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1. 发明授权

US09354195B2 Highly selective coated-electrode nanogap transducers for the detection of redox molecules 有权
标题翻译：用于检测氧化还原分子的高选择性涂层电极纳米胶片转换器
公开(公告)号：US09354195B2
公开(公告)日：2016-05-31
申请号：US14104546
申请日：2013-12-12
申请人： Noureddine Tayebi , Xing Su , Handong Li
发明人： Noureddine Tayebi , Xing Su , Handong Li
IPC分类号： G01N27/327
CPC分类号： G01N27/3278 , C23C16/00
摘要： Highly selective coated-electrode nanogap transducers for the detection of redox molecules are described. In an example, an analyte detection system includes one or more transducer electrodes having a surface for analyte detection. The surface includes a coating to inhibit direct contact of analyte with the surface of the one or more transducer electrodes.
摘要翻译：描述了用于检测氧化还原分子的高选择性涂层电极纳米胶片转换器。在一个示例中，分析物检测系统包括具有用于分析物检测的表面的一个或多个换能器电极。表面包括抑制分析物与一个或多个换能器电极的表面的直接接触的涂层。

2. 发明申请

US20150168341A1 Highly Selective Coated-Electrode Nanogap Transducers for the Detection of Redox Molecules 有权
标题翻译：高选择性涂层电极Nanogap传感器用于检测氧化还原分子
公开(公告)号：US20150168341A1
公开(公告)日：2015-06-18
申请号：US14104546
申请日：2013-12-12
申请人： Noureddine Tayebi , Xing Su , Handong Li
发明人： Noureddine Tayebi , Xing Su , Handong Li
IPC分类号： G01N27/327
CPC分类号： G01N27/3278 , C23C16/00
摘要： Highly selective coated-electrode nanogap transducers for the detection of redox molecules are described. In an example, an analyte detection system includes one or more transducer electrodes having a surface for analyte detection. The surface includes a coating to inhibit direct contact of analyte with the surface of the one or more transducer electrodes.
摘要翻译：描述了用于检测氧化还原分子的高选择性涂层电极纳米胶片转换器。在一个示例中，分析物检测系统包括具有用于分析物检测的表面的一个或多个换能器电极。表面包括抑制分析物与一个或多个换能器电极的表面的直接接触的涂层。

3. 发明申请

US20140083871A1 DEVICE AND METHOD FOR DETECTING REDOX REACTIONS IN SOLUTION 有权
标题翻译：用于检测溶液中的氧化还原反应的装置和方法
公开(公告)号：US20140083871A1
公开(公告)日：2014-03-27
申请号：US13628728
申请日：2012-09-27
申请人： Jonathan S. Daniels , Oguz H. Elibol , Grace M. Credo , Xing Su
发明人： Jonathan S. Daniels , Oguz H. Elibol , Grace M. Credo , Xing Su
IPC分类号： G01N27/30 , B82Y30/00
CPC分类号： G01N27/3277 , B82Y30/00 , C12Q1/68 , G01D5/24 , G01K7/34 , G01L1/14 , G01N27/22 , G01R27/26 , G06K7/08
摘要： Described herein is a device comprising a plurality of first reaction electrodes arranged in an array, the plurality of first reaction electrodes configured to be exposed to a solution and having a capacitance; first circuitry configured to controllably connect the plurality of first reaction electrodes to a bias source and controllably disconnect the plurality of first reaction electrodes from the bias source; and second circuitry configured to measure a rate of charging or discharging of the capacitance. Also described herein is a method of using this device to sequence DNA.
摘要翻译：这里描述的是一种装置，其包括排列成阵列的多个第一反应电极，多个第一反应电极构造为暴露于溶液并具有电容; 第一电路，被配置为将多个第一反应电极可控地连接到偏置源并且可控制地将多个第一反应电极与偏置源分离; 以及第二电路，被配置为测量电容的充电或放电速率。本文还描述了使用该装置来对DNA进行序列化的方法。

4. 发明授权

US08679758B2 Complexity management of genomic DNA 有权
标题翻译：基因组DNA的复杂性管理
公开(公告)号：US08679758B2
公开(公告)日：2014-03-25
申请号：US13568111
申请日：2012-08-06
申请人： Hajime Matsuzaki , Xing Su , Sean Walsh , Giulia Kennedy , Rui Mei
发明人： Hajime Matsuzaki , Xing Su , Sean Walsh , Giulia Kennedy , Rui Mei
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6806 , C12Q1/6809 , C12Q1/683 , C12Q1/6837 , C12Q1/6844 , C12Q2600/156
摘要： The presently claimed invention provides for novel methods and kits for analyzing a collection of target sequences in a nucleic acid sample. A sample is amplified under conditions that enrich for a subset of fragments that includes a collection of target sequences. The invention further provides for analysis of the above sample by hybridization to an array, which may be specifically designed to interrogate the collection of target sequences for particular characteristics, such as, for example, the presence or absence of one or more polymorphisms.
摘要翻译：本发明提供了用于分析核酸样品中靶序列的集合的新方法和试剂盒。在富集包括靶序列集合的片段子集的条件下扩增样品。本发明进一步提供了通过与阵列杂交来分析上述样品，其可以被特别设计成询问用于特定特征的靶序列的收集，例如存在或不存在一个或多个多态性。

