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1. 发明申请

US20070014813A1 Conserved motif of hepatitis C virus E2/NS1 region 失效
标题翻译：丙型肝炎病毒E2 / NS1区域的保守主题
公开(公告)号：US20070014813A1
公开(公告)日：2007-01-18
申请号：US11522614
申请日：2006-09-18
申请人： Amy Weiner , Michael Houghton
发明人： Amy Weiner , Michael Houghton
IPC分类号： A61K39/395 , A61K39/12
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K16/109 , C07K2317/34 , C12N2770/24222 , Y10S436/82 , Y10S530/806 , Y10S530/826
摘要： The hypervariable region (E2HV) of the putative hepatitis C virus (HCV) glycoprotein E2/NS1, between about amino acid 384 to about amino acid 414, is a rapidly evolving region of HCV, and is likely to be under positive immune selection. A newly discovered motif within this hypervariable region is immunogenic and conserved with respect to the character of the amino acids. In many isolates, this motif falls between amino acids 401 to 406 or 407. The discovery of this motif allows for additional materials and methods to treat and diagnose HCV.
摘要翻译：推定的丙型肝炎病毒（HCV）糖蛋白E2 / NS1的高变区（E2HV）在约氨基酸384至约氨基酸414之间，是HCV的快速进化区域，并且可能处于阳性免疫选择。在这个高变区内新发现的基序是相对于氨基酸的特征而言是免疫原性的并且是保守的。在许多分离株中，该基序位于氨基酸401至406或407之间。该基序的发现允许另外的材料和方法来治疗和诊断HCV。

2. 发明申请

US20110150911A1 Methods and reagents for treating, preventing and diagnosing bunyavirus infection 审中-公开
标题翻译：治疗，预防和诊断布尼瓦病毒感染的方法和试剂
公开(公告)号：US20110150911A1
公开(公告)日：2011-06-23
申请号：US10580050
申请日：2004-11-19
申请人： Qui-Lim Choo , Michael Houghton , Elizabeth Scott , Amy Weiner
发明人： Qui-Lim Choo , Michael Houghton , Elizabeth Scott , Amy Weiner
IPC分类号： A61K39/12 , C07K14/175 , C07K1/14 , C07K1/16 , C07K1/18 , C07H21/04 , C12Q1/70 , A61P37/04 , A61P31/14
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/55566 , C12N2760/12022 , C12N2760/12034
摘要： Immunogenic compositions for use in treating, preventing and diagnosing infection caused by the California (CAL) serotype of the genus Bunyavirus, such as La Crosse virus (LACV), are disclosed. Also described are reagents for use in diagnostic assays.
摘要翻译：公开了用于治疗，预防和诊断由布尼亚病毒属的加利福尼亚（CAL）血清型如拉克罗斯病毒（LACV）引起的感染的免疫原性组合物。还描述了用于诊断测定的试剂。

3. 发明申请

US20060257852A1 Severe acute respiratory syndrome coronavirus 审中-公开
标题翻译：严重急性呼吸综合征冠状病毒
公开(公告)号：US20060257852A1
公开(公告)日：2006-11-16
申请号：US10822303
申请日：2004-04-09
申请人： Rino Rappuoli , Vega Masignani , Konrad Stadler , Jens Gregersen , David Chien , Jang Han , John Polo , Amy Weiner , Michael Houghton , Hyun Song , Mi-Young Seo , John Donnelly , Hans Klenk , Nicholas Valiante
发明人： Rino Rappuoli , Vega Masignani , Konrad Stadler , Jens Gregersen , David Chien , Jang Han , John Polo , Amy Weiner , Michael Houghton , Hyun Song , Mi-Young Seo , John Donnelly , Hans Klenk , Nicholas Valiante
IPC分类号： C12Q1/70 , C07H21/04 , C12N15/86 , C07K14/165
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/215 , A61K2039/5252 , A61K2039/545 , A61K2039/55505 , A61K2039/55511 , A61K2039/55566 , C07K16/10 , C07K2317/34 , C07K2317/76 , C07K2319/21 , C12N7/00 , C12N2770/20021 , C12N2770/20022 , C12N2770/20034 , C12N2770/20043 , C12N2770/20051 , C12N2770/20063 , C12Q1/701 , G01N2333/165 , G01N2469/20
摘要： An outbreak of a virulent respiratory virus, now known as Severe Acute Respiratory Syndrome (SARS), was identified in Hong Kong, China and a growing number of countries around the world in 2003. The invention relates to nucleic acids and proteins from the SARS coronavirus. These nucleic acids and proteins can be used in the preparation and manufacture of vaccine formulations, diagnostic reagents, kits, etc. The invention also provides methods for treating SARS by administering small molecule antiviral compounds, as well as methods of identifying potent small molecules for the treatment of SARS.
摘要翻译：在2003年，中国香港和世界各地越来越多的国家确定了现在称为严重急性呼吸综合征（SARS）的毒性呼吸道病毒的爆发。本发明涉及SARS冠状病毒的核酸和蛋白质。这些核酸和蛋白质可用于制备和制造疫苗制剂，诊断试剂，试剂盒等。本发明还提供了通过施用小分子抗病毒化合物治疗SARS的方法，以及鉴定用于治疗SARS的有效小分子的方法治疗SARS。

