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1. 发明申请

US20100094061A1 Stat3 phosphorylation inhibitor and notch1 expression inhibitor 有权
标题翻译： Stat3磷酸化抑制剂和缺口1表达抑制剂
公开(公告)号：US20100094061A1
公开(公告)日：2010-04-15
申请号：US11665375
申请日：2005-10-13
申请人： Bang Luu , Ellane Mohier , Masashi Yamada , Hiroto Suzuki
发明人： Bang Luu , Ellane Mohier , Masashi Yamada , Hiroto Suzuki
IPC分类号： C07C49/543
CPC分类号： A61K31/07 , A61K31/045 , A61K31/122
摘要： The present invention relates to an agent for suppressing STATS phosphorylation and for suppressing Notch1 expression comprising as an active ingredient a compound represented by the following formula (1): wherein R1, R2 and R3 each independently represents a hydrogen atom or a methyl group; and X represents a linear or branched alkyl, alkylene or alkenylene group having 10 to 28 carbon atoms.
摘要翻译：本发明涉及用于抑制STATS磷酸化和抑制Notch1表达的药剂，其包含作为活性成分的下式（1）表示的化合物：其中R1，R2和R3各自独立地表示氢原子或甲基; X表示碳原子数为10〜28的直链或支链烷基，亚烷基或亚烯基。

2. 发明授权

US07888395B2 STAT3 phosphorylation inhibitor and notch1 expression inhibitor 有权
标题翻译： STAT3磷酸化抑制剂和缺口1表达抑制剂
公开(公告)号：US07888395B2
公开(公告)日：2011-02-15
申请号：US11665375
申请日：2005-10-13
申请人： Bang Luu , Ellane Mohier , Masashi Yamada , Hiroto Suzuki
发明人： Bang Luu , Ellane Mohier , Masashi Yamada , Hiroto Suzuki
IPC分类号： A61K31/12
CPC分类号： A61K31/07 , A61K31/045 , A61K31/122
摘要： The present invention relates to an agent for suppressing STAT3 phosphorylation and for suppressing Notch1 expression comprising as an active ingredient a compound represented by the following formula (1): wherein R1, R2 and R3 each independently represents a hydrogen atom or a methyl group; and X represents a linear or branched alkyl, alkylene or alkenylene group having 10 to 28 carbon atoms.
摘要翻译：本发明涉及抑制STAT3磷酸化和抑制Notch1表达的药剂，其包含作为活性成分的下式（1）表示的化合物：其中R1，R2和R3各自独立地表示氢原子或甲基; X表示碳原子数为10〜28的直链或支链烷基，亚烷基或亚烯基。

3. 发明授权

US07307098B2 Indole derivatives and drugs containing the same 失效
标题翻译：吲哚衍生物和含有相同的药物
公开(公告)号：US07307098B2
公开(公告)日：2007-12-11
申请号：US10520136
申请日：2003-07-22
申请人： Bang Luu , Djalil Coowar , Ellane Mohier , Masashi Yamada , Yukie Suma , Hiroto Suzuki
发明人： Bang Luu , Djalil Coowar , Ellane Mohier , Masashi Yamada , Yukie Suma , Hiroto Suzuki
IPC分类号： A61K31/404 , C07D209/12
CPC分类号： C07D209/12
摘要： An indole derivative represented by the following general formula (1): wherein at least one of R1, R2, R3, and R4 represents an alkoxy group containing 1 to 20 carbon atoms, and other groups of the R1, R2, R3, and R4 represent hydrogen, an alkyl group containing 1 to 6 carbon atoms, acetyl group, or hydroxyl group; and either one of X and Y represents —(CH2)nOH wherein n is an integer of 0 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof; and a drug and an agent for promoting differentiation of a stem cell containing such indole derivative or its salt as an effective component, wherein the indole derivative (1) has action of inducing differentiation of neural stem cell specifically into a neuron, and this indole derivative is useful as a prophylactic or therapeutic drug for brain dysfunction or neuropathy caused by loss or degeneration of the neuron.
摘要翻译：由以下通式（1）表示的吲哚衍生物：其中R 1，R 2，R 3和R 3中的至少一个，R 3，R 3，代表含有1至20个碳原子的烷氧基，R 1，R 2，R 3，R 3， R 4表示氢，含有1至6个碳原子的烷基，乙酰基或羟基; 并且X和Y中的任一个表示 - （CH 2 CH 2）n OH其中n是0至30的整数，X和Y中的另一个表示氢原子; 或其盐; 以及用于促进含有这种吲哚衍生物或其盐作为有效成分的干细胞分化的药物和试剂，其中吲哚衍生物（1）具有诱导神经干细胞特异性分化为神经元的作用，该吲哚衍生物作为由神经元的损失或退化引起的脑功能障碍或神经病变的预防或治疗药物是有用的。

