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1. 发明授权

US10027855B2 System for synchronization in a line scanning imaging microscope 有权
公开(公告)号：US10027855B2
公开(公告)日：2018-07-17
申请号：US13704748
申请日：2011-06-29
申请人： Witold Bula , Pavel A. Fomitchov , Steve Goodson , Erwen Mei , Yang Zhang
发明人： Witold Bula , Pavel A. Fomitchov , Steve Goodson , Erwen Mei , Yang Zhang
IPC分类号： H04N5/04 , G02B21/00 , H04N1/113 , H04N1/195
CPC分类号： H04N5/04 , G02B21/0048 , H04N1/113 , H04N1/195 , H04N2201/04715 , H04N2201/04755
摘要： A line confocal microscope system, comprising a scanning unit in the form of a mechanically driven scanning unit with a controllable a scanning trajectory and a two dimensional sensor unit operated in a rolling line shutter mode in synchronization with the scanning unit, wherein the scanning trajectory is set to have an acceleration part outside the field of view of the sensor unit.

2. 发明申请

US20140140595A1 MICROSCOPY SYSTEM AND METHOD FOR BIOLOGICAL IMAGING 审中-公开
标题翻译：用于生物成像的微观系统和方法
公开(公告)号：US20140140595A1
公开(公告)日：2014-05-22
申请号：US14129640
申请日：2012-06-27
申请人： Pavel A. Fomitchov , Witold Bula
发明人： Pavel A. Fomitchov , Witold Bula
IPC分类号： G02B21/36 , G06T7/00
CPC分类号： G02B21/365 , G01N21/6458 , G02B21/0076 , G02B21/008 , G02B21/16 , G06T7/0012
摘要： Microscopy system for biological imaging, comprising an image quality monitoring system for monitoring image quality of an image of a biological sample comprising a biological object selection means arranged to let a user of the system to select one or more Biological Reference Objects (BRO) in the image of the biological sample, and an image quality evaluation means arranged to compare the signal level of image pixels of the one or more BROs with an image background signal level to calculate one or more image quality parameters for the image of the biological sample. The system is arranged to present the image quality parameters to the user as an indication of the image quality specific for the BRO(s).
摘要翻译：用于生物成像的显微镜系统，包括用于监测生物样品的图像的图像质量的图像质量监测系统，所述图像质量监测系统包括生物物体选择装置，所述生物物体选择装置被布置为使得所述系统的用户选择所述生物样本中的一个或多个生物参考对象图像质量评估装置，其被布置为将一个或多个BRO的图像像素的信号电平与图像背景信号电平进行比较，以计算生物样本的图像的一个或多个图像质量参数。系统被布置为向用户呈现图像质量参数作为对BRO特有的图像质量的指示。

3. 发明申请

US20130093873A1 SYSTEM FOR SYNCHRONIZATION IN A LINE SCANNING IMAGING MICROSCOPE 有权
标题翻译：用于同步扫描成像显微镜的系统
公开(公告)号：US20130093873A1
公开(公告)日：2013-04-18
申请号：US13704748
申请日：2011-06-29
申请人： Witold Bula , Pavel A. Fomitchov , Steve Goodson , Erwen Mei , Yang Zhang
发明人： Witold Bula , Pavel A. Fomitchov , Steve Goodson , Erwen Mei , Yang Zhang
IPC分类号： H04N5/04
CPC分类号： H04N5/04 , G02B21/0048 , H04N1/113 , H04N1/195 , H04N2201/04715 , H04N2201/04755
摘要： A line confocal microscope system, comprising a scanning unit in the form of a mechanically driven scanning unit with a controllable a scanning trajectory and a two dimensional sensor unit operated in a rolling line shutter mode in synchronization with the scanning unit, wherein the scanning trajectory is set to have an acceleration part outside the field of view of the sensor unit.
摘要翻译：一种线共聚焦显微镜系统，包括具有可控扫描轨迹的机械驱动扫描单元形式的扫描单元和与扫描单元同步地以滚动线快门模式操作的二维传感器单元，其中扫描轨迹为设置为在传感器单元的视场外具有加速部分。

