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1. 发明申请

US20110134254A1 MEASURING AND CORRECTING LENS DISTORTION IN A MULTISPOT SCANNING DEVICE 审中-公开
标题翻译：测量和校正多个扫描设备中的镜头失真
公开(公告)号：US20110134254A1
公开(公告)日：2011-06-09
申请号：US13058066
申请日：2009-08-07
申请人： Bas Hulsken , Sjoerd Stallinga
发明人： Bas Hulsken , Sjoerd Stallinga
IPC分类号： H04N17/00
CPC分类号： G01M11/0264 , G02B21/002 , G02B27/0031
摘要： The invention provides a method of determining the distortion of an imaging system (32), the imaging system having an object plane (40) and an image plane (42). The method comprises the steps of determining (204) the positions of the image light spots (46) on a sensitive area (44) of an image sensor (34) by analyzing the image data; and fitting (205) a mapping function such that the mapping function maps the lattice points of an auxiliary lattice (48) into the positions of the image light spots (46), wherein the auxiliary lattice (48) is geometrically similar to the Bravais lattice (8) of the probe light spots (6). The invention also provides a method of imaging a sample, using an imaging system (32) having an object plane (40) and an image plane (42), the method comprising the steps of determining (304) readout points on the sensitive area (44) of an image sensor (34) by applying a mapping function to the lattice points of an auxiliary lattice (48), the auxiliary lattice being geometrically similar to a Bravais lattice (8) of probe light spots (6); and reading (305) image data from the readout points on the sensitive area (44). Also disclosed are a measuring system (10) for determining the distortion of an imaging system, and a multispot optical scanning device (10).
摘要翻译：本发明提供了一种确定成像系统（32）的失真的方法，该成像系统具有物体平面（40）和图像平面（42）。该方法包括以下步骤：通过分析图像数据来确定（204）图像光点（46）在图像传感器（34）的敏感区域（44）上的位置; 以及拟合（205）映射函数，使得所述映射函数将辅助格子（48）的格点映射到所述图像光点（46）的位置，其中所述辅格（48）几何地类似于所述布拉维点阵（8）的探针光斑（6）。本发明还提供了一种使用具有物平面（40）和图像平面（42）的成像系统（32）对样本进行成像的方法，所述方法包括以下步骤：确定（304）敏感区域上的读出点 44）通过对辅助晶格（48）的格点施加映射函数，辅助晶格在几何上类似于探针光点（6）的布拉维点阵（8）; 以及从敏感区域（44）上的读出点读取（305）图像数据。还公开了一种用于确定成像系统的失真的测量系统（10）和多光学光学扫描装置（10）。

2. 发明授权

US09128016B2 Up-concentration of organic microobjects for microscopic imaging 有权
标题翻译：用于显微镜成像的有机微量物质的上调
公开(公告)号：US09128016B2
公开(公告)日：2015-09-08
申请号：US13263997
申请日：2010-04-14
申请人： Bas Hulsken , Stein Kuiper , Sjoerd Stallinga , Bo Joakim Isaksson , Mark W. G. Ponjee , Bart E. G. J. Van Meerbergen , Zeynep S. Unay
发明人： Bas Hulsken , Stein Kuiper , Sjoerd Stallinga , Bo Joakim Isaksson , Mark W. G. Ponjee , Bart E. G. J. Van Meerbergen , Zeynep S. Unay
IPC分类号： G01N15/06 , G01N1/40
CPC分类号： G01N1/4077 , G01N1/4005 , G01N15/0625 , G01N15/0631
摘要： A method of analyzing a sample fluid containing organic microobjects is proposed. The method comprises the steps of: up-concentrating (S1) the microobjects by removing, in a total time T1, a volume V1 of the sample fluid from the upconcentrate sample microobjects; immersing (S2) the microobjects in a transfer fluid, or leaving the microobjects in a remaining portion of the sample fluid, the remaining portion of the sample fluid then providing the transfer fluid; filtering (S3), in a total time T3, a volume V3 of the transfer fluid by a filter, thereby accumulating the microobjects on the filter; and generating (S4) an image of the microobjects accumulated on the filter; wherein the throughput V1/T1 of the step of up-concentrating (S1) is greater than the throughput V1/T1, of the step of filtering (S3). The filter may be a second filter, and the step of up-concentrating (S1) may involve: filtering the sample fluid by a first filter, thereby accumulating the microobjects on the first filter. An apparatus or system for analyzing a sample fluid containing organic microobjects is also disclosed.
摘要翻译：提出了一种分析含有机微物体样品液的方法。该方法包括以下步骤：通过在总时间T1中去除来自上升浓度样品微物体的样品流体的体积V1来上升（S1）微观对象; 将微量物体浸入（S2）到转移流体中，或将微量物体留在样品流体的剩余部分中，然后将样品流体的剩余部分提供转移流体; 在总时间T3中过滤（S3）通过过滤器传送流体的体积V3，从而将微物体累积在过滤器上; 以及生成（S4）累积在所述过滤器上的所述微物体的图像; 其特征在于，上述浓缩步骤（S1）的吞吐量V1 / T1大于滤波步骤的吞吐量V1 / T1（S3）。过滤器可以是第二过滤器，并且上集中（S1）的步骤可以包括：通过第一过滤器过滤样品流体，从而将微物体累积在第一过滤器上。还公开了一种用于分析含有机微物体的样品流体的装置或系统。

