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1. 发明申请

US20100278768A1 Compounds and Methods for Inhibiting Axillary Malodour 审中-公开
标题翻译：抑制腋窝恶臭的化合物和方法
公开(公告)号：US20100278768A1
公开(公告)日：2010-11-04
申请号：US11746401
申请日：2007-05-09
申请人： Andreas Natsch , Gonzalo Acuna , Marie-Claude Fournie-Zaluski , Hans Gfeller
发明人： Andreas Natsch , Gonzalo Acuna , Marie-Claude Fournie-Zaluski , Hans Gfeller
IPC分类号： C12N9/99 , C12N15/52 , C12N15/74 , C12N1/21 , C12P21/02 , C07C229/06 , A61K8/44 , A61Q15/00
CPC分类号： C07C323/60 , A61K8/27 , A61K8/442 , A61K8/46 , A61Q15/00 , C12N9/80
摘要： Enzymes mediating in the release of compounds characteristic of human malodour and in particular axillary malodour, and compounds that inhibit said enzymes having the general formula (I)
摘要翻译：介导人类恶臭，特别是腋窝恶臭特征化合物释放的酶和抑制所述具有通式（I）的酶的化合物，

2. 发明授权

US07264956B2 Compounds and methods for inhibiting axillary malodour 有权
标题翻译：用于抑制腋窝恶臭的化合物和方法
公开(公告)号：US07264956B2
公开(公告)日：2007-09-04
申请号：US10477858
申请日：2002-05-14
申请人： Andreas Natsch , Gonzalo Acuna , Marie-Claude Fournie-Zaluski , Hans Gfeller
发明人： Andreas Natsch , Gonzalo Acuna , Marie-Claude Fournie-Zaluski , Hans Gfeller
IPC分类号： C12N9/00 , C12N9/78 , C12N15/70 , C12N5/16 , C12P21/06 , C07H21/04
CPC分类号： C07C323/60 , A61K8/27 , A61K8/442 , A61K8/46 , A61Q15/00 , C12N9/80
摘要： Enzymes mediating in the release of compounds characteristic of human malodour and in particular axillary malodour, and compounds that inhibit said enzymes having the general formula (I)
摘要翻译：介导人类恶臭，特别是腋窝恶臭特征化合物释放的酶和抑制所述具有通式（I）的酶的化合物，

3. 发明申请

US20110124601A1 AMINOPHOSPHINIC DERIVATIVES THAT CAN BE USED IN THE TREATMENT OF PAIN 有权
标题翻译：可用于治疗疼痛的氨基磷酸衍生物
公开(公告)号：US20110124601A1
公开(公告)日：2011-05-26
申请号：US13055096
申请日：2009-07-22
申请人： Bernard Roques , Hervé Poras , Marie-Claude Fournie-Zaluski
发明人： Bernard Roques , Hervé Poras , Marie-Claude Fournie-Zaluski
IPC分类号： A61K31/662 , C07F9/30 , C07F9/32 , C07F9/6553 , A61K31/67 , C07F9/59 , A61K31/675 , A61P29/00 , A61P25/04
CPC分类号： C07F9/306 , A61K31/662 , A61K31/67 , A61K31/675 , A61K39/08 , A61K45/06 , C07F9/301 , C07F9/303 , C07F9/3211 , C07F9/3241 , C07F9/4816 , C07F9/59 , C07F9/655345
摘要： The present invention relates to a compound of the following general formula (I): R1—NH—CH(R2)—P(═O)(OR3)—CH2—C(R4)(R5)—CONH—CH(R6)—COOR7 (I) or a pharmaceutically acceptable salt of the latter, an isomer or a mixture of isomers in any proportions, especially a mixture of enantiomers, and in particular a racemic mixture, for which R1 represents a —C(═O)—O—C(R8)(R9)—OC(═O)—R10 group; R2 represents an optionally substituted hydrocarbon-based chain, an aryl or heteroaryl group or a methylene group substituted by a heterocycle; R3 represents a hydrogen atom or a —C(R12)(R13)—OC(═O)—R14 group; R4 and R5 form, together with the carbon that bears them, a saturated hydrocarbon-based ring or an optionally substituted piperidine ring or R4 represents a hydrogen atom and R5 represents a phenyl or a benzyl that is optionally substituted, a heteroaromatic ring or a methylene group substituted by a heterocycle; R6 represents an optionally substituted hydrocarbon-based chain or a phenyl or a benzyl that is optionally substituted; and R7 represents a hydrogen atom or a benzyl, alkyl, heteroaryl, alkylheteroaryl, —CHMe—COOR18, —CHR19—OC(═O)OR20 and —CHR19—OC(═O)OR20 group. The present invention also relates to the use of these compounds as a medicinal product, and in particular for the treatment of pain, more advantageously neuropathic and neuroinflammatory pain, to their method of synthesis and also to the compositions containing them.
摘要翻译：本发明涉及以下通式（I）的化合物：R1-NH-CH（R2）-P（= O）（OR3）-CH2-C（R4）（R5）-CONH-CH（R6） -COOR7（I）或其后者的药学上可接受的盐，任何比例的异构体或异构体混合物，特别是对映异构体的混合物，特别是外消旋混合物，其中R1表示-C（= O） - O-C（R 8）（R 9）-OC（= O）-R 10基; R2表示任选取代的烃基链，芳基或杂芳基或被杂环取代的亚甲基; R3表示氢原子或-C（R12）（R13）-OC（= O）-R14基团; R4和R5与带有它们的碳一起形成饱和烃基环或任选取代的哌啶环，或R4表示氢原子，R 5表示任选取代的苯基或苄基，杂芳环或亚甲基被杂环取代的基团; R6表示任选取代的烃基链或任选取代的苯基或苄基; 并且R 7表示氢原子或苄基，烷基，杂芳基，烷基杂芳基，-CHMe-COOR 18，-CHR 19 -OC（= O）OR 20和-CHR 19 -OC（= O）OR 20基团。本发明还涉及这些化合物作为药用产品的用途，特别是用于治疗其合成方法的疼痛，更有利的是神经性和神经炎性疼痛，以及含有它们的组合物。

