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1. 发明授权

US5008411A Glycidic acid ester and process of preparation 失效
标题翻译：糖苷酸酯及其制备方法
公开(公告)号：US5008411A
公开(公告)日：1991-04-16
申请号：US416295
申请日：1989-10-02
申请人： David L. Coffen , Pradeep B. Madan , Alan Schwartz
发明人： David L. Coffen , Pradeep B. Madan , Alan Schwartz
IPC分类号： C07C319/20 , C07C323/56 , C07D281/08 , C07D281/10
CPC分类号： C07C319/20 , C07D281/08 , C07D281/10 , C07C2101/14
摘要： A process for the preparing a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen, trifluoromethyl or nitro; or R.sub.1 and R.sub.2 taken together with the benzene ring to which they are attached are naphthalene, and Ar is p-lower alkoxy phenyl.which comprises reacting ##STR2## wherein R.sub.1 and R.sub.2 are as described above with the compound of the formula ##STR3## wherein Ar is as described above, in an aromatic organic compound. The intermediates formed by the process of the invention are useful in the production of thiazepin-4(5H)-ones which have activity as calcium channel blockers and accordingly are useful as agents for lowering blood pressure and agents for treating ischemia.
摘要翻译：制备式IV化合物的方法，其中R 1和R 2各自独立地为氢，1至4个碳原子的烷基，1至4个碳原子的烷氧基，卤素，三氟甲基或硝基; 或者R 1和R 2与它们所连接的苯环一起为萘，Ar为对低级烷氧基苯基。其中包括使其中R 1和R 2如上所述的其中Ar如上所述的式IIIa化合物在芳族有机化合物中反应。通过本发明的方法形成的中间体可用于制备具有钙通道阻断剂活性的硫氮平-4（5H）酮，因此可用作降低血压的药剂和用于治疗缺血的药剂。

2. 发明授权

US4770171A Cryogenic surgical tool 失效
标题翻译：低温手术工具
公开(公告)号：US4770171A
公开(公告)日：1988-09-13
申请号：US13949
申请日：1987-02-12
申请人： Ronald J. Sweren , Alan Schwartz
发明人： Ronald J. Sweren , Alan Schwartz
IPC分类号： A61B18/00 , A61B18/02 , A61B17/36
CPC分类号： A61B18/02 , A61B2018/00101
摘要： A cryogenic surgical tool (10) is provided to contact and freeze predetermined areas of tissue. The cryogenic surgical tool (10) consists of a low thermal conductivity handle (12) which is threadedly secured to an applicator member (20). The applicator member (20) includes an internal bore (26) within which is fitted an absorbent member (34) which absorbs a cryogenic liquid. The applicator member (20) includes an applicator first end surface (24) which contacts tissue and draws heat therefrom to extremely low temperatures, thus generally destroying the tissue contacted. The applicator member (20) includes a plurality of housing sidewall through openings (32) which are vent holes and allow for vaporization of the cryogenic liquid from the absorbent member (34) and prevents undue pressures from building up a cavity formed by bore (26) within housing member (20).
摘要翻译：提供一种低温外科手术工具（10）来接触和冻结组织的预定区域。低温外科手术工具（10）由低导热性手柄（12）组成，该手柄螺纹地固定到涂抹器构件（20）上。涂抹器构件（20）包括内孔（26），其内装有吸收低温液体的吸收构件（34）。涂抹器构件（20）包括施加器第一端表面（24），其接触组织并将热量从其中吸取到极低温度，从而通常破坏接触的组织。施用器构件（20）包括多个壳体侧壁通孔（32），其是通气孔并允许来自吸收构件（34）的低温液体蒸发，并且防止不必要的压力建立由孔（26）形成的空腔）在壳体构件（20）内。