4. 发明申请

US20050261357A1 Indole derivatives and drugs containing the same 失效
标题翻译：吲哚衍生物和含有相同的药物
公开(公告)号：US20050261357A1
公开(公告)日：2005-11-24
申请号：US10520136
申请日：2003-07-22
申请人： Bang Luu , Djalil Coowar , Ellane Mohier , Masashi Yamada , Yukie Suma , Hiroto Suzuki
发明人： Bang Luu , Djalil Coowar , Ellane Mohier , Masashi Yamada , Yukie Suma , Hiroto Suzuki
IPC分类号： A61P25/00 , A61P25/28 , A61P43/00 , C07D209/12 , A61K31/404 , C07D209/04
CPC分类号： C07D209/12
摘要： An indole derivative represented by the following general formula (1): wherein at least one of R1, R2, R3, and R4 represents an alkoxy group containing 1 to 20 carbon atoms, and other groups of the R1, R2, R3, and R4 represent hydrogen, an alkyl group containing 1 to 6 carbon atoms, acetyl group, or hydroxyl group; and either one of X and Y represents —(CH2)n OH wherein n is an integer of 0 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof; and a drug and an agent for promoting differentiation of a stem cell containing such indole derivative or its salt as an effective component. The indole derivative (1) of the present invention has action of inducing differentiation of neural stem cell specifically into a neuron, and this indole derivative is useful as a prophylactic or therapeutic drug for brain dysfunction or neuropathy caused by loss or degeneration of the neuron.
摘要翻译：由以下通式（1）表示的吲哚衍生物：其中R 1，R 2，R 3和R 3中的至少一个，R 3，R 3，代表含有1至20个碳原子的烷氧基，R 1，R 2，R 3，R 3， R 4表示氢，含有1至6个碳原子的烷基，乙酰基或羟基; 并且X和Y中的任一个表示 - （CH 2 CH 2）n OH其中n是0至30的整数，X和Y中的另一个表示氢原子; 或其盐; 以及用于促进含有这种吲哚衍生物或其盐作为有效成分的干细胞分化的药物和试剂。本发明的吲哚衍生物（1）具有诱导神经干细胞特异性分化为神经元的作用，该吲哚衍生物可用作由神经元的丧失或退化引起的脑功能障碍或神经病变的预防或治疗药物。

5. 发明申请

US20090069442A1 Therapeutic Agent for Sensory Abnormality 审中-公开
标题翻译：感觉异常的治疗剂
公开(公告)号：US20090069442A1
公开(公告)日：2009-03-12
申请号：US11814008
申请日：2006-01-18
申请人： Hirohito Shiomi , Yutaka Tamura , Bang Luu , Masashi Yamada , Keizou Koyama , Hiroto Suzuki
发明人： Hirohito Shiomi , Yutaka Tamura , Bang Luu , Masashi Yamada , Keizou Koyama , Hiroto Suzuki
IPC分类号： A61K31/122 , C07C49/743 , A61P27/00
CPC分类号： A61K31/122
摘要： The present invention provides therapeutic agents for sensory disorders represented by the following formula (1): [wherein R1, R2, and R3 each represent a hydrogen atom or a methyl group, and X represents a linear or branched C10-C28 alkylene or alkenylene group].The cyclohexenone long chain alcohol of the present invention improves hyperalgesia or hypoalgesia, and thus is useful as therapeutic agents for sensory disorders. Sensory disorders that can be prevented or treated by the present invention include chronic intractable pain, neurogenic pain, reduction of pain threshold caused by nerve injuries, hypesthesia or hyperesthesia caused by diabetes and nerve injuries, and the like.
摘要翻译：本发明提供由下式（1）表示的感觉障碍治疗剂：其中R1，R2和R3各自表示氢原子或甲基，X表示直链或支链C 10 -C 28亚烷基或亚烯基 ]。本发明的环己烯酮长链醇可以改善痛觉过敏或减轻痛觉过敏，因此可用作感觉障碍的治疗剂。可以通过本发明预防或治疗的感觉障碍包括慢性顽固性疼痛，神经性疼痛，由神经损伤引起的疼痛阈值的降低，由糖尿病和神经损伤引起的感觉过敏或感觉异常等。

