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1. 发明授权

US07655804B2 Diketohydrazine derivative compounds and drugs containing the compounds as the active ingredient 失效
标题翻译：二酮肼衍生物化合物和含有这些化合物作为活性成分的药物
公开(公告)号：US07655804B2
公开(公告)日：2010-02-02
申请号：US10512348
申请日：2003-04-24
申请人： Akira Hatayama , Hiroshi Tsuruta , Yasuo Ochi , Haruo Imawaka , Kazuyuki Ohmoto
发明人： Akira Hatayama , Hiroshi Tsuruta , Yasuo Ochi , Haruo Imawaka , Kazuyuki Ohmoto
IPC分类号： C07D417/12
CPC分类号： C07D209/48 , A61K31/16 , A61K31/165 , A61K31/341 , A61K31/351 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/4152 , A61K31/4166 , A61K31/4168 , A61K31/421 , A61K31/423 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/429 , C07C243/34 , C07C251/76 , C07C251/84 , C07C251/86 , C07C2601/08 , C07C2601/14 , C07D207/22 , C07D207/50 , C07D209/46 , C07D211/28 , C07D211/72 , C07D211/86 , C07D211/98 , C07D213/70 , C07D213/76 , C07D213/77 , C07D213/78 , C07D233/38 , C07D233/52 , C07D233/80 , C07D239/10 , C07D239/18 , C07D239/36 , C07D241/08 , C07D241/18 , C07D263/26 , C07D263/28 , C07D265/08 , C07D265/10 , C07D265/33 , C07D275/02 , C07D275/03 , C07D275/06 , C07D277/18 , C07D277/36 , C07D277/50 , C07D277/54 , C07D277/60 , C07D277/82 , C07D279/02 , C07D279/06 , C07D279/12 , C07D285/10 , C07D285/16 , C07D309/04 , C07D309/28 , C07D335/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D513/10 , C07F9/59 , C07F9/65583 , Y02A50/411
摘要： The present invention relates to a diketohydrazine derivative of formula (I) and a pharmaceutically acceptable salt thereof (the symbols in the formula have the same meaning as described in the specification). The compound of formula (I) has an inhibitory activity against cysteine protease, and it is useful for the treatment of inflammatory diseases, immune diseases, ischemic diseases, respiratory diseases, circulatory diseases, blood diseases, neuronal diseases, hepatic or biliary diseases, osseous or articular diseases, metabolic diseases, etc. And the compound has inhibitory activity against elastase and it is also useful for the treatment of COPD (chronic obstacle pulmonary diseases).
摘要翻译：本发明涉及式（I）的二酮肼衍生物及其药学上可接受的盐（式中的符号具有与说明书中所述相同的含义）。式（I）化合物对半胱氨酸蛋白酶具有抑制活性，可用于治疗炎性疾病，免疫疾病，缺血性疾病，呼吸系统疾病，循环系统疾病，血液病，神经元疾病，肝或胆道疾病，骨质或关节疾病，代谢疾病等。该化合物对弹性蛋白酶具有抑制活性，也可用于治疗慢性阻塞性肺疾病（慢性障碍性肺疾病）。