3. 发明申请

US20120034623A1 UP-CONCENTRATION OF ORGANIZ MICROOBJECTS FOR MICROSCOPIC IMAGING 有权
标题翻译：用于微观成像的组织微结构的上调
公开(公告)号：US20120034623A1
公开(公告)日：2012-02-09
申请号：US13263997
申请日：2010-04-14
申请人： Bas Hulsken , Stein Kuiper , Sjoerd Stallinga , Bo Joakim Isaksson , Mark W.G. Ponjee , Bart E.G.J. Van Meerbergen , Zeynep S. Unay
发明人： Bas Hulsken , Stein Kuiper , Sjoerd Stallinga , Bo Joakim Isaksson , Mark W.G. Ponjee , Bart E.G.J. Van Meerbergen , Zeynep S. Unay
IPC分类号： G01N33/566 , C12M1/34 , C12Q1/02
CPC分类号： G01N1/4077 , G01N1/4005 , G01N15/0625 , G01N15/0631
摘要： A method of analyzing a sample fluid containing organic microobjects is proposed. The method comprises the steps of: up-concentrating (S1) the microobjects by removing, in a total time T1, a volume V1 of the sample fluid from the upconcentrate sample microobjects; immersing (S2) the microobjects in a transfer fluid, or leaving the microobjects in a remaining portion of the sample fluid, the remaining portion of the sample fluid then providing the transfer fluid; filtering (S3), in a total time T3, a volume V3 of the transfer fluid by a filter, thereby accumulating the microobjects on the filter; and generating (S4) an image of the microobjects accumulated on the filter; wherein the throughput V1/T1 of the step of up-concentrating (S1) is greater than the throughput V1/T1, of the step of filtering (S3). The filter may be a second filter, and the step of up-concentrating (S1) may involve: filtering the sample fluid by a first filter, thereby accumulating the microobjects on the first filter. An apparatus or system for analyzing a sample fluid containing organic microobjects is also disclosed.
摘要翻译：提出了一种分析含有机微物体样品液的方法。该方法包括以下步骤：通过在总时间T1中去除来自上升浓度样品微物体的样品流体的体积V1来上升（S1）微观对象; 将微量物体浸入（S2）到转移流体中，或将微量物体留在样品流体的剩余部分中，然后将样品流体的剩余部分提供转移流体; 在总时间T3中过滤（S3）通过过滤器传送流体的体积V3，从而将微物体累积在过滤器上; 以及生成（S4）累积在所述过滤器上的所述微物体的图像; 其特征在于，上述浓缩步骤（S1）的吞吐量V1 / T1大于滤波步骤的吞吐量V1 / T1（S3）。过滤器可以是第二过滤器，并且上集中（S1）的步骤可以包括：通过第一过滤器过滤样品流体，从而将微物体累积在第一过滤器上。还公开了一种用于分析含有机微物体的样品流体的装置或系统。

4. 发明授权

US10061108B2 Autofocus imaging for a microscope 有权
公开(公告)号：US10061108B2
公开(公告)日：2018-08-28
申请号：US13697681
申请日：2011-05-04
申请人： Bas Hulsken , Sjoerd Stallinga
发明人： Bas Hulsken , Sjoerd Stallinga
IPC分类号： G02B21/24 , G02B21/36 , H04N5/232 , H04N3/14
CPC分类号： G02B21/245 , G02B21/36 , H04N3/1581 , H04N5/2258 , H04N5/23212
摘要： The present invention relates to the field of digital pathology and in particular to whole slide scanners. Autofocus imaging can be performed by sampling a first number of pixels of a primary image sensor and sampling a second number of pixels of an autofocus image sensor, wherein the second number is between one quarter and three quarters of the first number. Thus, continuous autofocus for rapid light scanning may be provided based on an additional image sensor that is tilted with respect to the optical axis.

