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1. 发明授权

US07161040B2 Method for preparation of carborane anions 失效
标题翻译：碳硼烷阴离子的制备方法
公开(公告)号：US07161040B2
公开(公告)日：2007-01-09
申请号：US10472329
申请日：2002-04-01
申请人： Andreas Franken , Benjamin T. King , Josef Michl
发明人： Andreas Franken , Benjamin T. King , Josef Michl
IPC分类号： C07C331/00 , C07C335/00 , C07C381/00
CPC分类号： C07F5/027
摘要： This invention relates to an improved method for making unsubstituted carborane anions and monosubstituted carborane anions of formula: (R—CBn—Hm′)− where n is an integer ranging from 5 to about 11 and m′ is an integer ranging from 5 to 16 where the relative values of n and m′ depend upon the exact structure of the carborane and the presence of a non-hydrogen substituent. m as used herein is an integer ranging from 5 to 16. When R is hydrogen the anion is unsubstituted. When R is a halogen, a phenyl, a substituted phenyl group, such as fluorophenyl group, or any other substituent, the carborane is substituted. The method is particularly useful for preparation of twelve-vertex carborane anions R—CB11H11−, where R is a defined above, and is specifically useful for preparation of the unsubstituted carborane CB11H12-??, where R is H.
摘要翻译：本发明涉及一种制备未取代的碳硼烷阴离子和具有下式的单取代的碳硼烷阴离子的改进方法：（R-CB N-H） - H SUP >其中n是5至约11的整数，m'是5至16的整数，其中n和m'的相对值取决于碳硼烷的精确结构和非氢取代基的存在。 m为5〜16的整数。当R为氢时，阴离子为未取代的。当R是卤素时，苯基，取代的苯基，例如氟苯基或任何其它取代基，碳硼烷被取代。该方法对于制备十二个顶点碳硼烷阴离子R-CB 11，其中R为上述定义，特别有用，以及特别适用于制备未取代的碳硼烷CB 11 H 12 -12，其中R为H.

2. 发明授权

US5731470A Weakly nucleophilic anions 失效
标题翻译：弱亲核阴离子
公开(公告)号：US5731470A
公开(公告)日：1998-03-24
申请号：US628357
申请日：1996-04-05
申请人： Josef Michl , Benjamin T. King , Zbynek Janousek
发明人： Josef Michl , Benjamin T. King , Zbynek Janousek
IPC分类号： C07F5/02
CPC分类号： C07F5/027
摘要： Substituted borate and carborate anions having unusual properties of being exceptionally weakly nucleophilic and being soluble in non-polar solvents. One-electron oxidation of the anions yields the corresponding radicals. The compounds are useful, e.g., as electrolytes, catalysts, and electrochromic materials.
摘要翻译：具有非常弱的亲核性并且可溶于非极性溶剂的不寻常的特性的取代硼酸盐和碳化硼阴离子。阴离子的一电子氧化产生相应的自由基。这些化合物是有用的，例如电解质，催化剂和电致变色材料。

3. 发明授权

US07737234B2 Catalysts for radical polymerization 失效
标题翻译：用于自由基聚合的催化剂
公开(公告)号：US07737234B2
公开(公告)日：2010-06-15
申请号：US11997895
申请日：2006-08-04
申请人： Josef Michl , Kamesh Vyakaranam , Stefanie Koerbe
发明人： Josef Michl , Kamesh Vyakaranam , Stefanie Koerbe
IPC分类号： C08F4/52 , C08F30/06 , C07F5/02
CPC分类号： C08F4/484 , C08F4/00 , C08F110/10 , C08F110/14 , C08F210/00
摘要： Provided is a method for polymerizing a polymer precursor, comprising: contacting a polymer precursor with a lithium carborane catalyst and an initiator under polymerizing conditions. A reaction solvent may be used, but is not necessary. Also provided is a method of preparing lithium carborane polymers, comprising: contacting a lithium carborane polymer precursor having a terminal alkenyl or alkynyl group with an initiator and an optional reaction solvent under polymerizing conditions. Functionalized carborane anions are also provided.
摘要翻译：本发明提供聚合物前体的聚合方法，其包括：在聚合条件下使聚合物前体与锂碳硼烷催化剂和引发剂接触。可以使用反应溶剂，但不是必需的。还提供了一种制备锂碳硼烷聚合物的方法，其包括：在聚合条件下使具有末端烯基或炔基的碳硼烷锂聚合物前体与引发剂和任选的反应溶剂接触。还提供功能化的碳硼烷阴离子。

