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1. 发明授权

US5807291A Method of forming an orthopedic cast 失效
标题翻译：成形矫形方法
公开(公告)号：US5807291A
公开(公告)日：1998-09-15
申请号：US450407
申请日：1995-05-25
申请人： Andrew W. Larson , Steven P. Bitler , Lawrence C. Greene , David D. Taft , Ray F. Stewart , Valentine Y. Yoon , Thomas W. Ross , David A. Kamp , Edward E. Schmitt
发明人： Andrew W. Larson , Steven P. Bitler , Lawrence C. Greene , David D. Taft , Ray F. Stewart , Valentine Y. Yoon , Thomas W. Ross , David A. Kamp , Edward E. Schmitt
IPC分类号： A61F5/058 , A61F13/04 , A61L15/12 , A61F5/00
CPC分类号： A61L15/12 , A61F13/04 , A61F5/058 , A61F13/041 , Y10S264/71 , Y10S428/913 , Y10S524/921 , Y10T428/1314 , Y10T428/1328 , Y10T428/1334 , Y10T428/1362 , Y10T428/1372 , Y10T428/1376 , Y10T428/1386 , Y10T428/139 , Y10T428/1393 , Y10T428/24322 , Y10T428/24331 , Y10T442/2811
摘要： Orthopedic casts which comprise an elastically deformed support which is held in its elastically deformed state by a solid casting composition. After the cast has been placed around a patient's limb, it is heated to soften the casting composition, thus permitting recovery of the cast into conforming contact with the limb. The support can for example be a fabric knitted from elastomeric fibers and glass fiber yarns. The casting composition can for example comprise polycaprolactone and/or a side chain crystallizable polymer, which melts at 45.degree.-60.degree. C. A padded liner can be placed between the cast and the limb. Recovery of the cast is preferably carried out by means of a hot air gun.
摘要翻译：整形矫形器，其包括通过固体铸造组合物保持在其弹性变形状态的弹性变形的支撑件。在将铸件放置在患者肢体周围之后，将其加热以使铸件组合物软化，从而允许将铸件回收成与肢体的适形接触。支撑体可以例如是由弹性体纤维和玻璃纤维纱线编织的织物。铸塑组合物可以例如包括聚己内酯和/或侧链可结晶聚合物，其在45°-60℃熔化。填充衬垫可以放置在铸件和肢体之间。铸件的回收优选通过热风枪进行。

2. 发明授权

US5752926A Orthopedic casts 失效
标题翻译：矫形外科
公开(公告)号：US5752926A
公开(公告)日：1998-05-19
申请号：US150683
申请日：1993-11-09
申请人： Andrew W. Larson , Steven P. Bitler , Lawrence C. Greene , David D. Taft , Ray F. Stewart , Valentine Y. Yoon , Thomas W. Ross , David A. Kamp , Edward E. Schmitt
发明人： Andrew W. Larson , Steven P. Bitler , Lawrence C. Greene , David D. Taft , Ray F. Stewart , Valentine Y. Yoon , Thomas W. Ross , David A. Kamp , Edward E. Schmitt
IPC分类号： A61F5/058 , A61F13/04 , A61L15/12 , A61F5/01
CPC分类号： A61L15/12 , A61F13/04 , A61F5/058 , A61F13/041 , Y10S264/71 , Y10S428/913 , Y10S524/921 , Y10T428/1314 , Y10T428/1328 , Y10T428/1334 , Y10T428/1362 , Y10T428/1372 , Y10T428/1376 , Y10T428/1386 , Y10T428/139 , Y10T428/1393 , Y10T428/24322 , Y10T428/24331 , Y10T442/2811
摘要： Orthopedic casts which comprise an elastically deformed support which is held in its elastically deformed state by a solid casting composition. After the cast has been placed around a patient's limb, it is heated to soften the casting composition, thus permitting recovery of the cast into conforming contact with the limb. The support can for example be a fabric knitted from elastomeric fibers and glass fiber yarns. The casting composition can for example comprise polycaprolactone and/or a side chain crystallizable polymer, which melts at 45.degree.-60.degree. C. A padded liner can be placed between the cast and the limb. Recovery of the cast is preferably carried out by means of a hot air gun.
摘要翻译：整形矫形器，其包括通过固体铸造组合物保持在其弹性变形状态的弹性变形的支撑件。在将铸件放置在患者肢体周围之后，将其加热以使铸件组合物软化，从而允许将铸件回收成与肢体的适形接触。支撑体可以例如是由弹性体纤维和玻璃纤维纱线编织的织物。铸塑组合物可以例如包括聚己内酯和/或侧链可结晶聚合物，其在45°-60℃熔化。填充衬垫可以放置在铸件和肢体之间。铸件的回收优选通过热风枪进行。

