专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06197964B1 Method for the production of 2,6-dichloro-5-fluoronicotinonitrile and the chemical compound 3-cyano-2-hydroxy-5-fluoropyride-6-one-monosodium salt its tautomers 失效
标题翻译：制备2,6-二氯-5-氟烟腈的方法及其化合物3-氰基-2-羟基-5-氟吡啶-6-酮单钠盐其互变异构体
公开(公告)号：US06197964B1
公开(公告)日：2001-03-06
申请号：US09402047
申请日：1999-09-27
申请人： Andreas Sattler , Guido Steffan , Bernd Griehsel
发明人： Andreas Sattler , Guido Steffan , Bernd Griehsel
IPC分类号： C07D21384
CPC分类号： C07B39/00 , C07D213/85
摘要： The process according to the invention can be illustrated by way of example by the following equation: The monosodium salt of the 3-cyano-2-hydroxy-5-fluoropyrid-6-one (cf. Formula (I)) and/or tautomers thereof are preferably employed in the process according to the invention. The use of a basic catalyst enables significantly lower amounts of chlorinating agent to be employed in the chlorination according to the invention than is necessary, for example, for chlorination of the free dihydroxy compound according to EP-A 333 020. Furthermore, the product 2,6-dichloro-5-fluoronicotinonitrile is obtained in a high purity and high yields after hydrolysis, which is not the case if the conditions according to EP-A 333 020 are applied. Basic catalysts which can be used for the process according to the invention are, for example, organic bases, for example aliphatic and aromatic amines and amides, and also inorganic bases, for example basic compounds of nitrogen and phosphorus and salts thereof. Preferred basic catalysts are: pyridine, pyridines alkylated with 1 to 3 C1-C6-alkyl groups, piperidine, piperidines, imidazoles and indoles alkylated with 1 to 3 C1-C6-alkyl groups, N—C1-C6-alkylaminopyridines, N—di-C1-C6-alkylated anilines, tertiary N—C1-C6-alkylamines, urea and urea derivatives. Particularly preferred basic catalysts are triethylamine, urea and ethylpiperidine.
摘要翻译：根据本发明的方法可以通过以下方程式举例说明：3-氰基-2-羟基-5-氟吡啶-6-酮的单钠盐（参见式（I））和/或互变异构体优选使用根据本发明的方法。碱性催化剂的使用使得根据本发明的氯化中所使用的氯化剂的量显着更低，例如根据需要氯化游离二羟基化合物，至EP-A 333 020.此外，产生2,6-二氯-5-氟烟腈的方法是在水解后以高纯度和高产率获得的，如果应用根据EP-A 333 020的条件，则不是这种情况。可用于本发明方法的碱性催化剂是例如有机碱，例如脂族和芳族胺和酰胺，以及无机碱，例如氮和磷的碱性化合物及其盐。优选的碱性催化剂是：吡啶，用1至3个C 1 -C 6 - 烷基烷基化的吡啶，哌啶，哌啶，咪唑和用1至3个C 1 -C 6 - 烷基烷基化的吲哚，N-C 1 -C 6 - 烷基氨基吡啶，N-二 -C 1 -C 6烷基化苯胺，叔N-C 1 -C 6烷基胺，脲和脲衍生物。特别优选的碱性催化剂是三乙胺，尿素和乙基哌啶。

2. 发明授权

US06525198B1 Method for producing 4,6-dichloropyrimidine with sulfur compounds and phosphorus compounds 失效
标题翻译：用硫化合物和磷化合物生产4,6-二氯嘧啶的方法
公开(公告)号：US06525198B1
公开(公告)日：2003-02-25
申请号：US10069089
申请日：2002-02-07
申请人： Franz-Josef Mais , Alexander Klausener , Günther Cramm , Guido Steffan
发明人： Franz-Josef Mais , Alexander Klausener , Günther Cramm , Guido Steffan
IPC分类号： C07D23930
CPC分类号： C07D239/30
摘要： The invention relates to a method for the preparation of 4,6-dichloropyrimidine by reacting 4-chloro-6-methoxypyrimidine with at least one sulphur-containing chlorinating agent selected from the group consisting of SCl2, SOCl2, and SO2Cl2 in the presence of at least one phosphorus compound having the formula R3P═Yn (1), in which R represents C1-C10-alkyl or C6-C10-aryl, each of which may optionally be substituted by up to five identical or different substituents selected from the group consisting of fluorine, chlorine, bromine, C1-C4-alkyl, and C1-C4-alkoxy, Y represents oxygen or sulphur, and n represents zero or 1.
摘要翻译：本发明涉及通过使4-氯-6-甲氧基嘧啶与至少一种选自SCl 2，SOCl 2和SO 2 Cl 2的含硫氯化剂在存在下进行反应来制备4,6-二氯嘧啶的方法至少一种具有式（I）的磷化合物，其中R表示C 1 -C 10 - 烷基或C 6 -C 10 - 芳基，其各自可任选被至多五个相同或不同的选自氟，氯，溴，C1- C 4 - 烷基和C 1 -C 4 - 烷氧基，Y表示氧或硫，并且n表示0或1。