4. 发明申请

US20120141529A1 NOROVIRUS AND SAPOVIRUS ANTIGENS 审中-公开
标题翻译： NOROVIRUS和SAPOVIRUS抗原
公开(公告)号：US20120141529A1
公开(公告)日：2012-06-07
申请号：US13355192
申请日：2012-01-20
申请人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
发明人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
IPC分类号： A61K39/125 , C12P21/06 , C12N15/63 , C12N1/19 , C12N15/40 , A61P31/14
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译：描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。

5. 发明授权

US08142793B2 Norovirus and Sapovirus antigens 有权
标题翻译：诺如病毒和痘病毒抗原
公开(公告)号：US08142793B2
公开(公告)日：2012-03-27
申请号：US12383425
申请日：2009-03-24
申请人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
发明人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
IPC分类号： A01N63/04 , A61K39/38 , A61K39/12 , A61K39/125 , C12P21/04 , C12N5/02 , C12N15/74
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译：描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。

6. 发明申请

US20110014652A1 Norovirus and sapovirus antigens 有权
标题翻译：诺如病毒和滑鼠病毒抗原
公开(公告)号：US20110014652A1
公开(公告)日：2011-01-20
申请号：US12383419
申请日：2009-03-24
申请人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
发明人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
IPC分类号： C12P21/02
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译：描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。

7. 发明申请

US20100291129A1 Norovirus and sapovirus antigens 有权
标题翻译：诺如病毒和滑鼠病毒抗原
公开(公告)号：US20100291129A1
公开(公告)日：2010-11-18
申请号：US12383420
申请日：2009-03-24
申请人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
发明人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
IPC分类号： A61K39/125 , A61K39/295 , A61P31/14 , A61P31/00 , A61K39/12
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译：描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。

8. 发明申请

US20100262178A1 Non-Shortening High Angle Wrapped Balloons 有权
标题翻译：不缩短高角度包裹气球
公开(公告)号：US20100262178A1
公开(公告)日：2010-10-14
申请号：US12824343
申请日：2010-06-28
申请人： Alfred A. Alpini , Michael Houghton , Kenneth Newcomb , Jeffrey Towler
发明人： Alfred A. Alpini , Michael Houghton , Kenneth Newcomb , Jeffrey Towler
IPC分类号： A61M29/02 , B29C41/36
CPC分类号： A61M29/02 , A61M25/1029 , A61M2025/1075 , A61M2025/1084
摘要： The present invention provides a balloon which achieves diameters greater than 6 mm for securement to a catheter. The balloon includes an elastomeric generally hollow pressure expandable body which exhibits essentially radial symmetry and constant length when expanded under an internally applied minimum working pressure from an uninflated state.
摘要翻译：本发明提供一种实现直径大于6mm的气囊，用于固定到导管。气囊包括弹性体大体中空压力可膨胀体，其在内部施加的最小工作压力下从未充气状态膨胀时，其基本上呈径向对称性和恒定长度。

9. 发明授权

US07785290B2 Non-shortening high angle wrapped balloons 有权
标题翻译：不缩短大角度包裹气球
公开(公告)号：US07785290B2
公开(公告)日：2010-08-31
申请号：US11501190
申请日：2006-08-07
申请人： Alfred A. Alpini , Michael Houghton , Kenneth Newcomb , Jeffrey Towler
发明人： Alfred A. Alpini , Michael Houghton , Kenneth Newcomb , Jeffrey Towler
IPC分类号： A61M31/00
CPC分类号： A61M29/02 , A61M25/1029 , A61M2025/1075 , A61M2025/1084
摘要： The present invention provides a balloon which achieves diameters greater than 6 mm for securement to a catheter. The balloon includes an elastomeric generally hollow pressure expandable body which exhibits essentially radial symmetry and constant length when expanded under an internally applied minimum working pressure from an uninflated state.
摘要翻译：本发明提供一种实现直径大于6mm的气囊，用于固定到导管。气囊包括弹性体大体中空压力可膨胀体，其在内部施加的最小工作压力下从未充气状态膨胀时，其基本上呈径向对称性和恒定长度。

10. 发明授权

US07527801B2 Norovirus and Sapovirus antigens 有权
标题翻译：诺如病毒和痘病毒抗原
公开(公告)号：US07527801B2
公开(公告)日：2009-05-05
申请号：US11603913
申请日：2006-11-22
申请人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
发明人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
IPC分类号： A01N63/04 , A61K39/38 , A61K39/12 , A61K39/125 , C12P21/04 , C12N5/02 , C12N15/74 , A61K39/187
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译：描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。

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