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1. 发明授权

US09168015B2 Method and apparatus for gate specific MR-based attenuation correction of time-gated PET studies 有权
标题翻译：时间门PET研究的门特定基于MR的衰减校正的方法和装置
公开(公告)号：US09168015B2
公开(公告)日：2015-10-27
申请号：US14138311
申请日：2013-12-23
申请人： Charles William Stearns , Scott David Wollenweber , David M. Goldhaber
发明人： Charles William Stearns , Scott David Wollenweber , David M. Goldhaber
IPC分类号： A61B6/00 , G06T5/50 , G06T7/00 , A61B5/00 , A61B5/05 , A61B5/085 , A61B6/03 , G01T1/161 , G01T1/29
CPC分类号： A61B6/5282 , A61B5/0033 , A61B5/0522 , A61B5/085 , A61B6/03 , A61B6/037 , A61B6/5247 , A61B6/5264 , A61B6/541 , G01R33/481 , G01T1/1611 , G01T1/2985 , G06T5/50 , G06T7/32 , G06T2207/10084 , G06T2207/10088 , G06T2207/10104 , G06T2207/20048 , G06T2207/20172 , G06T2207/30004
摘要： A method for attenuation correction of a plurality of time-gated PET images of a moving structure includes establishing an ACF matrix, based on a baseline MR image of the structure; developing a plurality of image transforms, each of the image transforms registering the baseline MR image to a respective cine MR image of the moving structure; applying each of the image transforms to the ACF matrix to generate a corresponding cine ACF matrix; time-correlating each of the cine MR images, and its corresponding cine ACF matrix, to one of the plurality of time-gated PET data sets; and producing from each of the time-gated PET data sets an attenuation-corrected time-gated PET image.
摘要翻译：一种用于移动结构的多个时间选择PET图像的衰减校正的方法包括基于该结构的基线MR图像来建立ACF矩阵; 开发多个图像变换，每个图像变换将基线MR图像登记到移动结构的相应电影MR图像; 将每个图像变换应用于ACF矩阵以生成相应的电影ACF矩阵; 将每个电影MR图像及其相应的电影ACF矩阵时间相关到多个时间选择的PET数据集之一; 并且从每个时间选择的PET数据集产生衰减校正的时间门控PET图像。

2. 发明授权

US08452064B2 Apparatus and methods for geometric calibration of positron emission tomography systems 有权
标题翻译：正电子发射断层扫描系统几何校准的装置和方法
公开(公告)号：US08452064B2
公开(公告)日：2013-05-28
申请号：US12632393
申请日：2009-12-07
申请人： Steven Gerard Ross , Timothy Deller , Charles William Stearns
发明人： Steven Gerard Ross , Timothy Deller , Charles William Stearns
IPC分类号： G06K9/36
CPC分类号： A61B6/037 , A61B6/583 , G06T11/005
摘要： Apparatus and methods for geometric calibration of positron emission tomography (PET) systems are provided. One method includes obtaining scan data for a uniform phantom and generating reference images based on the scan data for the uniform phantom. The method further includes reconstructing images of the uniform phantom using a PET imaging system and determining a geometric calibration for the PET imaging system based on a comparison of the reconstructed images and the reference images.
摘要翻译：提供了正电子发射断层摄影（PET）系统几何校准的装置和方法。一种方法包括获得用于均匀体模的扫描数据，并且基于用于均匀体模的扫描数据产生参考图像。该方法还包括使用PET成像系统重建均匀体模的图像，并且基于重建图像与参考图像的比较来确定PET成像系统的几何校准。