4. 发明申请

US20060258841A1 Pancreatic cancer associated antigen, antibody thereto, and diagnostic and treatment methods 审中-公开
标题翻译：胰腺癌相关抗原，抗体及其诊断和治疗方法
公开(公告)号：US20060258841A1
公开(公告)日：2006-11-16
申请号：US10542239
申请日：2004-01-16
申请人： Josef Michl , Stefan Bradu , Raquib Hannan , Matthew Pincus
发明人： Josef Michl , Stefan Bradu , Raquib Hannan , Matthew Pincus
IPC分类号： C07K14/82 , C07K16/30
CPC分类号： C07K16/303 , A61K47/6817 , A61K47/6859 , A61K51/1057 , A61K2039/505 , C07K14/47 , C07K2317/24 , C07K2317/734 , G01N33/57438 , G01N2333/705
摘要： The present invention is directed to an antigen found on the surface of rat and human pancreatic cancer cells and provides antibodies of high specificity and selectivity to this antigen as well as hybridomas secreting the subject antibodies. Methods for both the diagnosis and treatment of pancreatic cancer are also provided. This tissue marker of pancreatic adenocarcinoma, an approximately 43.5 kD surface membrane protein designated PaCa-Ag1, is completely unexpressed in normal pancreas but abundantly expressed in pancreatic carcinoma cells. Moreover, a soluble form of PaCa-Ag1 exists, having a molecular weight about 36 to about 38 kD, that is readily identified in sera and other body fluids of pancreatic cancer patients, using a subject antibody.
摘要翻译：本发明涉及在大鼠和人胰腺癌细胞表面上发现的抗原，并且提供对该抗原以及分泌本发明抗体的杂交瘤具有高特异性和选择性的抗体。还提供了胰腺癌诊断和治疗方法。胰腺腺癌组织标志物，一种约43.5 kD的表皮膜蛋白，称为PaCa-Ag1，在正常胰腺中完全未表达，但在胰腺癌细胞中大量表达。此外，使用受试抗体，存在可溶形式的PaCa-Ag1，其分子量约36至约38kD，其易于在胰腺癌患者的血清和其它体液中鉴定。

5. 发明申请

US20150320841A1 PHENOTYPIC REVERSION OF PANCREATIC CARCINOMA CELLS 审中-公开
公开(公告)号：US20150320841A1
公开(公告)日：2015-11-12
申请号：US14809666
申请日：2015-07-27
申请人： Matthew Pincus , Josef Michl
发明人： Matthew Pincus , Josef Michl
IPC分类号： A61K38/46 , C12N15/86
CPC分类号： A61K38/46 , A61K38/00 , A61K48/00 , C07K14/82 , C07K2319/10 , C12N15/86 , C12N2710/10032 , C12N2710/10043 , C12Y306/05002
摘要： The present invention provides peptides (including analogs and derivatives thereof) corresponding to residues 96-110 and 35-47 of ras-p21, which peptides have attached thereto a membrane-penetrating leader sequence. The subject peptides, analogs and derivatives thereof are useful in treatment of cancers and have been shown to induce phenotypic reversion of pancreatic cancer cells to non-cancerous cells. Pharmaceutical compositions comprising one or more subject peptides are also provided by the present invention. The present invention further provides replication incompetent Adenovirus (AdV) vectors comprising a promoter sequence and a nucleotide sequence encoding a subject peptide. Methods of treating cancer by administering one or more subject peptides, pharmaceutical compositions, and/or AdV vectors are also provided.