5. 发明申请

US20140081818A1 Matched Order Fulfillment with Linear Optimization 审中-公开
标题翻译：线性优化匹配订单履行
公开(公告)号：US20140081818A1
公开(公告)日：2014-03-20
申请号：US13617845
申请日：2012-09-14
申请人： Richard Co , John Nyhoff , Xing Su , Tuen Tuen Wang , John Labuszewski
发明人： Richard Co , John Nyhoff , Xing Su , Tuen Tuen Wang , John Labuszewski
IPC分类号： G06Q40/04
CPC分类号： G06Q40/04
摘要： A method for matching compound orders from a group of market participants includes receiving, via a communication network, compound order data, the compound order data specifying a maximum amount of a financial instrument of a plurality of financial instruments to be bought or sold by each market participant, accessing a memory in which price data is stored, the price data indicating a current price of each financial instrument, implementing, with a processor, a linear solver to maximize fulfillment of the compound orders via order matching for execution at the current prices in accordance with the maximum amounts specified in the compound order data and in accordance with a maximum net risk exposure level for each market participant arising from the fulfillment of the compound orders, and transmitting trade data indicative of the order matching for execution of trades among the market participants at the current prices.
摘要翻译：一种用于匹配来自一组市场参与者的复合订单的方法包括经由通信网络接收复合订单数据，指定每个市场要购买或出售的多种金融工具的金融工具的最大金额的复合订单数据参与者访问存储价格数据的存储器，指示每个金融工具的当前价格的价格数据，用处理器实现线性求解器，以通过以当前价格执行的订单匹配来最大限度地实现复合订单按照复合订单数据中规定的最大金额，并根据实现复合订单的每个市场参与者的最大净风险敞口水平，以及传达指示市场执行交易顺序匹配的交易数据参与者以目前的价格。

6. 发明申请

US20130110691A1 Futures Contracts Spread Packages 审中-公开
标题翻译：期货合约分期付款
公开(公告)号：US20130110691A1
公开(公告)日：2013-05-02
申请号：US13285538
申请日：2011-10-31
申请人： John Nyhoff , John Labuszewski , Richard Co , Xing Su
发明人： John Nyhoff , John Labuszewski , Richard Co , Xing Su
IPC分类号： G06Q40/06
CPC分类号： G06Q40/06 , G06Q40/04
摘要： Futures contract types forming opposing legs of a spread package type can be weighted by the degree to which return rates of subject matters of those legs vary relative to a benchmark. Individual spread package instances of the spread package type can be traded based on bids and/or offers specifying a price spread.
摘要翻译：形成展开包装类型的对立腿的期货合约类型可以通过这些腿的主题的回报率相对于基准的程度而加权。可以根据出价和/或指定价格差价的优惠来交易传播包类型的个人传播包实例。

7. 发明申请

US20120322683A1 ENZYMATIC SIGNAL GENERATION AND DETECTION OF BINDING COMPLEXES IN STATIONARY FLUIDIC CHIP 有权
标题翻译：固定信号生成和检测固定液流芯片中的结合复合物
公开(公告)号：US20120322683A1
公开(公告)日：2012-12-20
申请号：US13543488
申请日：2012-07-06
申请人： David J. Liu , Kai Wu , Xing Su
发明人： David J. Liu , Kai Wu , Xing Su
IPC分类号： G01N33/558 , G01N33/53 , C40B30/04 , G01N33/573 , G01N21/78 , G01N27/26 , G01N21/00 , G01N21/76 , C12Q1/70 , B82Y15/00
CPC分类号： G01N21/658 , B01L3/50273 , B01L3/502761 , B01L2300/0654 , B01L2400/043 , B01L2400/086 , B82Y15/00 , B82Y30/00 , G01N21/255 , G01N21/6428 , G01N21/645 , G01N21/76 , G01N33/54333 , G01N33/587
摘要： An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
摘要翻译：本发明的一个实施例涉及用于检测样品中的分析物的装置。该装置包括流体网络和集成电路部件。流体网络包括样品区，清洁区和检测区。流体网络包含磁性颗粒和/或信号颗粒。引入含有分析物的样品，并且分析物通过亲和试剂与磁性颗粒和/或信号颗粒相互作用。微线圈阵列或机械可移动永磁体在功能上耦合到流体网络，流体网络可激活以在流体网络的一部分内产生磁场，并将磁性颗粒从样品区域移动到检测区域。存在检测元件，其检测来自信号颗粒的光学或电信号，从而指示分析物的存在。