3. 发明申请

US20110142304A1 METHOD AND SYSTEM FOR FAULT-TOLERANT RECONSTRUCTION OF IMAGES 有权
标题翻译：用于图像故障重建的方法和系统
公开(公告)号：US20110142304A1
公开(公告)日：2011-06-16
申请号：US12635877
申请日：2009-12-11
申请人： Charles William Stearns
发明人： Charles William Stearns
IPC分类号： G06K9/00 , G06K9/40
CPC分类号： G06T5/005 , A61B6/037 , G06T5/50 , G06T11/005 , G06T2207/10072 , G06T2207/30004 , G06T2211/424
摘要： A method and system for reconstructing an image of an object. The method includes acquiring an image dataset of an object of interest, identifying valid data and invalid data in the image dataset, determining a time period that includes the valid data, weighting the valid data based on the determined time period, and reconstructing an image of the object using the weighted valid data.
摘要翻译：一种用于重建对象的图像的方法和系统。该方法包括获取感兴趣对象的图像数据集，识别图像数据集中的有效数据和无效数据，确定包括有效数据的时间段，基于确定的时间周期对有效数据进行加权，以及重建图像该对象使用加权有效数据。

4. 发明授权

US07348564B2 Multi modality imaging methods and apparatus 有权
标题翻译：多模态成像方法和装置
公开(公告)号：US07348564B2
公开(公告)日：2008-03-25
申请号：US11301149
申请日：2005-12-12
申请人： Scott David Wollenweber , Albert H. R. Lonn , Charles William Stearns , Diane Marie Miesbauer , Kathryn Mary Littlejohn
发明人： Scott David Wollenweber , Albert H. R. Lonn , Charles William Stearns , Diane Marie Miesbauer , Kathryn Mary Littlejohn
IPC分类号： G01T1/166
CPC分类号： A61B6/032 , A61B6/037 , G01T1/1611 , G06F19/00
摘要： A method for correcting emission data from Positron Emission Tomography (PET) or SPECT includes generating a plurality of computed tomography (CT) image data, selecting a portion of the CT image data, processing the selected CT data to generate a plurality of attenuation correction (CTAC) factors at the appropriate energy of the emission data, weighting the CTAC factors to generate an emission attenuation correction map wherein the weights are determined based on the axial location and the slice thickness of the CT data and the axial location and the slice thickness of the PET or SPECT data, and utilizing the generated attenuation correction map to generate an attenuation corrected PET image.
摘要翻译：用于校正来自正电子发射断层扫描（PET）或SPECT的发射数据的方法包括生成多个计算机断层摄影（CT）图像数据，选择CT图像数据的一部分，处理所选择的CT数据以产生多个衰减校正 CTAC）因子在发射数据的适当能量下，对CTAC因子加权以产生发射衰减校正图，其中基于CT数据的轴向位置和切片厚度以及轴向位置和切片厚度来确定权重 PET或SPECT数据，并且利用所生成的衰减校正图来生成衰减校正的PET图像。

5. 发明授权

US07129495B2 Method and apparatus for timing calibration in a PET scanner 失效
标题翻译： PET扫描仪中定时校准的方法和装置
公开(公告)号：US07129495B2
公开(公告)日：2006-10-31
申请号：US10986792
申请日：2004-11-15
申请人： John Jay Williams , Charles William Stearns , David Leo McDaniel , Alexander Ganin
发明人： John Jay Williams , Charles William Stearns , David Leo McDaniel , Alexander Ganin
IPC分类号： G01T1/164
CPC分类号： G01T1/172 , G01T1/2985
摘要： The invention is directed to a method and apparatus for timing calibration in a PET scanner. According to one embodiment, the invention relates to a method for timing calibration in a PET scanner having a plurality of scintillator blocks. The method comprises: detecting, in a first scintillator block, a first radiation event, wherein the first scintillator block time-stamps the first radiation event; detecting, in a second scintillator block that is adjacent to the first scintillator block, a second radiation event that corresponds to the first radiation event, wherein the second scintillator block time-stamps the second radiation event; and determining a timing characteristic of the first scintillator block with respect to the second scintillator block based on a comparison between the time-stamps of the first radiation event and the second radiation event.
摘要翻译：本发明涉及一种用于在PET扫描仪中定时校准的方法和装置。根据一个实施例，本发明涉及一种具有多个闪烁体块的PET扫描器中的定时校准方法。该方法包括：在第一闪烁体块中检测第一辐射事件，其中第一闪烁体块对第一辐射事件进行时间戳; 在与所述第一闪烁体块相邻的第二闪烁器块中检测对应于所述第一辐射事件的第二辐射事件，其中所述第二闪烁体块对所述第二辐射事件进行时间戳; 以及基于所述第一辐射事件和所述第二辐射事件的时间戳之间的比较来确定所述第一闪烁体块相对于所述第二闪烁体块的定时特性。