2. 发明授权

US08138182B2 Diketohydrazine derivative compounds and drugs containing the compounds as the active ingredient 失效
标题翻译：二酮肼衍生物化合物和含有这些化合物作为活性成分的药物
公开(公告)号：US08138182B2
公开(公告)日：2012-03-20
申请号：US12566416
申请日：2009-09-24
申请人： Akira Hatayama , Hiroshi Tsuruta , Yasuo Ochi , Haruo Imawaka , Kazuyuki Ohmoto
发明人： Akira Hatayama , Hiroshi Tsuruta , Yasuo Ochi , Haruo Imawaka , Kazuyuki Ohmoto
IPC分类号： C07D207/22 , C07D233/32 , C07D263/20 , C07D265/33 , C07D403/12 , C07D413/12 , C07D417/12
CPC分类号： C07D209/48 , A61K31/16 , A61K31/165 , A61K31/341 , A61K31/351 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/4152 , A61K31/4166 , A61K31/4168 , A61K31/421 , A61K31/423 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/429 , C07C243/34 , C07C251/76 , C07C251/84 , C07C251/86 , C07C2601/08 , C07C2601/14 , C07D207/22 , C07D207/50 , C07D209/46 , C07D211/28 , C07D211/72 , C07D211/86 , C07D211/98 , C07D213/70 , C07D213/76 , C07D213/77 , C07D213/78 , C07D233/38 , C07D233/52 , C07D233/80 , C07D239/10 , C07D239/18 , C07D239/36 , C07D241/08 , C07D241/18 , C07D263/26 , C07D263/28 , C07D265/08 , C07D265/10 , C07D265/33 , C07D275/02 , C07D275/03 , C07D275/06 , C07D277/18 , C07D277/36 , C07D277/50 , C07D277/54 , C07D277/60 , C07D277/82 , C07D279/02 , C07D279/06 , C07D279/12 , C07D285/10 , C07D285/16 , C07D309/04 , C07D309/28 , C07D335/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D513/10 , C07F9/59 , C07F9/65583 , Y02A50/411
摘要： The present invention relates to a diketohydrazine derivative of formula (I) and a pharmaceutically acceptable salt thereof (the symbols in the formula have the same meaning as described in the specification). The compound of formula (I) has an inhibitory activity against cysteine protease, and it is useful for the treatment of inflammatory diseases, immune diseases, ischemic diseases, respiratory diseases, circulatory diseases, blood diseases, neuronal diseases, hepatic or biliary diseases, osseous or articular diseases, metabolic diseases, etc. And the compound has inhibitory activity against elastase and it is also useful for the treatment of COPD (chronic obstacle pulmonary diseases).
摘要翻译：本发明涉及式（I）的二酮肼衍生物及其药学上可接受的盐（式中的符号具有与说明书中所述相同的含义）。式（I）化合物对半胱氨酸蛋白酶具有抑制活性，可用于治疗炎性疾病，免疫疾病，缺血性疾病，呼吸系统疾病，循环系统疾病，血液病，神经元疾病，肝或胆道疾病，骨质或关节疾病，代谢疾病等。该化合物对弹性蛋白酶具有抑制活性，也可用于治疗慢性阻塞性肺疾病（慢性障碍性肺疾病）。

3. 发明申请

US20100087442A1 DIKETOHYDRAZINE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT 失效
标题翻译：化合物衍生化合物和含有化合物作为活性成分的药物
公开(公告)号：US20100087442A1
公开(公告)日：2010-04-08
申请号：US12566416
申请日：2009-09-24
申请人： Akira Hatayama , Hiroshi Tsuruta , Yasuo Ochi , Haruo Imawaka , Kazuyuki Ohmoto
发明人： Akira Hatayama , Hiroshi Tsuruta , Yasuo Ochi , Haruo Imawaka , Kazuyuki Ohmoto
IPC分类号： A61K31/501 , C07D417/12 , C07D277/18 , C07D413/12 , C07D233/32 , C07D275/02 , C07D405/06 , A61K31/427 , A61K31/421 , A61K31/4164 , A61K31/425 , A61P35/00 , A61P19/00
CPC分类号： C07D209/48 , A61K31/16 , A61K31/165 , A61K31/341 , A61K31/351 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/4152 , A61K31/4166 , A61K31/4168 , A61K31/421 , A61K31/423 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/429 , C07C243/34 , C07C251/76 , C07C251/84 , C07C251/86 , C07C2601/08 , C07C2601/14 , C07D207/22 , C07D207/50 , C07D209/46 , C07D211/28 , C07D211/72 , C07D211/86 , C07D211/98 , C07D213/70 , C07D213/76 , C07D213/77 , C07D213/78 , C07D233/38 , C07D233/52 , C07D233/80 , C07D239/10 , C07D239/18 , C07D239/36 , C07D241/08 , C07D241/18 , C07D263/26 , C07D263/28 , C07D265/08 , C07D265/10 , C07D265/33 , C07D275/02 , C07D275/03 , C07D275/06 , C07D277/18 , C07D277/36 , C07D277/50 , C07D277/54 , C07D277/60 , C07D277/82 , C07D279/02 , C07D279/06 , C07D279/12 , C07D285/10 , C07D285/16 , C07D309/04 , C07D309/28 , C07D335/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D513/10 , C07F9/59 , C07F9/65583 , Y02A50/411
摘要： The present invention relates to a diketohydrazine derivative of formula (I) and a pharmaceutically acceptable salt thereof (the symbols in the formula have the same meaning as described in the specification). The compound of formula (I) has an inhibitory activity against cysteine protease, and it is useful for the treatment of inflammatory diseases, immune diseases, ischemic diseases, respiratory diseases, circulatory diseases, blood diseases, neuronal diseases, hepatic or biliary diseases, osseous or articular diseases, metabolic diseases, etc. And the compound has inhibitory activity against elastase and it is also useful for the treatment of COPD (chronic obstacle pulmonary diseases).
摘要翻译：本发明涉及式（I）的二酮肼衍生物及其药学上可接受的盐（式中的符号具有与说明书中所述相同的含义）。式（I）化合物对半胱氨酸蛋白酶具有抑制活性，可用于治疗炎性疾病，免疫疾病，缺血性疾病，呼吸系统疾病，循环系统疾病，血液病，神经元疾病，肝或胆道疾病，骨质或关节疾病，代谢疾病等。该化合物对弹性蛋白酶具有抑制活性，也可用于治疗慢性阻塞性肺疾病（慢性障碍性肺疾病）。