4. 发明授权

US08703747B2 Aminophosphinic derivatives that can be used in the treatment of pain 有权
标题翻译：可用于治疗疼痛的氨基亚磷酸衍生物
公开(公告)号：US08703747B2
公开(公告)日：2014-04-22
申请号：US13055096
申请日：2009-07-22
申请人： Bernard Roques , Hervé Poras , Marie-Claude Fournie-Zaluski
发明人： Bernard Roques , Hervé Poras , Marie-Claude Fournie-Zaluski
IPC分类号： A61K31/66 , A01N57/00 , A01N57/18
CPC分类号： C07F9/306 , A61K31/662 , A61K31/67 , A61K31/675 , A61K39/08 , A61K45/06 , C07F9/301 , C07F9/303 , C07F9/3211 , C07F9/3241 , C07F9/4816 , C07F9/59 , C07F9/655345
摘要： The present invention relates to a compound of the following general formula (I): R1—NH—CH(R2)—P(═O)(OR3)—CH2—C(R4)(R5)—CONH—CH(R6)—COOR7 (I) or a pharmaceutically acceptable salt of the latter, an isomer or a mixture of isomers in any proportions, especially a mixture of enantiomers, and in particular a racemic mixture, for which R1 represents a —C(═O)—O—C(R8)(R9)—OC(═O)—R10 group; R2 represents an optionally substituted hydrocarbon-based chain, an aryl or heteroaryl group or a methylene group substituted by a heterocycle; R3 represents a hydrogen atom or a —C(R12)(R13)—OC(═O)—R14 group; R4 and R5 form, together with the carbon that bears them, a saturated hydrocarbon-based ring or an optionally substituted piperidine ring or R4 represents a hydrogen atom and R5 represents a phenyl or a benzyl that is optionally substituted, a heteroaromatic ring or a methylene group substituted by a heterocycle; R6 represents an optionally substituted hydrocarbon-based chain or a phenyl or a benzyl that is optionally substituted; and R7 represents a hydrogen atom or a benzyl, alkyl, heteroaryl, alkylheteroaryl, —CHMe—COOR18, —CHR19—OC(═O)OR20 and —CHR19—OC(═O)OR20 group. The present invention also relates to the use of these compounds as a medicinal product, and in particular for the treatment of pain, more advantageously neuropathic and neuroinflammatory pain, to their method of synthesis and also to the compositions containing them.
摘要翻译：本发明涉及以下通式（I）的化合物：R1-NH-CH（R2）-P（= O）（OR3）-CH2-C（R4）（R5）-CONH-CH（R6） -COOR7（I）或其后者的药学上可接受的盐，任何比例的异构体或异构体混合物，特别是对映异构体的混合物，特别是外消旋混合物，其中R1表示-C（= O） - O-C（R 8）（R 9）-OC（= O）-R 10基; R2表示任选取代的烃基链，芳基或杂芳基或被杂环取代的亚甲基; R3表示氢原子或-C（R12）（R13）-OC（= O）-R14基团; R4和R5与带有它们的碳一起形成饱和烃基环或任选取代的哌啶环，或R4表示氢原子，R 5表示任选取代的苯基或苄基，杂芳环或亚甲基被杂环取代的基团; R6表示任选取代的烃基链或任选取代的苯基或苄基; 并且R 7表示氢原子或苄基，烷基，杂芳基，烷基杂芳基，-CHMe-COOR 18，-CHR 19 -OC（= O）OR 20和-CHR 19 -OC（= O）OR 20基团。本发明还涉及这些化合物作为药用产品的用途，特别是用于治疗其合成方法的疼痛，更有利的是神经性和神经炎性疼痛，以及含有它们的组合物。

