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    • 5. 发明申请
    • TECHNIQUES FOR PREDICTING, DETECTING AND REDUCING ASPECIFIC PROTEIN INTERFERENCE IN ASSAYS INVOLVING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS
    • 涉及免疫球蛋白单个可变区域的测定中预测,检测和降低相关蛋白质干扰的技术
    • US20140205597A1
    • 2014-07-24
    • US14138863
    • 2013-12-23
    • Ablynx N.V.
    • Judith BaumeisterMarie-Paule Lucienne Armanda BoucheCarlo BouttonMarie-Ange BuyseVeerle SnoeckStephanie StaelensBruno DombrechtPeter SchotteCedric Jozef Neotere VerverkenGerald BesteGuy HermansSoren SteffensenAlexander SzyrokiTinneke Denayer
    • G01N33/68C07K16/18
    • G01N33/6857A61K2039/505C07K16/18C07K16/2863C07K16/4258C07K2317/22C07K2317/34C07K2317/565C07K2317/567C07K2317/569C07K2317/73C07K2317/76C07K2317/92
    • This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or to giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have no or a low(er)/reduced tendency to give rise to such protein interference or such a signal.
    • 本发明提供并且在某些特定但非限制性方面涉及:可用于预测给定ISV是否将如本文所述受到蛋白质干扰和/或产生(特异性)信号的测定法 测定(例如在ADA免疫测定中)。 这样的预测测定可以例如用于测试给定的ISV是否可能具有引起这种蛋白质干扰和/或这种信号的倾向; 选择不是或不太容易发生蛋白质干扰的ISV或给出这样的信号; 作为可用于测试对ISV的某些修改(完全或部分)是否降低其引起这种干扰或这种信号的趋势的测定或测试; 和/或作为可用于指导ISV的修饰或改进的测定或测试,以便减少引起这种蛋白质干扰或信号的趋势; 修改和/或改善ISV以消除或减少其引起这种蛋白质干扰或这种信号的趋势的方法; 可以引入到ISV中的修饰,其可以去除或减少引起这种蛋白质干扰或这种信号的趋势; 已经特别选择的ISV(例如,使用本文所述的测定)具有没有或低(呃)/降低的趋势导致这种蛋白质干扰或这种信号; 修饰和/或改进的ISV,其没有或低(呃)/降低的趋势引起这种蛋白质干扰或这种信号。