4. 发明申请

US20060111303A1 Diketohydrazine derivative compounds and drugs contaiing the compounds as the active ingredient 失效
标题翻译：二酮肼衍生物化合物和化合物作为活性成分的药物
公开(公告)号：US20060111303A1
公开(公告)日：2006-05-25
申请号：US10512348
申请日：2003-04-24
申请人： Akira Hatayama , Hitoshi Tsuruta , Yasuo Ochi , Haruo Imawaka , Kazuyuki Ohmoto
发明人： Akira Hatayama , Hitoshi Tsuruta , Yasuo Ochi , Haruo Imawaka , Kazuyuki Ohmoto
IPC分类号： A61K38/04 , C07K5/04
CPC分类号： C07D209/48 , A61K31/16 , A61K31/165 , A61K31/341 , A61K31/351 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/4152 , A61K31/4166 , A61K31/4168 , A61K31/421 , A61K31/423 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/429 , C07C243/34 , C07C251/76 , C07C251/84 , C07C251/86 , C07C2601/08 , C07C2601/14 , C07D207/22 , C07D207/50 , C07D209/46 , C07D211/28 , C07D211/72 , C07D211/86 , C07D211/98 , C07D213/70 , C07D213/76 , C07D213/77 , C07D213/78 , C07D233/38 , C07D233/52 , C07D233/80 , C07D239/10 , C07D239/18 , C07D239/36 , C07D241/08 , C07D241/18 , C07D263/26 , C07D263/28 , C07D265/08 , C07D265/10 , C07D265/33 , C07D275/02 , C07D275/03 , C07D275/06 , C07D277/18 , C07D277/36 , C07D277/50 , C07D277/54 , C07D277/60 , C07D277/82 , C07D279/02 , C07D279/06 , C07D279/12 , C07D285/10 , C07D285/16 , C07D309/04 , C07D309/28 , C07D335/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D513/10 , C07F9/59 , C07F9/65583 , Y02A50/411
摘要： The present invention relates to a diketohydrazine derivative of formula (I) and a pharmaceutically acceptable salt thereof (the symbols in the formula have the same meaning as described in the specification). The compound of formula (I) has an inhibitory activity against cysteine protease, and it is useful for the treatment of inflammatory diseases, immune diseases, ischemic diseases, respiratory diseases, circulatory diseases, blood diseases, neuronal diseases, hepatic or biliary diseases, osseous or articular diseases, metabolic diseases, etc. And the compound has inhibitory activity against elastase and it is also useful for the treatment of COPD (chronic obstacle pulmonary diseases).
摘要翻译：本发明涉及式（I）的二酮肼衍生物及其药学上可接受的盐（式中的符号具有与说明书中所述相同的含义）。式（I）化合物对半胱氨酸蛋白酶具有抑制活性，可用于治疗炎性疾病，免疫疾病，缺血性疾病，呼吸系统疾病，循环系统疾病，血液病，神经元疾病，肝或胆道疾病，骨质或关节疾病，代谢疾病等。该化合物对弹性蛋白酶具有抑制活性，也可用于治疗慢性阻塞性肺疾病（慢性障碍性肺疾病）。

