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1. 发明授权

US07964569B2 Glycomimetic replacements for hexoses and N-acetyl hexosamines 有权
标题翻译：己糖和N-乙酰己胺的糖模拟替代物
公开(公告)号：US07964569B2
公开(公告)日：2011-06-21
申请号：US11973891
申请日：2007-10-09
申请人： Beat Ernst , Daniel Schwizer , Arun K Sarkar , John L Magnani
发明人： Beat Ernst , Daniel Schwizer , Arun K Sarkar , John L Magnani
IPC分类号： A61K31/7034
CPC分类号： C07H15/207
摘要： Compounds and methods are provided for obtaining oligosaccharide mimics. More specifically, compounds and methods are described wherein oligosaccharide mimics are obtained by incorporating or substituting in a cyclohexane derivative.
摘要翻译：提供了获得寡糖模拟物的化合物和方法。更具体地，描述了通过在环己烷衍生物中引入或取代而获得寡糖模拟物的化合物和方法。

2. 发明申请

US20080161546A1 Glycomimetic replacements for hexoses and N-acetyl hexosamines 有权
标题翻译：己糖和N-乙酰己胺的糖模拟替代物
公开(公告)号：US20080161546A1
公开(公告)日：2008-07-03
申请号：US11973891
申请日：2007-10-09
申请人： Beat Ernst , Daniel Schwizer , Arun K. Sarkar , John L. Magnani
发明人： Beat Ernst , Daniel Schwizer , Arun K. Sarkar , John L. Magnani
IPC分类号： C07H1/00 , C07H15/00
CPC分类号： C07H15/207
摘要： Compounds and methods are provided for obtaining oligosaccharide mimics. More specifically, compounds and methods are described wherein oligosaccharide mimics are obtained by incorporating or substituting in a cyclohexane derivative.
摘要翻译：提供了获得寡糖模拟物的化合物和方法。更具体地，描述了通过在环己烷衍生物中引入或取代而获得寡糖模拟物的化合物和方法。

3. 发明授权

US08633303B2 Heterobifunctional pan-selectin inhibitors 有权
公开(公告)号：US08633303B2
公开(公告)日：2014-01-21
申请号：US13165609
申请日：2011-06-21
申请人： John L. Magnani , John T. Patton, Jr. , Arun K. Sarkar , Sergei A. Svarovsky , Beat Ernst
发明人： John L. Magnani , John T. Patton, Jr. , Arun K. Sarkar , Sergei A. Svarovsky , Beat Ernst
IPC分类号： C07H17/04 , C07H15/22 , C07H5/04 , C07H1/00 , A61K31/715 , A61K38/36
CPC分类号： A61K31/706 , A61K47/549 , C07H15/22 , C07H15/26 , C07H17/00
摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).

4. 发明授权

US07728117B2 Heterobifunctional pan-selectin inhibitors 有权
标题翻译：异双功能泛选择素抑制剂
公开(公告)号：US07728117B2
公开(公告)日：2010-06-01
申请号：US11515343
申请日：2006-09-01
申请人： John L. Magnani , John T. Patton, Jr. , Arun K. Sarkar , Sergei A. Svarovsky , Beat Ernst
发明人： John L. Magnani , John T. Patton, Jr. , Arun K. Sarkar , Sergei A. Svarovsky , Beat Ernst
IPC分类号： C07H17/04 , C07H15/22
CPC分类号： A61K31/706 , A61K47/549 , C07H15/22 , C07H15/26 , C07H17/00
摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
摘要翻译：提供化合物和方法用于调节由选择素结合介导的体外和体内过程。更具体地，描述了选择素调节剂及其用途，其中调节（例如，抑制或增强）选择素介导的功能的选择素调节剂单独包含特定的糖模拟物或连接到称为BASAs的化合物类别（苄基氨基磺酸）或称为BACAs（苄基氨基羧酸）的一类化合物的成员。

5. 再颁专利

USRE44778E1 Heterobifunctional pan-selectin inhibitors 有权
标题翻译：异双功能泛选择素抑制剂
公开(公告)号：USRE44778E1
公开(公告)日：2014-02-25
申请号：US13484020
申请日：2012-05-30
申请人： John L. Magnani , John T. Patton, Jr. , Arun K. Sarkar , Sergei A. Svarovsky , Beat Ernst
发明人： John L. Magnani , John T. Patton, Jr. , Arun K. Sarkar , Sergei A. Svarovsky , Beat Ernst
IPC分类号： C07H15/22
CPC分类号： A61K31/706 , A61K47/549 , C07H15/22 , C07H15/26 , C07H17/00
摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
摘要翻译：提供化合物和方法用于调节由选择素结合介导的体外和体内过程。更具体地，描述了选择素调节剂及其用途，其中调节（例如，抑制或增强）选择素介导的功能的选择素调节剂单独包含特定的糖模拟物或连接到称为BASAs的化合物类别（苄基氨基磺酸）或称为BACAs（苄基氨基羧酸）的一类化合物的成员。