6. 发明申请

US20050131053A1 Indole derivatives substituted with long-chain alcolhols and medicaments containing them 失效
标题翻译：用长链醇盐取代的吲哚衍生物和含有它们的药物
公开(公告)号：US20050131053A1
公开(公告)日：2005-06-16
申请号：US10504484
申请日：2002-02-13
申请人： Bang Luu , Djalil Coowar , Masashi Yamada , Yukie Suma , Hiroto Suzuki
发明人： Bang Luu , Djalil Coowar , Masashi Yamada , Yukie Suma , Hiroto Suzuki
IPC分类号： C07D209/12 , A61K31/405 , C07D209/04
CPC分类号： C07D209/12
摘要： The invention relates to a flange coupling of two pipes, in particular the pipes of an exhaust system of a motor vehicle internal combustion engine. The coupling is characterized in that: each of the flanges is formed onto the corresponding pipe by the shaping of one of the pipe regions that form the respective flanges; a first of the two flanges is configured with a first connection pipe section, which engages radially in the interior of the second flange; a sealing ring is clamped between the flanges; the flanges are axially fixed by a clamping deice. The coupling is designed to be produced in an efficient manner, easy to mount and configured so that it functions reliably.
摘要翻译：本发明涉及两个管道，特别是机动车辆内燃机的排气系统的管道的法兰联接。联轴器的特征在于：每个凸缘通过形成相应凸缘的一个管区形成在相应的管上; 两个凸缘中的第一个被构造成具有径向接合在第二凸缘内部的第一连接管段; 密封环夹在凸缘之间; 凸缘由夹紧芯轴向固定。联轴器设计成能够以有效的方式生产，易于安装和配置，使其可靠运行。

7. 发明授权

US07902249B2 Indole derivatives substituted with long-chain alcohols and medicaments containing them 失效
标题翻译：被长链醇取代的吲哚衍生物和含有它们的药物
公开(公告)号：US07902249B2
公开(公告)日：2011-03-08
申请号：US12132345
申请日：2008-06-03
申请人： Bang Luu , Djalil Coowar , Masashi Yamada , Yukie Suma , Hiroto Suzuki
发明人： Bang Luu , Djalil Coowar , Masashi Yamada , Yukie Suma , Hiroto Suzuki
IPC分类号： A61K31/404 , C07D209/04
CPC分类号： C07D209/12
摘要： Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): wherein R1, R2, R3 and R4 each independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number from 0 to 20; and a medicinal composition comprising the same. The indole long-chain alcohol (I) exhibits an excellent nerve growth promoting effect, as well as potent antioxidative and anti-tumor effects, and is therefore useful as a prophylactic and/or therapeutic agent for cerebral diseases including dementia diseases, and malignant tumors including brain tumors.
摘要翻译：提供由下式（I）表示的吲哚长链醇或其水合物或异构体：其中R1，R2，R3和R4各自独立地表示氢原子，甲基，乙酰基或羟基，n表示0〜20的数; 以及含有该组合物的药物组合物。吲哚长链醇（I）表现出优异的神经生长促进作用，以及有效的抗氧化和抗肿瘤作用，因此可用作脑疾病包括痴呆症和恶性肿瘤的预防和/或治疗剂包括脑肿瘤。

