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1. 发明申请

US20070275962A1 Heterobicyclic Compounds as Pharmaceutically Active Agents 审中-公开
标题翻译：异双环化合物作为药物活性剂
公开(公告)号：US20070275962A1
公开(公告)日：2007-11-29
申请号：US10597120
申请日：2004-09-10
申请人： Anil Koul , Bert Klebl , Gerhard Muller , Andrea Missio , Wilfried Schwab , Doris Hafenbradl , Lars Neumann , Marc-Nicola Sommer , Stefan Muller , Edmund Hoppe , Achim Freisleben , Alexander Backes , Christian Hartung , Beatrice Felber , Birgit Zech , Ola Engkvist , Gyorgy Keri , Laszlo Orfi , Peter Banhegyi , Zoltan Greff , Zoltan Horvath , Zoltan Varga , Peter Marko , Janos Pato , Istvan Szabadkai , Zsolt Szekelyhid , Frigyes Waczek
发明人： Anil Koul , Bert Klebl , Gerhard Muller , Andrea Missio , Wilfried Schwab , Doris Hafenbradl , Lars Neumann , Marc-Nicola Sommer , Stefan Muller , Edmund Hoppe , Achim Freisleben , Alexander Backes , Christian Hartung , Beatrice Felber , Birgit Zech , Ola Engkvist , Gyorgy Keri , Laszlo Orfi , Peter Banhegyi , Zoltan Greff , Zoltan Horvath , Zoltan Varga , Peter Marko , Janos Pato , Istvan Szabadkai , Zsolt Szekelyhid , Frigyes Waczek
IPC分类号： C07D495/04 , A61P31/04 , C07D209/42 , C07D333/66 , C07D333/68 , C07D495/10 , C07D409/12 , C07D413/14 , C07D491/04 , C07D493/04
CPC分类号： C07D409/12 , C07D209/42 , C07D333/66 , C07D333/68 , C07D491/04 , C07D493/04 , C07D495/04 , C07D495/10
摘要： Described are heterobicyclic compounds such as 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]thiopyran 3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid amides, or benzo[b]thiophene-3-carboxylic acid amides and pharmaceutically acceptable salts thereof, the use of these derivatives for the prophylaxis and/or treatment of various diseases such as infectious diseases, including mycobacteriainduced infections and opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, as well as compositions containing at least one heterobicyclic compound and/or pharmaceutically acceptable salts thereof. Furthermore, reaction procedures for the synthesis of the heterobicyclic compound are disclosed.
摘要翻译：描述的是杂双环化合物，例如4,5,6,7-四氢苯并[b]噻吩-3-羧酸酰胺，4,7-二氢-5H-噻吩并[2,3-c]噻喃-3-羧酸酰胺，4 ，7-二氢-5H-噻吩并[2,3-c]吡喃-3-羧酸酰胺或苯并[b]噻吩-3-羧酸酰胺及其药学上可接受的盐，这些衍生物用于预防和 /或治疗诸如感染性疾病，包括分泌细菌感染和机会性疾病，朊病毒疾病，免疫疾病，自身免疫疾病，双相和临床病症，心血管疾病，细胞增殖性疾病，糖尿病，炎症，移植排斥，勃起功能障碍，神经变性疾病和中风，以及含有至少一种杂双环化合物和/或其药学上可接受的盐的组合物。此外，公开了用于合成杂双环化合物的反应程序。

