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1. 发明授权

US09381355B2 Ultra-high photosensitivity vertical nanowire arrays for retinal prosthesis 有权
标题翻译：用于视网膜假体的超高光敏性垂直纳米线阵列
公开(公告)号：US09381355B2
公开(公告)日：2016-07-05
申请号：US13806089
申请日：2011-06-21
申请人： Massoud L. Khraiche , Gabriel Silva , Gert Cauwenberghs , Yu-Hwa Lo , Deli Wang , William Freeman
发明人： Massoud L. Khraiche , Gabriel Silva , Gert Cauwenberghs , Yu-Hwa Lo , Deli Wang , William Freeman
IPC分类号： A61N1/36 , A61N1/05 , A61F2/14 , A61L27/18 , H01L31/0352
CPC分类号： A61N1/36046 , A61F2/14 , A61L27/18 , A61L2400/12 , A61L2430/16 , A61N1/0543 , H01L31/035227 , H01L31/035236 , C08L83/04 , C08L65/04
摘要： A prosthetic retina for implantation in an eye having a defective retina is formed from an array of nanowires having a predetermined spatial distribution, density, size and shape implanted in close proximity to the retina. An electrical conductor is formed at a first end of all nanowires in the array of nanowires and placed in contact with a bias source which biases the array. A plurality of electrodes is located on a second end of each of one nanowire or a bundle of nanowires in the array. Each nanowire produces a photocurrent at a corresponding electrode in response to detection of light impinging on the array of nanowires and the photocurrent stimulates one or more neurons adapted for visual perception. In the preferred embodiment, the predetermined spatial distribution mimics a distribution of rods and cones in a normal eye.
摘要翻译：用于植入具有缺陷视网膜的眼睛中的假视网膜由具有植入在视网膜附近的预定空间分布，密度，大小和形状的纳米线阵列形成。电导体形成在纳米线阵列中的所有纳米线的第一端，并与偏置源接触，偏压源偏置阵列。多个电极位于阵列中的一个纳米线或纳米线束中的每一个的第二端上。每个纳米线响应于入射到纳米线阵列上的光而在对应的电极处产生光电流，并且光电流刺激一个或多个适于视觉感知的神经元。在优选实施例中，预定空间分布模拟正常眼睛中的棒和锥体的分布。

2. 发明授权

US09134221B2 Fluidic flow cytometry devices and particle sensing based on signal-encoding 有权
标题翻译：基于信号编码的流式流式细胞术装置和粒子感测
公开(公告)号：US09134221B2
公开(公告)日：2015-09-15
申请号：US13254851
申请日：2010-03-10
申请人： Yu-Hwa Lo , Chun Hao Randy Chen , Sung Hwan Cho , Frank Tsai
发明人： Yu-Hwa Lo , Chun Hao Randy Chen , Sung Hwan Cho , Frank Tsai
IPC分类号： G01N15/14 , G01N15/10
CPC分类号： G01N15/1434 , G01N15/1425 , G01N15/1459 , G01N15/1484 , G01N2015/0065 , G01N2015/1006 , G01N2015/1415 , G01N2015/1447 , G01N2015/145 , G01N2015/149
摘要： Microfluidic devices, systems and techniques in connection with particle sorting in liquid, including cytometry devices and techniques and applications in chemical or biological testing and diagnostic measurements.
摘要翻译：与流体中颗粒分选有关的微流体装置，系统和技术，包括细胞计量装置和化学或生物测试和诊断测量中的技术和应用。

3. 发明授权

US08637875B2 Single photon IR detectors and their integration with silicon detectors 有权
标题翻译：单光子红外探测器及其与硅探测器的集成
公开(公告)号：US08637875B2
公开(公告)日：2014-01-28
申请号：US12502225
申请日：2009-07-13
申请人： Hod Finkelstein , Sadik C. Esener , Yu-Hwa Lo , Kai Zhao , James Cheng , Sifang You
发明人： Hod Finkelstein , Sadik C. Esener , Yu-Hwa Lo , Kai Zhao , James Cheng , Sifang You
IPC分类号： H01L31/12
CPC分类号： H01L31/055 , H01L31/0336 , Y02E10/52
摘要： Apparatuses and systems for photon detection can include a first optical sensing structure structured to absorb light at a first optical wavelength; and a second optical sensing structure engaged with the first optical sensing structure to allow optical communication between the first and the second optical sensing structures. The second optical sensing structure can be structured to absorb light at a second optical wavelength longer than the first optical wavelength and to emit light at the first optical wavelength which is absorbed by the first optical sensing structure. Apparatuses and systems can include a bandgap grading region.
摘要翻译：用于光子检测的装置和系统可以包括被构造为吸收第一光波长的光的第一光学感测结构; 以及与第一光学感测结构接合以允许第一和第二光学感测结构之间的光学通信的第二光学感测结构。第二光学感测结构可被构造为吸收长于第一光学波长的第二光学波长的光并且发射由第一光学感测结构吸收的第一光学波长的光。设备和系统可以包括带隙分级区域。

