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1. 发明申请

US20130289112A1 SALTS OF KUKOAMINE B, PREPARATION METHOD AND USE THEREOF 有权
标题翻译：库卡宾B的制备方法及其用途
公开(公告)号：US20130289112A1
公开(公告)日：2013-10-31
申请号：US13884558
申请日：2011-03-21
申请人： Jiang Zheng , Xinchuan Zheng , Xin Liu , Hong Zhou , Ning Wang , Hongwei Cao , Yan Li , Yongling Lu , Kecen Zhao , Jingcheng Yang , Yang Yang , Yuanfeng Zhu , Guo Wei , Min Huang
发明人： Jiang Zheng , Xinchuan Zheng , Xin Liu , Hong Zhou , Ning Wang , Hongwei Cao , Yan Li , Yongling Lu , Kecen Zhao , Jingcheng Yang , Yang Yang , Yuanfeng Zhu , Guo Wei , Min Huang
IPC分类号： C07C235/34 , C07C55/10 , C07C57/145 , C07C229/24 , C07C59/08 , C07C59/255 , C07C309/04 , C07C309/30 , C07C53/10 , C07C59/245
CPC分类号： C07C309/04 , C07C53/08 , C07C53/10 , C07C53/122 , C07C53/124 , C07C55/06 , C07C55/08 , C07C55/10 , C07C55/14 , C07C57/145 , C07C57/15 , C07C57/44 , C07C59/08 , C07C59/245 , C07C59/255 , C07C59/265 , C07C59/50 , C07C63/06 , C07C229/24 , C07C235/34 , C07C309/25 , C07C309/30
摘要： Salts of kukoamine B, their preparation method and their pharmaceutical use in preparation of drugs for preventing and treating sepsis. Experiments indicate that salts of kukoamine B have a good effect on antagonizing the key factors inducing sepsis, and can be used in the preparation of drugs for preventing and treating sepsis. Under the current circumstances of the lack of effective measures for the treatment of sepsis in clinical practice, the medicinal formulations, which comprise the salts of kukoamine B, pharmaceutically acceptable carrier and/or diluent, provide a new approach for the prevention and treatment of sepsis.
摘要翻译： kukoamine B的盐，它们的制备方法及其制备用于预防和治疗败血症药物的药物用途。实验表明，kukoamine B的盐对拮抗诱导败血症的关键因素具有很好的疗效，可用于制备预防和治疗败血症的药物。目前在临床实践中缺乏治疗败血症的有效措施的情况下，包含kukoamine B，药学上可接受的载体和/或稀释剂的盐的药物制剂提供了预防和治疗败血症的新方法。

2. 发明授权

US09365504B2 Salts of kukoamine B, preparation method and use thereof 有权
标题翻译： kukoamine B的盐，其制备方法和用途
公开(公告)号：US09365504B2
公开(公告)日：2016-06-14
申请号：US13884558
申请日：2011-03-21
申请人： Jiang Zheng , Xinchuan Zheng , Xin Liu , Hong Zhou , Ning Wang , Hongwei Cao , Yan Li , Yongling Lu , Kecen Zhao , Jingcheng Yang , Yang Yang , Yuanfeng Zhu , Guo Wei , Min Huang
发明人： Jiang Zheng , Xinchuan Zheng , Xin Liu , Hong Zhou , Ning Wang , Hongwei Cao , Yan Li , Yongling Lu , Kecen Zhao , Jingcheng Yang , Yang Yang , Yuanfeng Zhu , Guo Wei , Min Huang
IPC分类号： C07C37/02 , C07C235/34 , C07C309/04 , C07C53/08 , C07C55/10 , C07C59/08 , C07C59/245 , C07C59/255 , C07C53/10 , C07C57/145 , C07C229/24 , C07C309/30 , C07C53/122 , C07C53/124 , C07C55/06 , C07C55/08 , C07C55/14 , C07C57/15 , C07C57/44 , C07C59/265 , C07C59/50 , C07C63/06 , C07C309/25
CPC分类号： C07C309/04 , C07C53/08 , C07C53/10 , C07C53/122 , C07C53/124 , C07C55/06 , C07C55/08 , C07C55/10 , C07C55/14 , C07C57/145 , C07C57/15 , C07C57/44 , C07C59/08 , C07C59/245 , C07C59/255 , C07C59/265 , C07C59/50 , C07C63/06 , C07C229/24 , C07C235/34 , C07C309/25 , C07C309/30
摘要： Salts of kukoamine B, their preparation method and their pharmaceutical use in preparation of drugs for preventing and treating sepsis. Experiments indicate that salts of kukoamine B have a good effect on antagonizing the key factors inducing sepsis, and can be used in the preparation of drugs for preventing and treating sepsis. Under the current circumstances of the lack of effective measures for the treatment of sepsis in clinical practice, the medicinal formulations, which comprise the salts of kukoamine B, pharmaceutically acceptable carrier and/or diluent, provide a new approach for the prevention and treatment of sepsis.
摘要翻译： kukoamine B的盐，它们的制备方法及其制备用于预防和治疗败血症药物的药物用途。实验表明，kukoamine B的盐对拮抗诱导败血症的关键因素具有很好的疗效，可用于制备预防和治疗败血症的药物。目前在临床实践中缺乏治疗败血症的有效措施的情况下，包含kukoamine B，药学上可接受的载体和/或稀释剂的盐的药物制剂提供了预防和治疗败血症的新方法。

3. 发明申请

US20180043245A1 Simulation System for Balance Control in Interactive Motion 审中-公开
公开(公告)号：US20180043245A1
公开(公告)日：2018-02-15
申请号：US15168253
申请日：2016-08-10
申请人： Yuanfeng Zhu
发明人： Yuanfeng Zhu
IPC分类号： A63F13/211 , A63F13/65
CPC分类号： A63F13/577 , A63F2300/6607 , A63F2300/8082 , G06T13/40 , G06T19/20 , G06T2210/21 , G06T2219/2021
摘要： Action games and animation movies require engaging character interaction with other characters and/or objects in dynamic environment, which lead to many possible responsive motions. However, it remains di cult to simulate diverse balanced interactive motion in dynamic system, which are widely determined by physics laws related to collision, balance control, bio-mechanics constraints, un-expected external forces such as a hit to any body part from the opponent character, following a user-required motion goal. A simulation system to achieve this research goal is provided in this documentation.The input of this system is, given the current motion state such as a state after an hit from the opponent, a reasonable responsive motion goal required by the action director such as to give a counter-strike punch to the opponent head while decaying the energy of the hit to keep balance. The output is goal-directed balanced motion driven by joint torques in dynamic virtual environment.The significant contribution is two proposed Lyapunov-Function-based constraints, which are used in the proposed optimization framework to find the optimal motion strategy which achieves the responsive motion goal while keeping balance. The first advantage of this system is to use the first Lyapunov-Function-based constraint to more quickly converge the optimization progress by eliminating massive candidate strategies unworkable to achieve the motion goal, rather than to test each candidate strategy by a traditional way based on dynamic forward simulation which require much more computation resources especially on time. The second advantage is to use the second Lyapunov-Function-based constraint to more quickly and more precisely judge the current balance state of motion and then employ it to predict the future balance state under control of the current motion controller.In sum, our system would be unique to generate diverse balanced responsive fighting motion for action game and movies in a much more efficient manner. Namely the action designer are only required to provide an responsive motion goal (including objective action pose and timing information) like an action director in action movie, and then the system will automatically generate the controllable and balanced dynamics responsive fighting motion driven by joint torques, and motion capture data is not needed.

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