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1. 发明授权

US08715957B2 Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene 有权
标题翻译：用于生物合成芳烃，2,4-戊二烯酸和1,3-丁二烯的微生物和方法
公开(公告)号：US08715957B2
公开(公告)日：2014-05-06
申请号：US13191375
申请日：2011-07-26
申请人： Robin E. Osterhout , Anthony P. Burgard , Priti Pharkya , Mark J. Burk
发明人： Robin E. Osterhout , Anthony P. Burgard , Priti Pharkya , Mark J. Burk
IPC分类号： C12P1/00 , A61K38/00
CPC分类号： C12P7/62 , C12N15/52 , C12P5/005 , C12P5/026 , C12P7/16 , C12P7/40 , C12P9/00 , Y02E50/10
摘要： The invention provides non-naturally occurring microbial organisms having a toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4-pentadienoate, 3-butene-1ol or 1,3-butadiene pathway. The invention additionally provides methods of using such organisms to produce toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4-pentadienoate, 3-butene-1ol or 1,3-butadiene.
摘要翻译：本发明提供了具有甲苯，苯，对甲苯甲酸酯，对苯二甲酸酯，（2-羟基-3-甲基-4-氧代丁氧基）膦酸酯，（2-羟基-4-氧代丁氧基）膦酸酯，苯甲酸酯，苯乙烯，2,4-戊二烯酸酯，3-丁烯-1醇或1,3-丁二烯途径。本发明另外提供了使用这些生物体来生产甲苯，苯，对甲苯甲酸酯，对苯二甲酸酯，（2-羟基-3-甲基-4-氧代丁氧基）膦酸酯，（2-羟基-4-氧代丁氧基）膦酸酯，苯甲酸酯，苯乙烯，2,4-戊二烯酸酯，3-丁烯-1醇或1,3-丁二烯。

2. 发明申请

US20130066035A1 EUKARYOTIC ORGANISMS AND METHODS FOR INCREASING THE AVAILABILITY OF CYTOSOLIC ACETYL-COA, AND FOR PRODUCING 1,3-BUTANEDIOL 审中-公开
标题翻译：用于增加CYPOSOLIC ACETYL-COA和生产1,3-丁二醇的可用性的原始有机体和方法
公开(公告)号：US20130066035A1
公开(公告)日：2013-03-14
申请号：US13607527
申请日：2012-09-07
申请人： Anthony P. Burgard , Mark J. Burk , Robin E. Osterhout , Priti Pharkya , Jingyi Li
发明人： Anthony P. Burgard , Mark J. Burk , Robin E. Osterhout , Priti Pharkya , Jingyi Li
IPC分类号： C12N1/19 , C12Q1/32 , C08G63/00 , C07C31/20 , C08G18/32 , C12N1/15 , C12P7/18
CPC分类号： C12N15/52 , C08G63/16 , C12N1/14 , C12N1/16 , C12N1/20 , C12P7/18 , C12P19/32
摘要： Provided herein are non-naturally occurring eukaryotic organisms that can be engineered to produce and increase the availability of cytosolic acetyl-CoA. Also provided herein are non-naturally occurring eukaryotic organisms having a 1,3-butanediol (1,3-BDO) pathway. and methods of using such organisms to produce 1,3-BDO.
摘要翻译：本文提供的是非天然存在的真核生物，其可被工程化以产生和增加细胞溶质乙酰辅酶A的可用性。本文还提供具有1,3-丁二醇（1,3-BDO）途径的非天然存在的真核生物。以及使用这些生物体产生1,3-BDO的方法。

3. 发明申请

US20130011891A1 MICROORGANISMS FOR PRODUCING BUTADIENE AND METHODS RELATED THERETO 有权
标题翻译：用于生产二苯乙烯的微生物及其相关方法
公开(公告)号：US20130011891A1
公开(公告)日：2013-01-10
申请号：US13527440
申请日：2012-06-19
申请人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
发明人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
IPC分类号： C12P5/02 , C12N1/15 , C12N1/19 , C12P7/04 , C12N1/21
CPC分类号： C12P7/04 , C12N15/52 , C12N15/70 , C12P5/026 , C12P7/16
摘要： The invention provides non-naturally occurring microbial organisms having a butadiene or crotyl alcohol pathway. The invention additionally provides methods of using such organisms to produce butadiene or crotyl alcohol.
摘要翻译：本发明提供具有丁二烯或巴豆醇途径的非天然存在的微生物。本发明另外提供了使用这种生物体来生产丁二烯或巴豆醇的方法。