5. 发明授权

US08247608B2 Aminoacid derivatives containing a disulfanyl group in the form of mixed disulfanyl and aminopeptidase N inhibitors 有权
标题翻译：含有以二硫烷基和氨基肽酶N抑制剂形式的二硫烷基的氨基酸衍生物
公开(公告)号：US08247608B2
公开(公告)日：2012-08-21
申请号：US12084091
申请日：2006-10-24
申请人： Bernard Roques , Marie-Claude Fournie-Zaluski
发明人： Bernard Roques , Marie-Claude Fournie-Zaluski
IPC分类号： C07C321/00 , C07C323/00 , C07C381/00 , C07C211/00 , A61K31/38
CPC分类号： C07C323/60 , C07D333/24
摘要： The invention relates to novel compounds of formula (I): H2N—CH(R1)—CH2—S—S—CH2—CH(R2)—CONH—R5, wherein R1 is a hydrocarbon chain, phenyl or benzyl radical, methylene radical substituted by a 5 or 6 atom heterocycle; R2 is a phenyl or benzyl radical, a 5 or 6 atom aromatic heterocycle, methylene group substituted by a 5 or 6 atom heterocycle; R5 is a CH(R3)—COOR4 radical, wherein R3 is hydrogen, an OH or OR group, a saturated hydrocarbon group, a phenyl or benzyl radical and OR4 is hydrophile ester, or 5 or 6 membered heterocycle comprising several heteroatoms selected from a group consisting of nitrogen, sulphur and oxygen, with at least two nitrogene atoms, wherein said heterocycle is substitutable by an alkyl C1-C6, phenyl or benzyl radical. The use of the inventive compounds in the form of drugs, a pharmaceutical composition comprising said compounds, a pharmaceutically acceptable excipient, the use in conjunction of at least one type of cannabinoid derivative for potentiating the analgesic and antidepressant effect of the novel compounds of formula (I) and/or morphine or the derivatives thereof are also disclosed.
摘要翻译：本发明涉及新的式（I）化合物：H 2 N-CH（R 1）-CH 2 -S-S-CH 2 -CH（R 2）-CONH-R 5，其中R 1是烃链，苯基或苄基，亚甲基被5或6个原子杂环取代; R2是苯基或苄基，5或6个芳族杂环，被5或6个杂原子取代的亚甲基; R 5是CH（R 3）-COOR 4基团，其中R 3是氢，OH或OR基团，饱和烃基，苯基或苄基，OR 4是亲水酯，或包含若干个杂原子的5或6元杂环，由氮，硫和氧组成的组，具有至少两个氮原子，其中所述杂环可被C 1 -C 6烷基，苯基或苄基取代。药物形式的本发明化合物的使用，包含所述化合物的药物组合物，药学上可接受的赋形剂，联合至少一种类型的大麻素衍生物的用途，用于增强新型式（III）化合物的镇痛作用和抗抑郁作用 I）和/或吗啡或其衍生物也被公开。

