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1. 发明申请

US20070244203A1 Controlled-Release Composition for Topical Application and a Method of Delivering an Active Agent to a Substrate 有权
标题翻译：用于局部应用的控制释放组合物和向基质提供活性剂的方法
公开(公告)号：US20070244203A1
公开(公告)日：2007-10-18
申请号：US10576991
申请日：2004-10-27
申请人： Victor Raul , Xavier Thomas , Anne Shim , Gerald Schalau II , Janelle Cabala
发明人： Victor Raul , Xavier Thomas , Anne Shim , Gerald Schalau II , Janelle Cabala
IPC分类号： A61K47/30
CPC分类号： A61K9/107 , A61K8/06 , A61K8/062 , A61K8/89 , A61K9/0014 , A61K47/24 , A61K47/30 , A61Q19/00
摘要： A controlled-release composition for topical application to a substrate includes an oil-in-water emulsion and an active agent incorporated into the oil-in-water emulsion. The oil-in-water emulsion is substantially free of lipophilic solvent and is formed by mechanical inversion of a water-in-oil emulsion. The water-in-oil emulsion includes a silicone component, a surfactant, and water. A method of delivering the active agent to the substrate provides the oil-in-water emulsion and incorporates the active agent into the oil-in-water emulsion for delivery of the active agent to the substrate upon application of the oil-in-water emulsion to the substrate.
摘要翻译：用于局部施用于基材的控释组合物包括水包油乳液和掺入到水包油乳液中的活性剂。水包油乳液基本上不含亲脂性溶剂，并通过油包水乳液的机械倒置形成。油包水乳液包括硅氧烷组分，表面活性剂和水。将活性剂递送到基底的方法提供了水包油乳液，并将活性剂并入水包油乳液中，以在施用水包油乳剂后将活性剂递送至基底到基底。

2. 发明申请

US20060083776A1 Preparations for topical application and methods of delivering an active agent to a substrate 审中-公开
标题翻译：用于局部施用的制剂和将活性剂递送至基材的方法
公开(公告)号：US20060083776A1
公开(公告)日：2006-04-20
申请号：US11248017
申请日：2005-10-11
申请人： Richard Bott , Kurt Brandstadt , Csilla Kollar , Thomas Lane , Donald Liles , Mae Saldjeno , Xavier Thomas , Kevin Murphy , Gerald Schalau
发明人： Richard Bott , Kurt Brandstadt , Csilla Kollar , Thomas Lane , Donald Liles , Mae Saldjeno , Xavier Thomas , Kevin Murphy , Gerald Schalau
IPC分类号： A61L15/00
CPC分类号： A61L15/38 , A61K9/7084 , A61L15/26 , A61L15/58 , C08L83/04
摘要： A multi-layer dressing and controlled-release composition for topical application to a substrate include an emulsion and an active agent incorporated into the emulsion. The active agent includes a protein. A method of delivering the active agent to the substrate provides the emulsion and incorporates the active agent into the emulsion for delivery of the active agent to the substrate. Multi-layer dressings and methods particularly suited for management of wound exudate and effective debridement of wound eschar.
摘要翻译：用于局部施用于底物的多层敷料和控释组合物包括乳液和掺入乳液中的活性剂。活性剂包括蛋白质。将活性剂递送到底物的方法提供乳液并将活性剂并入乳液中以将活性剂递送至底物。多层敷料和方法特别适用于伤口渗出物的管理和伤口焦痂的有效清创。

3. 发明授权

US08907026B2 Crosslinkable saccharide-siloxane compositions, and networks, coatings and articles formed therefrom 有权
标题翻译：可交联的糖 - 硅氧烷组合物，以及由其形成的网络，涂层和制品
公开(公告)号：US08907026B2
公开(公告)日：2014-12-09
申请号：US11793067
申请日：2005-12-22
申请人： Eric Jude Joffre , Joseph C. McAuliffe , Csilla Kollar , Xavier Thomas , David C Gantner
发明人： Eric Jude Joffre , Joseph C. McAuliffe , Csilla Kollar , Xavier Thomas , David C Gantner
IPC分类号： C08G77/38 , C08L83/04 , D06M23/00 , D06M15/643 , A01N25/34 , A61K8/893 , C09D183/06 , C08G77/42 , D06M15/03 , A61Q19/00 , C08L83/06 , A61Q5/00 , A61Q19/08 , A61Q15/00
CPC分类号： A61K8/893 , A61Q5/00 , A61Q15/00 , A61Q19/00 , A61Q19/08 , C08G77/42 , C08L83/06 , C09D183/06 , D06M15/03 , D06M15/643 , C08L2666/28 , C08L83/00
摘要： The invention provides a cross-linkable composition comprising a saccharide-siloxane copolymer according to a specified structural formula, a crosslinking agent, and, optionally, solvent. Cross-linked polymeric networks, cured coatings, and articles of manufacture formed from the inventive compositions are also provided, as well as processes and methods of manufacturing the inventive cross-linkable compositions and applications thereof.
摘要翻译：本发明提供了一种可交联组合物，其包含根据特定结构式的糖 - 硅氧烷共聚物，交联剂和任选的溶剂。还提供由本发明组合物形成的交联聚合物网络，固化的涂层和制品，以及制造本发明的可交联组合物的方法和方法及其应用。