4. 发明申请

US20120282661A1 MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF ADIPATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROIC ACID 审中-公开
标题翻译：丙二酸，十六烷二胺和6-氨基酸的生物合成的微生物和方法
公开(公告)号：US20120282661A1
公开(公告)日：2012-11-08
申请号：US13549239
申请日：2012-07-13
申请人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Priti Pharkya
发明人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Priti Pharkya
IPC分类号： C12P13/00 , C12N15/52 , C12N1/15 , C12N1/21 , C12P17/10 , C12N1/19
CPC分类号： C12P17/10 , C12N1/38 , C12N15/52 , C12P7/40 , C12P7/44 , C12P13/001 , C12P13/005 , C12P13/02 , C12P17/12
摘要： The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.
摘要翻译：本发明提供了具有6-氨基己酸，己内酰胺，六亚甲基二胺或乙酰丙酸途径的非天然存在的微生物生物。微生物生物体含有至少一种编码各自的6-氨基己酸，己内酰胺，六亚甲基二胺或乙酰丙酸途径中的酶的外源核酸。本发明另外提供了制备6-氨基己酸，己内酰胺，己二胺或乙酰丙酸的方法。该方法可以包括培养6-氨基己酸，己内酰胺或六亚甲基二胺生产微生物，其中微生物生物体表达至少一种编码6-氨基己酸，己内酰胺，六亚甲基二胺或乙酰丙酸途径酶的外源核酸，其量足以产生各自的产物在条件下和足够的时间内产生6-氨基己酸，己内酰胺，六亚甲基二胺或乙酰丙酸。

5. 发明申请

US20120276604A1 MICROORGANISMS FOR THE PRODUCTION OF METHACRYLIC ACID 有权
标题翻译：用于生产甲基丙烯酸的微生物
公开(公告)号：US20120276604A1
公开(公告)日：2012-11-01
申请号：US13531377
申请日：2012-06-22
申请人： Anthony P. Burgard , Mark J. Burk , Robin E. Osterhout , Priti Pharkya
发明人： Anthony P. Burgard , Mark J. Burk , Robin E. Osterhout , Priti Pharkya
IPC分类号： C12P7/42 , C12N1/21
CPC分类号： C12P7/42 , C12N9/0008 , C12N9/1096 , C12N9/88 , C12N9/90 , C12P7/40 , C12Y102/01 , C12Y206/01022 , C12Y403/01 , C12Y504/99002
摘要： The invention provides a non-naturally occurring microbial organism having a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The invention additionally provides a method for producing 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid. The method can include culturing a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid producing microbial organism expressing at least one exogenous nucleic acid encoding a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway enzyme in a sufficient amount and culturing under conditions and for a sufficient period of time to produce 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid.
摘要翻译：本发明提供了具有2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸途径的非天然存在的微生物生物。微生物生物体含有编码2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸途径中的酶的至少一种外源核酸。本发明还提供了2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸的制备方法。该方法可以包括培养足够量的表达至少一种编码2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸途径酶的外源核酸的2-羟基异丁酸，3-羟基异丁酸或产生甲基丙烯酸的微生物，并培养在条件下和足够的时间内产生2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸。

6. 发明申请

US20120264179A1 MICROORGANISMS FOR THE PRODUCTION OF ADIPIC ACID AND OTHER COMPOUNDS 审中-公开
公开(公告)号：US20120264179A1
公开(公告)日：2012-10-18
申请号：US13452642
申请日：2012-04-20
申请人： Anthony P. Burgard , Priti Pharkya , Robin E. Osterhout
发明人： Anthony P. Burgard , Priti Pharkya , Robin E. Osterhout
IPC分类号： C12P7/44 , C12P7/24 , C12P13/00 , C12P17/10 , C12P11/00 , C12N9/10 , C12N1/15 , C12N1/19 , C12N9/02 , C12N9/16 , C12N9/06 , C12N15/53 , C12P7/62 , C12N1/21
CPC分类号： C12N15/52 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/1029 , C12N9/1096 , C12N9/80 , C12N9/88 , C12P7/44 , C12P7/46 , C12P7/62 , C12P13/001 , C12P13/005 , C12P13/02 , C12P17/10 , C12Y101/01035 , C12Y102/0101 , C12Y103/01031 , C12Y206/01 , C12Y402/01
摘要： The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6-aminocaproic acid or caprolactam. The method can include culturing an adipate, 6-aminocaproic acid or caprolactam producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an adipate, 6-aminocaproic acid or caprolactam pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce adipate, 6-aminocaproic acid or caprolactam.