2. 发明申请

US20070191344A1 Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases 有权
标题翻译：药物活性的4,6-二取代氨基嘧啶衍生物作为蛋白激酶的调节剂
公开(公告)号：US20070191344A1
公开(公告)日：2007-08-16
申请号：US10572043
申请日：2004-09-15
申请人： Axel Choidas , Alexander Backes , Matt Cotten , Ola Engkvist , Beatrice Felber , Achim Freisleben , Klaus Godl , Zoltan Greff , Peter Habenberger , Doris Hafenbradl , Christian Hartung , Thomas Herget , Edmund Hoppe , Bert Klebl , Andrea Missio , Gerhard Muller , Wilfried Schwab , Birgit Zech , Jose Bravo , John Harris , Joelle Le , Jackie Macritchie , Vladimir Savic , Brad Sherborne , Don Simpson
发明人： Axel Choidas , Alexander Backes , Matt Cotten , Ola Engkvist , Beatrice Felber , Achim Freisleben , Klaus Godl , Zoltan Greff , Peter Habenberger , Doris Hafenbradl , Christian Hartung , Thomas Herget , Edmund Hoppe , Bert Klebl , Andrea Missio , Gerhard Muller , Wilfried Schwab , Birgit Zech , Jose Bravo , John Harris , Joelle Le , Jackie Macritchie , Vladimir Savic , Brad Sherborne , Don Simpson
IPC分类号： A61K31/55 , A61K31/506 , C07D403/02
CPC分类号： C04B35/632 , C07D239/42 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present invention relates to 4,6-disubstituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, and pharmaceutical compositions containing at least one of said 4,6-di substituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said 4,6-disubstituted aminopyrimidine derivatives as inhibitors for a protein kinase and a medium comprising at least one of said 4,6-disubstituted aminopyrimidine derivatives in an immobilized form and the use of said medium for enriching, purifying and/or depleting nucleotide binding proteins which bind to the immobilized 4,6-disubstituted aminopyrimidine derivatives.
摘要翻译：本发明涉及4,6-二取代的氨基嘧啶衍生物和/或其药学上可接受的盐，这些衍生物作为药物活性剂的用途，特别是用于预防和/或治疗感染性疾病，包括机会性疾病，朊病毒疾病，免疫学疾病，自身免疫疾病，双相和临床疾病，心血管疾病，细胞增殖性疾病，糖尿病，炎症，移植排斥，勃起功能障碍，神经变性疾病和中风，以及含有所述4,6-二取代氨基嘧啶衍生物和 /或其药学上可接受的盐。此外，本发明涉及所述4,6-二取代氨基嘧啶衍生物作为蛋白激酶的抑制剂和包含至少一种固定化形式的所述4,6-二取代氨基嘧啶衍生物的介质和使用所述培养基用于富集，纯化和/或消除与固定的4,6-二取代氨基嘧啶衍生物结合的核苷酸结合蛋白。

3. 发明申请

US20080207677A1 Napthyridine Compounds As Rock Inhibitors 审中-公开
标题翻译：萘啶化合物作为岩石抑制剂
公开(公告)号：US20080207677A1
公开(公告)日：2008-08-28
申请号：US11813236
申请日：2006-01-02
申请人： Stefan Muller , Wilfried Schwab , Bert Klebl , Doris Hafenbradl , Edmund Hoppe , Zoltan Horvath , Gyorgy Keri , Zoltan Varga , Laszlo Orfi , Jeno Marosfalvi , Gerhard Muller
发明人： Stefan Muller , Wilfried Schwab , Bert Klebl , Doris Hafenbradl , Edmund Hoppe , Zoltan Horvath , Gyorgy Keri , Zoltan Varga , Laszlo Orfi , Jeno Marosfalvi , Gerhard Muller
IPC分类号： A61K31/4375 , C07D471/04 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention relates to compounds having a naphthyridine scaffold, and stereoisomeric forms, prodrugs, solvates, hydrates and/or pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions containing at least one of these naphthyridine derivatives together with pharmaceutically acceptable carrier, excipient and/or diluents. Said naphthyridine compounds have been identified as inhibitors of the protein kinase ROCK2, also known as Rho-kinase, and are useful for the treatment of cancers (tumor growth and metastases), erectile dysfunction, cardiovascular diseases, hypertension, angina pectoris, cerebral ischaemia, cerebral vasospasm, myocardial ischaemia, coronary vasospasm, heart failure, myocardial hypertrophy, atherosclerosis, restenosis, spinal cord injuries, neuronal degeneration, thrombotic disorders, asthma, glaucoma, inflammation, anti-viral diseases (e.g. HIV), and osteoporosis.
摘要翻译：本发明涉及具有萘啶支架的化合物，以及这些化合物的立体异构形式，前体药物，溶剂合物，水合物和/或药学上可接受的盐，以及含有这些萘啶衍生物中至少一种以及药学上可接受的载体，赋形剂和 /或稀释剂。所述萘啶化合物已被鉴定为蛋白激酶ROCK2（也称为Rho-激酶）的抑制剂，可用于治疗癌症（肿瘤生长和转移），勃起功能障碍，心血管疾病，高血压，心绞痛，脑缺血，脑血管痉挛，心肌缺血，冠状动脉血管痉挛，心力衰竭，心肌肥大，动脉粥样硬化，再狭窄，脊髓损伤，神经元变性，血栓形成障碍，哮喘，青光眼，炎症，抗病毒疾病（例如HIV）和骨质疏松症。