5. 发明授权

US06287993B1 Long-lasting phosphorescent glasses and glass-ceramics 失效
标题翻译：持久的磷光眼镜和玻璃陶瓷
公开(公告)号：US06287993B1
公开(公告)日：2001-09-11
申请号：US09398593
申请日：1999-09-17
申请人： Jie Fu , Yasuo Ochi , Susumu Uehara
发明人： Jie Fu , Yasuo Ochi , Susumu Uehara
IPC分类号： C09K1155
CPC分类号： C09K11/7792 , C03C3/078 , C03C3/095 , C03C4/12 , C03C10/0009 , C09K11/7734
摘要： Long-lasting phosphorescent glasses and glass-ceramics have a composition containing 30-65 mol % SiO2 and 20-50 mol % ZnO as basic ingredients and may also contain, as an activator or an auxiliary activator, 0-5 mol % LnxOy where L n is an element or elements selected from the group consisting of Y, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu and Mn. In one aspect of the invention, long-lasting phosphorescent glass-ceramics have a composition containing 30-70 mol % SiO2, 5-40 mol % MgO and 10-55 mol % MO where M is an element or elements selected from the group consisting of Ca, Sr and Ba as basic ingredients. The composition further includes 0.0001-5 mol % Eu2O3 as an activator and 0.0001-6 mol % Ln2O3 as an auxiliary activator where Ln is an element or elements selected from the group consisting of Ce, Pr, Nd, Sm, Gd, Tb, Dy, Ho, Er, Tm, Yb and Lu.
摘要翻译：长效磷光玻璃和玻璃陶瓷具有含有30-65mol％SiO 2和20-50mol％ZnO作为碱性成分的组合物，并且还可以含有0-5mol％LnxOy作为活化剂或辅助活化剂，其中L n是选自Y，Ce，Pr，Nd，Sm，Eu，Gd，Tb，Dy，Ho，Er，Tm，Yb，Lu和Mn中的元素或元素。在本发明的一个方面，持久的磷光玻璃陶瓷具有包含30-70mol％SiO 2，5-40mol％MgO和10-55mol％MO的组成，其中M是选自以下的元素或元素：的Ca，Sr和Ba作为基本成分。该组合物还含有作为活化剂的0.0001-5mol％Eu 2 O 3和作为辅助活化剂的0.0001-6mol％Ln 2 O 3，其中Ln是选自Ce，Pr，Nd，Sm，Gd，Tb，Dy ，Ho，Er，Tm，Yb和Lu。

6. 发明授权

US07053015B2 SBN glass ceramics system 失效
标题翻译： SBN玻璃陶瓷系统
公开(公告)号：US07053015B2
公开(公告)日：2006-05-30
申请号：US10506178
申请日：2003-03-10
申请人： Yasuo Ochi
发明人： Yasuo Ochi
IPC分类号： C03C10/02
CPC分类号： C03C10/00 , C03C10/0054
摘要： A glass ceramics having a chemical composition of aRO.bNb2.O5.cSiO2.dB2O3.eTeO2.fX (where R represents Ba and/or Sr, X represents one or more oxide selected from the group consisting of TiO2, ZrO2, P2O5 and ZnO, a>b≧0.05, 0.60≧c≧0, 0.70≧d≧0, 0.70≧e≧0, c+d+e≧0.175, a+b+c+d+e=1.0 and 0.10≧f≧0). The ratio dielectric constant at 1 kHz ε1 to dielectric constant at 100 kHz ε100 (ε1/ε100) is 10 or more.
摘要翻译：具有化学组成的玻璃陶瓷，其特征在于其具有的化学组成为：NbN 2 O 2·2SiO 2·2·2O 2 O 3，其中R表示Ba和/或Sr，X表示选自TiO 2的一种或多种氧化物。 >，ZrO 2，P 2 O 5和ZnO，a> b> = 0.05,0.60> = c> = 0,0.70> = d> = 0,0.70> = e> = 0，c + d + e> = 0.175，a + b + c + d + e = 1.0和0.10> = f> = 0）。在1kHzε-1 <1/2的介电常数与100kHz的介电常数εε（ε1 /ε1/100）之间的比介电常数 >）为10以上。

7. 发明授权

US06284156B1 Long-lasting phosphor, powdered long-lasting phosphor and method for manufacturing the powdered long-lasting phosphor 失效
标题翻译：持久的荧光粉，长寿命荧光粉和制造粉末状持久荧光粉的方法
公开(公告)号：US06284156B1
公开(公告)日：2001-09-04
申请号：US09439002
申请日：1999-11-12
申请人： Susumu Uehara , Yasuo Ochi
发明人： Susumu Uehara , Yasuo Ochi
IPC分类号： C09K1108
CPC分类号： C09K11/7731 , C09K11/773 , C09K11/7784 , C09K11/7785
摘要： There is provided a long-lasting phosphor having a base crystal of {dot over (a)}kermanite crystal structure consisting of R′ (where R′ is one or more elements selected from the group consisting of Ca, Sr and Ba), Mg, Si, O and N and comprising Eu as an activator and one or more co-activators such as Dy. The long-lasting phosphor is produced by sintering materials including strontium nitrate to grow the base crystal of {dot over (a)}kermanite crystal structure, or by changing a solution containing constituent elements or material in the state of suspension into fine particles of liquid by atomization and thereafter heating the fine particles of liquid in a gas stream under oxidating, neutral or reducing atmosphere. The new Mohs' scale of hardness of the long-lasting phosphor is less than 1. Phosphorescence brightness of the long-lasting phosphor 2 minutes after stoppage of irradiation of illuminance of 1000 lux for 30 minutes with a white fluorescent lamp is 200 mCd/m2 or over.
摘要翻译：提供了具有由R'（其中R'是选自Ca，Sr和Ba中的一种或多种元素）的{dot over（a）} kermanite晶体结构的基底晶体的长余辉荧光体，Mg ，Si，O和N，并且包含Eu作为活化剂和一种或多种共激活剂如Dy。长效荧光体是通过烧结包括硝酸锶在内的材料制造的，以生长{dot over（a）} kermanite晶体结构的基底晶体，或通过将悬浮液中含有构成元素或材料的溶液改变为液体的细小颗粒然后通过雾化，然后在氧化，中性或还原气氛下加热气流中的细颗粒。持久荧光体的新莫氏硬度小于1.长时间荧光灯的荧光亮度在用白色荧光灯照射1000勒克斯光照30分钟后2分钟为200mCd / m2 或以上。

