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1. 发明授权

US07507719B2 Use of peptidic conjugates for preparing compositions for alopecia preventive and curative treatment 有权
标题翻译：使用肽共轭物制备预防和治疗脱发的组合物
公开(公告)号：US07507719B2
公开(公告)日：2009-03-24
申请号：US10565007
申请日：2004-07-16
申请人： Anne-Marie Pinel , Michel Hocquaux
发明人： Anne-Marie Pinel , Michel Hocquaux
IPC分类号： A61K38/00 , A61K51/00 , A61K38/04
CPC分类号： A61Q7/00 , A23L33/18 , A23V2002/00 , A61K8/64 , A61K38/07 , A61K38/08 , A61K2800/57 , A23V2250/0622 , A23V2250/0624 , A23V2250/063
摘要： The invention relates to the use of peptidic conjugates containing Gly-His-Lys for producing dermatological or cosmetological compositions for stimulating hair growth or stopping hair fall.
摘要翻译：本发明涉及含有Gly-His-Lys的肽结合物用于产生用于刺激头发生长或阻止头发下垂的皮肤病学或美容组合物的用途。

2. 发明申请

US20070014747A1 Novel peptidic conjugates for alopecia preventive and curative treatment 有权
标题翻译：用于秃发预防和治疗性治疗的新型肽共轭物
公开(公告)号：US20070014747A1
公开(公告)日：2007-01-18
申请号：US10565009
申请日：2004-07-16
申请人： Anne-Marie Pinel , Michel Hocquaux
发明人： Anne-Marie Pinel , Michel Hocquaux
IPC分类号： A61K38/08 , A61K38/05 , A61K8/64
CPC分类号： C07K7/06 , A61K38/00 , C07K5/0815 , C07K5/1019 , C07K14/66
摘要： The invention relates to novel peptidic conjugates containing a Gly-His-Lys sequence and used for dermatology or cosmetology for stimulating hair growth or stopping hair fall.
摘要翻译：本发明涉及含有Gly-His-Lys序列并用于刺激毛发生长或阻止头发下垂的皮肤病学或美容学的新型肽缀合物。

3. 发明授权

US07785577B2 Peptides or peptidic conjugate derivatives of MSH and the use thereof for cosmetically fighting against canities 有权
标题翻译： MSH的肽或肽结合物衍生物及其用于美容防御的方法
公开(公告)号：US07785577B2
公开(公告)日：2010-08-31
申请号：US11596288
申请日：2005-05-10
申请人： Michel Hocquaux , Anne-Marie Pinel , Jean Martinez , Gilles Subra
发明人： Michel Hocquaux , Anne-Marie Pinel , Jean Martinez , Gilles Subra
IPC分类号： A61K8/64
CPC分类号： A61K47/54
摘要： The invention relates to a peptide of formula W-DPhe-Arg-Z (I) and to a conjugate thereof of a formula A-W-DPhe-Arg-Z (II), wherein A is a radical corresponding to a monocarboxylic acid of general formula HOOC—R (III), wherein R is an linear or branched possibly substituted by a hydroxy group aliphatic C1-C24 radical which can comprise one or several unsaturations, preferably from 1 to 6 unsaturations, a lipoic acid or the reduced form thereof, a dihydrolipoic acid, N-lipoyl-lysine or a phenylbutyric acid, W is His, Ala-His, Ala-Ala-His, Nle-Ala-His, DTrp-Ala-His, Nle-Trp-His, Lys, Ala-Lys, Nle-Ala-Lys, Orn, Ala-Orn, Nle-Ala-Orn, Ala, Nle-Ala-Ala, Arg, Ala-Arg. Nle-Ala-Arg, Nle-Ala-DTrp or a bond in case of compounds of formula (II), Z is NH2, OH and OR, wherein R is a linear or branched aliphatic C1-C24 radical, TrpNH2, NapNH2, TpiNH2, TicNH2, AlaNH2i TrpOH, NapOH, TpiOH, TicOH, AlaOH, PheNH2, or PheOH, exempting a peptidic conjugate for which A is a radical corresponding to an acetic acid, W is Nle-Ala-His and Z is TrpNH2 in the form of enantiomers or diastereoisomer and the mixtures thereof including racemic mixtures. The use of the inventive compounds for cosmetically fighting against canities is also disclosed.
摘要翻译：本发明涉及式W-DPhe-Arg-Z（I）的肽及其与式AW-DPhe-Arg-Z（II）的结合物，其中A是相应于通式 HOOC-R（III），其中R是可以被羟基脂族C 1 -C 24基取代的直链或支链，其可以包含一个或多个不饱和基团，优选1至6个不饱和基团，硫辛酸或其还原形式，二氢硫辛酸，N-脂酰赖氨酸或苯丁酸，W是His，Ala-His，Ala-Ala-His，Nle-Ala-His，DTrp-Ala-His，Nle-Trp-His，Lys，Ala-Lys ，Nle-Ala-Lys，Orn，Ala-Orn，Nle-Ala-Orn，Ala，Nle-Ala-Ala，Arg，Ala-Arg。 Nle-Ala-Arg，Nle-Ala-DTrp或在式（II）化合物的情况下为键，Z为NH 2，OH和OR，其中R为直链或支链脂族C 1 -C 24基团，TrpNH 2，NapNH 2，TpiNH 2 ，TicNH2，AlaNH2i TrpOH，NapOH，TpiOH，TicOH，AlaOH，PheNH2或PheOH，免除其中A是对应于乙酸的基团的肽结合物，W是Nle-Ala-His，Z是TrpNH2，其形式为对映异构体或非对映异构体及其混合物，包括外消旋混合物。还公开了本发明化合物用于美容化妆品的用途。