4. 发明申请

US20070201138A1 Fluidic Adaptive Lens Systems and Methods 有权
标题翻译：流体自适应透镜系统和方法
公开(公告)号：US20070201138A1
公开(公告)日：2007-08-30
申请号：US11683141
申请日：2007-03-07
申请人： Yu-Hwa Lo
发明人： Yu-Hwa Lo
IPC分类号： G02B3/12
CPC分类号： G02B3/14 , G02C7/085 , G02C7/088
摘要： Fluidic adaptive lens devices, and systems employing such lens devices, along with methods of fabricating and operating such lens devices, are disclosed. In one embodiment, a lens material is optimally selected to provide one or more desired characteristics for a variety of applications related to adaptive lens devices. In another embodiment, a fluidic medium is optimally chosen to provide one or more desired characteristics for a variety of applications related to adaptive lens devices.
摘要翻译：公开了流体自适应透镜装置，以及采用这种透镜装置的系统，以及制造和操作这种透镜装置的方法。在一个实施例中，最佳地选择透镜材料以为与自适应透镜装置相关的各种应用提供一个或多个期望特性。在另一个实施例中，最佳地选择流体介质以为与自适应透镜装置相关的各种应用提供一个或多个期望的特性。

5. 发明授权

US06329063B2 Method for producing high quality heteroepitaxial growth using stress engineering and innovative substrates 失效
标题翻译：使用应力工程和创新底物生产高品质异质外延生长的方法
公开(公告)号：US06329063B2
公开(公告)日：2001-12-11
申请号：US09210166
申请日：1998-12-11
申请人： Yu-Hwa Lo , Felix Ejeckam
发明人： Yu-Hwa Lo , Felix Ejeckam
IPC分类号： B32B906
CPC分类号： H01L33/0066 , H01L21/02381 , H01L21/0245 , H01L21/02461 , H01L21/02505 , H01L21/02543 , H01L21/02546 , H01L31/1852 , Y02E10/544 , Y02P70/521 , Y10T428/12674 , Y10T428/12681
摘要： A method for producing a stress-engineered substrate includes selecting first and second materials for forming the substrate. An epitaxial material for forming a heteroepitaxial layer is then selected. If the lattice constant of the heteroepitaxial layer (aepi) is greater than that (asub) of the immediate substrate layer the epitaxial layer is deposited on, then the epitaxial layer is kept under “compressive stress” (negative stress) at all temperatures of concern. On the other hand, if the lattice constant of the heteroepitaxial layer (aepi) is less than that (asub) of the immediate substrate layer the epitaxial layer is deposited on, then the epitaxial layer is kept under “tensile stress” (positive stress). The temperatures of concern range from the annealing temperature to the lowest temperature where dislocations are still mobile.
摘要翻译：用于生产应力工程衬底的方法包括选择用于形成衬底的第一和第二材料。然后选择用于形成异质外延层的外延材料。如果异质外延层（aepi）的晶格常数大于直立衬底层的（asub），则外延层被沉积，则外延层在所关注的所有温度下保持在“压应力”（负应力）下。另一方面，如果异质外延层（aepi）的晶格常数小于即刻衬底层的（asub），则沉积外延层，则外延层保持在“拉伸应力”（正应力）。关注的温度范围从退火温度到位错仍然移动的最低温度。