4. 发明授权

US08667689B2 Method and arrangement for supplying essentially hollow bodies with equipment 有权
标题翻译：用于为基本上空心体供给设备的方法和装置
公开(公告)号：US08667689B2
公开(公告)日：2014-03-11
申请号：US11786927
申请日：2007-04-13
申请人： Eckart Frankenberger , Eike Klemkow , Horst Zapp , Gerhard Muller , Holger Frauen
发明人： Eckart Frankenberger , Eike Klemkow , Horst Zapp , Gerhard Muller , Holger Frauen
IPC分类号： B21D39/03
CPC分类号： B64F5/50 , B64F5/10 , Y10T29/49622 , Y10T29/49828 , Y10T29/49829 , Y10T29/53548
摘要： Method and arrangement for supplying essentially hollow bodies with equipment wherein the hollow bodies each have a transverse dimension and a longitudinal dimension being larger than the transverse dimension. The bodies have at least one opening for accessing their interior from outside along their longitudinal dimension. The hollow bodies are arranged essentially side-by-side along the longitudinal dimension and they are moved along their transverse dimension in a clocked fashion. An arrangement comprises a plurality of conveyor means for moving hollow bodies, wherein the conveyor means are arranged such that the hollow bodies are arranged side-by-side along their longitudinal dimension and moved along their transverse dimension in a clocked fashion.
摘要翻译：用于向基本上具有中空体的设备供应设备，其中中空体各自具有横向尺寸和纵向尺寸大于横向尺寸。主体具有至少一个开口，用于沿其纵向尺寸从外部进入其内部。中空体沿着纵向尺寸基本上并排布置，并且它们以其时钟方式沿其横向尺寸移动。一种装置包括用于移动中空体的多个传送装置，其中传送装置被布置成使得中空体沿着它们的纵向尺寸并排布置，并且以它们的横向尺寸以时钟方式移动。

5. 发明授权

US07064229B2 Succinic acid derivatives 失效
标题翻译：琥珀酸衍生物
公开(公告)号：US07064229B2
公开(公告)日：2006-06-20
申请号：US10482860
申请日：2002-06-24
申请人： Thomas Rolle , Thomas Lehmann , Markus Albers , Gerhard Muller , Gerhard Hessler , Rudiger Fischer , Masaomi Tajimi , Karl Ziegelbauer , Kevin Bacon , Haruki Hasegawa , Hiromi Okigami
发明人： Thomas Rolle , Thomas Lehmann , Markus Albers , Gerhard Muller , Gerhard Hessler , Rudiger Fischer , Masaomi Tajimi , Karl Ziegelbauer , Kevin Bacon , Haruki Hasegawa , Hiromi Okigami
IPC分类号： C07C229/00 , A61K31/24
CPC分类号： C07C233/55 , C07C275/40
摘要： The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of inflammatory diseases
摘要翻译：本发明涉及通式（I）的化合物，其制备方法，含有它们的药物组合物及其用于制备用于治疗炎性疾病的药物组合物的用途