5. 发明申请

US20110025837A1 METHOD OF IMAGING A SAMPLE 审中-公开
标题翻译：成像方法
公开(公告)号：US20110025837A1
公开(公告)日：2011-02-03
申请号：US12672551
申请日：2008-08-12
申请人： Dirk Vossen , Levinus Bakker , Bas Hulsken , Sjoerd Stallinga
发明人： Dirk Vossen , Levinus Bakker , Bas Hulsken , Sjoerd Stallinga
IPC分类号： G06K9/60 , H04N7/18
CPC分类号： G02B21/002 , G02B21/004 , G02B21/008 , G02B21/086 , G02B21/14
摘要： A method of imaging a sample comprises the steps of: -providing S1 a reference array of spots 104, -illuminating the sample 106 with the reference array of spots 104 and acquiring S2 at least one sample image IMSi comprising a sample related array of spots 107 resulting from the reference array of spots interacting with the sample 106, -determining S3 a spot characterizing parameter for each of a plurality of sample related spots, and -constructing S4 an image of the sample IM, By plotting the spot characterizing parameter for each of the plurality of sample related spots at the respective sample related spot position.
摘要翻译：一种对样本进行成像的方法包括以下步骤： - 提供斑点104的参考阵列， - 用点104的参考阵列照亮样本106，并且获取S2至少一个样本图像IMSi，其包括样本相关的点阵列107 由与样本106相互作用的点的参考阵列产生， - 确定S3是多个样本相关斑点中的每一个的斑点特征参数，以及 - 构造样本IM的图像，通过绘制样本IM的图像在相应样品相关点位置处的多个样品相关斑点。

6. 发明申请

US20100314533A1 SCANNING MICROSCOPE AND METHOD OF IMAGING A SAMPLE 审中-公开
标题翻译：扫描显微镜和成像方法
公开(公告)号：US20100314533A1
公开(公告)日：2010-12-16
申请号：US12809355
申请日：2008-12-18
申请人： Sjoerd Stallinga , Bas Hulsken
发明人： Sjoerd Stallinga , Bas Hulsken
IPC分类号： G02B21/36
CPC分类号： G02B21/0084 , G02B21/0032 , G02B21/0036
摘要： The invention relates to a method of imaging a sample with a scanning microscope and an imaging system for a scanning microscope, comprising the steps of: initiating an exposure phase of a detector (34) by a pulsed laser source (12); generating an optical image of the sample on the detector with a lens system (32); and terminating the exposure phase. According to the invention, the step of generating the optical image comprises a step of displacing the optical image on the detector with an image displacement means (40) between two consecutive laser pulses. The image displacement means comprise a rotatable mirror (40) situated on an optical path from the sample (26) to the detector (34).
摘要翻译：本发明涉及一种利用扫描显微镜和用于扫描显微镜的成像系统对样品进行成像的方法，包括以下步骤：通过脉冲激光源（12）启动检测器（34）的曝光阶段; 用透镜系统（32）在检测器上产生样品的光学图像; 并终止曝光阶段。根据本发明，产生光学图像的步骤包括用两个连续激光脉冲之间的图像位移装置（40）移动检测器上的光学图像的步骤。图像位移装置包括位于从样品（26）到检测器（34）的光路上的可旋转镜（40）。

7. 发明授权

US10353190B2 Sensor for microscopy 有权
公开(公告)号：US10353190B2
公开(公告)日：2019-07-16
申请号：US13519360
申请日：2010-12-22
申请人： Bas Hulsken , Sjoerd Stallinga
发明人： Bas Hulsken , Sjoerd Stallinga
IPC分类号： H04N7/18 , G02B21/36 , G02B21/24
摘要： This invention pertains to a method for microscopically imaging a sample, with a digital scanner comprising a sensor including a 2D array of pixels and to a digital scanning microscope carrying out this method. It is notably provided a method for microscopically imaging a sample with a scanner comprising a sensor including a 2D array of pixels in an XY coordinate system, the axis Y being substantially perpendicular to the scan direction, wherein the scanner is arranged such that the sensor can image an oblique cross section of the sample, and wherein the method comprises the steps of: • activating a first sub-array of the 2D array of pixels, the first sub-array extending mainly along the Y axis at a first X coordinate (X1), • creating a first image by imaging a first area of the sample by means of the first sub-array of pixels. According to aspects of the invention, it is further proposed a scanner carryout this method and using the same 2D array sensor for imaging and auto-focusing purpose.