6. 发明授权

US06518260B1 (&agr;-aminophosphino) peptide derivatives, method for making same and therapeutic applications thereof 失效
标题翻译：（α-氨基膦基）肽衍生物，其制备方法和治疗应用
公开(公告)号：US06518260B1
公开(公告)日：2003-02-11
申请号：US09284882
申请日：1999-04-22
申请人： Marie-Claude Fournie-Zaluski , Huixiong Chen , Bernard Pierre Roques
发明人： Marie-Claude Fournie-Zaluski , Huixiong Chen , Bernard Pierre Roques
IPC分类号： A61K3166
CPC分类号： C07F9/301 , C07F9/3211
摘要： The invention concerns compounds derived from (&agr;-aminophosphino) peptides, of general formula (I), in which R1 and R2 each represents a hydrogen atom or taken together form an imine with the adjacent nitrogen atom; R3 represents an alkyl group, an alkenyl group, a phenyl group, a benzyl group, all these groups capable of being substituted or not, a hydrogen atom, a cycloalkyl group, a cycloalkylmethyl group or finally, a methyl group substituted by a heterocyclic, aromatic or saturated group; R4 represents a phenyl group, a benzyl group, these groups capable of being substituted or not, a hydrogen atom, an alkyl group, analkenyl group or a cycloalkyl group; R5 represents an alkyl group, an alkenyl group, a phenyl group, a benzyl group, all these groups capable of being substituted or not, a hydrogen atom, a cycloalkyl, cycloalkylmethyl group or finally a methyl group substituted by a heterocyclic, aromatic or saturated group; R6, R7 and R8 can in particular represent a hydrogen atom, an alkyl group, a phenyl group substituted or not . . . n is equal to 0 or 1, in the form of enantiomers, diastereoisomers or racemic mixtures, their salts, their method of preparation and their therapeutic applications.
摘要翻译：本发明涉及衍生自通式（I）的（α-氨基膦基）肽的化合物，其中R 1和R 2各自代表氢原子或与其相邻的氮原子一起形成亚胺; R3表示烷基，烯基，苯基，苄基，所有这些能够被取代的基团，氢原子，环烷基，环烷基甲基或最后被杂环取代的甲基，芳族或饱和基团; R4表示苯基，苄基，这些能够被取代的基团，氢原子，烷基，断链基或环烷基; R5表示烷基，烯基，苯基，苄基，所有这些能够被取代的基团，氢原子，环烷基，环烷基甲基或最后被杂环，芳族或饱和的取代的甲基组; R6，R7和R8可以特别表示氢原子，烷基，被取代的苯基。。。 n等于0或1，以对映异构体，非对映异构体或外消旋混合物，其盐，其制备方法及其治疗应用的形式。

7. 发明授权

US6136842A Sulphur derivatives comprising an amide bond, method for preparing same, use thereof as drugs, and pharmaceutical compositions containing such derivatives 失效
标题翻译：含有酰胺键的硫衍生物，其制备方法，作为药物的用途，以及含有该衍生物的药物组合物
公开(公告)号：US6136842A
公开(公告)日：2000-10-24
申请号：US142286
申请日：1999-01-12
申请人： Pierre Deprez , Jacques Dumas , Marie-Claude Fournie-Zaluski , Jacques Guillaume , Bernard Pierre Roques
发明人： Pierre Deprez , Jacques Dumas , Marie-Claude Fournie-Zaluski , Jacques Guillaume , Bernard Pierre Roques
IPC分类号： A61K31/405 , A61K31/00 , A61K31/165 , A61K31/195 , A61K31/198 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/4045 , A61P9/00 , A61P13/00 , A61P13/12 , A61P43/00 , C07C323/60 , C07D209/18 , C07D209/20 , C07D209/22 , C07D257/04 , C07D333/24 , C07D405/12
CPC分类号： C07D257/04 , C07C323/60 , C07D209/18 , C07D333/24 , C07D405/12
摘要： Products of formula (I), wherein n is 0 or 1, R.sub.1 is particularly phenyl or biphenyl optionally substituted particularly by benzyloxy, dioxol or halogen, R.sub.2 is particularly hydrogen or methyl substituted particularly by indolyl, phenylthio or phenyl, which may in turn be substituted, and A is carboxy, tetrazolyl or substituted alkyl as well as all salts and isomers thereof, are disclosed. ##STR1##
摘要翻译： PCT No.PCT / FR97 / 00367 Sec。 371日期1999年1月12日 102（e）1999年1月12日PCT PCT 1997年3月3日PCT公布。出版物WO97 / 32874 日本公报（日本专利公开公报）1997年9月12日，式（I）的化合物，其中n为0或1，R1特别是苯基或联苯，特别是被苄氧基，二氧杂环戊烯或卤素取代，R 2特别是氢或被吲哚基，苯硫基或苯基取代的甲基，其可以被取代，并且A是羧基，四唑基或取代的烷基，以及其所有的盐和异构体。