6. 发明申请

US20130065953A1 PHENOTYPIC REVERSION OF PANCREATIC CARCINOMA CELLS 审中-公开
公开(公告)号：US20130065953A1
公开(公告)日：2013-03-14
申请号：US13677876
申请日：2012-11-15
申请人： Matthew Pincus , Josef Michl
发明人： Matthew Pincus , Josef Michl
IPC分类号： A61K31/711 , A61P35/00 , C12N15/861
CPC分类号： A61K38/46 , A61K38/00 , A61K48/00 , C07K14/82 , C07K2319/10 , C12N15/86 , C12N2710/10032 , C12N2710/10043 , C12Y306/05002
摘要： The present invention provides peptides (including analogs and derivatives thereof) corresponding to residues 96-110 and 35-47 of ras-p21, which peptides have attached thereto a membrane-penetrating leader sequence. The subject peptides, analogs and derivatives thereof are useful in treatment of cancers and have been shown to induce phenotypic reversion of pancreatic cancer cells to non-cancerous cells. Pharmaceutical compositions comprising one or more subject peptides are also provided by the present invention. The present invention further provides replication incompetent Adenovirus (AdV) vectors comprising a promoter sequence and a nucleotide sequence encoding a subject peptide. Methods of treating cancer by administering one or more subject peptides, pharmaceutical compositions, and/or AdV vectors are also provided.

7. 发明授权

US06482566B1 Hydroxycarborane photoresists and process for using same in bilayer thin film imaging lithography 有权
标题翻译：羟基碳硼烷光刻胶及其在双层薄膜成像光刻中的应用方法
公开(公告)号：US06482566B1
公开(公告)日：2002-11-19
申请号：US09507522
申请日：2000-02-18
申请人： Donald C. Hofer , Scott A. MacDonald , Arpan P. Mahorowala , Robert D. Miller , Josef Michl , Gregory M. Wallraff
发明人： Donald C. Hofer , Scott A. MacDonald , Arpan P. Mahorowala , Robert D. Miller , Josef Michl , Gregory M. Wallraff
IPC分类号： G03C173
CPC分类号： G03F7/0392 , G03F7/0042 , Y10S430/106 , Y10S430/111 , Y10S430/115
摘要： A photoresist composition which includes hydroxycarborane either incorporated as a monomeric dissolution modifier or as pendent groups on a polymer backbone. The photoresist composition is particularly useful in a bilayer thin film imaging lithographic process in which ultraviolet radiation-imaging in a wavelength range of between about 365 nm and about 13 nm is employed.
摘要翻译：一种光致抗蚀剂组合物，其包括作为单体溶解改性剂掺入或作为聚合物主链上的悬挂基团引入的羟基碳硼烷。光致抗蚀剂组合物在双层薄膜成像光刻工艺中特别有用，其中采用波长范围在约365nm至约13nm之间的紫外线辐射成像。

8. 发明授权

US5405550A Compounds and methods based on [1.1.1]propellane 失效
标题翻译：基于[1.1.1]推进剂的化合物和方法
公开(公告)号：US5405550A
公开(公告)日：1995-04-11
申请号：US927228
申请日：1992-08-10
申请人： Josef Michl , Piotr Kaszynski , Andrienne C. Friedli
发明人： Josef Michl , Piotr Kaszynski , Andrienne C. Friedli
IPC分类号： B01F17/00 , C07C13/36 , C07C23/24 , C07C49/323 , C07C61/125 , C07C61/13 , C07C61/15 , C07C69/753 , C07C255/31 , C07C255/47 , C07C255/55 , C07C309/66 , C07C317/14 , C07C321/22 , C07C323/22 , C07C327/24 , C08F8/14 , C08F18/04 , C08F20/02 , C08F220/04 , C08F222/06 , C08G18/32 , C08G61/04 , C08G63/16 , C08G63/18 , C08L25/04 , C09K19/32 , C07C255/00 , C09K19/52
CPC分类号： C07C255/55 , C07C23/24 , C07C255/47 , C07C309/66 , C07C317/14 , C07C61/13 , C08G61/04 , C09K19/32 , C07C2102/38 , C07C2103/08
摘要： Molecular bulding beams, liquid crystals, and surfactants in the form of compounds based on [1.1.1]propellane, including poly[1.1.1]propellanes. Molecular building beams having a telomeric or polymeric chain staff, and linking groups functionalized on one or both ends of the staff. A system for linking the beams to connecting units to construct molecular structures of various forms, such as whips, combs, scaffoldings, nets, or stars. Other broad aspects of the invention provide liquid crystals and surfactants. The liquid crystals include telomeric or polymeric compounds functionalized with flexible end groups, while the surfactant compounds are functionalized with surface active end groups. Methods of synthesizing the various compounds ar also provided.
摘要翻译：基于[1.1.1]推进剂的化合物形式的分子束，液晶和表面活性剂，包括聚[1.1.1]推进剂。具有端粒或聚合物链工作人员的分子建筑梁，以及在工作人员的一端或两端上功能化的连接组。用于将梁连接到连接单元以构建各种形式的分子结构的系统，例如鞭子，梳子，脚手架，网或星。本发明的其它广泛方面提供液晶和表面活性剂。液晶包括用柔性端基官能化的端粒或聚合物，而表面活性剂化合物用表面活性端基官能化。还提供了合成各种化合物的方法。

