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1. 发明申请

US20090305299A1 Method for Determination of Prognosis of Prostate Cancer, and Diagnostic Agent for Use in the Method 有权
标题翻译：测定前列腺癌预后的方法和方法中使用的诊断剂
公开(公告)号：US20090305299A1
公开(公告)日：2009-12-10
申请号：US12225998
申请日：2007-03-30
申请人： Akihide Ryo , Ichiro Aoki , Takeshi Sasaki
发明人： Akihide Ryo , Ichiro Aoki , Takeshi Sasaki
IPC分类号： G01N33/53
CPC分类号： G01N33/57434
摘要： A method for determining probability that prostate cancer will metastasize, as well as a diagnostic reagent used therefor is disclosed. It was discovered that the percentage that NF-κB-p65/RelA has the 254th amino acid threonine which is phosphorylated is significantly higher in the prostate cancer cells in the cases where the bone metastasis was observed than in the cases where bone metastasis was not observed. Thus, the method for determining probability that prostate cancer will metastasize comprises measuring human NF-κB-p65/RelA in which 254th amino acid threonine is phosphorylated, which human NF-κB-p65/RelA is contained in a prostate tissue separated from human.
摘要翻译：公开了一种确定前列腺癌转移概率的方法以及用于其的诊断试剂。发现在观察到骨转移的情况下，前列腺癌细胞中NF-κB-p65 / RelA具有磷酸化的第254位氨基酸苏氨酸的百分比明显高于未观察到骨转移的情况。因此，用于确定前列腺癌将转移的可能性的方法包括测量人类NF-κB-p65 / RelA，其中第254位氨基酸苏氨酸被磷酸化，人NF-κB-p65 / RelA包含在与人分离的前列腺组织中。

2. 发明授权

US08080384B2 Method for determination of prognosis of prostate cancer, and diagnostic agent for use in the method 有权
标题翻译：用于确定前列腺癌预后的方法和用于该方法的诊断剂
公开(公告)号：US08080384B2
公开(公告)日：2011-12-20
申请号：US12225998
申请日：2007-03-30
申请人： Akihide Ryo , Ichiro Aoki , Takeshi Sasaki
发明人： Akihide Ryo , Ichiro Aoki , Takeshi Sasaki
IPC分类号： G01N33/574
CPC分类号： G01N33/57434
摘要： A method for determining probability that prostate cancer will metastasize, as well as a diagnostic reagent used therefor is disclosed. It was discovered that the percentage that NF-κB-p65/RelA has the 254th amino acid threonine which is phosphorylated is significantly higher in the prostate cancer cells in the cases where the bone metastasis was observed than in the cases where bone metastasis was not observed. Thus, the method for determining probability that prostate cancer will metastasize comprises measuring human NF-κB-p65/RelA in which 254th amino acid threonine is phosphorylated, which human NF-κB-p65/RelA is contained in a prostate tissue separated from human.
摘要翻译：公开了一种确定前列腺癌转移概率的方法以及用于其的诊断试剂。发现在观察到骨转移的情况下，NF-κB-p65 / RelA具有磷酸化的第254位氨基酸苏氨酸的百分比在前列腺癌细胞中显着高于在骨转移为没有观察到。因此，用于确定前列腺癌将转移的可能性的方法包括测量其中第254位氨基酸苏氨酸被磷酸化的人NF-和kgr; B-p65 / RelA，哪种人NF-＆kgr B-p65 / RelA包含在前列腺组织中与人分离。

