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1. 发明授权

US09765129B2 Treatment of obesity 有权
公开(公告)号：US09765129B2
公开(公告)日：2017-09-19
申请号：US13968977
申请日：2013-08-16
申请人： Baker Medical Research Institute , Christian-Albrechts-Universität zu Kiel
发明人： Mark Anthony Febbraio , Stefan Rose-John
IPC分类号： A61K38/20 , C07K14/54 , C07K14/475 , C07K14/48 , A61K38/00
CPC分类号： C07K14/5412 , A61K38/00 , C07K14/475 , C07K14/48 , C07K2319/00
摘要： The present invention relates generally to a method of increasing lipid oxidation in a mammal and to agents useful for same. More particularly, the present invention relates to a method of increasing lipid oxidation in a mammal by administering a ligand which interacts with the IL-6 receptor and signals via interaction with a gp130/LIF receptor heterodimer. In a related aspect, the present invention provides a method of increasing insulin sensitivity in a mammal. The method of present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterized by unwanted lipid accumulation (such as obesity, obesity induced-metabolic disorders, type II diabetes, dyslipidemia, glucose intolerance, insulin resistance, obstructive sleep apnea, cardiovascular disease or non-alcoholic fatty liver disease) or inadequate insulin sensitivity.

2. 发明申请

US20140140949A1 TREATMENT OF OBESITY 有权
标题翻译：治疗肥胖
公开(公告)号：US20140140949A1
公开(公告)日：2014-05-22
申请号：US13968977
申请日：2013-08-16
申请人： Christian-Albrechts-Universität Zu Kiel , Baker Medical Research Institute
发明人： Mark Anthony Febbraio , Stefan Rose-John
IPC分类号： C07K14/54 , C07K14/48
CPC分类号： C07K14/5412 , A61K38/00 , C07K14/475 , C07K14/48 , C07K2319/00
摘要： The present invention relates generally to a method of increasing lipid oxidation in a mammal and to agents useful for same. More particularly, the present invention relates to a method of increasing lipid oxidation in a mammal by administering a ligand which interacts with the IL-6 receptor and signals via interaction with a gp130/LIF receptor heterodimer. In a related aspect, the present invention provides a method of increasing insulin sensitivity in a mammal. The method of present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by unwanted lipid accumulation (such as obesity, obesity induced-metabolic disorders, type II diabetes, dyslipidemia, glucose intolerance, insulin resistance, obstructive sleep apnea, cardiovascular disease or non-alcoholic fatty liver disease) or inadequate insulin sensitivity.
摘要翻译：本发明一般涉及增加哺乳动物中脂质氧化的方法以及可用于其的药剂。更具体地，本发明涉及通过施用与IL-6受体相互作用的配体和通过与gp130 / LIF受体异源二聚体的相互作用信号来增加哺乳动物中的脂质氧化的方法。在相关方面，本发明提供了增加哺乳动物胰岛素敏感性的方法。本发明的方法尤其用于治疗和/或预防特征在于不希望的脂质积聚（如肥胖，肥胖诱导的代谢紊乱，II型糖尿病，血脂异常，葡萄糖不耐受，胰岛素抵抗，阻塞性睡眠呼吸暂停，心血管疾病或非酒精性脂肪肝疾病）或胰岛素敏感性不足。

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