9. 发明申请

US20110183915A1 Small Molecule Cancer Treatments that cause Necrosis in Cancer Cells but do not Affect Normal Cells 有权
标题翻译：小分子癌症治疗导致癌细胞坏死，但不影响正常细胞
公开(公告)号：US20110183915A1
公开(公告)日：2011-07-28
申请号：US12744831
申请日：2008-11-26
申请人： Matthew R. Pincus , Josef Michl
发明人： Matthew R. Pincus , Josef Michl
IPC分类号： A61K38/16 , C12Q1/02 , C12N5/09 , C07D403/04 , A61K38/10 , A61K31/496 , A61P35/00
CPC分类号： A61K38/03 , A61K31/155 , A61K31/4995 , A61K38/10 , A61K38/1709 , A61K38/1758 , A61K45/06 , A61K47/54 , C07K14/4746 , C07K2319/03 , A61K2300/00
摘要： A method of treating cancer in a subject, including: providing a subject having a plurality of cancer cells; and administering to the subject, a therapeutically effective amount of a composition including: an HDM-2 binding component; and a membrane resident component, the membrane resident component bound to the HDM-2 binding component. Also provided are a method of selectively necrosing cancer cells, a method of causing membranolysis in cancer cells, and a cancer treatment composition.
摘要翻译：一种治疗受试者的癌症的方法，包括：提供具有多个癌细胞的受试者; 并向受试者施用治疗有效量的组合物，其包含：HDM-2结合组分; 和膜驻留组分，膜驻留组分结合到HDM-2结合组分。还提供了选择性坏死癌细胞的方法，癌细胞中膜分解的方法和癌症治疗组合物。

10. 发明授权

US07883888B2 Peptides selectively lethal to malignant and transformed mammalian cells 有权
标题翻译：对恶性和转化的哺乳动物细胞选择性致死的肽
公开(公告)号：US07883888B2
公开(公告)日：2011-02-08
申请号：US10549048
申请日：2004-01-13
申请人： Josef Michl , Jesko Koehnke , Matthew R. Pincus
发明人： Josef Michl , Jesko Koehnke , Matthew R. Pincus
IPC分类号： C12N15/00
CPC分类号： C07K14/4746 , A61K38/00
摘要： The present invention provides peptides corresponding to all or a portion of amino acid residues 12-26 of human p53 protein, which peptides are lethal to malignant or transformed cells when fused to a membrane-penetrating leader sequence. The subject peptides are thus useful in treating neoplastic disease in an animal, preferably a human. Also provided are pharmaceutical compositions comprising the subject peptides admixed with a pharmaceutical acceptable carrier. Methods of treating neoplastic disease in a patient by administering a subject peptide fused at its carboxy terminal end to a membrane penetrating leader sequence are also provided. The present invention also provides replication incompetent Adenovirus (AdV) vectors comprising a promoter sequence operably linked to a nucleotide sequence encoding a subject peptide. Methods of selectively killing cancer cells in a subject by administering a therapeutically effective amount of a subject AdV vector are also provided by the present invention.
摘要翻译：本发明提供对应于人p53蛋白的全部或部分氨基酸残基12-26的肽，当与透膜前导序列融合时，该肽对恶性或转化细胞致死。因此，本发明的肽可用于治疗动物，优选人类的肿瘤性疾病。还提供了包含与药学上可接受的载体混合的受试肽的药物组合物。还提供了通过将其羧基末端融合的受试肽施用于穿透前导序列的方法来治疗患者的肿瘤疾病。本发明还提供了复制无能力的腺病毒（Adv）载体，其包含可操作地连接到编码目标肽的核苷酸序列的启动子序列。通过施用治疗有效量的受试者AdV载体选择性地杀死受试者的癌细胞的方法也由本发明提供。

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