3. 发明申请

US20150119740A1 WHOLE-BODY PLETYSMOGRAPHY SYSTEM FOR THE CONTINUOUS CHARACTERIZATION OF SLEEP AND BREATHING IN A MOUSE 审中-公开
标题翻译：用于连续表征小鼠睡眠和呼吸的全身体育系统
公开(公告)号：US20150119740A1
公开(公告)日：2015-04-30
申请号：US14129556
申请日：2012-07-02
申请人： Adam Breaux Hernandez , Jason Kirkness , Hartmut Schneider , Mikhael Polotsky , Alan Schwartz , Philip Smith , Walter Hernandez
发明人： Adam Breaux Hernandez , Jason Kirkness , Hartmut Schneider , Mikhael Polotsky , Alan Schwartz , Philip Smith , Walter Hernandez
IPC分类号： A61B5/08 , A61B5/0488 , A61B5/00 , A61B5/0476
CPC分类号： A61B5/0806 , A61B5/0476 , A61B5/0488 , A61B5/4812 , A61B5/4818 , A61B5/7203 , A61B2503/40
摘要： An embodiment in accordance with the present invention provides a device for whole-body plethysmography (WBP) of a mouse for the continuous characterization of sleep and breathing. The inherent limitations of standard WBP are addressed to enable the continuous recording of validated measures of tidal volume, tidal airflow, and respiratory effort surrogate in an unrestrained, unanesthetized mouse. The addition of standard EEG and EMG recording technology allows for respiratory patterns to be fully characterized during sleep and wakefulness. The present invention also allows for the demonstration of the development of dynamic upper airway obstruction [inspiratory flow limitation (IFL)] during sleep in a susceptible, obese murine strain.
摘要翻译：根据本发明的实施例提供了用于连续表征睡眠和呼吸的小鼠的全身体积描记术（WBP）的装置。标准WBP的固有限制是为了能够在无限制，未经麻醉的鼠标中连续记录潮气量，潮气量和呼吸力代用品的有效措施。标准EEG和EMG记录技术的添加允许在睡眠和觉醒期间充分表征呼吸模式。本发明还允许在易感，肥胖的鼠类菌株中睡眠期间动态上呼吸道阻塞[吸气流量限制（IFL）]的发展的证明。

4. 发明授权

US08966569B2 Collaborative structured analysis system and method 有权
标题翻译：协同结构分析系统和方法
公开(公告)号：US08966569B2
公开(公告)日：2015-02-24
申请号：US13192425
申请日：2011-07-27
申请人： Alan Schwartz , Katherine Pherson , Diana Manfredi , Grace Scarborough , Randolph Pherson , Sarah Beebe , Karl Ginter , Mike Bartman
发明人： Alan Schwartz , Katherine Pherson , Diana Manfredi , Grace Scarborough , Randolph Pherson , Sarah Beebe , Karl Ginter , Mike Bartman
IPC分类号： G06F21/00 , G06Q10/06 , G06Q10/10
CPC分类号： H04L63/105 , G06N5/04 , G06Q10/0633 , G06Q10/103
摘要： Methods, systems, and apparatus for providing compartmented, collaborative, integrated, automated analytics to analysts are provided. In a first aspect, the present invention provides a computer-implemented method for providing compartmented, collaborative, integrated, automated analytics to analysts including: selecting a computer-encoded project-specific workflow; determining a computer-encoded compartment manager, said computer-encoded compartment manager including computer-encoded information about the context of said project-specific workflow; retrieving said computer-encoded information about the context; selecting a computer-implemented automated analytic using said computer-encoded project-specific workflow; providing under control of said computer-encoded compartment manager said information about the context to said automated analytic; processing said computer-encoded information using said computer-implemented automated analytic, to generate thereby analytical information representing an outcome to said analysts; and processing said analytical information in accordance with said computer-encoded compartment manager and said computer-encoded project-specific workflow.
摘要翻译：提供了为分析人员提供隔离，协同，集成，自动化分析的方法，系统和设备。在第一方面，本发明提供了一种计算机实现的方法，用于向分析人员提供隔离的，协作的，综合的，自动化的分析，包括：选择计算机编码的项目特定工作流程; 确定计算机编码的分区管理器，所述计算机编码的分区管理器包括关于所述项目特定工作流的上下文的计算机编码信息; 检索关于上下文的所述计算机编码信息; 使用所述计算机编码的项目特定工作流选择计算机实现的自动分析; 在所述计算机编码的间隔管理器的控制下提供关于所述自动分析的上下文的信息; 使用所述计算机实现的自动分析处理所述计算机编码信息，从而生成表示所述分析人员的结果的分析信息; 以及根据所述计算机编码的分区管理器和所述计算机编码的项目特定工作流处理所述分析信息。