3. 发明授权

US09310380B2 Method for analyzing proteins contributing to autoimmune diseases, and method for testing for said diseases 有权
标题翻译：用于分析有助于自身免疫疾病的蛋白质的方法，以及用于测试所述疾病的方法
公开(公告)号：US09310380B2
公开(公告)日：2016-04-12
申请号：US13988269
申请日：2011-11-16
申请人： Tatsuya Sawasaki , Yaeta Endo , Tomoaki Ishigami , Ichiro Aoki
发明人： Tatsuya Sawasaki , Yaeta Endo , Tomoaki Ishigami , Ichiro Aoki
IPC分类号： G01N33/53 , G01N33/564 , G01N33/68
CPC分类号： G01N33/6869 , G01N33/564 , G01N33/6845 , G01N2800/323
摘要： Provided are a detection method for a myriad of proteins involved in an autoimmune disease with high sensitivity and high efficiency, and an analysis method for data resulting from the detection method. In order to construct the detection method and analysis method, there is provided means for comprehensively analyzing the proteins involved in an autoimmune disease by bringing a mammal-derived protein expressed in a cell-free protein synthesis system into contact with a sample derived from a patient with an autoimmune disease to detect autoantibody production, and subjecting the detected data to statistical analysis processing, and further, gene ontology analysis and/or pathway analysis.
摘要翻译：提供了涉及高灵敏度，高效率的自身免疫性疾病的无数蛋白质的检测方法以及由检测方法得到的数据的分析方法。为了构建检测方法和分析方法，提供了通过将在无细胞蛋白质合成系统中表达的哺乳动物衍生的蛋白质与来自患者的样品接触来全面分析参与自身免疫疾病的蛋白质的方法具有自身免疫疾病以检测自身抗体产生，并对检测到的数据进行统计分析处理，以及基因本体分析和/或途径分析。

4. 发明授权

US08049563B2 Distributed circular geometry power amplifier architecture 有权
标题翻译：分布式圆形几何功率放大器架构
公开(公告)号：US08049563B2
公开(公告)日：2011-11-01
申请号：US12209944
申请日：2008-09-12
申请人： Ichiro Aoki , Seyed-Ali Hajimiri , David B. Ruthledge , Scott D. Kee
发明人： Ichiro Aoki , Seyed-Ali Hajimiri , David B. Ruthledge , Scott D. Kee
IPC分类号： H03F3/26
CPC分类号： H03F1/223 , H03F3/265 , H03F3/423 , H03F3/604 , H03F2200/534 , H03F2200/537 , H03F2200/541
摘要： The present invention discloses a distributed power amplifier topology and device that efficiently and economically enhances the power output of an RF signal to be amplified. The power amplifier comprises a plurality of push-pull amplifiers interconnected in a novel circular geometry that preferably function as a first winding of an active transformer having signal inputs of adjacent amplification devices driven with an input signal of equal magnitude and opposite phase. The topology also discloses the use of a secondary winding that matches the geometry of primary winding and variations thereof that serve to efficiently combine the power of the individual power amplifiers. The novel architecture enables the design of low-cost, fully-integrated, high-power amplifiers in the RF, microwave, and millimeter-wave frequencies.
摘要翻译：本发明公开了一种分布式功率放大器拓扑和器件，其有效且经济地增强待放大的RF信号的功率输出。功率放大器包括以新颖的圆形几何互连的多个推挽放大器，其优选地用作有源变压器的第一绕组，该有源变压器的信号输入由相等幅度和相反相位的输入信号驱动的相邻放大器件的信号输入。该拓扑还公开了使用与初级绕组的几何形状及其变化相匹配的次级绕组，其用于有效地组合各个功率放大器的功率。新颖的架构使得能够在RF，微波和毫米波频率中设计低成本，完全集成的大功率放大器。

5. 发明授权

US07733183B2 Reconfigurable distributed active transformers 有权
标题翻译：可重构分布式有源变压器
公开(公告)号：US07733183B2
公开(公告)日：2010-06-08
申请号：US12069263
申请日：2008-02-08
申请人： Abbas Komijani , Seyed-Ali Hajimiri , Scott D. Kee , Ichiro Aoki
发明人： Abbas Komijani , Seyed-Ali Hajimiri , Scott D. Kee , Ichiro Aoki
IPC分类号： H03F3/26
CPC分类号： H03F3/265 , H03F1/223 , H03F3/423 , H03F3/602 , H03F3/604 , H03F2200/372 , H03F2200/421 , H03F2200/534 , H03F2200/537 , H03F2200/541
摘要： Reconfigurable distributed active transformers are provided. The exemplary embodiments provided allow changing of the effective number and configuration of the primary and secondary windings, where the distributed active transformer structures can be reconfigured dynamically to control the output power levels, allow operation at multiple frequency bands, maintain a high performance across multiple channels, and sustain desired characteristics across process, temperature and other environmental variations. Integration of the distributed active transformer power amplifiers and a low noise amplifier on a semiconductor substrate can also be provided.
摘要翻译：提供可重配置的分布式有源变压器。提供的示例性实施例允许改变主和次级绕组的有效数量和配置，其中分布式有源变压器结构可以动态地重新配置以控制输出功率电平，允许在多个频带上操作，在多个通道上保持高性能并保持过程，温度和其他环境变化的期望特征。还可以提供分布式有源变压器功率放大器和低噪声放大器在半导体衬底上的集成。