3. 发明授权

US5412035A Pressure-sensitive adhesives 失效
标题翻译：压敏粘合剂
公开(公告)号：US5412035A
公开(公告)日：1995-05-02
申请号：US928800
申请日：1992-08-12
申请人： Edward E. Schmitt , Raymond Clarke , Andrew W. Larson , Steven P. Bitler , Ross S. Tsugita , Donald A. Schultz
发明人： Edward E. Schmitt , Raymond Clarke , Andrew W. Larson , Steven P. Bitler , Ross S. Tsugita , Donald A. Schultz
IPC分类号： C08F8/00 , C08F12/00 , C08F212/12 , C08F220/10 , C08F220/18 , C08L29/10 , C09J7/00 , C09J7/02 , C09J9/00 , C09J109/06 , C09J121/00 , C09J133/00 , C09J133/04 , C09J133/06 , C09J151/00 , C09J201/00 , C08L53/00 , B32B7/12 , A61F13/02
CPC分类号： C09J109/06 , C09J133/06 , C09J2201/606 , Y10T428/1452 , Y10T428/1462 , Y10T428/24843 , Y10T428/2839 , Y10T428/2852
摘要： Pressure-sensitive adhesive (PSA) compositions containing a crystalline polymeric additive having an M.sub.w of less than 25,000 and a melting point (T.sub.a) greater than 23.degree. C., preferably 30.degree. to 60.degree. , and PSA composites of a backing, preferably a flexible backing, with such a PSA composition coated thereon. The presence of the additive causes the PSA to lose adhesive strength when heated to T.sub.a. The base resin of the PSA is preferably a polyacrylate or a styrene/butadiene copolymer. The additive, which is preferably present in amount 1 to 35%, e.g. 5 to 30%, is preferably a side chain crystallizable (SCC) polymer.
摘要翻译：含有Mw小于25,000，熔点（Ta）大于23℃，优选30-60℃的结晶聚合物添加剂的压敏粘合剂（PSA）组合物和背衬的PSA复合材料，优选为柔性背衬，其上涂覆有这样的PSA组合物。添加剂的存在导致PSA在加热到Ta时失去粘合强度。 PSA的基础树脂优选为聚丙烯酸酯或苯乙烯/丁二烯共聚物。该添加剂优选以1至35％的量存在，例如。 5〜30％优选为侧链可结晶（SCC）聚合物。

4. 发明授权

US07291389B1 Article having temperature-dependent shape 有权
标题翻译：文章具有温度依赖的形状
公开(公告)号：US07291389B1
公开(公告)日：2007-11-06
申请号：US10777520
申请日：2004-02-12
申请人： Steven P. Bitler , Edward E. Schmitt , Quiang Zheng
发明人： Steven P. Bitler , Edward E. Schmitt , Quiang Zheng
IPC分类号： B32B7/02 , B65B53/00 , D02G3/00
CPC分类号： D01F8/04 , D02G1/18 , Y10T428/1328 , Y10T428/24942 , Y10T428/2913 , Y10T428/2924 , Y10T428/2929 , Y10T428/2931 , Y10T442/638 , Y10T442/641
摘要： Articles, particularly fibers, whose shape is dependent on temperature. The articles have a first component composed of a sharply-melting crystalline polymer and an overlapping second component. As the crystalline polymer is cooled through its melting range, the volume of the first component increases much more rapidly than the volume of the second component. As a result, the shape of the article changes. Such fibers can be incorporated into fibrous articles having temperature-dependent thermal insulation properties.
摘要翻译：制品，特别是纤维，其形状取决于温度。制品具有由锐利熔融的结晶聚合物和重叠的第二组分组成的第一组分。当结晶聚合物在其熔融范围内被冷却时，第一组分的体积比第二组分的体积快得多。结果，物品的形状改变了。这种纤维可以掺入具有温度依赖性热绝缘性能的纤维制品中。

