 失效
标题翻译： 4-苯基-1-哌嗪基，哌啶基和四氢吡啶基衍生物
公开(公告)号：US20060148815A1
公开(公告)日：2006-07-06
申请号：US11377772
申请日：2006-03-15
申请人： Benny Bang-Andersen , Jan Kehler , Jakob Felding
发明人： Benny Bang-Andersen , Jan Kehler , Jakob Felding
IPC分类号： A61K31/496 , A61K31/454 , C07D403/02 , C07D401/02
CPC分类号： C07D215/227 , C07D209/08 , C07D209/30 , C07D217/06 , C07D295/073
摘要： The present invention relates to substituted 4-phenyl-1-piperazinyl derivatives having the formula I wherein W is C, CH or N, and the dotted line emanating from W indicates a bond when W is C and no bond when W is N or CH; X is CH2, O, S, CO, CS, SO or SO2; and Q is a group of formula wherein Z is a chain of 3 to 4 chain members; wherein the chain members are selected from C, CH, CH2, CO, N and NH, provided that only one of the chain members may be N or NH, and said chain optionally containing one or two double bonds; provided that X is not O or S when the group Q is attached via an N atom; and any of its enantiomers and acid addition salts thereof. These compounds have high affinity for D4 receptors.
摘要翻译：本发明涉及具有式I的取代的4-苯基-1-哌嗪基衍生物，其中W是C，CH或N，当W是C时，由W发出的虚线表示键，当W是N或CH时，没有键 ; X是CH 2，O，S，CO，CS，SO或SO 2; Q为下式的基团，其中Z为3至4个链成员的链; 其中链成员选自C，CH，CH 2，CO，N和NH，条件是链中只有一个可以是N或NH，并且所述链任选地含有一个或两个双债券条件是当基团Q经由N原子连接时，X不为O或S; 及其任何对映异构体及其酸加成盐。这些化合物对D 4 S受体具有高亲和力。

6. 发明授权

US07074796B2 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives 失效
标题翻译： 4-苯基-1-哌嗪基，哌啶基和四氢吡啶基衍生物
公开(公告)号：US07074796B2
公开(公告)日：2006-07-11
申请号：US10186339
申请日：2002-06-27
申请人： Benny Bang-Andersen , Jan Kehler , Jakob Felding
发明人： Benny Bang-Andersen , Jan Kehler , Jakob Felding
IPC分类号： A61K31/496 , C07D403/06
CPC分类号： C07D215/227 , C07D209/08 , C07D209/30 , C07D217/06 , C07D295/073
摘要： The present invention relates to substituted 4-phenyl-1-piperazinyl derivatives having the formula I wherein W is C, CH or N, and the dotted line emanating from W indicates a bond when W is C and no bond when W is N or CH; R1 and R2 are independently selected from hydrogen and halogen, provided at least one of R1 and R2 is a halogen atom; R3 is selected from hydrogen, halogen, C1-6 alkyl, trifluoromethyl, C1-6 alkoxy, aryloxy, aralkoxy, hydroxy, amino, C1-6 alkylamino, di(C1-6 alkyl)amino, nitro and cyano n is 2, 3, 4 or 5; X is CH2, O, S, CO, CS, SO or SO2; and Q is a group of formula wherein Z is a chain of 3 to 4 chain members; wherein the chain members are selected from C, CH, CH2, CO, N and NH, provided that only one of the chain members may be N or NH, and said chain optionally containing one or two double bonds; hvad med acyl?? R4, R5, R6, R7, R8, R9 and R10 are independently selected from hydrogen, halogen, C1-6 alkyl, trifluoromethyl, C1-6 alkoxy, hydroxy, amino, C1-6 alkylamino, di(C1-6 alkyl)amino nitro and cyano; provided that X is not O or S when the group Q is attached via an N atom; and any of its enantiomers and acid addition salts thereof. These compounds have high affinity for D4 receptors.
摘要翻译：本发明涉及具有式I的取代的4-苯基-1-哌嗪基衍生物，其中W是C，CH或N，当W是C时，由W发出的虚线表示键，当W是N或CH时，没有键 ; R 1和R 2独立地选自氢和卤素，条件是R 1和R 2中的至少一个和/或 >是卤原子; R 3选自氢，卤素，C 1-6烷基，三氟甲基，C 1-6烷氧基，芳氧基，芳烷氧基，羟基，氨基，C 1-6烷基氨基，二（C 1-6烷基）氨基，硝基和氰基n为2,3,4或5; X是CH 2，O，S，CO，CS，SO或SO 2; Q为下式的基团，其中Z为3至4个链成员的链; 其中链成员选自C，CH，CH 2，CO，N和NH，条件是链中只有一个可以是N或NH，并且所述链任选地含有一个或两个双债券 hvad med acyl？ R 4，R 5，R 6，R 7，R 8， R 9和R 10独立地选自氢，卤素，C 1-6烷基，三氟甲基，C 1-6烷基，羟基，氨基，C 1-6烷基氨基，二（C 1-6烷基）氨基硝基和氰基; 条件是当基团Q经由N原子连接时，X不为O或S; 及其任何对映异构体及其酸加成盐。这些化合物对D 4 S受体具有高亲和力。