6. 发明授权

US07649411B2 Segmented power amplifier 有权
标题翻译：分段功率放大器
公开(公告)号：US07649411B2
公开(公告)日：2010-01-19
申请号：US11827186
申请日：2007-07-11
申请人： Ichiro Aoki , Scott Kee , Seyed-Ali Hajimiri , Roberto Aparicio Joo , Rahul Magoon , Donald McClymont
发明人： Ichiro Aoki , Scott Kee , Seyed-Ali Hajimiri , Roberto Aparicio Joo , Rahul Magoon , Donald McClymont
IPC分类号： H03F1/14
CPC分类号： H03F3/72 , H03F1/0277 , H03F3/245
摘要： A system for amplifying a signal is provided. The system includes a plurality of driver stages, each having an input, an output, and a disable control. An output stage having an input is coupled to the outputs of the plurality of driver stages. A plurality of disable control signals is provided to the driver stages so as to controllably enable and disable one or more of the driver stages.
摘要翻译：提供一种放大信号的系统。该系统包括多个驱动器级，每个具有输入，输出和禁用控制。具有输入的输出级耦合到多个驱动级的输出。多个禁用控制信号被提供给驱动器级，以便可控制地启用和禁用一个或多个驱动器级。

7. 发明申请

US20090015295A1 Envelope detector having reduced harmonic interference 审中-公开
标题翻译：包络检测器具有减少的谐波干扰
公开(公告)号：US20090015295A1
公开(公告)日：2009-01-15
申请号：US11827184
申请日：2007-07-11
申请人： Ichiro Aoki , Setu Mohta , David Kang
发明人： Ichiro Aoki , Setu Mohta , David Kang
IPC分类号： H03K5/153
CPC分类号： H03D1/18 , H03D2200/0086
摘要： A system for detecting the envelope of a signal is provided. The system includes a first envelope detector generating a first envelope signal of an input RF signal, such as an envelope signal representing the positive peak envelope of the input RF signal. A second envelope detector generates a second envelope signal of the input RF signal, such as an envelope signal representing the negative peak envelope of the input RF signal. A signal combiner receives the first envelope signal and the second envelope signal and generates an even-order harmonic compensated envelope signal, such as by compensating for the difference between the positive peak envelope and the negative peak envelope.
摘要翻译：提供一种用于检测信号包络的系统。该系统包括产生输入RF信号的第一包络信号的第一包络检测器，例如表示输入RF信号的正峰值包络的包络信号。第二包络检测器产生输入RF信号的第二包络信号，例如表示输入RF信号的负峰值包络的包络信号。信号组合器接收第一包络信号和第二包络信号，并且通过补偿正峰值包络和负峰值包络之间的差异来产生偶次谐波补偿的包络信号。

8. 发明申请

US20080211584A1 Cross-differential amplifier 有权
标题翻译：交叉差分放大器
公开(公告)号：US20080211584A1
公开(公告)日：2008-09-04
申请号：US12075194
申请日：2008-03-10
申请人： Seyed-Ali Hajimiri , Scott D. Kee , Ichiro Aoki
发明人： Seyed-Ali Hajimiri , Scott D. Kee , Ichiro Aoki
IPC分类号： H03F3/04
CPC分类号： H03F1/0211 , H03F3/04 , H03F3/191 , H03F3/217 , H03F3/2176 , H03F3/45475 , H03F3/605 , H03F3/68 , H03F2200/507 , H03F2200/537 , H03F2200/541 , H03F2203/45464 , H03F2203/45704 , H03F2203/45731
摘要： A cross-differential amplifier is provided. The cross-differential amplifier includes an inductor connected to a direct current power source at a first terminal. A first and second switch, such as transistors, are connected to the inductor at a second terminal. A first and second amplifier are connected at their supply terminals to the first and second switch. The first and second switches are operated to commutate the inductor between the amplifiers so as to provide an amplified signal while limiting the ripple voltage on the inductor and thus limiting the maximum voltage imposed across the amplifiers and switches.
摘要翻译：提供了一个交叉差分放大器。交叉差分放大器包括在第一端子处连接到直流电源的电感器。诸如晶体管的第一和第二开关在第二端子处连接到电感器。第一和第二放大器在其电源端连接到第一和第二开关。第一和第二开关被操作以在放大器之间换向电感器，以便提供放大的信号，同时限制电感器上的纹波电压，从而限制放大器和开关上施加的最大电压。