8. 发明授权

US08273242B2 Nanofabricated structures for electric field-assisted nucleic acid extraction 有权
标题翻译：用于电场辅助核酸提取的纳米结构
公开(公告)号：US08273242B2
公开(公告)日：2012-09-25
申请号：US13273934
申请日：2011-10-14
申请人： Steven A. Sundberg , Xing Su , Grace Credo
发明人： Steven A. Sundberg , Xing Su , Grace Credo
IPC分类号： G01N27/327 , G01N27/26 , G01N27/447 , C12N11/02 , C12Q1/00
CPC分类号： C12N15/1006
摘要： Embodiments of the invention provide devices and methods for extracting nucleic acid molecules from solution using electric fields. The structures and methods of embodiments of the invention are suited to incorporation into micro and nano fluidic devices, such as lab-on-a-chip devices and micro total analysis systems.
摘要翻译：本发明的实施方案提供了使用电场从溶液中提取核酸分子的装置和方法。本发明的实施例的结构和方法适合于并入微纳米流体装置，例如片上实验室装置和微总体分析系统。

9. 发明申请

US20120101931A1 SYSTEM AND METHOD FOR IMPLEMENTING AND MANAGING BUNDLED OPTION BOX FUTURES 有权
标题翻译：用于实施和管理整套选购盒期货的系统和方法
公开(公告)号：US20120101931A1
公开(公告)日：2012-04-26
申请号：US12911516
申请日：2010-10-25
申请人： Richard Co , Tuen Tuen Wang , Xing Su , John Labuszewski
发明人： Richard Co , Tuen Tuen Wang , Xing Su , John Labuszewski
IPC分类号： G06Q40/00
CPC分类号： G06Q40/04
摘要： A system and method of providing a collateralized loan utilizing a clearing counterparty is disclosed. The method includes receiving an order at a match engine module, the order related to a futures contract based on an options box spread as the deliverable asset such that the futures contract represents a collateralized loan and such that the order includes an interest rate associated with the collateralized loan, analyzing, at the match engine, the order to determine a strike interval, scanning an order book module in communication with the match engine module, such that the scan is based on the determined strike interval, and automatically defining a first pair of options at a first strike price and a second pair of options at a second strike price, such that the determined strike interval defines the first and second strike prices, such that the first and second pair of options cooperate to define the option box spread.
摘要翻译：披露了利用清算交易对手提供抵押贷款的制度和方法。该方法包括：在匹配引擎模块处接收与期货合约有关的订单，该期货合约基于作为可交付资产分散的期权箱，使得期货合约代表抵押贷款，并且使得该订单包括与该期权合约相关联的利率抵押贷款，在匹配引擎处分析确定打击间隔的顺序，扫描与匹配引擎模块通信的订单簿模块，使得扫描基于确定的打击间隔，并且自动定义第一对第一行使价的期权和第二行使价的第二对期权，使得所确定的敲击间隔定义第一和第二行使价格，使得第一和第二对选项合作以定义期权票据价差。

10. 发明授权

US08029999B2 Complexity management of genomic DNA 有权
标题翻译：基因组DNA的复杂性管理
公开(公告)号：US08029999B2
公开(公告)日：2011-10-04
申请号：US11874858
申请日：2007-10-18
申请人： Hajime Matsuzaki , Xing Su , Sean Walsh , Giulia Kennedy , Rui Mei
发明人： Hajime Matsuzaki , Xing Su , Sean Walsh , Giulia Kennedy , Rui Mei
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/6809 , C12Q1/683 , C12Q1/6837 , C12Q1/6844 , C12Q2600/156
摘要： The presently claimed invention provides for novel methods and kits for analyzing a collection of target sequences in a nucleic acid sample. A sample is amplified under conditions that enrich for a subset of fragments that includes a collection of target sequences. The invention further provides for analysis of the above sample by hybridization to an array, which may be specifically designed to interrogate the collection of target sequences for particular characteristics, such as, for example, the presence or absence of one or more polymorphisms.
摘要翻译：本发明提供了用于分析核酸样品中靶序列的集合的新颖方法和试剂盒。在富集包括靶序列集合的片段子集的条件下扩增样品。本发明进一步提供了通过与阵列杂交来分析上述样品，其可以被特别设计成询问用于特定特征的靶序列的收集，例如存在或不存在一个或多个多态性。

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