8. 发明授权

US08466309B2 Amino acid derivatives, method for preparing same, and therapeutic use thereof 有权
标题翻译：氨基酸衍生物，其制备方法及其治疗用途
公开(公告)号：US08466309B2
公开(公告)日：2013-06-18
申请号：US12991999
申请日：2009-05-13
申请人： Marie-Claude Fournie-Zaluski , Hervé Poras , Bernard Roques
发明人： Marie-Claude Fournie-Zaluski , Hervé Poras , Bernard Roques
IPC分类号： C07C69/74 , C07C321/00 , C07C323/00 , C07C381/00 , A01N43/16
CPC分类号： C07C323/65 , C07C323/60
摘要： The disclosure relates to novel compounds of the formula (I) R1NH—CH(R2)CH2—S—S—CH2—C(R3)(R4)—CONH—C(R5)(R6)—COOR7, in which R1 is a (acyloxy)alkyl carbamate-C(O)—O—C(R8)(R9)—OC(O)—R10 group; R2 is a hydrocarbon chain, a methylene radical substituted by a heterocycle, R4 is a hydrogen atom and R3 is a phenyl or benzyl radical, a heteroaryl, a methylene group substituted by a heterocycle or R3 and R4 form together a saturated cycle; R5 and R6 are hydrogen, a hydrocarbon chain, a phenyl or benzyl radical or R5 and R6 form together a saturated cycle; R7 is hydrogen, a phenyl or benzyl radical, a group of the formula CR12(R13)C(O)OR14 or OCR12(R13)OC(O)R14 or OCR12(R13)OC(O)OR14. The disclosure also relates to the use of these compounds as a drug, and to a pharmaceutical composition containing said compounds and a pharmaceutically acceptable carrier. The disclosure further relates to the combined use of at least one cannabinoid derivative and/or morphine or one derivative thereof and/or Gaba derivatives for enhancing the analgesic and anti-depressive effect of the compounds of the formula (I).
摘要翻译：本发明涉及式（I）的新化合物：R1NH-CH（R2）CH2-SS-CH2-C（R3）（R4）-CONH-C（R5）（R6）-COOR7，其中R1是（酰氧基）烷基氨基甲酸酯-C（O）-OC（R 8）（R 9）-OC（O）-R 10基团; R2是烃链，被杂环取代的亚甲基，R4是氢原子，R3是苯基或苄基，杂芳基，被杂环取代的亚甲基或R3和R4一起形成饱和环; R5和R6是氢，烃链，苯基或苄基或R5和R6一起形成饱和循环; R 7是氢，苯基或苄基，式CR 12（R 13）C（O）OR 14或OCR 12（R 13）OC（O）R 14或OCR 12（R 13）OC（O）OR 14的基团。本公开还涉及这些化合物作为药物的用途，以及含有所述化合物和药学上可接受的载体的药物组合物。本公开还涉及至少一种大麻素衍生物和/或吗啡或其一种衍生物和/或Gaba衍生物用于增强式（I）化合物的止痛和抗抑郁作用的组合使用。

9. 发明申请

US20090131509A1 Aminoacid Derivatives Containing a Disulfanyl Group in the form of Mixed Disulfanyl and Aminopeptidase N Inhibitors 有权
标题翻译：含二硫烷基和氨基肽酶N抑制剂形式的二硫烷基的氨基酸衍生物
公开(公告)号：US20090131509A1
公开(公告)日：2009-05-21
申请号：US12084091
申请日：2006-10-24
申请人： Bernard Roques , Marie-Claude Fournie-Zaluski
发明人： Bernard Roques , Marie-Claude Fournie-Zaluski
IPC分类号： A61K31/381 , C07D333/24 , C07D409/02 , A61P25/24 , A61P25/00 , A61P29/00 , A61K31/215 , C07C69/66
CPC分类号： C07C323/60 , C07D333/24
摘要： The invention relates to novel compounds of formula (I): H2N—CH(R1)—CH2—S—S—CH2—CH(R2)—COONH—R5, wherein R1 is a hydrocarbon chain, phenyl or benzyl radical, methylene radical substituted by a 5 or 6 atom heterocycle; R2 is a phenyl or benzyl radical, a 5 or 6 atom aromatic heterocycle, methylene group substituted by a 5 or 6 atom heterocycle; R5 is a CH(R3)—COOR4 radical, wherein R3 is hydrogen, an OH or OR group, a saturated hydrocarbon group, a phenyl or benzyl radical and OR4 is hydrophile ester, or 5 or 6 membered heterocycle comprising several heteroatoms selected from a group consisting of nitrogen, sulphur and oxygen, with at least two nitrogene atoms, wherein said heterocycle is substitutable by an alkyl C1-C6, phenyl or benzyl radical. The use of the inventive compounds in the form of drugs, a pharmaceutical composition comprising said compounds, a pharmaceutically acceptable excipient, the use in conjunction of at least one type of cannabinoid derivative for potentiating the analgesic and antidepressant effect of the novel compounds of formula (I) and/or morphine or the derivatives thereof are also disclosed.
摘要翻译：本发明涉及新的式（I）化合物：H 2 N-CH（R 1）-CH 2 -S-CH 2 -CH（R 2）-COONH-R 5，其中R 1是烃链，苯基或苄基，被 5或6原子杂环; R2是苯基或苄基，5或6个芳族杂环，被5或6个原子杂环取代的亚甲基; R 5是CH（R 3）-COOR 4基团，其中R 3是氢，OH或OR基团，饱和烃基，苯基或苄基，OR 4是亲水酯，或包含若干个杂原子的5或6元杂环，由氮，硫和氧组成的组，具有至少两个氮原子，其中所述杂环可被C 1 -C 6烷基，苯基或苄基取代。药物形式的本发明化合物的使用，包含所述化合物的药物组合物，药学上可接受的赋形剂，联合至少一种类型的大麻素衍生物的用途，用于增强新型式（III）化合物的镇痛作用和抗抑郁作用 I）和/或吗啡或其衍生物也被公开。

