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1. 发明申请

US20110189192A1 NOVEL COMPOUNDS THAT ARE ERK INHIBITORS 有权
标题翻译：新的化合物是ERK抑制剂
公开(公告)号：US20110189192A1
公开(公告)日：2011-08-04
申请号：US12918099
申请日：2009-02-19
申请人： Alan B. Cooper , Yang Nan , Yongqi Deng , Gerald W. Shipps, JR. , Neng-Yang Shih , Hugh Y. Zhu , Joseph M. Kelly , Subrahmanyam Gudipati , Ronald J. Doll , Mehul F. Patel , Jagdish A. Desai , James J-S Wang , Sunil Paliwal , Hon-Chung Tsui , Sobhana Babu Boga , Abdul-Basit Alhassan , Xiaolei Gao , Liang Zhu , Xin Yao
发明人： Alan B. Cooper , Yang Nan , Yongqi Deng , Gerald W. Shipps, JR. , Neng-Yang Shih , Hugh Y. Zhu , Joseph M. Kelly , Subrahmanyam Gudipati , Ronald J. Doll , Mehul F. Patel , Jagdish A. Desai , James J-S Wang , Sunil Paliwal , Hon-Chung Tsui , Sobhana Babu Boga , Abdul-Basit Alhassan , Xiaolei Gao , Liang Zhu , Xin Yao
IPC分类号： A61K31/444 , C07D401/14 , C07D409/14 , C07D417/14 , A61K31/501 , A61K39/395 , A61K31/7052 , A61P35/02 , A61P35/00
CPC分类号： C07D403/14
摘要： Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts, and solvates thereof. Q is a tetrahydropyridinyl ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
摘要翻译：公开了式1.0的ERK抑制剂及其药学上可接受的盐和溶剂化物。 Q是四氢吡啶环。所有其他取代基如本文所定义。还公开了使用式1.0化合物治疗癌症的方法。

2. 发明授权

US08999966B2 Compounds that are ERK inhibitors 有权
标题翻译： ERK抑制剂的化合物
公开(公告)号：US08999966B2
公开(公告)日：2015-04-07
申请号：US13881050
申请日：2011-10-24
申请人： Sobhana Babu Boga , Joseph M. Kelly , Hugh Y. Zhu , Abdul-Basit Alhassan , Xin Yao , Xiaolei Gao , James J-S Wang , Jagdish A. Desai , Subrahmanyam Gudipati , Sie-Mun Lo , Liang Zhu , Alan B. Cooper , Yongqi Deng , Gerald W. Shipps, Jr.
发明人： Sobhana Babu Boga , Joseph M. Kelly , Hugh Y. Zhu , Abdul-Basit Alhassan , Xin Yao , Xiaolei Gao , James J-S Wang , Jagdish A. Desai , Subrahmanyam Gudipati , Sie-Mun Lo , Liang Zhu , Alan B. Cooper , Yongqi Deng , Gerald W. Shipps, Jr.
IPC分类号： A61K31/397 , A61K31/5377 , A61K31/506 , A61K31/4545 , A61K31/454 , A61K31/4523 , A61K31/4427 , A61K31/4439 , A61K31/444 , C07D413/14 , C07D401/14 , C07D403/14 , C07D221/00 , C07D221/02 , C07D211/80 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , A61K45/06
CPC分类号： C07D401/14 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K45/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof, wherein: A is a five membered monocyclic heteroaryl ring; and B is a monocyclic heterocycloalkyl ring, or a monocyclic heterocycloalkenyl ring, or a bridged monocyclic heterocycloalkyl ring, or a fused (monocyclic heterocycloalkyl ring) cyclopropyl ring. Also disclosed are methods of treating cancer using the compounds of formula (1).
摘要翻译：公开了式（1）的ERK抑制剂及其药学上可接受的盐，其中：A是五元单环杂芳基环; 和B是单环杂环烷基环，或单环杂环烯基环，或桥连单环杂环烷基环，或稠合（单环杂环烷基环）环丙基环。还公开了使用式（1）的化合物治疗癌症的方法。