6. 发明授权

US08270781B2 Apparatus and method for improved optical detection of particles in fluid 有权
标题翻译：用于改善流体中颗粒的光学检测的装置和方法
公开(公告)号：US08270781B2
公开(公告)日：2012-09-18
申请号：US12091414
申请日：2006-10-27
申请人： Yu-Hwa Lo , Victor Jie Lien , Chun Hao Randy Chen
发明人： Yu-Hwa Lo , Victor Jie Lien , Chun Hao Randy Chen
IPC分类号： G02B6/00
CPC分类号： G01N15/1429 , B01L3/502707 , B01L3/502715 , B01L2200/0668 , B01L2300/0654 , B01L2300/0816 , B01L2400/0424 , B01L2400/0487 , G01N15/1434 , G01N15/1484 , G01N21/05 , G01N21/49 , G01N21/53 , G01N21/6408 , G01N2021/0346 , Y10T29/49124
摘要： A number of fluidic-photonic devices for allowing optical detection, systems employing such devices, and related methods of operation and fabrication of such devices are disclosed herein. In at least some embodiments, the devices can serve as flow cytometry devices and/or employ microfluidic channels. Also, in at least some embodiments, the devices are fluidic-photonic integrated circuit (FPIC) devices that employ both fluidic channels and one or more waveguides capable of receiving and/or delivering light, and that can be fabricated using polymeric materials. The fluidic-photonic devices in at least some embodiments are capable of functionality such as on-chip excitation, time-of-flight measurement, and can experience enhanced fluorescence detection sensitivity. In at least some embodiments, the devices employ detection waveguides that are joined by way of a waveguide demultiplexer. In additional embodiments, a variety of techniques can be used to process information received via the waveguides, including an iterative cross-correlation process.
摘要翻译：本文公开了许多用于允许光学检测的流体光子学装置，采用这种装置的系统以及这些装置的相关操作和制造方法。在至少一些实施方案中，装置可以用作流式细胞术装置和/或使用微流体通道。此外，在至少一些实施例中，装置是采用流体通道和能够接收和/或传送光的一个或多个波导的流体 - 光子学集成电路（FPIC）装置，并且可以使用聚合材料制造。至少一些实施例中的流体光子学装置能够具有诸如片上激发，飞行时间测量等功能，并且可以体验增强的荧光检测灵敏度。在至少一些实施例中，器件采用通过波导解复用器连接的检测波导。在另外的实施例中，可以使用各种技术来处理经由波导接收的信息，包括迭代互相关过程。

7. 发明申请

US20120078531A1 FLUIDIC FLOW CYTOMETRY DEVICES AND PARTICLE SENSING BASED ON SIGNAL-ENCODING 有权
标题翻译：基于信号编码的流体流式细胞仪装置和颗粒感测
公开(公告)号：US20120078531A1
公开(公告)日：2012-03-29
申请号：US13254851
申请日：2010-03-10
申请人： Yu-Hwa Lo , Chun Hao Randy Chen , Sung Hwan Cho , Frank Tsai
发明人： Yu-Hwa Lo , Chun Hao Randy Chen , Sung Hwan Cho , Frank Tsai
IPC分类号： G06F19/00 , G01N21/00
CPC分类号： G01N15/1434 , G01N15/1425 , G01N15/1459 , G01N15/1484 , G01N2015/0065 , G01N2015/1006 , G01N2015/1415 , G01N2015/1447 , G01N2015/145 , G01N2015/149
摘要： Microfluidic devices, systems and techniques in connection with particle sorting in liquid, including cytometry devices and techniques and applications in chemical or biological testing and diagnostic measurements.
摘要翻译：与流体中颗粒分选有关的微流体装置，系统和技术，包括细胞计量装置和化学或生物测试和诊断测量中的技术和应用。

8. 发明申请

US20110261178A1 CAMERA SYSTEM WITH AUTONOMOUS MINIATURE CAMERA AND LIGHT SOURCE ASSEMBLY AND METHOD FOR IMAGE ENHANCEMENT 有权
标题翻译：具有自动微型摄像机和光源组件的摄像机系统和图像增强方法
公开(公告)号：US20110261178A1
公开(公告)日：2011-10-27
申请号：US13124659
申请日：2009-10-15
申请人： Yu-Hwa Lo , Yoav Mintz , Truong Nguyen , Jack Tzeng
发明人： Yu-Hwa Lo , Yoav Mintz , Truong Nguyen , Jack Tzeng
IPC分类号： H04N7/18
CPC分类号： A61B1/05 , A61B1/0676 , A61B1/0684 , A61B90/361 , A61B2090/309 , G03B15/05 , G03B2215/0528
摘要： The present Invention relates to a camera system suitable for use in minimally invasive surgery (MIS), among other applications. In at least one embodiment, the camera system includes an autonomous miniature camera, a light source assembly providing features such as steerable illumination and a variable radiation angle, and a control and processing unit for processing images acquired by the camera Io generate improved images having reduced blurring using a deblurring algorithm.
摘要翻译：本发明涉及适用于微创手术（MIS）的照相机系统以及其它应用。在至少一个实施例中，照相机系统包括自主微型照相机，提供诸如可转向照明和可变辐射角等特征的光源组件，以及用于处理由摄像机获取的图像的控制和处理单元，使用去模糊算法进行模糊处理。