8. 发明授权

US4861572A Process for manufacture of metal oxide 失效
标题翻译：金属氧化物的制造方法
公开(公告)号：US4861572A
公开(公告)日：1989-08-29
申请号：US137736
申请日：1987-12-24
申请人： Yoshihisa Sugoh , Yasuo Ochi
发明人： Yoshihisa Sugoh , Yasuo Ochi
IPC分类号： C01F7/02 , C01B13/32 , C01B33/16 , C01B33/18 , C01D1/02 , C01F7/36 , C01F11/02 , C01G15/00 , C01G17/02 , C01G23/053
CPC分类号： C01F11/02 , C01B13/32 , C01B33/163 , C01F7/36 , C01G15/00 , C01G23/053 , C01P2002/72 , C01P2004/03 , C01P2004/32 , C01P2004/61 , C01P2004/62
摘要： An improved process for the manufacture of a metal oxide is disclosed. In the process wherein a hydrolyzable organometallic compound is hydrolyzed by an alkaline hydrolyzing agent in an alkaline organic solvent, and thereafter, the metal oxide is formed by a condensation reaction of a metal hydroxide resulting from the hydrolysis of the organometallic compound, the improvement comprises feeding the organometallic compound and the hydrolyzing agent into the organic solvent so that a concentration of the hydrolyzed compound is initially above a critical level of supersaturation, and thereafter, is maintained in a range from above an upper limit of solubility to the critical level of super-saturation. According to the above process, the metal oxide can be obtained in the form of a powder material with a uniform particle size distribution.

9. 发明授权

US06261477B1 Long-lasting phosphor 失效
标题翻译：持久的荧光粉
公开(公告)号：US06261477B1
公开(公告)日：2001-07-17
申请号：US09304416
申请日：1999-05-03
申请人： Jie Fu , Yasuo Ochi , Susumu Uehara
发明人： Jie Fu , Yasuo Ochi , Susumu Uehara
IPC分类号： C09K1159
CPC分类号： C09K11/774 , C09K11/7797
摘要： There is provided a long-lasting phosphor being activated by divalent europium and having a chemical composition RO.a(Al1−xGax)2O3.bMmOn.cB2O3.dEu3+ (where R is at least one selected from the group consisting of alkaline-earth metals and Zn, and M is at least one selected from the group consisting of Y, Sc and Si) wherein a, b, c, d and x are within ranges of 0.3≦a≦8, 0
摘要翻译：提供了由二价铕活化并具有化学组成RO.a（Al1-xGax）2O3bMmOn.cB2O3.dEu3 +（其中R是选自碱土金属中的至少一种）的长效荧光体和Zn，M是选自Y，Sc和Si中的至少一种），其中a，b，c，d和x在0.3 <= a <= 8,0

10. 发明授权

US5708233A Thermoelectric semiconductor material 失效
标题翻译：热电半导体材料
公开(公告)号：US5708233A
公开(公告)日：1998-01-13
申请号：US688014
申请日：1996-07-29
申请人： Yasuo Ochi , Kazuo Ohara
发明人： Yasuo Ochi , Kazuo Ohara
IPC分类号： H01L35/22
CPC分类号： H01L35/22
摘要： A thermoelectric semiconductor material is used for thermoelectric conversion in a thermoelectric conversion device. The material comprises a double oxide having one of a normal spinel crystal structure and an inverse spinel crystal structure, the double oxide comprising a composition that is represented by MIn.sub.2 O.sub.4, wherein M represents a metal element that can be changed into a divalent ion.
摘要翻译：热电半导体材料用于热电转换装置中的热电转换。所述材料包括具有正常尖晶石晶体结构和反尖晶石晶体结构之一的双氧化物，所述双氧化物包含由MIn 2 O 4表示的组成，其中M表示可以变为二价离子的金属元素。

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