3. 发明申请

US20130237518A1 NOVEL COMPOUNDS THAT ARE ERK INHIBITORS 有权
标题翻译：新的化合物是ERK抑制剂
公开(公告)号：US20130237518A1
公开(公告)日：2013-09-12
申请号：US13881050
申请日：2011-10-24
申请人： Sobhana Babu Boga , Joseph M. Kelly , Hugh Y. Zhu , Abdul-Basit Alhassan , Xin Yao , Xiaolei Gao , James J-S Wang , Jagdish A. Desai , Subrahmanyam Gudipati , Sie-Mun Lo , Liang Zhu , Alan B. Cooper , Yongqi Deng , Gerald W. Shipps, JR.
发明人： Sobhana Babu Boga , Joseph M. Kelly , Hugh Y. Zhu , Abdul-Basit Alhassan , Xin Yao , Xiaolei Gao , James J-S Wang , Jagdish A. Desai , Subrahmanyam Gudipati , Sie-Mun Lo , Liang Zhu , Alan B. Cooper , Yongqi Deng , Gerald W. Shipps, JR.
IPC分类号： C07D401/14 , C07D471/04 , C07D417/14 , C07D409/14 , A61K31/5377 , A61K45/06 , A61K31/4545 , A61K31/444 , A61K31/454 , C07D413/14 , C07D405/14
CPC分类号： C07D401/14 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K45/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof, wherein: A is a five membered monocyclic heteroaryl ring; and B is a monocyclic heterocycloalkyl ring, or a monocyclic heterocycloalkenyl ring, or a bridged monocyclic heterocycloalkyl ring, or a fused (monocyclic heterocycloalkyl ring) cyclopropyl ring. Also disclosed are methods of treating cancer using the compounds of formula (1).
摘要翻译：公开了式（1）的ERK抑制剂及其药学上可接受的盐，其中：A是五元单环杂芳基环; 和B是单环杂环烷基环，或单环杂环烯基环，或桥连单环杂环烷基环，或稠合（单环杂环烷基环）环丙基环。还公开了使用式（1）的化合物治疗癌症的方法。

4. 发明授权

US08999957B2 Heterocyclic compounds as ERK inhibitors 有权
标题翻译：杂环化合物作为ERK抑制剂
公开(公告)号：US08999957B2
公开(公告)日：2015-04-07
申请号：US13703250
申请日：2011-06-22
申请人： Yongqi Deng , Liang Zhu , Gerald W. Shipps, Jr. , Sie-Mun Lo , Binyuan Sun , Xiaohua Huang , Corey Bienstock , Alan B. Cooper , Xiaolei Gao , Xin Yao , Hugh Y. Zhu , Joseph M. Kelly , Sobhana Babu Boga , Abdul-Basit Alhassan , Jayaram R. Tagat , Umar Faruk Mansoor , Kevin J. Wilson , Brendan M. O'Boyle , Matthew Hersh Daniels , Adam Schell , Phieng Siliphaivanh , Christian Fischer
发明人： Yongqi Deng , Liang Zhu , Gerald W. Shipps, Jr. , Sie-Mun Lo , Binyuan Sun , Xiaohua Huang , Corey Bienstock , Alan B. Cooper , Xiaolei Gao , Xin Yao , Hugh Y. Zhu , Joseph M. Kelly , Sobhana Babu Boga , Abdul-Basit Alhassan , Jayaram R. Tagat , Umar Faruk Mansoor , Kevin J. Wilson , Brendan M. O'Boyle , Matthew Hersh Daniels , Adam Schell , Phieng Siliphaivanh , Christian Fischer
IPC分类号： C07D401/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D401/14 , C07D405/14 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07F7/18
CPC分类号： C07D401/14 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/1804
摘要： The present invention provides a compound of the Formula I: (Formular I should be inserted here) or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2 and R3 are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译：本发明提供了式I化合物：（式I应在此插入）或其药学上可接受的盐，溶剂化物或酯，其中R，R 1，R 2和R 3如本文所定义。这些化合物是ERK抑制剂。还公开了包含上述化合物的药物组合物和使用其治疗癌症的方法。