6. 发明授权

US06856666B2 Multi modality imaging methods and apparatus 失效
标题翻译：多模态成像方法和装置
公开(公告)号：US06856666B2
公开(公告)日：2005-02-15
申请号：US10428906
申请日：2003-05-02
申请人： Albert Henry Roger Lonn , Jiang Hsieh , Charles William Stearns , Edward Henry Chao , Brian Grekowicz
发明人： Albert Henry Roger Lonn , Jiang Hsieh , Charles William Stearns , Edward Henry Chao , Brian Grekowicz
IPC分类号： A61B6/03
CPC分类号： A61B6/037 , A61B6/027 , A61B6/032 , A61B6/5235 , A61B6/583 , Y10S378/901
摘要： A method includes scanning an object in a first modality having a first field of view to obtain first modality data including fully sampled field of view data and partially sampled field of view data. The method also includes scanning the object in a second modality having a second field of view larger than the first field of view of obtain second modality data, and reconstructing an image of the object using the second modality data and the first modality partially sampled field of view data.
摘要翻译：一种方法包括以具有第一视野的第一模态扫描对象以获得包括完全采样的视场数据和部分采样的视野数据的第一模态数据。该方法还包括以具有大于获得第二模态数据的第一视场的第二视场的第二模式扫描对象，并且使用第二模态数据和第一模态部分采样场来重建对象的图像查看数据。

7. 发明申请

US20150178906A1 METHOD AND APPARATUS FOR GATE SPECIFIC MR-BASED ATTENUATION CORRECTION OF TIME-GATED PET STUDIES 有权
标题翻译：用于门特定基于MR的衰减PET测量的衰减校正方法与装置
公开(公告)号：US20150178906A1
公开(公告)日：2015-06-25
申请号：US14138311
申请日：2013-12-23
申请人： Charles William Stearns , Scott David Wollenweber , David M. Goldhaber
发明人： Charles William Stearns , Scott David Wollenweber , David M. Goldhaber
IPC分类号： G06T5/50 , G06T7/00
CPC分类号： A61B6/5282 , A61B5/0033 , A61B5/0522 , A61B5/085 , A61B6/03 , A61B6/037 , A61B6/5247 , A61B6/5264 , A61B6/541 , G01R33/481 , G01T1/1611 , G01T1/2985 , G06T5/50 , G06T7/32 , G06T2207/10084 , G06T2207/10088 , G06T2207/10104 , G06T2207/20048 , G06T2207/20172 , G06T2207/30004
摘要： A method for attenuation correction of a plurality of time-gated PET images of a moving structure includes establishing an ACF matrix, based on a baseline MR image of the structure; developing a plurality of image transforms, each of the image transforms registering the baseline MR image to a respective cine MR image of the moving structure; applying each of the image transforms to the ACF matrix to generate a corresponding cine ACF matrix; time-correlating each of the cine MR images, and its corresponding cine ACF matrix, to one of the plurality of time-gated PET data sets; and producing from each of the time-gated PET data sets an attenuation-corrected time-gated PET image.
摘要翻译：一种用于移动结构的多个时间选择PET图像的衰减校正的方法包括基于该结构的基线MR图像来建立ACF矩阵; 开发多个图像变换，每个图像变换将基线MR图像登记到移动结构的相应电影MR图像; 将每个图像变换应用于ACF矩阵以生成相应的电影ACF矩阵; 将每个电影MR图像及其相应的电影ACF矩阵时间相关到多个时间选择的PET数据集之一; 并且从每个时间选择的PET数据集产生衰减校正的时间门控PET图像。