6. 发明申请

US20120004190A1 HETEROBIFUNCTIONAL PAN-SELECTIN INHIBITORS 有权
标题翻译：异种PAN选择素抑制剂
公开(公告)号：US20120004190A1
公开(公告)日：2012-01-05
申请号：US13165609
申请日：2011-06-21
申请人： John L. MAGNANI , John T. Patton, JR. , Arun K. Sarkar , Sergei A. Svarovsky , Beat Ernst
发明人： John L. MAGNANI , John T. Patton, JR. , Arun K. Sarkar , Sergei A. Svarovsky , Beat Ernst
IPC分类号： A61K31/7064 , A61K31/7056 , C12Q1/02 , A61P31/00 , G01N21/59 , C07H15/26 , A61P29/00
CPC分类号： A61K31/706 , A61K47/549 , C07H15/22 , C07H15/26 , C07H17/00
摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
摘要翻译：提供化合物和方法用于调节由选择素结合介导的体外和体内过程。更具体地，描述了选择素调节剂及其用途，其中调节（例如，抑制或增强）选择素介导的功能的选择素调节剂单独包含特定的糖模拟物或连接到称为BASAs的化合物类别（苄基氨基磺酸）或称为BACAs（苄基氨基羧酸）的一类化合物的成员。

7. 发明授权

US07989601B2 Heterobifunctional pan-selectin inhibitors 有权
标题翻译：异双功能泛选择素抑制剂
公开(公告)号：US07989601B2
公开(公告)日：2011-08-02
申请号：US12764027
申请日：2010-04-20
申请人： John L. Magnani , John T. Patton, Jr. , Arun K. Sarkar , Sergei A. Svarovsky , Beat Ernst
发明人： John L. Magnani , John T. Patton, Jr. , Arun K. Sarkar , Sergei A. Svarovsky , Beat Ernst
IPC分类号： C07H17/04 , C07H15/224 , C07H15/22 , C07H5/04 , A61K31/715
CPC分类号： A61K31/706 , A61K47/549 , C07H15/22 , C07H15/26 , C07H17/00
摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
摘要翻译：提供化合物和方法用于调节由选择素结合介导的体外和体内过程。更具体地，描述了选择素调节剂及其用途，其中调节（例如，抑制或增强）选择素介导的功能的选择素调节剂单独包含特定的糖模拟物或连接到称为BASAs的化合物类别（苄基氨基磺酸）或称为BACAs（苄基氨基羧酸）的一类化合物的成员。

8. 发明授权

US08157901B2 Apparatus for purifying air, in particular for ventilation and air-conditioning systems 失效
标题翻译：用于净化空气的装置，特别是用于通风和空调系统
公开(公告)号：US08157901B2
公开(公告)日：2012-04-17
申请号：US12161978
申请日：2007-01-24
申请人： Kurt Tiefenauer , Theodor Ernst , Beat Ernst
发明人： Kurt Tiefenauer , Theodor Ernst , Beat Ernst
IPC分类号： B03C3/155
CPC分类号： B01D46/50 , B01D46/10 , B01D2273/12 , B01D2279/50 , B03C3/08 , B03C3/155 , B03C3/41 , F24F3/166 , F24F2003/1635 , Y02A50/21 , Y10S55/12
摘要： An apparatus for purifying air, in particular for ventilation and air-conditioning systems, has an air filter (11), which is inserted in an air channel (10) or in a filter wall for collecting dust. A dust agglomerator (12) with a DC voltage field is connected directly upstream of the air filter (11). In conventional filters, the efficiency is increased to such an extent that the dust throughput can be approximately halved. In addition, the initial efficiency is only insignificantly reduced during the operating time.
摘要翻译：用于净化空气的设备，特别是用于通风和空调系统的设备具有空气过滤器（11），其插入空气通道（10）或过滤器壁中以收集灰尘。具有直流电压场的集尘器（12）直接连接在空气过滤器（11）的上游。在常规的过滤器中，效率提高到这样的程度，即粉尘产量可以大致减半。此外，在运行时间内，初始效率仅显着降低。