8. 发明授权

US07838565B2 Use of cyclohexenone derivatives in the manufacture of a medicament for treating diabetic complications 有权
标题翻译：环己烯酮衍生物在制备用于治疗糖尿病并发症的药物中的应用
公开(公告)号：US07838565B2
公开(公告)日：2010-11-23
申请号：US10467063
申请日：2002-02-15
申请人： Masao Miyagawa , Takeshi Watanabe , Motoaki Saito , Bang Luu , Masashi Yamada , Hiroto Suzuki
发明人： Masao Miyagawa , Takeshi Watanabe , Motoaki Saito , Bang Luu , Masashi Yamada , Hiroto Suzuki
IPC分类号： A61K31/12 , A01N35/00
CPC分类号： C07C49/713 , A61K31/12 , A61K31/122 , C07C45/511 , C07C45/59 , C07C45/673 , C07C403/08 , C07C2601/16 , C07C49/603
摘要： A preventive and/or therapeutic agent for diabetes complications, which comprises as an effective ingredient a cyclohexenone long-chain alcoholic derivative represented by the following formula (1): wherein, R1, R2 and R3 each independently represents a hydrogen atom or a methyl group and X represents a linear or branched C10-28 alkylene or alkenylene group. The cyclohexenone long-chain alcoholic derivative of the present invention significantly suppresses a reduction in a peripheral nerve conduction rate and alleviates the hypofunction of the bladder so that it is useful as a preventive and/or therapeutic agent for diabetes complications, particularly, for diabetic neuropathy.
摘要翻译：糖尿病并发症的预防和/或治疗剂，其包含作为有效成分的由下式（1）表示的环己烯酮长链醇衍生物：其中，R 1，R 2和R 3各自独立地表示氢原子或甲基 X表示直链或支链C 10-28亚烷基或亚烯基。本发明的环己烯酮长链醇衍生物显着抑制周围神经传导速率的降低并减轻膀胱的功能缺失，因此其可用作糖尿病并发症的预防和/或治疗剂，特别是糖尿病性神经病变。

9. 发明授权

US07407983B2 Indole derivatives substituted with long-chain alcohols and medicaments containing them 失效
公开(公告)号：US07407983B2
公开(公告)日：2008-08-05
申请号：US10504484
申请日：2002-02-13
申请人： Bang Luu , Djalil Coowar , Masashi Yamada , Yukie Suma , Hiroto Suzuki
发明人： Bang Luu , Djalil Coowar , Masashi Yamada , Yukie Suma , Hiroto Suzuki
IPC分类号： A61K31/404 , C07D209/04
CPC分类号： C07D209/12
摘要： Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): wherein R1, R2, R3 and R4 each independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number from 0 to 20; and a medicinal composition comprising the same. The indole long-chain alcohol (I) exhibits an excellent nerve growth promoting effect, as well as potent antioxidative and anti-tumor effects, and is therefore useful as a prophylactic and/or therapeutic agent for cerebral diseases including dementia diseases, and malignant tumors including brain tumors.

10. 发明申请

US20080234357A1 Indole derivatives substituted with long-chain alcohols and medicaments containing them 失效
标题翻译：被长链醇取代的吲哚衍生物和含有它们的药物
公开(公告)号：US20080234357A1
公开(公告)日：2008-09-25
申请号：US12132345
申请日：2008-06-03
申请人： Bang LUU , Djalil Coowar , Masashi Yamada , Yukie Suma , Hiroto Suzuki
发明人： Bang LUU , Djalil Coowar , Masashi Yamada , Yukie Suma , Hiroto Suzuki
IPC分类号： A61K31/404 , A61P35/00
CPC分类号： C07D209/12
摘要： Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): wherein R1, R2, R3 and R4 each independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number from 0 to 20; and a medicinal composition comprising the same. The indole long-chain alcohol (I) exhibits an excellent nerve growth promoting effect, as well as potent antioxidative and anti-tumor effects, and is therefore useful as a prophylactic and/or therapeutic agent for cerebral diseases including dementia diseases, and malignant tumors including brain tumors.
摘要翻译：提供由下式（I）表示的吲哚长链醇或其水合物或异构体：其中R 1，R 2，R 2， > 3和R 4各自独立地表示氢原子，甲基，乙酰基或羟基，n表示0〜20的数。以及含有该组合物的药物组合物。吲哚长链醇（I）表现出优异的神经生长促进作用，以及有效的抗氧化和抗肿瘤作用，因此可用作脑疾病包括痴呆症和恶性肿瘤的预防和/或治疗剂包括脑肿瘤。

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