10. 发明申请

US20090012153A1 AMINOACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF MIXED DISULFANYL AND AMINOPEPTIDASE N INHIBITORS 有权
标题翻译：含有不同组合的混合衍生物和氨基酸N抑制剂的氨基酸衍生物
公开(公告)号：US20090012153A1
公开(公告)日：2009-01-08
申请号：US12146941
申请日：2008-06-26
申请人： Bernard Roques , Marie-Claude Fournie-Zaluski
发明人： Bernard Roques , Marie-Claude Fournie-Zaluski
IPC分类号： A61K31/16 , C07C233/01 , C07D333/22 , A61K31/381 , C07D309/00 , A61K31/35 , A61K31/195 , A61P25/00 , A61P25/24
CPC分类号： C07D285/135 , C07C323/52 , C07D333/22
摘要： The invention relates to novel compounds of formula (I): H2N—CH(R1)—CH2—S—S—CH2—CH(R2)—CONH—R5, wherein R1 is a hydrocarbon chain, phenyl or benzyl radical, methylene radical substituted by a 5 or 6 atom heterocycle; R2 is a phenyl or benzyl radical, a 5 or 6 atom aromatic heterocycle, methylene group substituted by a 5 or 6 atom heterocycle; R5 is a CH(R3)—COOR4 radical, wherein R3 is hydrogen, an OH or OR group, a saturated hydrocarbon group, a phenyl or benzyl radical and OR4 is hydrophile ester, or 5 or 6 membered heterocycle comprising several heteroatoms selected from a group consisting of nitrogen, sulphur and oxygen, with at least two nitrogene atoms, wherein said heterocycle is substitutable by an alkyl C1-C6, phenyl or benzyl radical. The use of the inventive compounds in the form of drugs, a pharmaceutical composition comprising said compounds, a pharmaceutically acceptable excipient, the use in conjunction of at least one type of cannabinoid derivative for potentiating the analgesic and antidepressant effect of the novel compounds of formula (I) and/or morphine or the derivatives thereof are also disclosed.
摘要翻译：本发明涉及新的式（I）化合物：H 2 N-CH（R 1）-CH 2 -S-CH 2 -CH（R 2）-CONH-R 5，其中R 1是烃链，苯基或苄基，被 5或6原子杂环; R2是苯基或苄基，5或6个芳族杂环，被5或6个杂原子取代的亚甲基; R 5是CH（R 3）-COOR 4基团，其中R 3是氢，OH或OR基团，饱和烃基，苯基或苄基，OR 4是亲水酯，或包含若干个杂原子的5或6元杂环，由氮，硫和氧组成的组，具有至少两个氮原子，其中所述杂环可被C 1 -C 6烷基，苯基或苄基取代。药物形式的本发明化合物的使用，包含所述化合物的药物组合物，药学上可接受的赋形剂，联合至少一种类型的大麻素衍生物的用途，用于增强新型式（III）化合物的镇痛作用和抗抑郁作用 I）和/或吗啡或其衍生物也被公开。

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