6. 发明授权

US6042126A Snowboard and anchoring system for attachment of a binding of similar function element thereto 失效
标题翻译：用于将类似功能元件的绑定附接到其上的滑雪板和锚固系统
公开(公告)号：US6042126A
公开(公告)日：2000-03-28
申请号：US845
申请日：1997-12-30
申请人： Gerhard Muller , Franz Lindner
发明人： Gerhard Muller , Franz Lindner
IPC分类号： A63C5/03 , A63C9/00 , B62B9/04 , F16B39/282
CPC分类号： A63C9/00 , A63C5/03
摘要： A surf-type board, such as a snowboard. Several threaded sleeves which are anchored in the body of the surf-type board and each have an inner thread accessible from the top of the body of the surf-type board, and which form an anchoring system for attachment of a binding or similar function element to the body of the surf-type board, and to an anchoring system for a binding or similar function element to be attached to the top of a surf-type board.
摘要翻译：冲浪板，如滑雪板。几个螺纹套筒锚定在冲浪板的主体中，并且每个具有可从冲浪板的主体的顶部接近的内螺纹，并且其形成用于附接结合或类似功能元件的锚定系统到冲浪板的主体，以及用于绑定或类似功能元件的锚固系统以附接到冲浪板的顶部。

7. 发明授权

US5866540A Cyclic adhesion inhibitors 失效
标题翻译：环状粘连抑制剂
公开(公告)号：US5866540A
公开(公告)日：1999-02-02
申请号：US368760
申请日：1995-01-04
申请人： Alfred Jonczyk , Gunter Holzemann , Brunhilde Felding-Habermann , Guido Melzer , Beate Diefenbach , David A. Cheresh , Horst Kessler , Marion Gurrath , Gerhard Muller
发明人： Alfred Jonczyk , Gunter Holzemann , Brunhilde Felding-Habermann , Guido Melzer , Beate Diefenbach , David A. Cheresh , Horst Kessler , Marion Gurrath , Gerhard Muller
IPC分类号： A61K38/00 , A61K38/12 , A61P7/02 , A61P9/00 , A61P9/10 , A61P17/02 , A61P19/08 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07K7/64 , C07K14/75 , C07K14/78 , C07K7/54
CPC分类号： C07K14/75 , C07K14/78 , A61K38/00
摘要： The present invention relates to pharmaceutical compositions which contain at least one cyclopeptide of formula I (a)-(r):(a) cyclo(-Arg-Gly-Asp-D-Phe-Val-Ala);(b) cyclo(-Arg-Gly-Asp-D-Phe-Leu-Ala);(c) cyclo(-Arg-Gly-Asp-Phe-Val-D-Ala);(d) cyclo(-Arg-Gly-Asp-Phe-Leu-D-Ala);(e) cyclo(-Arg-Gly-Asp-D-Phe-Val-Gly);(f) cyclo(-Arg-Gly-Asp-D-Phe-Leu-Gly);(g) cyclo(-D-Arg-Gly-Asp-Phe-Val-Ala);(h) cyclo(-D-Arg-Gly-Asp-Phe-Val-Gly);(i) cyclo(-Arg-Gly-Asp-Phe-Pro-Gly);(j) cyclo(-Arg-Gly-Asp-Phe-D-Pro-Gly);(k) cyclo(-Arg-Gly-Asp-Phe-Pro-Ala);(l) cyclo(-Arg-Gly-Asp-Phe-D-Pro-Ala);(m) cyclo(-D-Arg-Gly-Asp-Phe-Val);(n) cyclo(-Arg-D-Ala-Asp-Phe-Val);(o) cyclo(-Arg-Gly-Asp-D-Phe-Val);(p) cyclo(-Arg-Ala-Asp-D-Phe-Val);(q) cyclo(-Arg-Gly-Asp-Phe-D-Val);(r) cyclo(-Arg-Gly-D-Asp-Phe-Val);or a salt thereof. The pharmaceutical compositions can be used as cell adhesion inhibitors, e.g., in the treatment of thrombosis, myocardial infarct, apoplexy, arteriosclerosis, inflammations, angina pectoris, and/or tumors.
摘要翻译：本发明涉及含有至少一种式I（a） - （r）的环肽的药物组合物：（a）环（-Arg-Gly-Asp-D-Phe-Val-Ala）; （b）环（-Arg-Gly-Asp-D-Phe-Leu-Ala）; （c）环（-Arg-Gly-Asp-Phe-Val-D-Ala）; （d）环（-Arg-Gly-Asp-Phe-Leu-D-Ala）; （e）环（-Arg-Gly-Asp-D-Phe-Val-Gly）; （f）环（-Arg-Gly-Asp-D-Phe-Leu-Gly）; （g）环（-D-Arg-Gly-Asp-Phe-Val-Ala）; （h）环（-D-Arg-Gly-Asp-Phe-Val-Gly）; （i）环（-Arg-Gly-Asp-Phe-Pro-Gly）; （j）环（-Arg-Gly-Asp-Phe-D-Pro-Gly）; （k）环（-Arg-Gly-Asp-Phe-Pro-Ala）; （1）环（-Arg-Gly-Asp-Phe-D-Pro-Ala）; （m）环（-D-Arg-Gly-Asp-Phe-Val）; （n）环（-Arg-D-Ala-Asp-Phe-Val）; （o）环（-Arg-Gly-Asp-D-Phe-Val）; （p）环（-Arg-Ala-Asp-D-Phe-Val）; （q）环（-Arg-Gly-Asp-Phe-D-Val）; （r）环（-Arg-Gly-D-Asp-Phe-Val）; 或其盐。药物组合物可用作细胞粘附抑制剂，例如用于治疗血栓形成，心肌梗塞，中风，动脉硬化，炎症，心绞痛和/或肿瘤。