7. 发明申请

US20120021478A1 MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF AROMATICS, 2,4-PENTADIENOATE AND 1,3-BUTADIENE 有权
标题翻译：芳香族化合物的2,4-二戊二酸和1,3-丁二烯的生物合成的微生物和方法
公开(公告)号：US20120021478A1
公开(公告)日：2012-01-26
申请号：US13191375
申请日：2011-07-26
申请人： Robin E. Osterhout , Anthony P. Burgard , Priti Pharkya , Mark J. Burk
发明人： Robin E. Osterhout , Anthony P. Burgard , Priti Pharkya , Mark J. Burk
IPC分类号： C12P5/02 , C12N1/00
CPC分类号： C12P7/62 , C12N15/52 , C12P5/005 , C12P5/026 , C12P7/16 , C12P7/40 , C12P9/00 , Y02E50/10
摘要： The invention provides non-naturally occurring microbial organisms having a toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4-pentadienoate, 3-butene-1ol or 1,3-butadiene pathway. The invention additionally provides methods of using such organisms to produce toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4-pentadienoate, 3-butene-1ol or 1,3-butadiene.
摘要翻译：本发明提供了具有甲苯，苯，对甲苯甲酸酯，对苯二甲酸酯，（2-羟基-3-甲基-4-氧代丁氧基）膦酸酯，（2-羟基-4-氧代丁氧基）膦酸酯，苯甲酸酯，苯乙烯，2,4-戊二烯酸酯，3-丁烯-1醇或1,3-丁二烯途径。本发明另外提供了使用这些生物体来生产甲苯，苯，对甲苯甲酸酯，对苯二甲酸酯，（2-羟基-3-甲基-4-氧代丁氧基）膦酸酯，（2-羟基-4-氧代丁氧基）膦酸酯，苯甲酸酯，苯乙烯，2,4-戊二烯酸酯，3-丁烯-1醇或1,3-丁二烯。

8. 发明授权

US08062871B2 Microorganisms for the production of adipic acid and other compounds 有权
标题翻译：用于生产己二酸等化合物的微生物
公开(公告)号：US08062871B2
公开(公告)日：2011-11-22
申请号：US13088256
申请日：2011-04-15
申请人： Anthony P. Burgard , Priti Pharkya , Robin E. Osterhout
发明人： Anthony P. Burgard , Priti Pharkya , Robin E. Osterhout
IPC分类号： C12P7/62 , C12P7/44
CPC分类号： C12N15/52 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/1029 , C12N9/1096 , C12N9/80 , C12N9/88 , C12P7/44 , C12P7/46 , C12P7/62 , C12P13/001 , C12P13/005 , C12P13/02 , C12P17/10 , C12Y101/01035 , C12Y102/0101 , C12Y103/01031 , C12Y206/01 , C12Y402/01
摘要： The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6-aminocaproic acid or caprolactam. The method can include culturing an adipate, 6-aminocaproic acid or caprolactam producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an adipate, 6-aminocaproic acid or caprolactam pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce adipate, 6-aminocaproic acid or caprolactam.
摘要翻译：本发明提供了具有己二酸，6-氨基己酸或己内酰胺途径的非天然存在的微生物。微生物生物体含有至少一种编码相应己二酸，6-氨基己酸或己内酰胺途径中的酶的外源核酸。本发明另外提供了生产己二酸，6-氨基己酸或己内酰胺的方法。该方法可以包括培养己二酸，6-氨基己酸或己内酰胺生产微生物，其中微生物生物体表达至少一种编码己二酸，6-氨基己酸或己内酰胺途径酶的外源核酸，其量足以产生相应的产物在条件下和足够的时间内生产己二酸，6-氨基己酸或己内酰胺。

