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    • 5. 发明授权
    • Method and apparatus of uniform gas-phase molecular matrix deposition for imaging mass spectrometry
    • 用于成像质谱的均匀气相分子基质沉积的方法和装置
    • US07880139B2
    • 2011-02-01
    • US12154912
    • 2008-05-28
    • Yanfeng ChenM. Cameron SullardsThomas M. OrlandoJoseph A. HankinRobert C. MurphyRobert M. Barkley
    • Yanfeng ChenM. Cameron SullardsThomas M. OrlandoJoseph A. HankinRobert C. MurphyRobert M. Barkley
    • H01J49/04
    • H01J49/0004G01N1/2813H01J49/0418
    • Disclosed are apparatus and methods for depositing solvent-free molecules on surfaces of samples, with particular application to imaging mass spectrometry. A vacuum chamber is configured to have controllable matrix translation apparatus for controlling the position of one or more solvent-free matrices within the chamber. Sublimation apparatus is used to sublimate molecules from the solid phase matrices. One or more samples are placed separately from the solvent-free matrices within the chamber. Condensation apparatus individually cools the samples to deposit sublimated molecules on the samples. Controllable sample translation apparatus is used to control the position of the samples within the chamber. Rotatable sample holding apparatus may be used to hold and move the samples to allow deposition of molecules on multiple samples at substantially the same time. Rotatable matrix holding apparatus may also be used to hold and move a plurality of matrices to create a homogenous mixture of molecules that are deposited onto one or more samples. As surface characterization system may be used to monitor deposition of the molecules to determine their thickness and roughness. A computer may be configured to control the matrix translation apparatus, the sublimation apparatus, the condensation apparatus, and the sample translation apparatus to provide for automated deposition of solvent-free molecules on the samples.
    • 公开了用于在样品表面上沉积无溶剂分子的装置和方法,特别适用于成像质谱法。 真空室被配置为具有用于控制腔室内的一种或多种无溶剂基质的位置的可控矩阵平移装置。 升华装置用于升华固相基质中的分子。 将一个或多个样品与腔室内的无溶剂基质分开放置。 冷凝装置分别冷却样品以将升华的分子沉积在样品上。 可控样品转换装置用于控制室内样品的位置。 可旋转的样品保持装置可用于保持和移动样品,以允许分子在基本上同时沉积在多个样品上。 可旋转矩阵保持装置还可以用于保持和移动多个矩阵以产生沉积在一个或多个样本上的分子的均匀混合物。 由于表面表征系统可用于监测分子的沉积以确定其厚度和粗糙度。 计算机可以被配置为控制矩阵翻译装置,升华装置,冷凝装置和样品翻译装置,以提供样品上无溶剂分子的自动沉积。
    • 7. 发明申请
    • Method and apparatus of uniform gas-phase molecular matrix deposition for imaging mass spectrometry
    • 用于成像质谱的均匀气相分子基质沉积的方法和装置
    • US20100090099A1
    • 2010-04-15
    • US12154912
    • 2008-05-28
    • Yanfeng ChenM. Cameron SullardsThomas M. OrlandoJoseph A. HankinRobert C. MurphyRobert M. Barkley
    • Yanfeng ChenM. Cameron SullardsThomas M. OrlandoJoseph A. HankinRobert C. MurphyRobert M. Barkley
    • H01J49/00
    • H01J49/0004G01N1/2813H01J49/0418
    • Disclosed are apparatus and methods for depositing solvent-free molecules on surfaces of samples, with particular application to imaging mass spectrometry. A vacuum chamber is configured to have controllable matrix translation apparatus for controlling the position of one or more solvent-free matrices within the chamber. Sublimation apparatus is used to sublimate molecules from the solid phase matrices. One or more samples are placed separately from the solvent-free matrices within the chamber. Condensation apparatus individually cools the samples to deposit sublimated molecules on the samples. Controllable sample translation apparatus is used to control the position of the samples within the chamber. Rotatable sample holding apparatus may be used to hold and move the samples to allow deposition of molecules on multiple samples at substantially the same time. Rotatable matrix holding apparatus may also be used to hold and move a plurality of matrices to create a homogenous mixture of molecules that are deposited onto one or more samples. As surface characterization system may be used to monitor deposition of the molecules to determine their thickness and roughness. A computer may be configured to control the matrix translation apparatus, the sublimation apparatus, the condensation apparatus, and the sample translation apparatus to provide for automated deposition of solvent-free molecules on the samples.
    • 公开了用于在样品表面上沉积无溶剂分子的装置和方法,特别适用于成像质谱法。 真空室被配置为具有用于控制腔室内的一种或多种无溶剂基质的位置的可控矩阵平移装置。 升华装置用于升华固相基质中的分子。 将一个或多个样品与腔室内的无溶剂基质分开放置。 冷凝装置分别冷却样品以将升华的分子沉积在样品上。 可控样品转换装置用于控制室内样品的位置。 可旋转的样品保持装置可用于保持和移动样品,以允许分子在基本上同时沉积在多个样品上。 可旋转矩阵保持装置还可以用于保持和移动多个矩阵以产生沉积在一个或多个样本上的分子的均匀混合物。 由于表面表征系统可用于监测分子的沉积以确定其厚度和粗糙度。 计算机可以被配置为控制矩阵翻译装置,升华装置,冷凝装置和样品翻译装置,以提供样品上无溶剂分子的自动沉积。