5. 发明授权

US4155992A Pharmaceutical composition of poly(orthoester) co- and homopolymers and poly(orthocarbonate) co- and homopolymers having carbonyloxy functionality with drug 失效
标题翻译：具有羰基氧基官能团的聚（原酸酯）共聚物和均聚物和聚（原碳酸酯）共聚物和均聚物的药物组合物
公开(公告)号：US4155992A
公开(公告)日：1979-05-22
申请号：US843750
申请日：1977-10-19
申请人： Edward E. Schmitt
发明人： Edward E. Schmitt
IPC分类号： A61K9/20 , C05G3/00 , C08G65/34 , A61K9/22 , A61K9/32 , A61K9/58 , A61K31/765
CPC分类号： C08G65/34 , A61K9/204 , C05G3/0029
摘要： Poly(orthoester) co- and homopolymers and poly(orthocarbonate) co- and homopolymers comprising (1) a repeating dioxycarbon unit in the polymeric backbone having a plurality of organic groups pendant therefrom, and (2) a bridging moiety having at least one carbonyloxy group contained therein are disclosed. The polymers are represented by the formula: ##STR1## WHEREIN R is a bridging moiety and is either R.sub.1 or R.sub.2 arranged in a random manner along the polymeric backbone to form a copolymer containing both R.sub.1 and R.sub.2 with R.sub.1 an aliphatic, an alicyclic or an aromatic group and R.sub.2 is a ##STR2## GROUP WITH R.sub.1 as defined and R.sub.3 an aliphatic, an alicyclic or aromatic group, or wherein R is a bridging moiety and is only R.sub.2 to form a homopolymer with R.sub.1, R.sub.2, and R.sub.3 as defined above, and a is 0 to 1, b is 2 to 6, and n and the sum of x and y are positive integers. The copolymers are useful for making articles of manufacture, including devices and coatings for delivering beneficial agents.
摘要翻译：聚（原酸酯）共聚物和均聚物和聚（原碳酸酯）共聚物和均聚物，其包含（1）聚合物主链中的重复二氧碳单元，其具有从其悬挂的多个有机基团，和（2）具有至少一个羰氧基公开了其中包含的组。聚合物由下式表示：其中R是桥连部分，并且是沿着聚合物主链以随机方式排列的R 1或R 2，以形成含有R 1和R 2的共聚物，R 1是脂族基，脂环族或芳族基团，R 2是具有如下定义的R 1的一个图，R 3是脂族，脂环族或芳族基团，或其中R是桥连部分，并且只有R2与如上定义的R 1，R 2和R 3形成均聚物 a为0〜1，b为2〜6，n和x与y的和为正整数。共聚物可用于制造制品，包括用于递送有益试剂的装置和涂层。

6. 发明授权

US07195774B2 Implantable and sealable system for unidirectional delivery of therapeutic agents to tissues 有权
标题翻译：用于将治疗剂单向递送至组织的可植入和密封系统
公开(公告)号：US07195774B2
公开(公告)日：2007-03-27
申请号：US10231767
申请日：2002-08-28
申请人： Ricardo Azevedo Pontes de Carvalho , Alan Linn Murphree , Edward E. Schmitt
发明人： Ricardo Azevedo Pontes de Carvalho , Alan Linn Murphree , Edward E. Schmitt
IPC分类号： A61F2/00
CPC分类号： A61F2/02 , A61F9/0017 , A61F2210/0004 , A61F2250/0067 , A61F2250/0068 , A61K9/0051
摘要： A surgically implantable and sealable delivery device that upon contact of its contents via an interface window or port therein with an organ or tissue exposes a therapeutic agent to the organ or tissue surface, allowing a controlled, selective and unidirectional diffusion of the agent into the tissue or organ. The device protects adjacent organs or tissue structures from unnecessary high levels of the delivered agent. Novel methods to deliver chemotherapeutics or bioactive agents to mammalian organs or tissues through a surgically implanted device by the way of a selective and protected diffusion mechanism are disclosed as well as method to achieve the sealing properties of the device.
摘要翻译：手术可植入和可密封的递送装置，其内容物经由其中的界面窗口或口与其中的器官或组织接触将治疗剂暴露于器官或组织表面，允许药剂受控的，选择性的和单向的扩散到组织中或器官。该装置保护邻近的器官或组织结构免受不必要的高水平的递送的药剂。公开了通过选择性和保护的扩散机制通过手术植入的装置将化学治疗剂或生物活性剂递送到哺乳动物器官或组织的新方法以及实现装置密封性能的方法。