4. 发明申请

US20080200396A1 Peptides or Peptidic Conjugate Derivatives of Msh and the Use Thereof for Cosmetically Fighting Against Canities 有权
标题翻译： Msh的肽或肽结合物衍生物及其用于化妆品抗争的用途
公开(公告)号：US20080200396A1
公开(公告)日：2008-08-21
申请号：US11596288
申请日：2005-05-10
申请人： Michel Hocquaux , Anne-Marie Pinel , Jean Martinez , Gilles Subra
发明人： Michel Hocquaux , Anne-Marie Pinel , Jean Martinez , Gilles Subra
IPC分类号： A61K8/64 , A61Q5/00
CPC分类号： A61K47/54
摘要： The invention relates to a peptide of formula W-DPhe-Arg-Z (I) and to a conjugate thereof of a formula A-W-DPhe-Arg-Z (II), wherein A is a radical corresponding to a nionocarboxylic acid of general formula HOOC—R (III), wherein R is an linear or branched possibly substituted by a hydroxy group aliphatic C1-C24 radical which can comprise one or several unsaturations, preferably from 1 to 6 unsaturations, a lipoic acid or the reduced form thereof, a dihydrolipoic acid, N-lipoyl-lysine or a phenylbutyric acid, W is His, Ala-His, Ala-Ala-His, Nle-Ala-His, DTrp-Ala-His, Nle-Trp-His, Lys, Ala-Lys, Nle-Ala-Lys, Orn, Ala-Orn, Nle-Ala-Orn, Ala, Nle-Ala-Ala, Arg, Ala-Arg. Nle-Ala-Arg, Nle-Ala-DTrp or a bond in case of compounds of formula (II), Z is NH2, OH and OR, wherein R is a linear or branched aliphatic C1-C24 radical, TrpNH2, NapNH2, TpiNH2, TicNH2, AlaNH2i TrpOH, NapOH, TpiOH, TicOH, AlaOH, PheNH2, or PheOH, exempting a peptidic conjugate for which A is a radical corresponding to an acetic acid, W is Nle-Ala-His and Z is TrpNH2 in the form of enantiomers or diastereoisomer and the mixtures thereof including racemic mixtures. The use of the inventive compounds for cosmetically fighting against canities is also disclosed.
摘要翻译：本发明涉及式W-DPhe-Arg-Z（I）的肽及其与式AW-DPhe-Arg-Z（II）的共轭物，其中A是相应于通式 HOOC-R（III），其中R是可以被羟基脂族C 1 -C 24 - 基团取代的直链或支链，其可以包含一个或几个不饱和基团，优选 1至6个不饱和键，硫辛酸或其还原形式，二氢硫辛酸，N-脂酰赖氨酸或苯丁酸，W是His，Ala-His，Ala-Ala-His，Nle-Ala-His，DTrp -Ale-His，Nle-Trp-His，Lys，Ala-Lys，Nle-Ala-Lys，Orn，Ala-Orn，Nle-Ala-Orn，Ala，Nle-Ala-Ala，Arg，Ala-Arg。 Nle-Ala-Arg，Nle-Ala-DTrp或在式（II）化合物的情况下为键，Z为NH 2，OH和OR，其中R为直链或支链脂族C 1， N，N，N，N，N，N，N，N，N， 2 N，AlaNH 2，TrpOH，NapOH，TpiOH，TicOH，AlaOH，PheNH 2 H或PheOH，可以免除A为对应于乙酸的基团，W是Nle-Ala-His，Z是对映异构体或非对映异构体形式的TrpNH 2 H 2，其混合物包括外消旋混合物。还公开了本发明化合物用于美容化妆品的用途。