5. 发明申请

US20130096084A1 NOVEL HETEROCYCLIC COMPOUNDS AS ERK INHBITORS 有权
标题翻译：新型杂环化合物作为ERK抑制剂
公开(公告)号：US20130096084A1
公开(公告)日：2013-04-18
申请号：US13703250
申请日：2011-06-22
申请人： Yongqi Deng , Liang Zhu , Gerald W. Shipps, JR. , Sie-Mun Lo , Binyuan Sun , Xiaohua Huang , Corey Bienstock , Alan B. Cooper , Xiaolei Gao , Xin Yao , Hugh Y. Zhu , Joseph M. Kelly , Sobhana Babu Boga , Abdul-Basit Alhassan , Jayaram R. Tagat , Umar Faruk Mansoor , Kevin J. Wilson , Brendan M. O'Boyle , Matthew Hersh Daniels , Adam Schell , Phieng Siliphaivanh , Christian Fischer
发明人： Yongqi Deng , Liang Zhu , Gerald W. Shipps, JR. , Sie-Mun Lo , Binyuan Sun , Xiaohua Huang , Corey Bienstock , Alan B. Cooper , Xiaolei Gao , Xin Yao , Hugh Y. Zhu , Joseph M. Kelly , Sobhana Babu Boga , Abdul-Basit Alhassan , Jayaram R. Tagat , Umar Faruk Mansoor , Kevin J. Wilson , Brendan M. O'Boyle , Matthew Hersh Daniels , Adam Schell , Phieng Siliphaivanh , Christian Fischer
IPC分类号： C07D401/14 , A61K45/06 , C07D405/14 , A61K31/454 , A61K31/55 , A61K31/551 , C07D401/12 , C07D409/14 , C07D417/14 , A61K31/506 , C07D471/04 , C07F7/18 , A61K31/695 , C07D413/14 , A61K31/5377 , A61K31/4545
CPC分类号： C07D401/14 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/1804
摘要： The present invention provides a compound of the Formula I: (Formular I should be inserted here) or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2 and R3 are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译：本发明提供了式I化合物：（式I应在此插入）或其药学上可接受的盐，溶剂化物或酯，其中R，R 1，R 2和R 3如本文所定义。这些化合物是ERK抑制剂。还公开了包含上述化合物的药物组合物和使用其治疗癌症的方法。

6. 发明申请

US20140221333A1 BTK INHIBITORS 审中-公开
标题翻译： BTK抑制剂
公开(公告)号：US20140221333A1
公开(公告)日：2014-08-07
申请号：US14233478
申请日：2012-07-19
申请人： Adrianus Petrus Antonius De Man , Jan-Gerard Sterrenburg , Han C.A. Raaijmakers , Allard Kaptein , Arthura A. Oubrie , Johannes Bernardus Maria Rewinkel , Christiaan Gerardus Johannes Maria Jans , Jacobus C.H.M. Wijkamans , Tjeerd A. Barf , Alan B. Cooper , Ronald M. Kim , Sobhana Babu Boga , Hugh Y. Zhu , Xiaolei Gao , Xin Yao , Rajan Anand , Hao Wu , Shilan Liu , Chundao Yang , Abdul-Basit Alhassan , James Wang , Younong Yu , Jian Liu , Henry M. Vaccaro
发明人： Adrianus Petrus Antonius De Man , Jan-Gerard Sterrenburg , Han C.A. Raaijmakers , Allard Kaptein , Arthura A. Oubrie , Johannes Bernardus Maria Rewinkel , Christiaan Gerardus Johannes Maria Jans , Jacobus C.H.M. Wijkamans , Tjeerd A. Barf , Alan B. Cooper , Ronald M. Kim , Sobhana Babu Boga , Hugh Y. Zhu , Xiaolei Gao , Xin Yao , Rajan Anand , Hao Wu , Shilan Liu , Chundao Yang , Abdul-Basit Alhassan , James Wang , Younong Yu , Jian Liu , Henry M. Vaccaro
IPC分类号： C07D487/04 , C07D513/04 , A61K31/55 , A61K31/5377 , A61K31/53 , A61K31/4985 , A61K31/541
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D471/04 , C07D513/04 , C07D519/00
摘要： Provided are 6-5 membered fused pyridine ring compounds according to Formula (I) or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds and their use in therapy. In particular, provided is the use of membered fused pyridine ring compounds in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.
摘要翻译：提供根据式（I）的6-5元稠合吡啶环化合物或其药学上可接受的盐，包含这些化合物的药物组合物及其在治疗中的用途。特别地，提供了使用元稠合的吡啶环化合物来治疗布鲁丁的酪氨酸激酶（Btk）介导的病症。