9. 发明授权

US5611830A Air filter having pockets, and method of assembly thereof 失效
标题翻译：具有袋的空气过滤器及其组装方法
公开(公告)号：US5611830A
公开(公告)日：1997-03-18
申请号：US494443
申请日：1995-06-26
申请人： Beat Ernst
发明人： Beat Ernst
IPC分类号： B01D46/02 , B01D46/12 , B01D46/42
CPC分类号： B01D46/02 , B01D46/0005 , B01D46/023 , B01D2265/05 , B01D2275/203
摘要： The filter, typically an air cleaning filter, has a frame element, preferably rectangular or square, retaining a plurality of adjacently located filter bags (4). The filter bags, themselves, are retained in the frame by bag-supporting ribs (6) which are folded from blanks (11, 11') in zig-zag fashion to define a central folded part 9, and two lateral folded portions (10, 10"10). To assemble the filter, adjacent filter bags are inserted and then clamped between the central portion and a lateral folded portion, and held together for example by adhesives, staples, or the like. The ends of the rib structures (6) define support legs (12, 12") which are secured to the frame element (1). The position of the ribs (6) determines the spacing of the filter bags (4). A spacing comb (14) formed with slits (16) determines the spacing between the opening of adjacent filter bags. The structure permits easy matching of filter bags to different dimensions of frame elements. Preferably, all materials used, frame element (1), filter bags (4) and ribs (6), are made of combustible material, for example paper and cardboard, or the like, so that the filter, including contents, can be incinerated as a unit.
摘要翻译：过滤器（通常为空气净化过滤器）具有保持多个相邻的过滤袋（4）的框架元件，优选为矩形或正方形。过滤袋本身通过袋支撑肋（6）保持在框架中，该肋（6）以锯齿形的方式从坯料（11,11'）折叠以限定中心折叠部分9和两个横向折叠部分（10 ，10'10）。为了组装过滤器，相邻的过滤袋被插入，然后夹在中心部分和侧面折叠部分之间，并且例如通过粘合剂，订书钉等保持在一起。肋结构（6）的端部限定固定到框架元件（1）的支撑腿（12,12“）。肋（6）的位置确定过滤袋（4）的间距。形成有狭缝（16）的间隔梳（14）确定相邻过滤袋的开口之间的间隔。该结构允许过滤袋容易地匹配框架元件的不同尺寸。优选地，所使用的所有材料，框架元件（1），过滤袋（4）和肋（6）由可燃材料制成，例如纸和纸板等，使得可以将包括内容物的过滤器焚烧作为一个单位。

10. 发明授权

US5505755A Recyclable or entirely combustible filter bag holding frame for the reception of filter bags, and method of its manufacture 失效
标题翻译：用于接收过滤袋的可回收或完全可燃的过滤袋保持框架及其制造方法
公开(公告)号：US5505755A
公开(公告)日：1996-04-09
申请号：US394636
申请日：1995-02-27
申请人： Beat Ernst
发明人： Beat Ernst
IPC分类号： B01D46/00 , B01D46/02 , B01D46/06 , B01D46/42
CPC分类号： B01D46/0001 , B01D46/0015 , B01D46/02 , B01D46/023 , Y10S55/31
摘要： To provide a completely recyclable or incineratable filter bag holding frame, so that the holding frame together with the filter bags can be recycled as a unit, the holding frame is made entirely of recyclable and incineratable material in this manner: two essentially rectangular flat partial frames (1, 4) are made of groups of strips (1, 4), adhered together. Another group of strips (2), is placed on edge; the strips (2) have slits (8) therein extending from opposite edges, and spaced from the ends of the strips by distance slightly less than the width of the strips forming the partial frames. This provides an auxiliary frame (15), which is adhered to (1) of the partial frames. Core elements (5) of corrugated cardboard material are then placed against the assembly of the first partial frame (1) and the auxiliary frame (15), preferably adhered to both the partial end auxiliary frame. The outer surfaces of the core elements are then adhesively connected to on-edge strips (3) which, preferably, are also adhesively connected to the end edges (14) of the auxiliary frame (15) as well as to the first partial frame (1). The entire assembly is covered by a second partial frame (4), which is also adhered to the auxiliary frame (15) the outer strips (3) and the core elements (5). Preferably a hot, or hot-melted adhesive is used. One or both of the partial frames may be formed with inwardly extending projections (16) to be engaged by holding clips (18) of the filter bags (12).
摘要翻译：为了提供完全可回收或可焚烧的过滤袋保持框架，使得保持框架与过滤袋一起可以作为一个单元再循环，保持框架以这种方式完全由可回收和可焚烧的材料制成：两个基本上矩形的平坦部分框架（1,4）由条带（1,4）组成，粘合在一起。另一组条（2）放置在边缘上; 条带（2）具有从相对边缘延伸的狭缝（8），并且与条的端部间隔开的距离略小于形成部分框架的条带的宽度。这提供了附接到部分框架的（1）的辅助框架（15）。然后将瓦楞纸板材料的芯元件（5）放置在第一部分框架（1）和辅助框架（15）的组件上，优选地粘附在部分端辅助框架上。芯元件的外表面然后粘合地连接到边缘条（3），其优选地也粘附地连接到辅助框架（15）的端边缘（14）以及第一部分框架（ 1）。整个组件被第二部分框架（4）覆盖，第二部分框架（4）也粘附到辅助框架（15）外条带（3）和芯元件（5）上。优选使用热的或热熔融的粘合剂。一个或两个部分框架可以形成有向内延伸的突起（16），以通过保持过滤袋（12）的夹子（18）来接合。

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