4. 发明申请

US20120135225A1 Multi-layer Transdermal Patch 审中-公开
标题翻译：多层透皮贴剂
公开(公告)号：US20120135225A1
公开(公告)日：2012-05-31
申请号：US13376914
申请日：2010-08-03
申请人： Andre Colas , Gerald K. Schalau, II , Xavier Thomas
发明人： Andre Colas , Gerald K. Schalau, II , Xavier Thomas
IPC分类号： B32B3/00 , B32B7/12
CPC分类号： A61K9/7084 , A61L15/44 , A61L15/58 , A61L2300/222 , A61L2300/41 , A61L2300/428 , A61L2300/602 , Y10T428/26 , Y10T428/2848
摘要： This invention pertains to a construction consisting of in the order from the outside towards the inside: An occlusive or non occlusive external film layer; a non-curing pressure sensitive adhesive (PSA) that has been blended with a therapeutic concentration of at least one or a combination of cosmetic or pharmaceutical active ingredients; and a silicone gel adhesive that is used as the skin contact layer.
摘要翻译：本发明涉及从外部到内部的顺序的结构：闭塞或非闭塞的外部薄膜层; 已经与化妆品或药物活性成分的至少一种或组合的治疗浓度混合的非固化压敏粘合剂（PSA）和用作皮肤接触层的硅胶粘合剂。

5. 发明申请

US20120095109A1 Film Forming, Silicone Containing Compositions 有权
标题翻译：胶片成型，含硅胶组合物
公开(公告)号：US20120095109A1
公开(公告)日：2012-04-19
申请号：US13379893
申请日：2010-07-02
申请人： Jean- Luc Garaud , Guillaume Kergosien , Xavier Thomas
发明人： Jean- Luc Garaud , Guillaume Kergosien , Xavier Thomas
IPC分类号： A61K47/34 , C09D183/07
CPC分类号： C08G77/12 , C08G77/20 , C08G77/70 , C08G77/80 , C08L83/04 , C09D183/04 , C08L83/00
摘要： The invention relates to silicone containing compositions able to form adhesive films on substrates, which typically comprises a curable silicone composition comprising components (a), (d) and at least one of (b) or (c): a. a polyorganosiloxane resin, composed of M and Q units having at least 3 alkenyl groups per molecule, herein after called “SiVi” groups, b. a poly-organosiloxane compound having at least 2 Si-bonded hydrogen groups on the polysiloxane chain, hereinafter called “SiH” groups, c. a telechelic polyorganosiloxane compound having terminal Si—H groups, and d. a hydrosilylation catalyst for the reaction of SiH groups with SiVi groups, e. a liquid diluent in an amount of from 0% to maximum 40% by weight of composition said components reacting together by hydrosilylation at a temperature below 400 C when they are brought into contact on a substrate and cure to form a continuous film on the substrate. Such formulation can cure quickly at room temperature and can provide good balance between adhesion and tack.
摘要翻译：本发明涉及能够在基材上形成粘合剂膜的含硅氧烷的组合物，其通常包含包含组分（a），（d）和（b）或（c））中的至少一种的可固化的有机硅组合物：a。 b，由分子中具有至少3个烯基的M和Q单元组成的聚有机硅氧烷树脂，这里称为“SiVi”基团。 c）在聚硅氧烷链上具有至少2个Si键合氢基团的聚有机硅氧烷化合物，以下称为“SiH”基团。具有末端Si-H基团的遥爪聚有机硅氧烷化合物，和d。 SiH基团与SiVi基团反应的氢化硅烷化催化剂，液体稀释剂的量为组合物的0重量％至最大40重量％，当所述组分在基材上接触并固化以在基材上形成连续的膜时，在低于400℃的温度下通过氢化硅烷化反应而一起反应。这种制剂可以在室温下快速固化，并且可以在粘合和粘性之间提供良好的平衡。