4. 发明申请

US20140152800A1 IMAGE QUALITY OPTIMIZATION OF BIOLOGICAL IMAGING 审中-公开
标题翻译：图像质量优化生物成像
公开(公告)号：US20140152800A1
公开(公告)日：2014-06-05
申请号：US14129699
申请日：2012-06-27
申请人： Pavel A. Fomitchov , Witold Bula
发明人： Pavel A. Fomitchov , Witold Bula
IPC分类号： G01N21/64 , G02B21/36
CPC分类号： G01N21/6458 , G02B21/0076 , G02B21/008 , G02B21/16 , G02B21/365
摘要： Microscopy system for biological imaging, comprising an image quality optimizer for optimizing image quality of an image of a biological sample, allowing a user to select an optimization mode from a list of functionally defined optimization modes, and wherein the system is arranged to automatically set one or more image acquisition parameters to achieve optimal imaging for the selected optimization mode based on at least one image quality parameter derived from one or more Biological Reference Objects (BRO) in the image of the biological sample selected by the user or automatically by the system.
摘要翻译：用于生物成像的显微镜系统，包括用于优化生物样品的图像的图像质量的图像质量优化器，允许用户从功能定义的优化模式列表中选择优化模式，并且其中所述系统被布置成自动设置一个或更多的图像采集参数，以基于从用户选择的或由系统自动选择的生物样品的图像中的一个或多个生物参考对象（BRO）导出的至少一个图像质量参数来实现所选优化模式的最佳成像。

5. 发明申请

US20130129212A1 METHOD FOR REDUCING IMAGE ARTIFACTS PRODUCED BY A CMOS CAMERA 有权
标题翻译：降低由CMOS相机产生的图像制品的方法
公开(公告)号：US20130129212A1
公开(公告)日：2013-05-23
申请号：US13813197
申请日：2011-07-19
申请人： Pavel A. Fomitchov , Witold Bula , Carlos Zarate , Yang Zhang
发明人： Pavel A. Fomitchov , Witold Bula , Carlos Zarate , Yang Zhang
IPC分类号： G06T5/00
CPC分类号： G06T5/00 , G06T5/005 , H04N1/409 , H04N5/357
摘要： The present invention relates to a system and method for reducing image artifacts for a CMOS camera used as an optical detector for a line confocal fluorescent imager. The method for reducing image artifacts in a monochromatic image comprises subtracting RGB channel offset mismatch; and correcting random row offset for each row. Preferably, the method also comprises correcting random column offset and gain. Optionally, the method also comprises clipping of defective pixels, and/or subtracting dark current. When the monochromatic image is a fluorescence image, the method also comprises a step of compressing CMOS camera noise. Also provided are a system for reducing image artifacts in a monochromatic image from a CMOS camera, as well as an image artifact reduction system for a CMOS camera-based line confocal fluorescent microscope.
摘要翻译：本发明涉及一种用于减少用作线共焦荧光成像仪的光学检测器的CMOS相机的图像伪影的系统和方法。用于减少单色图像中的图像伪像的方法包括减去RGB信道偏移不匹配; 并校正每行的随机行偏移量。优选地，该方法还包括校正随机列偏移和增益。可选地，该方法还包括限制缺陷像素和/或减去暗电流。当单色图像是荧光图像时，该方法还包括压缩CMOS相机噪声的步骤。还提供了一种用于减少来自CMOS照相机的单色图像中的图像伪影的系统，以及用于基于CMOS照相机的线共聚焦荧光显微镜的图像伪像减少系统。

6. 发明授权

US09373158B2 Method for reducing image artifacts produced by a CMOS camera 有权
标题翻译：降低CMOS相机产生的图像伪影的方法
公开(公告)号：US09373158B2
公开(公告)日：2016-06-21
申请号：US13813197
申请日：2011-07-19
申请人： Pavel A. Fomitchov , Witold Bula , Carlos Zarate , Yang Zhang
发明人： Pavel A. Fomitchov , Witold Bula , Carlos Zarate , Yang Zhang
IPC分类号： G06K9/00 , G06T5/00 , H04N1/409 , H04N5/357
CPC分类号： G06T5/00 , G06T5/005 , H04N1/409 , H04N5/357
摘要： The present invention relates to a system and method for reducing image artifacts for a CMOS camera used as an optical detector for a line confocal fluorescent imager. The method for reducing image artifacts in a monochromatic image comprises subtracting RGB channel offset mismatch; and correcting random row offset for each row. Preferably, the method also comprises correcting random column offset and gain. Optionally, the method also comprises clipping of defective pixels, and/or subtracting dark current. When the monochromatic image is a fluorescence image, the method also comprises a step of compressing CMOS camera noise. Also provided are a system for reducing image artifacts in a monochromatic image from a CMOS camera, as well as an image artifact reduction system for a CMOS camera-based line confocal fluorescent microscope.
摘要翻译：本发明涉及一种用于减少用作线共焦荧光成像仪的光学检测器的CMOS相机的图像伪影的系统和方法。用于减少单色图像中的图像伪像的方法包括减去RGB信道偏移不匹配; 并校正每行的随机行偏移量。优选地，该方法还包括校正随机列偏移和增益。可选地，该方法还包括限制缺陷像素和/或减去暗电流。当单色图像是荧光图像时，该方法还包括压缩CMOS相机噪声的步骤。还提供了一种用于减少来自CMOS照相机的单色图像中的图像伪影的系统，以及用于基于CMOS照相机的线共聚焦荧光显微镜的图像伪像减少系统。

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