5. 发明授权

US07404948B2 Peptidic conjugates for alopecia prevention and treatment 有权
标题翻译：用于秃发预防和治疗的肽类共轭物
公开(公告)号：US07404948B2
公开(公告)日：2008-07-29
申请号：US10565009
申请日：2004-07-16
申请人： Anne-Marie Pinel , Michel Hocquaux
发明人： Anne-Marie Pinel , Michel Hocquaux
IPC分类号： A61K38/06 , A61K38/07 , A61K38/08 , A61K8/64
CPC分类号： C07K7/06 , A61K38/00 , C07K5/0815 , C07K5/1019 , C07K14/66
摘要： The invention relates to novel peptidic conjugates containing a Gly-His-Lys sequence and used for dermatology or cosmetology for stimulating hair growth or stopping hair fall.
摘要翻译：本发明涉及含有Gly-His-Lys序列并用于刺激毛发生长或阻止头发下垂的皮肤病学或美容学的新型肽缀合物。

6. 发明申请

US20070004633A1 Use of peptidic conjugates for preparing compositions for alopecia preventive and curative treatment 有权
标题翻译：使用肽共轭物制备预防和治疗脱发的组合物
公开(公告)号：US20070004633A1
公开(公告)日：2007-01-04
申请号：US10565007
申请日：2004-07-16
申请人： Anne-Marie Pinel , Michel Hocquaux
发明人： Anne-Marie Pinel , Michel Hocquaux
IPC分类号： A61K38/08 , A61K38/06 , C07K7/06
CPC分类号： A61Q7/00 , A23L33/18 , A23V2002/00 , A61K8/64 , A61K38/07 , A61K38/08 , A61K2800/57 , A23V2250/0622 , A23V2250/0624 , A23V2250/063
摘要： The invention relates to the use of peptidic conjugates containing Gly-His-Lys for producing dermatological or cosmetological compositions for stimulating hair growth or stopping hair fall.
摘要翻译：本发明涉及含有Gly-His-Lys的肽结合物用于产生用于刺激头发生长或阻止头发下垂的皮肤病学或美容组合物的用途。

7. 发明申请

US20110251271A1 COSMETIC COMPOSITION WITH ANTI-FREE RADICAL ACTIVITY 有权
标题翻译：具有抗菌活性的化妆品组合物
公开(公告)号：US20110251271A1
公开(公告)日：2011-10-13
申请号：US13165401
申请日：2011-06-21
申请人： Patrice ANDRE , Isabelle Renimel , Celine Godenir , Michel Hocquaux
发明人： Patrice ANDRE , Isabelle Renimel , Celine Godenir , Michel Hocquaux
IPC分类号： A61K8/49 , A61Q19/00 , A61Q90/00
CPC分类号： A61K8/355 , A61K8/447 , A61K8/498 , A61K8/58 , A61K8/676 , A61K8/97 , A61K31/122 , A61K31/197 , A61K31/355 , A61K31/375 , A61K31/41 , A61K33/04 , A61K36/28 , A61K36/47 , A61K45/06 , A61K2800/522 , A61Q1/02 , A61Q17/04 , A61Q19/00 , A61Q19/001 , A61Q19/004 , A61Q19/08 , A61K2300/00
摘要： Cosmetic compositions with anti-free radical activity have been developed. Such compositions preferably contain an association of at least the following three substances with anti-free radical activity: idebenone; N-acetylcysteine, and alpha-tocotrienol or an ester thereof with a C2-C4 organic acid.
摘要翻译：开发了具有抗自由基活性的化妆品组合物。这样的组合物优选含有至少以下具有抗自由基活性的三种物质的缔合：艾地苯醌; N-乙酰半胱氨酸和α-生育三烯酚或其与C 2 -C 4有机酸的酯。

8. 发明申请

US20110250304A1 COSMETIC COMPOSITION WITH ANTI-FREE RADICAL ACTIVITY 有权
标题翻译：具有抗菌活性的化妆品组合物
公开(公告)号：US20110250304A1
公开(公告)日：2011-10-13
申请号：US13165453
申请日：2011-06-21
申请人： Patrice ANDRE , Isabells Renimel , Celine Godenir , Michel Hocquaux
发明人： Patrice ANDRE , Isabells Renimel , Celine Godenir , Michel Hocquaux
IPC分类号： A61K8/97 , A61Q90/00 , A61Q19/00
CPC分类号： A61K8/355 , A61K8/447 , A61K8/498 , A61K8/58 , A61K8/676 , A61K8/97 , A61K31/122 , A61K31/197 , A61K31/198 , A61K31/375 , A61K31/41 , A61K33/04 , A61K36/28 , A61K36/47 , A61K45/06 , A61K2800/522 , A61Q1/02 , A61Q17/04 , A61Q19/00 , A61Q19/001 , A61Q19/004 , A61Q19/08 , A61K2300/00
摘要： Cosmetic compositions with anti-free radical activity have been developed. Such compositions preferably contain an association of at least the following three substances with anti-free radical activity: an extract of emblica, idebenone and N-acetylcysteine.
摘要翻译：开发了具有抗自由基活性的化妆品组合物。这样的组合物优选含有至少以下三种具有抗自由基活性的物质的缔合：栓剂，艾地苯醌和N-乙酰半胱氨酸的提取物。