3. 发明授权

US6162917A Method of preparing 4,5,6-trichloro- and 2,4,5,6-tetrachloropyrimidine 失效
标题翻译：制备4,5,6-三氯 - 和2,4,5,6-四氯嘧啶的方法
公开(公告)号：US6162917A
公开(公告)日：2000-12-19
申请号：US194983
申请日：1998-12-07
申请人： Guido Steffan , Georg Hardenbicker
发明人： Guido Steffan , Georg Hardenbicker
IPC分类号： C07C255/24 , C07D239/30
CPC分类号： C07D239/30 , C07C255/24
摘要： The invention relates to a process for the preparation of 4,5,6-trichloro- and 2,4,5,6-tetrachloropyrimidine starting from 3-dimethylamino-propionitrile, to its use and also to a crystalline intermediate product form.
摘要翻译： PCT No.PCT / EP97 / 02933 371日期1998年12月7日第 102（e）日期1998年12月7日PCT提交1997年6月6日PCT公布。公开号WO97 / 47605 日期：1997年12月18日本发明涉及从3-二甲基氨基 - 丙腈开始制备4,5,6-三氯 - 和2,4,5,6-四氯嘧啶的方法，其用途和结晶中间体产品形式。

4. 发明授权

US5679826A Process for the preparation of 2-chloroacrylonitrile 失效
标题翻译：制备2-氯丙烯腈的方法
公开(公告)号：US5679826A
公开(公告)日：1997-10-21
申请号：US735717
申请日：1996-10-23
申请人： Franz-Josef Mais , Thomas Essert , Helmut Fiege , Friedrich Durholz , Guido Steffan
发明人： Franz-Josef Mais , Thomas Essert , Helmut Fiege , Friedrich Durholz , Guido Steffan
IPC分类号： B01J31/02 , C07B61/00 , C07C253/30 , C07C255/10
CPC分类号： C07C253/30
摘要： 2-Chloroacrylonitrile is prepared in a particularly advantageous and readily industrially practicable manner by chlorinating acrylonitrile and then thermally cleaving the 2,3-diehloropropionitrile formed, by chlorinating acrylonitrile in the presence of a catalyst system comprising dimethylformamide and pyridine and/or pyridine derivatives and subjecting the resulting crude 2,3-dichloropropionitrile to thermal cleavage in the presence of the same catalyst system without the addition of further catalysts.
摘要翻译：通过氯化丙烯腈，然后在包含二甲基甲酰胺和吡啶和/或吡啶衍生物的催化剂体系存在下，通过氯化丙烯腈热分解形成的2,3-二氯丙腈，制备2-氯丙烯腈，所得粗制的2,3-二氯丙腈在相同的催化剂体系的存在下进行热裂解而不加入另外的催化剂。

5. 发明授权

US4325889A Process for the preparation of 1-amino-8-naphthol-3,6-disulphonic acid (H-acid) 失效
标题翻译：制备1-氨基-8-萘酚-3,6-二磺酸（H酸）的方法
公开(公告)号：US4325889A
公开(公告)日：1982-04-20
申请号：US186884
申请日：1980-09-12
申请人： Horst Behre , Albert Hullen , Bruno Kruger , Guido Steffan
发明人： Horst Behre , Albert Hullen , Bruno Kruger , Guido Steffan
IPC分类号： C07C143/66
摘要： The invention relates to a process for the preparation of 1-amino-8-naphthol-3,6-disulphonic acid (H-acid) as the mono-alkali metal salt from napthylamine-trisulphonic acid isomer mixtures by alkaline hydrolysis under pressure. The separation of the H-acid is effected by utilizing an aqueous sulphuric acid which contains naphthalene- and/or nitronaphthalene- and/or naphthylamine- and/or naphthol- and/or aminonaphthol-mono-, -di-and/or-tri-sulphonic acids.
摘要翻译：本发明涉及通过碱性水解在压力下从萘胺 - 三磺酸异构体混合物制备作为单碱金属盐的1-氨基-8-萘酚-3,6-二磺酸（H-酸）的方法。 H酸的分离是通过利用含有萘和/或硝基萘和/或萘胺和/或萘酚和/或氨基萘酚 - 单 - 和 - 或 - 三 - 磺酸。