9. 发明授权

US08048661B2 Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes 有权
标题翻译：包含编码还原型TCA途径酶的外源核酸的微生物生物
公开(公告)号：US08048661B2
公开(公告)日：2011-11-01
申请号：US13011796
申请日：2011-01-21
申请人： Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
发明人： Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
IPC分类号： C12N9/00 , C12N1/20
CPC分类号： C12P7/00 , C12N9/0006 , C12N9/001 , C12N9/0095 , C12N9/1029 , C12N9/1217 , C12N9/88 , C12N9/93 , C12P7/04 , C12P7/18 , C12P7/42 , C12P19/42
摘要： A non-naturally occurring microbial organism includes a microbial organism having a reductive TCA or Wood-Ljungdahl pathway in which at least one exogenous nucleic acid encoding these pathway enzymes is expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. A method for enhancing carbon flux through acetyl-CoA includes culturing theses non-naturally occurring microbial organisms under conditions and for a sufficient period of time to produce a product having acetyl-CoA as a building block. Another non-naturally occurring microbial organism includes at least one exogenous nucleic acid encoding an enzyme expressed in a sufficient amount to enhance the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, thereby increasing the yield of redox-limited products via carbohydrate-based carbon feedstock. A method for enhancing the availability of reducing equivalents in the presence of carbon monoxide or hydrogen includes culturing this organism for a sufficient period of time to produce a product.
摘要翻译：非天然存在的微生物体包括具有还原性TCA或Wood-Ljungdahl途径的微生物生物体，其中至少一种编码这些途径酶的外源核酸以足够的量表达以增强通过乙酰辅酶A的碳通量。通过乙酰辅酶A增强碳通量的方法包括在条件和足够的时间段内培养这些非天然存在的微生物，以产生具有乙酰辅酶A作为结构单元的产物。另一种非天然存在的微生物生物体包括至少一种编码以足够量表达的酶的外源核酸，以增强在一氧化碳或氢气存在下还原当量的可用性，从而通过碳水化合物 - 碳原料。在一氧化碳或氢气存在下增强还原当量的可用性的方法包括在足够的时间内培养该生物体以产生产物。

10. 发明申请

US20110195466A1 MICROORGANISMS FOR THE PRODUCTION OF ADIPIC ACID AND OTHER COMPOUNDS 有权
标题翻译：用于生产对苯二酸和其他化合物的微生物
公开(公告)号：US20110195466A1
公开(公告)日：2011-08-11
申请号：US13088256
申请日：2011-04-15
申请人： Anthony P. Burgard , Priti Pharkya , Robin E. Osterhout
发明人： Anthony P. Burgard , Priti Pharkya , Robin E. Osterhout
IPC分类号： C12P11/00 , C12N1/00 , C12P7/46
CPC分类号： C12N15/52 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/1029 , C12N9/1096 , C12N9/80 , C12N9/88 , C12P7/44 , C12P7/46 , C12P7/62 , C12P13/001 , C12P13/005 , C12P13/02 , C12P17/10 , C12Y101/01035 , C12Y102/0101 , C12Y103/01031 , C12Y206/01 , C12Y402/01
摘要： The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6-aminocaproic acid or caprolactam. The method can include culturing an adipate, 6-aminocaproic acid or caprolactam producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an adipate, 6-aminocaproic acid or caprolactam pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce adipate, 6-aminocaproic acid or caprolactam.
摘要翻译：本发明提供了具有己二酸，6-氨基己酸或己内酰胺途径的非天然存在的微生物。微生物生物体含有至少一种编码相应己二酸，6-氨基己酸或己内酰胺途径中的酶的外源核酸。本发明另外提供了生产己二酸，6-氨基己酸或己内酰胺的方法。该方法可以包括培养己二酸，6-氨基己酸或己内酰胺生产微生物，其中微生物生物体表达至少一种编码己二酸，6-氨基己酸或己内酰胺途径酶的外源核酸，其量足以产生相应的产物在条件下和足够的时间内生产己二酸，6-氨基己酸或己内酰胺。

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