7. 发明授权

US4346709A Drug delivery devices comprising erodible polymer and erosion rate modifier 失效
标题翻译：药物输送装置包括可侵蚀聚合物和侵蚀速率调节剂
公开(公告)号：US4346709A
公开(公告)日：1982-08-31
申请号：US205636
申请日：1980-11-10
申请人： Edward E. Schmitt
发明人： Edward E. Schmitt
IPC分类号： A61K9/00 , A61K9/20 , A61K9/70 , C08K5/098 , A61M7/00
CPC分类号： A61K9/0024 , A61K9/0051 , A61K9/204 , A61K9/7084 , C08K5/098
摘要： Erodible devices are disclosed for delivering a drug to an environment of use. The devices comprise a body sized and adapted for delivering the drug to the environment of use, which body comprises (1) a poly(orthoester) or a poly(orthocarbonate) having a repeating unit consisting of a hydrocarbon radical and a symmetrical dioxycarbon unit of the general formula: ##STR1## wherein R.sub.1 is a multivalent hydrocarbon radical, R.sub.2 and R.sub.3 are hydrocarbon radicals with at least one of the R.sub.2 or R.sub.3 bonded to the dioxycarbon through an oxygen covalent bond, (2) a beneficial drug, and (3) an erosion rate modifier. The devices are useful for delivering both locally and systemically acting drugs over a prolonged period of time. A composition of matter is also disclosed comprising the poly(orthoesters) or the poly(orthocarbonates) and an erosion rate modifier.
摘要翻译：公开了用于将药物递送到使用环境的可辐射装置。所述装置包括尺寸适于将药物输送到使用环境的主体，该主体包括（1）聚（原酸酯）或聚（原碳酸酯），其具有由烃基和对称二氧代碳单元组成的重复单元通式：其中R1是多价烃基，R2和R3是具有通过氧共价键与二氧碳原子键合的R2或R3中的至少一个的烃基，（2）有益药物，和（3 ）侵蚀速率调节剂。这些装置可用于在长时间内递送局部和全身作用的药物。还公开了包含聚（原酸酯）或聚（原碳酸酯）和侵蚀速率改性剂的物质组合物。

8. 发明申请

US20100256746A1 BIODEGRADABLE POLYMERS 审中-公开
标题翻译：生物可降解聚合物
公开(公告)号：US20100256746A1
公开(公告)日：2010-10-07
申请号：US12729603
申请日：2010-03-23
申请人： Douglas Taylor , James B. McClain , Edward E. Schmitt
发明人： Douglas Taylor , James B. McClain , Edward E. Schmitt
IPC分类号： A61F2/06 , C08G63/02 , A61K31/436 , B05D7/00
CPC分类号： A61L31/10 , A61K31/435 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2420/02 , A61L2420/06 , A61L2420/08 , B05D3/12 , B05D2254/06 , C08G63/06 , C08G63/08 , C08G63/90 , C08G2150/20 , C08G2230/00 , C08J7/047 , C08L67/04 , C09D5/033 , C09D167/04
摘要： Provided herein is a composition comprising a poly(alpha-hydroxycarboxylic acid) substantially free of acidic impurities wherein the poly(alpha-hydroxycarboxylic acid) is selected from poly(D,L-lactic-co-glycolic acid), poly(L-lactic acid), poly(D-lactic acid) and poly(D,L-lactic acid). Also provided is a device comprising: a substrate, and a coating wherein the coating comprises poly(D,L-lactic-co-glycolic acid) substantially free of acidic impurities.
摘要翻译：本文提供的是包含基本上不含酸性杂质的聚（α-羟基羧酸）的组合物，其中聚（α-羟基羧酸）选自聚（D，L-乳酸 - 共 - 乙醇酸），聚（L-乳酸酸），聚（D-乳酸）和聚（D，L-乳酸）。还提供了一种装置，其包括：基底和涂层，其中所述涂层包含基本上不含酸性杂质的聚（D，L-乳酸 - 共 - 乙醇酸）。