8. 发明申请

US20130057674A1 AUTOFOCUS IMAGING 审中-公开
标题翻译：自动成像
公开(公告)号：US20130057674A1
公开(公告)日：2013-03-07
申请号：US13697681
申请日：2011-05-04
申请人： Bas Hulsken , Sjoerd Stallinga
发明人： Bas Hulsken , Sjoerd Stallinga
IPC分类号： G03B13/00 , H04N7/18
CPC分类号： G02B21/245 , G02B21/36 , H04N3/1581 , H04N5/23212
摘要： The present invention relates to the field of digital pathology and in particular to whole slide scanners. Autofocus imaging can be performed by sampling a first number of pixels of a primary image sensor and sampling a second number of pixels of an autofocus image sensor, wherein the second number is between one quarter and three quarters of the first number. Thus, continuous autofocus for rapid light scanning may be provided based on an additional image sensor that is tilted with respect to the optical axis.
摘要翻译：本发明涉及数字病理学领域，特别涉及整个幻灯片扫描器。可以通过对主图像传感器的第一数量的像素进行采样并对自动聚焦图像传感器的第二数量的像素进行采样来执行自动聚焦成像，其中第二数量在第一数量的四分之一到四分之三之间。因此，可以基于相对于光轴倾斜的附加图像传感器来提供用于快速光扫描的连续自动对焦。

9. 发明申请

US20120287256A1 SENSOR FOR MICROSCOPY 审中-公开
标题翻译：传感器用于显微镜
公开(公告)号：US20120287256A1
公开(公告)日：2012-11-15
申请号：US13519360
申请日：2010-12-22
申请人： Bas Hulsken , Sjoerd Stallinga
发明人： Bas Hulsken , Sjoerd Stallinga
IPC分类号： H04N7/18
CPC分类号： G02B21/367 , G02B21/241 , G02B21/361
摘要： This invention pertains to a method for microscopically imaging a sample, with a digital scanner comprising a sensor including a 2D array of pixels and to a digital scanning microscope carrying out this method. It is notably provided a method for microscopically imaging a sample with a scanner comprising a sensor including a 2D array of pixels in an XY coordinate system, the axis Y being substantially perpendicular to the scan direction, wherein the scanner is arranged such that the sensor can image an oblique cross section of the sample, and wherein the method comprises the steps of: • activating a first sub-array of the 2D array of pixels, the first sub-array extending mainly along the Y axis at a first X coordinate (X1), • creating a first image by imaging a first area of the sample by means of the first sub-array of pixels. According to aspects of the invention, it is further proposed a scanner carryout this method and using the same 2D array sensor for imaging and auto-focusing purpose.
摘要翻译：本发明涉及一种用于对样品进行微观成像的方法，数字扫描器包括包含2D阵列像素的传感器和执行该方法的数字扫描显微镜。特别提供了一种用于使用扫描仪对样品进行显微成像的方法，所述扫描器包括在XY坐标系中包括像素的2D阵列的传感器，所述轴线Y基本上垂直于扫描方向，其中扫描器被布置成使得传感器可对样本的倾斜横截面进行成像，并且其中所述方法包括以下步骤：•激活所述2D阵列的第一子阵列，所述第一子阵列主要沿着所述Y轴在第一X坐标（X1 ），•通过借助于第一像素子阵列对样本的第一区域进行成像来创建第一图像。根据本发明的方面，进一步提出扫描器执行该方法并使用相同的2D阵列传感器用于成像和自动聚焦目的。

10. 发明授权

US08995790B2 Image processing method in microscopy 有权
标题翻译：显微镜图像处理方法
公开(公告)号：US08995790B2
公开(公告)日：2015-03-31
申请号：US13703513
申请日：2011-06-10
申请人： Daniel Carl Mueller , Dirk Leo Joep Vossen , Bas Hulsken
发明人： Daniel Carl Mueller , Dirk Leo Joep Vossen , Bas Hulsken
IPC分类号： G06K9/32 , G06K9/00 , G06T3/00
CPC分类号： G06K9/0014 , G06T3/0068 , G06T2200/24 , G06T2207/10056 , G06T2207/20016 , G06T2207/20104
摘要： The invention pertains to the field of image processing in digital pathology. It notably proposes a method for processing a first digital image, representing a sample in a region, and which image has been acquired from the sample by means of a microscopic imaging system (1) and is stored in a multi-resolution image data structure (80), comprising the steps of:—retrieving (104) a sub-region of the first digital image at a first resolution, —executing (105) a transform function on the retrieved sub-region, the transform function modifying a content of the sub-region according to at least one metric derived from a second resolution representation of the first digital image.
摘要翻译：本发明涉及数字病理学中的图像处理领域。特别提出了一种用于处理第一数字图像的方法，其表示区域中的样本，并且已经通过显微镜成像系统（1）从样本获取了哪个图像，并且被存储在多分辨率图像数据结构中 80），包括以下步骤：以第一分辨率恢复（104）第一数字图像的子区域， - 对所检索的子区域执行（105）变换函数，所述变换函数修改所述第一数字图像的内容根据从第一数字图像的第二分辨率表示导出的至少一个量度的子区域。

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