8. 发明授权

US5690834A Process and apparatus for separating off suspended matter from liquids 失效
标题翻译：用于将悬浮物质与液体分离的方法和装置
公开(公告)号：US5690834A
公开(公告)日：1997-11-25
申请号：US553697
申请日：1995-12-01
申请人： Horst Bennoit , Gerhard Muller , Friedhelm Zorn
发明人： Horst Bennoit , Gerhard Muller , Friedhelm Zorn
IPC分类号： B03D1/04 , B03D1/24 , B03D1/26 , C02F1/24 , C02F3/22
CPC分类号： B03D1/1431 , B03D1/247 , C02F1/24 , C02F3/223 , B03D1/1412 , Y02W10/15
摘要： In the process for separating off by flotation (pressure release) suspended matter from liquids which are present in a gas-introduction reactor, the suspension to be withdrawn for flotation is conducted at a flow velocity .ltoreq.0.3 m/s against the natural direction of bubble rise, gas being additionally introduced into the suspension. The gas-treated suspension is withdrawn at the bottom of the gas-introduction apparatus and it is fed to flotation.
摘要翻译： PCT No.PCT / EP95 / 01156 Sec。 371 1995年12月1日第 102（e）1995年12月1日日期PCT 1995年3月28日PCT PCT。 WO95 / 27566 PCT公开号日期1995年10月19日在通过浮选（压力释放）悬浮物质从存在于气体导入反应器中的液体中分离的方法中，待浮出的悬浮液以流速为0.3m / 反对气泡上升的自然方向，气体另外被引入到悬浮液中。气体处理的悬浮液在气体引入装置的底部被抽出，并被送入浮选。

