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1. 发明授权

US08518407B2 Therapeutic human anti-IL-1R1 monoclonal antibody 有权
标题翻译：治疗性人类抗IL-1R1单克隆抗体
公开(公告)号：US08518407B2
公开(公告)日：2013-08-27
申请号：US13450126
申请日：2012-04-18
申请人： Brian Varnum , Chris Vezina , Alison Witte , Xueming Qian , Francis Hall Martin , Haichun Huang , Gary Elliott
发明人： Brian Varnum , Chris Vezina , Alison Witte , Xueming Qian , Francis Hall Martin , Haichun Huang , Gary Elliott
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
摘要翻译：描述了与白细胞介素-1受体1型（IL-1R1）相互作用的抗体。描述了通过向IL-1R1施用药学有效量的抗体来治疗IL-1介导的疾病的方法。描述了使用IL-1R1抗体检测样品中IL-1R1的量的方法。

2. 发明申请

US20120269824A1 THERAPEUTIC HUMAN ANTI-IL-1R1 MONOCLONAL ANTIBODY 有权
标题翻译：治疗人类抗IL-1R1单克隆抗体
公开(公告)号：US20120269824A1
公开(公告)日：2012-10-25
申请号：US13450126
申请日：2012-04-18
申请人： Brian Varnum , Chris Vezina , Alison Witte , Xueming Qian , Francis Hall Martin , Haichun Huang , Gary Elliott
发明人： Brian Varnum , Chris Vezina , Alison Witte , Xueming Qian , Francis Hall Martin , Haichun Huang , Gary Elliott
IPC分类号： A61K39/395 , A61P19/02 , A61P29/00 , C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
摘要翻译：描述了与白细胞介素-1受体1型（IL-1R1）相互作用的抗体。描述了通过向IL-1R1施用药学有效量的抗体来治疗IL-1介导的疾病的方法。描述了使用IL-1R1抗体检测样品中IL-1R1的量的方法。

3. 发明申请

US20120003237A1 WISE BINDING AGENTS AND EPITOPES 有权
标题翻译： WISE BINDING代理和外套
公开(公告)号：US20120003237A1
公开(公告)日：2012-01-05
申请号：US13233983
申请日：2011-09-15
申请人： Xueming QIAN , Kevin Graham , Grant Shimamoto , Barbara S. Tipton , Mei-Mei Tsai , Aaron George Winters , Li Zhang
发明人： Xueming QIAN , Kevin Graham , Grant Shimamoto , Barbara S. Tipton , Mei-Mei Tsai , Aaron George Winters , Li Zhang
IPC分类号： A61K39/395 , C07K17/08 , A61P13/00 , A61P11/00 , A61P13/12 , A61P29/00 , C07K16/18 , C07K19/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/92
摘要： The present invention relates to binding agents for WISE, and includes for their manufacture and use.
摘要翻译：本发明涉及用于WISE的粘合剂，并且包括其制造和使用。

4. 发明申请

US20090214559A1 Therapeutic Human Anti-IL-1R1 Monoclonal Antibody 有权
标题翻译：治疗人类抗IL-1R1单克隆抗体
公开(公告)号：US20090214559A1
公开(公告)日：2009-08-27
申请号：US12210313
申请日：2008-09-15
申请人： Brian Varnum , Chris Vezina , Alison Witte , Xueming Qian , Francis Hall Martin , Haichun Huang , Gary Elliott
发明人： Brian Varnum , Chris Vezina , Alison Witte , Xueming Qian , Francis Hall Martin , Haichun Huang , Gary Elliott
IPC分类号： A61K39/395 , C07K16/18 , C12N15/11 , C12N15/00 , C12N5/06 , C12N1/21 , C12P21/08
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
摘要翻译：描述了与白细胞介素-1受体1型（IL-1R1）相互作用的抗体。描述了通过向IL-1R1施用药学有效量的抗体来治疗IL-1介导的疾病的方法。描述了使用IL-1R1抗体检测样品中IL-1R1的量的方法。

5. 发明授权

US08309092B2 Wise binding agents and epitopes 有权
标题翻译：明智的结合剂和表位
公开(公告)号：US08309092B2
公开(公告)日：2012-11-13
申请号：US13233983
申请日：2011-09-15
申请人： Xueming Qian , Kevin Graham , Grant Shimamoto , Barbara S. Tipton , Mei-Mei Tsai , Aaron George Winters , Li Zhang
发明人： Xueming Qian , Kevin Graham , Grant Shimamoto , Barbara S. Tipton , Mei-Mei Tsai , Aaron George Winters , Li Zhang
IPC分类号： A61K39/395 , C07K16/22 , C07K16/46
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/92
摘要： The present invention relates to binding agents for WISE, and includes for their manufacture and use.
摘要翻译：本发明涉及用于WISE的粘合剂，并且包括其制造和使用。