6. 发明申请

US20080138386A1 Crosslinkable Saccharide-Siloxane Compositions, and Networks, Coatings and Articles Formed Therefrom 有权
标题翻译：可交联的糖 - 硅氧烷组合物，以及形成的网络，涂料和制品
公开(公告)号：US20080138386A1
公开(公告)日：2008-06-12
申请号：US11793067
申请日：2005-12-22
申请人： Eric Jude Joffre , Joseph C. McAuliffe , Csilla Kollar , Xavier Thomas , David C. Gantner
发明人： Eric Jude Joffre , Joseph C. McAuliffe , Csilla Kollar , Xavier Thomas , David C. Gantner
IPC分类号： C08L83/10 , A61K9/70
CPC分类号： A61K8/893 , A61Q5/00 , A61Q15/00 , A61Q19/00 , A61Q19/08 , C08G77/42 , C08L83/06 , C09D183/06 , D06M15/03 , D06M15/643 , C08L2666/28 , C08L83/00
摘要： The invention provides a cross-linkable composition comprising a saccharide-siloxane copolymer according to a specified structural formula, a crosslinking agent, and, optionally, solvent. Cross-linked polymeric networks, cured coatings, and articles of manufacture formed from the inventive compositions are also provided, as well as processes and methods of manufacturing the inventive cross-linkable compositions and applications thereof.
摘要翻译：本发明提供了一种可交联组合物，其包含根据特定结构式的糖 - 硅氧烷共聚物，交联剂和任选的溶剂。还提供由本发明组合物形成的交联聚合物网络，固化的涂层和制品，以及制造本发明的可交联组合物的方法和方法及其应用。

7. 发明授权

US06846508B1 Method for adhering substrates using adhesive devices containing silicone gels 失效
标题翻译：使用含有硅胶的粘合剂粘合基材的方法
公开(公告)号：US06846508B1
公开(公告)日：2005-01-25
申请号：US09304393
申请日：1999-05-04
申请人： Andre Rudolf Louis Colas , Gary Lord , Marie Therese Valencia , Xavier Thomas
发明人： Andre Rudolf Louis Colas , Gary Lord , Marie Therese Valencia , Xavier Thomas
IPC分类号： A61L24/00 , A61L15/58 , A61L24/04 , A61L31/06 , C08L83/04 , C09J5/00 , C09J7/04 , A61L27/00 , C09J7/02
CPC分类号： C09J5/00 , A61L15/58 , A61L24/046 , A61L31/06 , C08L83/04 , C09J7/21 , C09J7/38 , C09J2201/128 , C09J2201/606 , C09J2483/00 , Y10T428/2852 , Y10T428/31663 , Y10T442/2754 , Y10T442/60
摘要： A method for adhering a first substrate to a second substrate using a double sided adhesive device based on silicone gels. The method is particularly useful for adhering a medical prosthesis to a human or animal body.
摘要翻译：使用基于有机硅凝胶的双面粘合装置将第一基板粘附到第二基板的方法。该方法对于将医疗假体粘附到人或动物身体特别有用。

8. 发明授权

US5953458A Method and device for motion estimation 失效
标题翻译：运动估计的方法和装置
公开(公告)号：US5953458A
公开(公告)日：1999-09-14
申请号：US758113
申请日：1996-11-25
申请人： Alain Pirson , Pierre-Xavier Thomas
发明人： Alain Pirson , Pierre-Xavier Thomas
IPC分类号： G06T7/20 , G06K9/36
CPC分类号： G06T7/202 , G06T2207/10016
摘要： The invention relates to a device for blockwise estimation of motion. This device includes on the one hand a matrix array (300) for calculating an error function, the said array including storage elements (S, 406, 407) for plural blocks (a, a') of current pixels and means (403) for switching between the storage elements corresponding to the various blocks and on the other hand a memory (801) for feeding the said array with pixels of a search window, linked to the said array.The device according to the invention is characterized in thatthe said memory (801) is a random access memory,the said memory contains a band of the search window corresponding to the entirety of the current blocks stored in the array (300),the said device including means (812) for read-addressing partial sections of the said band of the memory as a function of the block processed (a, a') by the said array, the said sections being introduced column by column into the said array.The invention also relates to a corresponding method and applies especially in the field of digital television.FIG. 7.
摘要翻译：本发明涉及一种用于块状运动估计的装置。该装置一方面包括用于计算误差函数的矩阵阵列（300），所述阵列包括用于当前像素的多个块（a，a'）的存储元件（S，406,407），以及用于在对应于各个块的存储元件之间进行切换，另一方面，用于将与所述阵列链接的搜索窗口的像素馈送到所述阵列的存储器（801）。根据本发明的装置的特征在于，所述存储器（801）是随机存取存储器，所述存储器包含与存储在阵列（300）中的整个当前块相对应的搜索窗口的频带，所述设备包括用于根据由所述阵列处理的块（a，a'）的函数读取寻址存储器的所述频带的部分部分的装置（812），所述部分逐列地引入所述阵列。本发明还涉及一种相应的方法，特别适用于数字电视领域。图。 7。