9. 发明授权

US07749528B2 Implantable and sealable medical device for unidirectional delivery of therapeutic agents to tissues 有权
标题翻译：用于将治疗剂单向递送至组织的可植入和密封的医疗装置
公开(公告)号：US07749528B2
公开(公告)日：2010-07-06
申请号：US10801508
申请日：2004-03-15
申请人： Ricardo Azevedo Pontes De Carvalho , Alan Linn Murphree , Edward E. Schmitt
发明人： Ricardo Azevedo Pontes De Carvalho , Alan Linn Murphree , Edward E. Schmitt
IPC分类号： A61K9/22 , A61F2/00
CPC分类号： A61F9/0017 , A61F2/02 , A61F2210/0004 , A61F2250/0067 , A61K9/0051
摘要： A device for selective delivery of therapeutic agents to internal body tissues is disclosed. Upon tight sealing of the device to targeted tissues the diffusion of therapeutic agents to the targeted tissue can be controlled, while minimizing exposure of adjacent organs to the agents being delivered. Mechanisms for replenishment of the device and methods for application of the device in remote sites of the body are disclosed.
摘要翻译：公开了用于将治疗剂选择性递送至内部身体组织的装置。在将装置紧密密封到目标组织上时，可以控制治疗剂向目标组织的扩散，同时最小化相邻器官暴露于所递送的药剂。公开了用于补充装置的机构和在身体的远程位置应用装置的方法。

10. 发明授权

US5826584A Devices for occluding channels in living mammals 失效
标题翻译：用于封闭活体哺乳动物通道的装置
公开(公告)号：US5826584A
公开(公告)日：1998-10-27
申请号：US539168
申请日：1995-10-04
申请人： Edward E. Schmitt
发明人： Edward E. Schmitt
IPC分类号： A61B17/12 , A61F2/36 , A61F2/46 , A61F6/02 , A61F6/06 , A61F6/20 , A61F6/22 , A61F9/007 , A61L31/00 , A61L31/04 , A61L31/18 , A61B19/00
CPC分类号： A61B17/8802 , A61B17/12022 , A61B17/12099 , A61B17/12186 , A61F2/3607 , A61F6/20 , A61F6/22 , A61F9/007 , A61F9/00772 , A61L31/048 , A61L31/18 , A61B2017/1205 , A61F2/36 , A61F2002/4631
摘要： A method of blocking channels in a mammal which channels normally carry a material from one point to another is carried out by injecting a heated flowable polymer into the channel and allowing the polymer to cool and solidify, thus creating a plug or channel occluder. The plug can be later removed physically in its solid form or removed gradually by softening and/or fluidizing it by heating and/or chemical means. The channel occluder is preferably comprised of a main chain or side-chain crystallizable polymer but may be comprised of other polymers provided the polymers are formulated to have certain characteristics. The polymers must be solid and/or non-flowable at body temperature or lower and flowable when heated slightly above body temperature, i.e., 10 centigrade degrees or less above body temperature. The polymer is capable of changing quickly from a flowable state to a non-flowable state by moving through only a few centigrade degrees of temperature and is a non-immunogenic, biocompatible material. Typical channels which may be reversibly occluded via the present invention include the vas deferens, the mature sperm excretory channel of the testis; the fallopian tube or oviduct, the viaduct conveying the ovum from the ovary to the uterus; the canaliculus lacrimalis, the passageway that allows excess tears to flow from the puncta of the eye to the lacrimal sac; and the cavity of the femoral shaft to fix the stem of replacement hip joint (ball and neck).
摘要翻译：通过将加热的可流动聚合物注入通道并允许聚合物冷却和固化，从而产生塞子或通道封堵器来进行阻塞哺乳动物通道的方法，该通道通常将物质从一个点携带到另一个点。该塞子可以随后以其固体形式物理移除或通过软化和/或通过加热和/或化学方式使其流化而逐渐除去。通道阻塞剂优选由主链或侧链可结晶聚合物组成，但是可以由其它聚合物组成，只要聚合物配制成具有某些特性即可。聚合物在体温下必须是固体和/或不可流动的或较低的，并且在加热时稍微超过体温即在体温以上10摄氏度以下时可流动。聚合物能够通过仅通过几摄氏度的温度而从可流动状态快速变化到不可流动状态，并且是非免疫原性的生物相容性材料。通过本发明可以可逆地闭塞的典型通道包括输精管，睾丸的成熟精子排泄通道; 输卵管或输卵管，高架桥将卵子从卵巢输送到子宫; 泪小管，允许多余的眼泪从眼睛的泪点流到泪囊的通道; 和股骨轴的腔体，以固定替换髋关节（球和颈部）的杆。

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