5. 发明授权

US4939252A Novel intermediates for the preparation of Carbovir 失效
标题翻译：用于制备Carbovir的新型中间体
公开(公告)号：US4939252A
公开(公告)日：1990-07-03
申请号：US340648
申请日：1989-04-20
申请人： Alan Schwartz
发明人： Alan Schwartz
IPC分类号： C07D239/48 , C07D473/18 , C07F7/18
CPC分类号： C07D239/48 , C07F7/1856
摘要： The invention provides novel cyclopentenyl carbinol compounds which are useful as intermediates for the preparation of the anti-AIDS drug, Carbovir. Processes for the preparation of such novel compounds and for the use of the compounds to make Carbovir are also provided.
摘要翻译：本发明提供了可用作制备抗艾滋病药物Carbovir的中间体的新型环戊烯基甲醇化合物。还提供了制备这种新型化合物和使用该化合物制备卡博维尔的方法。

6. 发明授权

US08883783B2 Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith 有权
标题翻译：包含N-（5-叔丁基 - 异恶唑-3-基）-N' - {4- [7-（2-吗啉-4-基 - 乙氧基）咪唑并[2,1-b] [1,3] 3]苯并噻唑-2-基]苯基}脲，其组合物及其用途
公开(公告)号：US08883783B2
公开(公告)日：2014-11-11
申请号：US12233906
申请日：2008-09-19
申请人： Shripad S. Bhagwat , Wei Lai , Stephan D. Parent , Melanie J. Roe , Alan Schwartz , Valeriya N. Smolenskaya
发明人： Shripad S. Bhagwat , Wei Lai , Stephan D. Parent , Melanie J. Roe , Alan Schwartz , Valeriya N. Smolenskaya
IPC分类号： A61K31/535 , C07D415/00 , C07D417/00 , C07D513/04
CPC分类号： A61K31/5377 , A61K31/185 , C07D513/04
摘要： Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions comprising the solid forms, methods of making the solid forms and methods of their use for the treatment of various diseases and/or disorders are disclosed.
摘要翻译：包含N-（5-叔丁基 - 异恶唑-3-基）-N' - {4- [7-（2-吗啉-4-基 - 乙氧基）咪唑并[2,1-b] [1,3] 3]苯并噻唑-2-基]苯基}脲，包含固体形式的组合物，制备固体形式的方法及其用于治疗各种疾病和/或病症的方法。

7. 发明申请

US20120164612A1 IDENTIFICATION AND DETECTION OF SPEECH ERRORS IN LANGUAGE INSTRUCTION 审中-公开
标题翻译：语言指导中的语音错误的识别和检测
公开(公告)号：US20120164612A1
公开(公告)日：2012-06-28
申请号：US13338383
申请日：2011-12-28
申请人： Laurence Gillick , Alan Schwartz , Jean-Manuel Van Thong , Peter Wolf , Don McAllaster
发明人： Laurence Gillick , Alan Schwartz , Jean-Manuel Van Thong , Peter Wolf , Don McAllaster
IPC分类号： G09B19/04
CPC分类号： G09B19/04
摘要： Speech errors for a learner of a language (e.g., an English language learner) are identified automatically based on aggregated characteristics of that learner's speech.
摘要翻译：基于学习者言语的综合特征，自动识别语言学习者（例如，英语学习者）的言语错误。