9. 发明授权

US5132106A Halogenated pyrimidine 3-oxide derivatives, their use for the treatment and prevention of hair loss and for stimulating its regrowth 失效
标题翻译：卤代嘧啶3-氧化物衍生物，它们用于治疗和预防脱发和刺激其再生长
公开(公告)号：US5132106A
公开(公告)日：1992-07-21
申请号：US551534
申请日：1990-07-12
申请人： Remy Tuloup , Alex Junino , Michel Hocquaux , Jacqueline Dumats , Quintino Gaetani
发明人： Remy Tuloup , Alex Junino , Michel Hocquaux , Jacqueline Dumats , Quintino Gaetani
IPC分类号： A61K8/00 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/365 , A61K8/37 , A61K8/39 , A61K8/42 , A61K8/49 , A61K31/505 , A61P17/00 , A61Q5/00 , A61Q5/02 , A61Q7/00 , C07D239/48
CPC分类号： A61K8/4953 , A61Q7/00 , C07D239/48
摘要： The invention relates to compounds of formula: ##STR1## in which: R.sub.1 and R.sub.2 denote, independently of one another, a hydrogen atom or alternatively a carbamoyl group of formula: ##STR2## with R'.sub.3 denoting hydrogen or R.sub.3 ; an alkoxycarbonyl group of formula: ##STR3## or an acyl group of formula: ##STR4## in which formulae R.sub.3 denotes an alkyl, alkenyl or cycloalkyl radical; R.sub.3 can also denote an aryl or aralkyl radical; andR denotes a linear or braanched C.sub.1 -C.sub.8 alkyl radical substituted with one or more halogen atoms, and to their use for the treatment and prevention of hair loss and for stimulating its regrowth.
摘要翻译：本发明涉及下式的化合物：其中：R 1和R 2彼此独立地表示氢原子或者另外可以是具有式（B）的氨基甲酰基，其中R 3表示氢原子或R3; （C）的酰氧基或式（Ⅵ）的酰基，式中R 3表示烷基，链烯基或环烷基; R3也可以表示芳基或芳烷基; 并且R表示被一个或多个卤素原子取代的直链或bra ched的C 1 -C 8烷基，并且用于治疗和预防脱发并刺激其再生长。

10. 发明授权

US4895575A Use of 5-hydroxynaphthoquinones for dyeing human keratin fibres 失效
标题翻译：使用5-羟基萘醌染色人角蛋白纤维
公开(公告)号：US4895575A
公开(公告)日：1990-01-23
申请号：US210506
申请日：1988-06-23
申请人： Michel Hocquaux , Jean Cotteret , Georges Rosenbaum
发明人： Michel Hocquaux , Jean Cotteret , Georges Rosenbaum
IPC分类号： A61K8/00 , A61K20060101 , A61K8/35 , A61K8/40 , A61K8/73 , A61Q5/02 , A61Q5/10 , C07C20060101 , C09B20060101 , C09B61/00 , C11D3/40 , D06P3/04 , D06P3/14
CPC分类号： A61K8/355 , A61Q5/065 , A61K2800/432
摘要： The invention relates to the use of 5-hydroxy-1,4-naphthoquinones of the formula: ##STR1## in which R.sub.1 and R.sub.2, which are identical or different, independently of one another denote a hydrogen atom, a methyl, methoxy or nitro group or a halogen atom; R.sub.3 and R.sub.4, which are identical or different, independently of one another denote a hydrogen atom or a hydroxyl, methyl or methoxy group; and R.sub.5 denotes a hydrogen atom or a methyl or methoxy group, with the proviso that at least one of the substituents R.sub.1 and R.sub.2 is different from hydrogen, if R.sub.3, R.sub.4 and R.sub.5 simultaneously denote a hydrogen atom, for dyeing human keratin fibres, in particular the hair.
摘要翻译：本发明涉及下式的5-羟基-1,4-萘醌的用途：其中相同或不同的相同或不同的R 1和R 2彼此表示氢原子，甲基，甲氧基或硝基或卤素原子; R 3和R 4相同或不同，彼此独立地表示氢原子或羟基，甲基或甲氧基; 并且R 5表示氢原子或甲基或甲氧基，条件是至少一个取代基R 1和R 2不同于氢，如果R 3，R 4和R 5同时表示氢原子，用于染色人角蛋白纤维，特别是头发。

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