7. 发明授权

US09173006B2 Method for live broadcasting in a distributed network and apparatus for the same 有权
标题翻译：分布式网络中实时广播的方法及其设备
公开(公告)号：US09173006B2
公开(公告)日：2015-10-27
申请号：US12952964
申请日：2010-11-23
申请人： Wenyu Wang , Wei Zhu , Xin Yao
发明人： Wenyu Wang , Wei Zhu , Xin Yao
IPC分类号： H04N21/63 , H04L29/08 , H04L29/06 , H04N21/236 , H04N21/434 , H04N21/435 , H04N21/222 , H04N21/232 , H04N21/462 , H04L12/18
CPC分类号： H04N21/63 , H04L12/1863 , H04L67/104 , H04L67/1063 , H04L67/1074 , H04L67/1095 , H04L67/42 , H04N21/222 , H04N21/232 , H04N21/236 , H04N21/4344 , H04N21/435 , H04N21/4622 , H04N21/632
摘要： The present invention has provided a method for live broadcasting in distributed network and means for the same. Wherein the method mainly comprises steps of: tracker servers receive the status report information from the program source connected to the tracker server; generates the status information of the program source based on said status report information; sends status information of the program source to the information synchronization means.
摘要翻译：本发明提供了一种用于分布式网络中的直播的方法及其方法。其中方法主要包括以下步骤：跟踪服务器从连接到跟踪服务器的程序源接收状态报告信息; 基于所述状态报告信息生成所述节目源的状态信息; 将该程序源的状态信息发送到信息同步装置。

8. 发明申请

US20110024961A1 Combined Driving Spring in The Slide Cover Hinge of The Mobile Communication Terminal 有权
标题翻译：移动通信终端滑盖铰链组合驱动弹簧
公开(公告)号：US20110024961A1
公开(公告)日：2011-02-03
申请号：US12936047
申请日：2008-06-19
申请人： Guanlun Cheng , Xin Yao
发明人： Guanlun Cheng , Xin Yao
IPC分类号： H04M1/02 , F16F3/02
CPC分类号： H04M1/0237
摘要： This invention provides the combined driving spring in the slide cover hinge of the mobile communication terminal. It comprises multiple springs in the same shape, the multiple springs are arranged and combined in turn on the same plane, with their both ends fixed; the driving spring is provided with connections on its both ends to match with the slide in the slide hinge. The shape of the spring is similar to the shape W. The driving spring provided by this invention can be directly used as a driving mechanism in the slide hinge for the mobile communication terminals, simplifying the structure of the driving mechanism. In particular, when the spring in the shape of W is employed, the spring can not only facilitate the combination connection, but also provide a greater force. Besides, when the slide cover slides, less area is occupied when the spring deforms, making it easier to arrange other parts of the mobiles device.
摘要翻译：本发明提供了移动通信终端的滑盖铰链中的组合驱动弹簧。它包括多个相同形状的弹簧，多个弹簧依次布置并组合在同一平面上，两端固定; 驱动弹簧在其两端设置有与滑动铰链中的滑块相配合的连接。弹簧的形状与形状W相似。本发明提供的驱动弹簧可以直接用作移动通信终端的滑动铰链中的驱动机构，从而简化了驱动机构的结构。特别地，当使用具有W形状的弹簧时，弹簧不仅可以促进组合连接，而且还可以提供更大的力。此外，当滑动盖滑动时，当弹簧变形时占用较少的面积，使得更容易布置移动设备的其他部分。