9. 发明授权

US06384462B1 Planar hetero-interface photodetector 失效
标题翻译：平面异质界面光电探测器
公开(公告)号：US06384462B1
公开(公告)日：2002-05-07
申请号：US09730692
申请日：2000-12-06
申请人： Alexandre Pauchard , Yu-Hwa Lo
发明人： Alexandre Pauchard , Yu-Hwa Lo
IPC分类号： H01L31072
CPC分类号： H01L31/1075 , H01L31/02327 , H01L31/1844 , H01L31/1852 , Y02E10/544
摘要： A planar avalanche photodetector (APD) is fabricated by forming a, for example, InGaAs absorption layer on a p+-type semiconductor substrate, such as InP, and wafer-bonding to the absorption layer a second p-type semiconductor, such as Si, to form a multiplication layer. The layer thickness of the multiplication layer is substantially identical to that of the absorption layer. A region in a top surface of the p-type Si multiplication layer is doped n+-type to form a carrier separation region and a high electric field in the multiplication region. The APD can further include a guard-ring to reduce leakage currents as well as a resonant mirror structure to provide to wavelength selectivity. The planar geometry furthermore favors the integration of high-speed electronic circuits on the same substrate to fabricate monolithic optoelectronic transceivers.
摘要翻译：通过在诸如InP的p +型半导体衬底上形成例如InGaAs吸收层并且与吸收层晶片接合来制造平面雪崩光电检测器（APD），第二p型半导体例如Si，以形成乘法层。倍增层的层厚与吸收层基本相同。 p型Si倍增层的上表面的区域掺杂n +型，以在乘法区域中形成载流子分离区域和高电场。 APD还可以包括保护环以减少泄漏电流以及谐振反射镜结构以提供波长选择性。平面几何形状还有利于将高速电子电路集成在同一衬底上以制造单片光电收发器。

10. 发明授权

US5981400A Compliant universal substrate for epitaxial growth 失效
标题翻译：符合通用衬底的外延生长
公开(公告)号：US5981400A
公开(公告)日：1999-11-09
申请号：US929871
申请日：1997-09-18
申请人： Yu-Hwa Lo
发明人： Yu-Hwa Lo
IPC分类号： C30B25/18 , H01L21/20 , H01L21/00
CPC分类号： C30B25/18 , H01L21/2007
摘要： Compliant universal (CU) substrates and techniques for forming the same facilitate growth of epitaxial layers comprised of materials which are highly lattice mismatched with the substrate material. The CU substrates employ very thin (e.g., 1-20 nm or less) substrate layers which are loosely bonded to a thick bulk material base layer. Because of the loose bonding, the bonding energy of the atoms in the thin substrate layer is reduced, thus greatly increasing the flexibility of the thin substrate layer. This enables the substrate layer to absorb strain or stress imparted during the growth of lattice mismatched epitaxial layers, thus avoiding the formation of defects in the epitaxial layers. The "loose" bonding of the thin substrate layer to the base layer can be achieved in any of a number of ways. First, the thin substrate layer can be bonded at an angle relative to the base layer so that screw dislocations form which provide the desired reduction in bonding energy and increase in flexibility. Other techniques rely on reducing the top surface area of the base layer to reduce the bonding energy. This can be accomplished by making the base material porous at the top surface, or by patterning or roughing the top surface of the base layer.
摘要翻译：合适的通用（CU）衬底和用于形成其的技术有助于由与衬底材料高度晶格失配的材料组成的外延层的生长。 CU衬底使用非常薄（例如，1-20nm或更少）衬底层，其松散地结合到厚的体积材料基底层。由于松散的结合，薄的衬底层中的原子的键合能被减小，从而大大提高了薄衬底层的柔性。这使得衬底层能够吸收在晶格失配的外延层的生长期间施加的应变或应力，从而避免在外延层中形成缺陷。薄衬底层与基层的“松散”结合可以以多种方式中的任一种来实现。首先，可以相对于基底层以一定角度粘结薄的基底层，从而形成提供期望的键合能量降低和增加柔性的螺旋位错。其他技术依赖于减小基层的顶表面积以降低结合能。这可以通过使基材在顶表面多孔，或通过图案化或粗糙化基层的顶表面来实现。

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