6. 发明授权

US4180521A Process for the preparation of naphthalene-1,3,6-trisulphonic acid 失效
标题翻译：制备萘-1,3,6-三磺酸的方法
公开(公告)号：US4180521A
公开(公告)日：1979-12-25
申请号：US886696
申请日：1978-03-15
申请人： Horst Behre , Rolf Putter , Guido Steffan
发明人： Horst Behre , Rolf Putter , Guido Steffan
IPC分类号： C07C309/35 , C07C20060101 , C07C67/00 , C07C301/00 , C07C303/06 , C07C143/30
CPC分类号： C07C309/00
摘要： A process has been invented for the preparation of naphthalene-1,3,6-trisulphonic acid by sulphonating naphthalene with sulphuric acid and oleum, characterized in that naphthalene and most of the oleum are simultaneously metered into sulphuric acid or oleum of low concentration, which has been initially introduced, at about 140.degree. to 240.degree. C., the temperature is kept at about 140.degree. to 240.degree. C. for some time, the remainder of the oleum is then added at about 140.degree. to 240.degree. C. and the mixture is then further stirred for some time.Naphthalene-1,3,6-trisulphonic acid is a known important intermediate used, for example, in the preparation of T-acid, H-acid and chromotropic acid.
摘要翻译：已经发明了通过用硫酸和发烟硫酸磺化萘来制备萘-1,3,6-三磺酸的方法，其特征在于萘和大多数发烟硫酸同时计量成低浓度的硫酸或发烟硫酸，其中最初在约140℃至240℃下引入，温度保持在约140℃至240℃一段时间，然后在约140℃至240℃加入发烟硫酸的其余部分，然后将混合物进一步搅拌一段时间。萘-1,3,6-三磺酸是已知的重要中间体，例如用于制备T酸，H酸和变色酸。

7. 发明授权

US06441171B1 Method for the production of 4,6-dichloropyrimidine with the aid of phosgene 失效
标题翻译：借助光气生产4,6-二氯嘧啶的方法
公开(公告)号：US06441171B1
公开(公告)日：2002-08-27
申请号：US10048087
申请日：2002-01-24
申请人： Franz-Josef Mais , Günther Cramm , Alexander Klausener , Guido Steffan
发明人： Franz-Josef Mais , Günther Cramm , Alexander Klausener , Guido Steffan
IPC分类号： C07D23930
CPC分类号： C07D237/12
摘要： The invention relates to a method for the preparation of 4,6-dichloropyrimidine by reacting 4-chloro-6-methoxypyrimidine with phosgene as chlorinating agent in the presence of a nitrogen-containing auxiliary.
摘要翻译：本发明涉及通过在含氮辅助剂存在下使4-氯-6-甲氧基嘧啶与光气作为氯化剂反应来制备4,6-二氯嘧啶的方法。

8. 发明授权

US06296788B1 Process for the preparation of Grignard reagents and novel Grignard reagents 失效
标题翻译：格氏试剂和新型格氏试剂的制备方法
公开(公告)号：US06296788B1
公开(公告)日：2001-10-02
申请号：US09615434
申请日：2000-07-13
申请人： Guido Giffels , Guido Steffan
发明人： Guido Giffels , Guido Steffan
IPC分类号： C07F302
CPC分类号： C07F3/02
摘要： Grignard reagents which contain a protected aldehyde function are obtained in a particularly advantageous manner from a halogenated aldehyde by reaction with a secondary monoamine to give an open-chain aminal, and conversion of the latter into a Grignard reagent using metallic magnesium. The invention also relates to novel Grignard reagents of this type.
摘要翻译：通过与二级单胺反应，以卤代醛特别有利的方式得到含有保护的醛官能团的格氏试剂，得到开链的氨基甲酸酯，并使用金属镁将其转化成格氏试剂。本发明还涉及这种类型的新型格氏试剂。

9. 发明授权

US06294502B1 Thermally-responsive record material 失效
标题翻译：耐热响应记录材料
公开(公告)号：US06294502B1
公开(公告)日：2001-09-25
申请号：US09312884
申请日：1999-05-14
申请人： Mark Robert Fisher , John Charles DeBraal , Guido Steffan , Peter P. Wenzl
发明人： Mark Robert Fisher , John Charles DeBraal , Guido Steffan , Peter P. Wenzl
IPC分类号： B41M526
CPC分类号： B41M5/3375
摘要： The invention discloses a novel thermally-responsive record material comprising a support having coated thereon a thermally sensitive color forming composition comprising a chromogenic material, an acidic developer material and a certain carbamate component that does not include dodecyl-N-phenylcarbamate. The novel record material displays enhanced image intensity or improved thermal response.
摘要翻译：本发明公开了一种新型热响应记录材料，其包括其上涂覆有热敏成色组合物的载体，其包含显色材料，酸性显影剂材料和不包括十二烷基-N-苯基氨基甲酸盐的某些氨基甲酸酯组分。新颖的记录材料显示增强的图像强度或改善的热响应。

10. 发明授权

US5847217A Process for the preparation of 2-amino-5-alkyl-phenols 失效
标题翻译： 2-氨基-5-烷基苯酚的制备方法
公开(公告)号：US5847217A
公开(公告)日：1998-12-08
申请号：US982360
申请日：1997-12-02
申请人： Horst Behre , Guido Steffan
发明人： Horst Behre , Guido Steffan
IPC分类号： C07C213/00 , C07C215/76 , G03C7/34 , C07C209/68
CPC分类号： G03C7/346 , C07C213/00
摘要： 2-Amino-5-alkyl-phenols, which are suitable as intermediates in the production of crop-protection agents or photographic couplers, can be prepared by subjecting 2-amino-5-alkyl-benzenesulphonic acids or their salts to alkaline hydrolysis.
摘要翻译： 2-氨基-5-烷基苯酚，其适用作为农作物保护剂或照相成色剂生产中的中间体，可通过使2-氨基-5-烷基 - 苯磺酸或其盐进行碱水解来制备。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式