9. 发明申请

US20080253539A1 Control Method Of Telephone User Call And Short Message Transmission 审中-公开
标题翻译：电话用户呼叫和短消息传输的控制方法
公开(公告)号：US20080253539A1
公开(公告)日：2008-10-16
申请号：US12143191
申请日：2008-06-20
申请人： Xin Yao
发明人： Xin Yao
IPC分类号： H04M1/56 , H04Q7/20
CPC分类号： H04M1/67 , H04M1/677 , H04M1/72552 , H04M3/38 , H04M3/436 , H04M15/68 , H04M2215/0196 , H04W12/12
摘要： A control method of telephone user call is provided, which includes the following steps. A telephone user makes a call, and transmits a calling message to a corresponding processing device. The processing device extracts calling information of the user from the calling message, compares with a trap identification (trap ID) database, and determines whether a called number matches with one of the trap IDs in the database. If the called number does not match with any of the trap IDs, the call continues. If the called number matches with one of the trap IDs, the processing device notifies the query result and warning information to the user.
摘要翻译：提供电话用户呼叫的控制方法，其包括以下步骤。电话用户进行呼叫，并将呼叫消息发送到相应的处理设备。处理装置从呼叫消息中提取用户的呼叫信息，与陷阱识别（trap ID）数据库进行比较，并确定被叫号码是否与数据库中的一个陷阱ID匹配。如果被叫号码与任何陷阱ID不匹配，则呼叫继续。如果被叫号码与其中一个trap ID相匹配，则处理设备向用户通知查询结果和警告信息。

10. 发明授权

US08615594B2 Virtual media with folder-mount function 有权
标题翻译：具有文件夹安装功能的虚拟介质
公开(公告)号：US08615594B2
公开(公告)日：2013-12-24
申请号：US12503814
申请日：2009-07-15
申请人： YiLi Liu , Xin Yao
发明人： YiLi Liu , Xin Yao
IPC分类号： G06F15/16
CPC分类号： G06F17/30067
摘要： A virtual media (VM) method for mounting a folder stored in a storage device of a client for accessed by a server as a virtual drive. The client assigns virtual cluster indices to each file in the folder, and creates a file-cluster index table to store the assigned virtual cluster indices. The client also creates a VM file system complying with the FAT file system standard except that only subdirectories and no data files are stored in the VM FAT file system. The VM FAT table uses virtual cluster indices rather than actual cluster indices. Data written by the server are stored in a temporary data area without modifying the actual file system of the storage device. The virtual sectors requested to be written are “dirty”, and the dirty sector numbers and corresponding temporary sector numbers are stored in a dirty sector index table for use in a write-back step.
摘要翻译：一种虚拟媒体（VM）方法，用于将存储在客户机的存储设备中的文件夹安装为由服务器访问作为虚拟驱动器。客户端为文件夹中的每个文件分配虚拟集群索引，并创建一个文件集群索引表来存储分配的虚拟集群索引。客户端还创建符合FAT文件系统标准的VM文件系统，除了只有子目录和没有数据文件存储在VM FAT文件系统中。 VM FAT表使用虚拟集群索引而不是实际的集群索引。由服务器写入的数据存储在临时数据区，而不修改存储设备的实际文件系统。请求写入的虚拟扇区为“脏”，脏扇区号和相应的临时扇区号存储在脏扇区索引表中以用于回写步骤。

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