9. 发明授权

US5294266A Process for a passivating postrinsing of conversion layers 失效
标题翻译：转化层的钝化方法
公开(公告)号：US5294266A
公开(公告)日：1994-03-15
申请号：US978193
申请日：1992-11-18
申请人： Dieter Hauffe , Thomas Kolberg , Gerhard Muller , Horst Gehmecker , Werner Rausch , Peter Schubach , Thomas Wendel
发明人： Dieter Hauffe , Thomas Kolberg , Gerhard Muller , Horst Gehmecker , Werner Rausch , Peter Schubach , Thomas Wendel
IPC分类号： C23C22/34 , C23C22/36 , C23C22/60 , C23C22/83
CPC分类号： C23C22/73 , C23C22/34 , C23C22/361 , C23C22/60 , C23C22/83
摘要： The invention is in a composition and process for the chromium free passivating postrinsing of conversion layers on metals before the application of a paint or adhesive. The conversion layers can be on the bases of phosphate layers, at least two polyvalent metal ions with complex formers, titanium, zirconium and/or hafnium. The postrinsing agent is an aqueous solution which has been adjusted to a pH value of up to 5 and which contains an aluminum fluorozirconate having an Al:Zr:F mole ratio of (0.15 to 8.0):1:(5 to 52), and in which solutions the total concentration of Al+Zr+F is 0.1 to 8.0 g/l. The postrinsing solutions may additionally contain at least one of the anions benzoate, caprylate, ethyl hexoate, salicylate in a total concentration of 0.05 to 0.5 g/1 and may preferably be adjusted to the required pH value with cations of volatile bases, such as ammonium, ethanolammonium and di- and triethanolammonium. The paint is subsequently applied suitably by cathodic electrocoating or powder coating or from a low-solvent high-solids paint.The rinsing treatment is over a period of 1 to 120 seconds at temperatures of 20.degree. to 80.degree. C. The invention is used as a pretreatment to the application of a paint coating, film coating or adhesive coating.
摘要翻译：本发明是用于在施加涂料或粘合剂之前的金属上的转化层的无铬钝化的组合物和方法。转化层可以在磷酸盐层，至少两种具有复合成型剂的多价金属离子，钛，锆和/或铪的基础上。 postrinsing剂是一种水溶液，其pH值调至5以下，并含有Al：Zr：F摩尔比为（0.15〜8.0）：1：（5〜52）的氟锆酸铝，其中Al + Zr + F的总浓度为0.1〜8.0g / l。 postrinsing溶液还可以含有至少一种阴离子苯甲酸酯，辛酸酯，己酸乙酯，水杨酸酯，总浓度为0.05至0.5g / l，并且可优选用挥发性碱如铵的阳离子调节至所需的pH值，乙醇铵和二乙醇胺和三乙醇铵。随后通过阴极电涂或粉末涂料或低溶剂高固体涂料适当地施涂涂料。在20〜80℃的温度下，漂洗处理时间为1〜120秒。本发明用作涂料涂料，薄膜包衣或粘合剂涂料的预处理。

10. 发明授权

US5138850A Spring biased pattern bars having electromagnetic selectors 失效
标题翻译：具有电磁选择器的弹簧偏心图案条
公开(公告)号：US5138850A
公开(公告)日：1992-08-18
申请号：US743981
申请日：1991-08-12
申请人： Gerhard Muller , Werner Engelfried
发明人： Gerhard Muller , Werner Engelfried
IPC分类号： D04B15/34 , D04B15/68 , D04B15/82
CPC分类号： D04B15/68
摘要： A circular knitting machine having knitting needles actuated by pattern bars, electromagnetic selectors for adjusting the knitting needles into various operating positions, mechanical controls cooperating with the electromagnetic selectors, selector elements biased by springs and slidingly displaceable in the pattern bars as well as first and second control cams for pivoting the pattern bars. Only one single, spring-biased selector element is mounted for displacement in each pattern bar. The electromagnetic selectors have individually controllable magnetic poles which are arranged one behind the other in the direction of rotation of the needle cylinder.
摘要翻译：一种圆形针织机，其具有由图案棒致动的织针，用于将织针调节到各种操作位置的电磁选择器，与电磁选择器配合的机械控制器，由弹簧偏置并在图案条中滑动移位的选择器元件以及第一和第二用于枢转图案条的控制凸轮。只有一个单一的弹簧偏置选择器元件安装在每个图案条中的位移。电磁选择器具有在针筒旋转方向上一个接一个地布置的可独立控制的磁极。

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