7. 发明授权

US06743809B2 Indole Derivatives useful for the treatment of CNS disorders 失效
标题翻译：吲哚衍生物可用于治疗CNS疾病
公开(公告)号：US06743809B2
公开(公告)日：2004-06-01
申请号：US10347574
申请日：2003-01-17
申请人： Jakob Felding , Benny Bang-Andersen , Garrick Paul Smith , Kim Andersen
发明人： Jakob Felding , Benny Bang-Andersen , Garrick Paul Smith , Kim Andersen
IPC分类号： A61K31454
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The present invention relates to substituted indole derivatives of formula I wherein R1 is hydrogen or optionally substituted C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-8-cycloalkyl or C3-8-cycloalkyl-C1-6-alkyl, or R1 is optionally substituted aryl, aryl-C1-6-alkyl, heteroaryl, heteroaryl-C1-6-alkyl or R1 is —NR′R″ wherein R′ and R″ are independently selected from hydrogen and optionally substituted C1-6-alkyl, aryl, aryl-C1-6-alkyl, heteroaryl and heteroaryl-C1-6-alkyl, or R1 is a saturated or partially saturated 5- to 6-membered ring containing one, two or three hetero atoms selected from O or S, and a group N—R9 wherein R9 is hydrogen or optionally substituted C1-6-alkyl; R2 is C1-6-alkyl W, n, X, R3-R8 are as defined in the description. The compounds of the invention are potent dopamine D4 ligands.
摘要翻译：本发明涉及式I的取代的吲哚衍生物，其中R 1是氢或任选取代的C 1-6 - 烷基，C 2-6烯基，C 2-6 - 炔基，C 3-8 - 环烷基或C 3-8 - C 1-6 - 烷基或R 1是任选取代的芳基，芳基-C 1-6 - 烷基，杂芳基，杂芳基-C 1-6 - 烷基或R 1是-NR'R“，其中R'和R “独立地选自氢和任选取代的C 1-6 - 烷基，芳基，芳基-C 1-6 - 烷基，杂芳基和杂芳基-C 1-6 - 烷基，或R 1是饱和或部分饱和的5-至含有一个，两个或三个选自O或S的杂原子的6元环和NR 9基团，其中R 9是氢或任选取代的C 1-6 - 烷基; R 2是C 1-6 - 烷基W，n，X，R 3 -R 8如说明书中所定义。本发明的化合物是有效的多巴胺D4配体。

8. 发明申请

US20070173522A1 4-(2-Phenylsulfanyl-phenyl)-1,2,3,6- tetrahydropyridine derivatives as serotonin reuptake inhibitors 审中-公开
标题翻译： 4-（2-苯硫基 - 苯基）-1,2,3,6-四氢吡啶衍生物作为血清素再摄取抑制剂
公开(公告)号：US20070173522A1
公开(公告)日：2007-07-26
申请号：US10551869
申请日：2004-04-02
申请人： Ask Puschl , Benny Bang-Andersen , Morten Jorgensen , Karsten Juhl , Thomas Ruhland , Kim Andersen , Jan Kehler
发明人： Ask Puschl , Benny Bang-Andersen , Morten Jorgensen , Karsten Juhl , Thomas Ruhland , Kim Andersen , Jan Kehler
IPC分类号： A61K31/44 , C07D211/70
CPC分类号： C07D211/70 , C07D405/12
摘要： The invention provides compounds represented by the general formula (I) wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译：本发明提供由通式（I）表示的化合物，其中取代基在本申请中定义。这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。

9. 发明授权

US08592449B1 Radiolabelled phenylimidazole-based ligands 有权
标题翻译：放射性标记的苯基咪唑基配体
公开(公告)号：US08592449B1
公开(公告)日：2013-11-26
申请号：US13890705
申请日：2011-11-10
申请人： Jan Kehler , Benny Bang-Andersen
发明人： Jan Kehler , Benny Bang-Andersen
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： C07D471/04 , A61K51/0455 , C07B59/002 , G01N33/60
摘要： The present invention relates to radiolabelled PDE10A ligands which are useful for imaging and quantifying the PDE10A enzyme using positron emission tomography (PET).
摘要翻译：本发明涉及放射性标记的PDE10A配体，其可用于使用正电子发射断层摄影（PET）成像和定量PDE10A酶。

10. 发明申请

US20060293360A1 4-(2-Phenyloxyphenyl)-piperidine or-1,2,3,6-tetrahydropyridine derivatives as serotonin reuptake inhibitors 审中-公开
标题翻译： 4-（2-苯氧基苯基） - 哌啶或1,2,3,6-四氢吡啶衍生物作为血清素再摄取抑制剂
公开(公告)号：US20060293360A1
公开(公告)日：2006-12-28
申请号：US10551870
申请日：2004-04-02
申请人： Benny Bang-Andersen , Friedrich Kroll , Jan Kehler
发明人： Benny Bang-Andersen , Friedrich Kroll , Jan Kehler
IPC分类号： A61K31/452 , A61K31/445 , C07D405/02 , C07D211/22
CPC分类号： C07D405/12 , C07D211/22 , C07D211/70 , C07D409/12
摘要： The invention provides compounds represented by the general formula (I) wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译：本发明提供由通式（I）表示的化合物，其中取代基在本申请中定义。这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。

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