8. 发明申请

US20120030729A1 COLLABORATIVE STRUCTURED ANALYSIS SYSTEM AND METHOD 有权
标题翻译：协同结构分析系统与方法
公开(公告)号：US20120030729A1
公开(公告)日：2012-02-02
申请号：US13192425
申请日：2011-07-27
申请人： Alan Schwartz , Katherine Pherson , Diana Manfredi , Grace Scarborough , Randolph Pherson , Sarah Beebe , Karl Ginter , Mike Bartman
发明人： Alan Schwartz , Katherine Pherson , Diana Manfredi , Grace Scarborough , Randolph Pherson , Sarah Beebe , Karl Ginter , Mike Bartman
IPC分类号： G06F21/00 , G06N5/02
CPC分类号： H04L63/105 , G06N5/04 , G06Q10/0633 , G06Q10/103
摘要： Methods, systems, and apparatus for providing compartmented, collaborative, integrated, automated analytics to analysts are provided. In a first aspect, the present invention provides a computer-implemented method for providing compartmented, collaborative, integrated, automated analytics to analysts including: selecting a computer-encoded project-specific workflow; determining a computer-encoded compartment manager, said computer-encoded compartment manager including computer-encoded information about the context of said project-specific workflow; retrieving said computer-encoded information about the context; selecting a computer-implemented automated analytic using said computer-encoded project-specific workflow; providing under control of said computer-encoded compartment manager said information about the context to said automated analytic; processing said computer-encoded information using said computer-implemented automated analytic, to generate thereby analytical information representing an outcome to said analysts; and processing said analytical information in accordance with said computer-encoded compartment manager and said computer-encoded project-specific workflow.
摘要翻译：提供了为分析人员提供隔离，协同，集成，自动化分析的方法，系统和设备。在第一方面，本发明提供了一种计算机实现的方法，用于向分析人员提供隔离的，协作的，综合的，自动化的分析，包括：选择计算机编码的项目特定工作流程; 确定计算机编码的分区管理器，所述计算机编码的分区管理器包括关于所述项目特定工作流的上下文的计算机编码信息; 检索关于上下文的所述计算机编码信息; 使用所述计算机编码的项目特定工作流选择计算机实现的自动分析; 在所述计算机编码的间隔管理器的控制下提供关于所述自动分析的上下文的信息; 使用所述计算机实现的自动分析处理所述计算机编码信息，从而生成表示所述分析人员的结果的分析信息; 以及根据所述计算机编码的分区管理器和所述计算机编码的项目特定工作流处理所述分析信息。

9. 发明申请

US20090131426A1 SOLID FORMS COMPRISING N-(5-TERT-BUTYL-ISOXAZOL-3-YL)-N'-UREA, COMPOSITIONS THEREOF, AND USES THEREWITH 有权
标题翻译：包含N-（5-叔丁基 - 异唑-3-基）-N'-尿素的固体形式，其组合物及其用途
公开(公告)号：US20090131426A1
公开(公告)日：2009-05-21
申请号：US12233906
申请日：2008-09-19
申请人： Shripad S. Bhagwat , Wei Lai , Stephan D. Parent , Melanie J. Roe , Alan Schwartz , Valeriya N. Smolenskaya
发明人： Shripad S. Bhagwat , Wei Lai , Stephan D. Parent , Melanie J. Roe , Alan Schwartz , Valeriya N. Smolenskaya
IPC分类号： A61K31/5377 , C07D513/04 , A61P35/00
CPC分类号： A61K31/5377 , A61K31/185 , C07D513/04
摘要： Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions comprising the solid forms, methods of making the solid forms and methods of their use for the treatment of various diseases and/or disorders are disclosed.
摘要翻译：包含N-（5-叔丁基 - 异恶唑-3-基）-N' - {4- [7-（2-吗啉-4-基 - 乙氧基）咪唑并[2,1-b] [1,3] 3]苯并噻唑-2-基]苯基}脲，包含固体形式的组合物，制备固体形式的方法及其用于治疗各种疾病和/或病症的方法。

10. 发明申请

US20080092898A1 Disposable Sleep And Breathing Monitor 有权
标题翻译：一次性睡眠呼吸监护仪
公开(公告)号：US20080092898A1
公开(公告)日：2008-04-24
申请号：US11661405
申请日：2005-08-26
申请人： Hartmut Schneider , Benjamin Lane , Alan Schwartz , Philip Smith , Jennifer Regan
发明人： Hartmut Schneider , Benjamin Lane , Alan Schwartz , Philip Smith , Jennifer Regan
IPC分类号： A61M16/06
CPC分类号： A61M16/0858 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/0878 , A61B5/1455 , A61B5/4806 , A61M16/0051 , A61M16/021 , A61M16/06 , A61M16/0683 , A61M16/0816 , A61M2016/0036 , A61M2210/0618 , A61M2230/62
摘要： An apparatus comprises a mask, a sensor body configured to be attached to the mask, and an electronic module for producing an output in response to air flow through the sensor body.
摘要翻译：一种装置包括掩模，构造成附接到掩模的传感器主体，以及用于响应于通过传感器主体的空气流而产生输出的电子模块。

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