6. 发明申请

US20120075033A1 SINGLE MATCHING NETWORK FOR MATCHING MULTI-FREQUENCY AND METHOD OF CONSTRUCTURING THE SAME AND RADIO FREQUENCY POWER SOURCE SYSTEM USING THE SAME 审中-公开
标题翻译：用于匹配多个频率的单一匹配网络和使用该方法的相同方法和无线电频率电源系统
公开(公告)号：US20120075033A1
公开(公告)日：2012-03-29
申请号：US13239316
申请日：2011-09-21
申请人： Liang OUYANG , Lei Liu , Xueming Qian , Jinyuan Chen
发明人： Liang OUYANG , Lei Liu , Xueming Qian , Jinyuan Chen
IPC分类号： H03H7/38 , H01R43/00
CPC分类号： H03H7/38 , H01J37/32183 , H03H2007/386 , Y10T29/49117
摘要： A single matching network is adapted to input at least two frequencies, which is used to selectively provide an RF power match at any one of the at least two frequencies to a plasma load, and the single matching network includes an input terminal connected to a multi-frequency input and an output terminal connected to the plasma load. A capacitor and an inductor connected in series with each other are provided between the input terminal and the output terminal to form a branch, the capacitance value of the capacitor is C0, and the inductance value of the inductor is Lo, wherein, the capacitance value C0 and the inductance value L0 satisfy the following relations: jω1L0+1/jω1C0=jy1 jω2L0+1/jω2C0=jy2 wherein, ω1=2πf1, ω2=2πf2, the f1 and f2 are respectively the two frequencies, y1 is the impedance required for the branch when achieving a matching state at frequency f1, and y2 is the impedance required for the branch when achieving a matching state at frequency f2.
摘要翻译：单个匹配网络适于输入至少两个频率，其用于选择性地将所述至少两个频率中的任一个处的RF功率匹配提供给等离子体负载，并且所述单个匹配网络包括连接到多个频率输入和连接到等离子体负载的输出端子。在输入端子和输出端子之间设置串联连接的电容器和电感器，以形成分支，电容器的电容值为C0，电感器的电感值为Lo，其中，电容值 C0和电感值L0满足以下关系：jω1L0+ 1 /jω1C0= jy1jω2L0+ 1 /jω2C0= jy2其中，ω1= 2＆pgr; f1，ω2= 2＆pgr; f2，f1和f2分别为两个频率，y1 是当在频率f1处实现匹配状态时分支所需的阻抗，并且y2是当在频率f2达到匹配状态时分支所需的阻抗。

7. 发明申请

US20090130114A1 WISE BINDING AGENTS AND EPITOPES 失效
标题翻译： WISE BINDING代理和外套
公开(公告)号：US20090130114A1
公开(公告)日：2009-05-21
申请号：US12275850
申请日：2008-11-21
申请人： Xueming Qian , Kevin Graham , Grant Shimamoto , Barbara S. Tipton , Mei-Mei Tsai , Aaron George Winters , Li Zhang
发明人： Xueming Qian , Kevin Graham , Grant Shimamoto , Barbara S. Tipton , Mei-Mei Tsai , Aaron George Winters , Li Zhang
IPC分类号： A61K39/395 , C07K16/18 , C07K14/47 , A61P43/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/92
摘要： The present invention relates to binding agents for WISE, and includes for their manufacture and use.
摘要翻译：本发明涉及用于WISE的粘合剂，并且包括其制造和使用。

8. 发明授权

US07438910B2 Therapeutic human anti-IL1-R1 monoclonal antibody 有权
标题翻译：治疗人类抗IL1-R1单克隆抗体
公开(公告)号：US07438910B2
公开(公告)日：2008-10-21
申请号：US10656769
申请日：2003-09-05
申请人： Brian Varnum , Chris Vezina , Alison Witte , Xueming Qian , Francis Hall Martin , Haichun Huang , Gary Elliott
发明人： Brian Varnum , Chris Vezina , Alison Witte , Xueming Qian , Francis Hall Martin , Haichun Huang , Gary Elliott
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
摘要翻译：描述了与白细胞介素-1受体1型（IL-1R1）相互作用的抗体。描述了通过向IL-1R1施用药学有效量的抗体来治疗IL-1介导的疾病的方法。描述了使用IL-1R1抗体检测样品中IL-1R1的量的方法。

9. 发明申请

US20050084493A1 Screening method for antibodies and other selective IL-1 binding agents that allow binding to IL-1 receptor but not activation thereof 审中-公开
标题翻译：用于抗体和其它选择性IL-1结合剂的筛选方法，其允许结合IL-1受体但不与其结合
公开(公告)号：US20050084493A1
公开(公告)日：2005-04-21
申请号：US10985299
申请日：2004-11-09
申请人： Alison Witte , Brian Varnum , Xueming Qian , Chris Vezina
发明人： Alison Witte , Brian Varnum , Xueming Qian , Chris Vezina
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/245 , A61K2039/505 , C07K2317/24
摘要： The invention concerns methods of treating IL-1-mediated disease by administering a selective IL-1 binding agents that form an antagonist complex with the IL-1 ligand. The antagonist complex can bind to the IL-1 receptor without activating the receptor. The selective binding agents contemplated by this invention thus have the properties of free ligand absorption (through binding of the selective binding agent to free IL-1α or β) and receptor activation inhibition (through binding of the antagonist complex to the receptor and preventing its activation).
摘要翻译：本发明涉及通过施用与IL-1配体形成拮抗剂复合物的选择性IL-1结合剂来治疗IL-1介导的疾病的方法。拮抗剂复合物可以结合IL-1受体而不活化受体。因此，本发明考虑的选择性结合剂具有游离配体吸收（通过结合选择性结合剂与游离IL-1α或β）和受体活化抑制（通过拮抗剂复合物与受体结合并防止其活化）的性质）。

10. 发明申请

US20120288507A1 WISE BINDING AGENTS AND EPITOPES 审中-公开
标题翻译： WISE BINDING代理和外套
公开(公告)号：US20120288507A1
公开(公告)日：2012-11-15
申请号：US13516161
申请日：2010-12-17
申请人： Xueming Qian , Aaron George Winters , Michelle Hortter , Kevin Graham , Mei-Mei Tsai
发明人： Xueming Qian , Aaron George Winters , Michelle Hortter , Kevin Graham , Mei-Mei Tsai
IPC分类号： C07K16/18 , A61P13/12 , C07K19/00 , A61K39/395 , C07K14/47
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76
摘要： The present invention relates to binding agents for WISE, and includes methods for their manufacture and use.
摘要翻译：本发明涉及WISE的粘合剂，并且包括其制造和使用的方法。

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