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1. 发明授权

US5830431A Radiolabeled peptide compositions for site-specific targeting 失效
标题翻译：用于位点特异性靶向的放射性标记肽组合物
公开(公告)号：US5830431A
公开(公告)日：1998-11-03
申请号：US480373
申请日：1995-06-07
申请人： Ananthachari Srinivasan , Mary Marmion Dyszlewski , Joseph E. Bugaj , Jack L. Erion
发明人： Ananthachari Srinivasan , Mary Marmion Dyszlewski , Joseph E. Bugaj , Jack L. Erion
IPC分类号： A61K51/00 , A61K51/08 , A61P35/00 , C07K14/655 , A61M36/14
CPC分类号： C07K14/6555 , A61K51/083 , A61K51/088
摘要： This invention relates to radiolabeled peptide compositions for radiopharmaceutical use and, more specifically, to radiolabeled peptides for diagnostic or therapeutic use having an unmodified carboxy terminal amino acid. The radiopharmaceutical composition may be used for targeting a selected biological site. The radiolabeled peptide is characterized by having its carboxy terminal amino acid in its carboxylic acid form and the peptide is coupled to a diagnostic or therapeutic radionuclide by a chelating agent. The radiopharmaceutical composition preferably comprises a radiolabeled peptide selected from the group consisting of somatostatin, an analog of somatostatin, a derivative of somatostatin and peptides capable of binding to the somatostatin receptor, where the peptide is coupled to a diagnostic or therapeutic radionuclide by a chelating agent has its carboxy terminal amino acid in its carboxylic acid form.
摘要翻译：本发明涉及用于放射性药物用途的放射性标记肽组合物，更具体地，涉及具有未修饰的羧基末端氨基酸的用于诊断或治疗用途的放射性标记肽。放射性药物组合物可以用于靶向选定的生物部位。放射性标记的肽的特征在于其羧基末端氨基酸为羧酸形式，肽通过螯合剂偶联至诊断或治疗放射性核素。放射性药物组合物优选包含选自生长抑素，生长抑素类似物，生长抑素衍生物和能够结合生长抑素受体的肽的放射性标记的肽，其中肽通过螯合剂偶联至诊断或治疗放射性核素其羧基末端氨基酸呈羧酸形式。

2. 发明授权

US5804157A Peptide compositions and method of radiolabeling 失效
标题翻译：肽组合物和放射性标记方法
公开(公告)号：US5804157A
公开(公告)日：1998-09-08
申请号：US989434
申请日：1997-12-12
申请人： Ananthachari Srinivasan , Mary Marmion Dyszlewski , Joseph E. Bugaj
发明人： Ananthachari Srinivasan , Mary Marmion Dyszlewski , Joseph E. Bugaj
IPC分类号： A61K51/00 , A61K51/08 , A61P35/00 , C07K14/655 , A61M36/14
CPC分类号： C07K14/6555 , A61K51/083 , A61K51/088
摘要： This invention relates to radiolabeled peptide compositions for radiopharmaceutical use and, more specifically, to radiolabeled peptides for diagnostic or therapeutic use having an unmodified carboxy terminal amino acid. The radiopharmaceutical composition may be used for targeting a selected biological site. The radiolabeled peptide is characterized by having its carboxy terminal amino acid in its carboxylic acid form and the peptide is coupled to a diagnostic or therapeutic radionuclide by a chelating agent. The radiopharmaceutical composition preferably comprises a radiolabeled peptide selected from the group consisting of somatostatin, an analog of somatostatin, a derivative of somatostatin and peptides capable of binding to the somatostatin receptor, where the peptide is coupled to a diagnostic or therapeutic radionuclide by a chelating agent has its carboxy terminal amino acid in its carboxylic acid form.
摘要翻译：本发明涉及用于放射性药物用途的放射性标记肽组合物，更具体地，涉及具有未修饰的羧基末端氨基酸的用于诊断或治疗用途的放射性标记肽。放射性药物组合物可以用于靶向选定的生物部位。放射性标记的肽的特征在于其羧基末端氨基酸为羧酸形式，肽通过螯合剂偶联至诊断或治疗放射性核素。放射性药物组合物优选包含选自生长抑素，生长抑素类似物，生长抑素衍生物和能够结合生长抑素受体的肽的放射性标记的肽，其中肽通过螯合剂偶联至诊断或治疗放射性核素其羧基末端氨基酸呈羧酸形式。

3. 发明授权

US06428768B1 Stabilized radiopharmaceutical kits 失效
标题翻译：稳定的放射性药物包
公开(公告)号：US06428768B1
公开(公告)日：2002-08-06
申请号：US08442252
申请日：1995-05-15
申请人： Mark A. DeRosch , Edward A. Deutsch , Mary Marmion Dyszlewski , Dennis L. Nosco
发明人： Mark A. DeRosch , Edward A. Deutsch , Mary Marmion Dyszlewski , Dennis L. Nosco
IPC分类号： A61K5100
CPC分类号： A61K51/1282 , A61K2121/00
摘要： The present invention relates to the stabilization of radiopharmaceutical preparations and to the stabilization of components of radiopharmaceutical kits. In particular, the present invention relates to stabilization of lyophilized components of radiopharmaceutical kits by the addition of a cyclic oligosaccharide, such as, a modified or unmodified cyclodextrin, to the kit.
摘要翻译：本发明涉及放射性药物制剂的稳定化和放射性药物试剂盒组分的稳定化。特别地，本发明涉及通过向试剂盒中加入环状寡糖例如改性或未改性的环糊精来稳定放射性药物试剂盒的冻干组分。

4. 发明授权

US5662882A Radiopharmaceutical formulations having non-stannous reductants 失效
标题翻译：具有非亚锡还原剂的放射性药物制剂
公开(公告)号：US5662882A
公开(公告)日：1997-09-02
申请号：US410642
申请日：1995-03-23
申请人： James W. Brodack , Mark A. DeRosch , Edward A. Deutsch , Mary Marmion Dyszlewski
发明人： James W. Brodack , Mark A. DeRosch , Edward A. Deutsch , Mary Marmion Dyszlewski
IPC分类号： A61K51/00 , A61K51/04 , A61K51/12
CPC分类号： A61K51/1282 , A61K51/0476 , A61K2123/00
摘要： The present invention relates to novel radiopharmaceutical imaging agents having non-stannous reductants. The present invention further relates to kits for forming radiopharmaceutical imaging agents, such kits including non-stannous reducing agents.
摘要翻译：本发明涉及具有非亚锡还原剂的新型放射性药物显像剂。本发明还涉及用于形成放射性药物成像剂的试剂盒，所述试剂盒包括非亚锡还原剂。

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