9. 发明申请

US20080207138A1 Phase Detector 有权
标题翻译：相位检测器
公开(公告)号：US20080207138A1
公开(公告)日：2008-08-28
申请号：US11771267
申请日：2007-06-29
申请人： Ichiro Aoki , Scott D. Kee , Dongjiang Qiao , Alyosha C. Molnar
发明人： Ichiro Aoki , Scott D. Kee , Dongjiang Qiao , Alyosha C. Molnar
IPC分类号： H04B1/40 , H03D13/00
CPC分类号： H03L7/0812 , H03L7/085 , H03L7/087
摘要： A phase detector includes a plurality of phase detectors located in a phase correction loop, each phase detector configured to receive as input a radio frequency (RF) input signal and an RF reference signal, each of the plurality of phase detectors also configured to provide a signal representing a different phase offset based on the phase difference between the RE input signal and the RF reference signal; and a switch configured to receive an output of each of the plurality of phase detectors and configured to select the output representing the phase offset, that is closest to a phase of an output of an amplifier.
摘要翻译：相位检测器包括位于相位校正回路中的多个相位检测器，每个相位检测器被配置为接收射频（RF）输入信号和RF参考信号作为输入，多个相位检测器中的每一个还被配置为提供一个基于RE输入信号和RF参考信号之间的相位差表示不同的相位偏移的信号; 以及开关，被配置为接收所述多个相位检测器中的每一个的输出，并被配置为选择表示最接近放大器的输出的相位的相位偏移的输出。

10. 发明授权

US07256573B2 Distributed active transformer power control techiques 有权
标题翻译：分布式有源变压器功率控制技术
公开(公告)号：US07256573B2
公开(公告)日：2007-08-14
申请号：US11095231
申请日：2005-03-31
申请人： Rahul Magoon , Scott Kee , Ichiro Aoki , Frank Carr , Hui Wu , Jerry Twomey , Seyed-Ali Hajimiri
发明人： Rahul Magoon , Scott Kee , Ichiro Aoki , Frank Carr , Hui Wu , Jerry Twomey , Seyed-Ali Hajimiri
IPC分类号： G01R27/02
CPC分类号： H03F3/602 , G01R15/09 , G01R21/01 , H03F1/52 , H03F3/19 , H03F3/26 , H03F3/45475 , H03F3/604 , H03F3/605 , H03F2200/435 , H03F2200/451 , H03F2200/456 , H03F2200/462 , H03F2200/471 , H03F2200/541 , H03G3/004 , H03G3/3042 , H03G3/3047
摘要： A distributed active transformer on a semiconducting substrate is provided. The distributed active transformer includes an outer primary, a secondary disposed adjacent to the outer primary, and an inner primary disposed adjacent to the outer primary and the secondary. A plurality of first three terminal devices is coupled to the outer primary at a plurality of locations. A plurality of second three terminal devices coupled to the inner primary at a plurality of locations, and each second three terminal device is disposed opposite from and coupled to one of the plurality of first three terminal devices. A plurality of power control actuation circuits is also provided, where each power control actuation circuit is coupled to one of the first three terminal devices and the second three terminal devices.
摘要翻译：提供了一种在半导体衬底上的分布式有源变压器。分布式有源变压器包括外部初级，邻近外部初级设置的次级和邻近外部初级和次级设置的内部主体。多个前三个终端设备在多个位置耦合到外部主设备。多个第二三个终端设备在多个位置耦合到内部主设备，并且每个第二三个终端设备设置成与多个前三个终端设备中的一个终端设备相对并耦合。还提供了多个功率控制致动电路，其中每个功率控制致动电路耦合到前三个终端设备和第二三个终端设备之一。

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