8. 发明授权

US08450693B2 Method and system for fault-tolerant reconstruction of images 有权
标题翻译：图像容错重建的方法和系统
公开(公告)号：US08450693B2
公开(公告)日：2013-05-28
申请号：US12635877
申请日：2009-12-11
申请人： Charles William Stearns
发明人： Charles William Stearns
IPC分类号： G01T1/163 , A61B6/03 , H05G1/64
CPC分类号： G06T5/005 , A61B6/037 , G06T5/50 , G06T11/005 , G06T2207/10072 , G06T2207/30004 , G06T2211/424
摘要： A method and system for reconstructing an image of an object. The method includes acquiring an image dataset of an object of interest, identifying valid data and invalid data in the image dataset, determining a time period that includes the valid data, weighting the valid data based on the determined time period, and reconstructing an image of the object using the weighted valid data.
摘要翻译：一种用于重建对象的图像的方法和系统。该方法包括获取感兴趣对象的图像数据集，识别图像数据集中的有效数据和无效数据，确定包括有效数据的时间段，基于确定的时间周期对有效数据进行加权，以及重建图像该对象使用加权有效数据。

9. 发明授权

US08415630B2 Apparatus and methods for determining a boundary of an object for positron emission tomography scatter correction 有权
标题翻译：用于确定正电子发射断层扫描物体的边界的装置和方法
公开(公告)号：US08415630B2
公开(公告)日：2013-04-09
申请号：US12643735
申请日：2009-12-21
申请人： Steven Gerard Ross , Timothy Wayne Deller , Ravindra Mohan Manjeshwar , Scott David Wollenweber , Charles William Stearns
发明人： Steven Gerard Ross , Timothy Wayne Deller , Ravindra Mohan Manjeshwar , Scott David Wollenweber , Charles William Stearns
IPC分类号： G01T1/161 , G01T1/166 , A61B6/00
CPC分类号： A61B6/032 , A61B6/037 , A61B6/5211 , G01T1/1611 , G01T1/2985 , G06T11/005
摘要： Apparatus and methods for determining a boundary of an object for positron emission tomography (PET) scatter correction are provided. One method includes obtaining positron emission tomography (PET) data and computed tomography (CT) data for an object. The PET data and CT data is acquired from an imaging system. The method further includes determining a PET data boundary of the object based on the PET data and determining a CT data boundary of the object based on the CT data. The method further includes determining a combined boundary for PET scatter correction. The combined boundary encompasses the PET data boundary and the CT data boundary.
摘要翻译：提供了用于确定正电子发射断层摄影（PET）散射校正物体边界的装置和方法。一种方法包括获得对象的正电子发射断层摄影（PET）数据和计算机断层摄影（CT）数据。从成像系统获取PET数据和CT数据。该方法还包括基于PET数据确定对象的PET数据边界，并且基于CT数据确定对象的CT数据边界。该方法还包括确定PET散射校正的组合边界。组合边界包含PET数据边界和CT数据边界。

10. 发明授权

US08017914B2 Method and system for scatter correction 有权
标题翻译：散射校正的方法和系统
公开(公告)号：US08017914B2
公开(公告)日：2011-09-13
申请号：US12270437
申请日：2008-11-13
申请人： Scott David Wollenweber , David Leo McDaniel , Charles William Stearns
发明人： Scott David Wollenweber , David Leo McDaniel , Charles William Stearns
IPC分类号： G01T1/166
CPC分类号： G01T1/1648 , G01T1/1611
摘要： A method and apparatus are provided for correcting primary and secondary emission data. The method includes obtaining an emission data set having primary and secondary emission data representative of primary and secondary emission particles emitting from a region of interest and applying a scatter correction model to the emission data set to derive an estimated scatter vector. The method also includes comparing the emission data set to the estimated scatter vector to identify an amount of secondary emission data in the emission data set and correcting the emission data set based on the amount of secondary emission data identified in the comparing operation.
摘要翻译：提供了一种用于校正一次和二次发射数据的方法和装置。该方法包括获得具有代表从感兴趣区域发射的初级和次级发射粒子的初级和次级发射数据的发射数据集，并向发射数据集应用散射校正模型以导出估计的散射矢量。该方法还包括将发射数据集与估计的散射矢量进行比较，以识别发射数据组中的二次发射数据的量，并且基于在比较操作中识别的二次发射数据的量来校正发射数据集。

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