9. 发明授权

US08968773B2 Silicone film former for delivery of actives 有权
标题翻译：有机硅膜用于传递活性物质
公开(公告)号：US08968773B2
公开(公告)日：2015-03-03
申请号：US12300875
申请日：2007-05-23
申请人： Xavier Thomas , Virginie Caprasse , Eric Jude Joffre , Csilla Kollar , David Clayton Gantner , Victor A. Raul
发明人： Xavier Thomas , Virginie Caprasse , Eric Jude Joffre , Csilla Kollar , David Clayton Gantner , Victor A. Raul
IPC分类号： A61K9/70 , A01N25/34 , A61K9/14 , C08L83/04 , C08G77/14 , C08G77/388 , C08L83/06 , C08K5/55 , C08L83/08
CPC分类号： A61K9/7015 , A61K9/7069 , C08G77/14 , C08G77/388 , C08K5/55 , C08L83/06 , C08L83/08 , C08L83/00
摘要： The invention provides: a cross-linkable therapeutic composition comprising a) a saccharide-siloxane copolymer; b) a crosslinking agent; c) one or more active/inactive ingredients; and d) optionally, a solvent, or solvent mixture, wherein the saccharide-siloxane copolymer has the following formula: R2aR1(3-a)SiO—[(SiR2R1O)m-(SiR12O)n]y-SiR1(3-a)R2a that is further formulaically defined and wherein the saccharide-siloxane copolymer is a reaction product of a functionalized organosiloxane polymer and at least one hydroxy-functional saccharide such that the organosiloxane component is covalently linked via a linking group to the saccharide component; films; and methods related thereto. The composition has therapeutic properties. The invention also provides articles of manufacture including topical and transdermal agent delivery patches comprising the novel film-forming composition and/or films.
摘要翻译：本发明提供：可交联的治疗组合物，其包含a）糖 - 硅氧烷共聚物; b）交联剂; c）一种或多种活性/非活性成分; 其中糖 - 硅氧烷共聚物具有下式：R2aR1（3-a）SiO - [（SiR2R10）m-（SiR12O）n] y-SiR1（3-a） R2a，其进一步公式定义，其中糖 - 硅氧烷共聚物是官能化有机硅氧烷聚合物和至少一种羟基官能糖的反应产物，使得有机硅氧烷组分通过连接基团与糖组分共价连接; 电影和相关的方法。该组合物具有治疗性质。本发明还提供了包括局部和透皮剂递送贴片的制品，其包含新的成膜组合物和/或膜。

10. 发明申请

US20110046242A1 Film Forming, Silicone Containing Compositions 审中-公开
标题翻译：胶片成型，含硅胶组合物
公开(公告)号：US20110046242A1
公开(公告)日：2011-02-24
申请号：US12863006
申请日：2009-01-16
申请人： Jean-Luc Garaud , Guillaume Kergosien , Xavier Thomas
发明人： Jean-Luc Garaud , Guillaume Kergosien , Xavier Thomas
IPC分类号： A61K47/34
CPC分类号： A61K9/7015 , C08G77/12 , C08G77/20 , C08G77/70 , C08L83/04 , C08L83/00
摘要： The invention relates to silicone containing compositions able to form adhesive films on substrates, which typically comprises a curable silicone formulation containing: (a) a polyorganosiloxane polymer having at least two functional SiVi groups per molecule, each SiVi group containing an alkenyl functionality directly bonded to a silicon atom; (b) a crosslinker polyorganosiloxane compound having at least 3 Si-bonded hydrogen groups or SiH groups per molecule; (c) a chain extender compound which is a telechelic polyorganosiloxane having terminal SiH groups; (d) a hydrosilylation catalyst for the reaction of SiH groups with SiVi groups; (e) with RHV>1.5 wherein RHV is the ratio of the number of SiH moles in (b) and (c) to the number of SiVi moles in (a) and (d), and 0
摘要翻译：本发明涉及能够在基材上形成粘合剂膜的含硅氧烷的组合物，其通常包含可固化的硅氧烷制剂，其包含：（a）每分子具有至少两个功能性SiVi基团的聚有机硅氧烷聚合物，每个含有链烯基官能团的SiVi基团直接键合到硅原子; （b）每分子具有至少3个Si键合氢基团或SiH基团的交联剂聚有机硅氧烷化合物; （c）扩链剂化合物，其是具有末端SiH基团的遥爪聚有机硅氧烷; （d）SiH基团与SiVi基团反应的氢化硅烷化催化剂; （e）RHV> 1.5，其中RHV是（a）和（d）中的SiH摩尔数与（b）和（c）中的SiH摩尔数之比，0

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