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1. 发明公开

US20230390370A1 NEOANTIGEN VACCINES FOR PANCREATIC CANCER 审中-公开
公开(公告)号：US20230390370A1
公开(公告)日：2023-12-07
申请号：US18328209
申请日：2023-06-02
申请人： William Gillanders , William Hawkins , Simon Goedegebuure , Hui Peng , Lijin Li
发明人： William Gillanders , William Hawkins , Simon Goedegebuure , Hui Peng , Lijin Li
IPC分类号： A61K39/00 , A61P35/00 , A61K39/395
CPC分类号： A61K39/001152 , A61P35/00 , A61K39/3955 , A61K39/39566 , A61K39/0011 , A61K2039/53 , A61K2039/852 , A61K2039/585
摘要： The present disclosure is directed to compositions and methods for treating pancreatic cancer. A method of treating pancreatic cancer includes administering a therapeutically effective amount of a composition including a neoantigen vaccine including at least one pancreatic cancer-associated neoantigen and at least one immune checkpoint inhibitor. The methods and compositions of the present disclosure are particularly useful for inducing a neoantigen-specific CD4 or CD8 T cell response against a tumor.

2. 发明授权

US07952187B2 System and method of forming a wafer scale package 有权
标题翻译：形成晶片级封装的系统及方法
公开(公告)号：US07952187B2
公开(公告)日：2011-05-31
申请号：US12059075
申请日：2008-03-31
申请人： Christopher James Kapusta , Donald Cunningham , Richard Joseph Saia , Kevin Durocher , Joseph Iannotti , William Hawkins
发明人： Christopher James Kapusta , Donald Cunningham , Richard Joseph Saia , Kevin Durocher , Joseph Iannotti , William Hawkins
IPC分类号： H01L29/34 , H01L23/48
CPC分类号： H01L23/3114 , B81B7/007 , H01L23/5223 , H01L23/5228 , H01L23/525 , H01L24/11 , H01L24/12 , H01L2224/02313 , H01L2224/02319 , H01L2224/0401 , H01L2224/1134 , H01L2224/13099 , H01L2224/13144 , H01L2924/01006 , H01L2924/01033 , H01L2924/01075 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/014 , H01L2924/12042 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19042 , H01L2924/19043 , H01L2924/3025 , H01L2924/00 , H01L2924/00014
摘要： A system and method for forming a wafer level package (WLP) (i.e., wafer level chip size package) is disclosed. The WLP includes a silicon integrated circuit (IC) substrate having a plurality of die pads formed on a top surface thereof and a plurality of polymer laminates positioned thereon. Each of the polymer laminates is comprised of a separate pre-formed laminate sheet and has a plurality of vias formed therein that correspond to a respective die pad. A plurality of metal interconnects are formed on each of the plurality of polymer laminates so as to cover a portion of a top surface of a polymer laminate and extend down through the via and into contact with a metal interconnect on a neighboring polymer laminate positioned below. An input/output (I/O) system interconnect is positioned on a top surface of the wafer level package and is attached to the plurality of metal interconnects.
摘要翻译：公开了一种用于形成晶片级封装（WLP）（即晶片级芯片尺寸封装）的系统和方法。 WLP包括硅集成电路（IC）基板，其具有形成在其顶表面上的多个管芯焊盘和位于其上的多个聚合物层压板。每个聚合物层压体由单独的预成型层压片材组成，并且其中形成有多个对应于相应的芯片焊盘的通孔。在多个聚合物层压体中的每一个上形成多个金属互连，以覆盖聚合物层压体的顶表面的一部分并向下延伸通过该通孔并与位于下方的相邻聚合物层压体上的金属互连接触。输入/输出（I / O）系统互连位于晶片级封装的顶表面上，并且附接到多个金属互连。

3. 发明申请

US20100048614A1 THERAPEUTIC USES OF BICYCLIC LIGANDS OF SIGMA 2 RECEPTOR 有权
标题翻译： SIGMA 2受体的双相配体的治疗用途
公开(公告)号：US20100048614A1
公开(公告)日：2010-02-25
申请号：US12543647
申请日：2009-08-19
申请人： Robert H. Mach , Richard Hotchkiss , William Hawkins , Rebecca Aft , Zhude Tu
发明人： Robert H. Mach , Richard Hotchkiss , William Hawkins , Rebecca Aft , Zhude Tu
IPC分类号： A61K31/439 , A61P35/00
CPC分类号： C07D451/14 , C07D451/02
摘要： A series of N-substituted 9-azabicyclo[3.3.1]nonan-3α-yl phenylcarbamate analogs are disclosed, as well as methods of their preparation. Their affinities for sigma (σ1 and σ2) receptors are described. Two new compounds, N-(9-(4-aminobutyl)-9-azabicyclo[3.3.1]nonan-3α-yl)-N′-(2-methoxy-5-methylphenyl)carbamate and N-(9-(6-aminohexyl)-9-azabicyclo[3.3.1]nonan-3α-yl)-N′-(2-methoxy-5-methylphenyl)carbamate, are shown to have a high affinity and selectivity for σ2 versus σ1 receptors. Among the disclosed compounds are biotinylated and fluorescent analogs. These compounds can serve as probes to the σ2 receptor. In addition, some disclosed compounds can induce apoptotic cell death by both caspase-dependent and caspase-independent mechanisms, and are effective for treatment of tumors. The compounds can be used as chemotherapeutics or chemosensitizers in the treatment of a wide variety of solid tumors.
摘要翻译：公开了一系列N-取代的9-氮杂双环[3.3.1]壬烷-3α-基苯基氨基甲酸酯类似物及其制备方法。描述了它们对西格玛（＆sgr。1和＆sgr; 2）受体的亲和力。两种新化合物N-（9-（4-氨基丁基）-9-氮杂双环[3.3.1]壬烷-3α-基）-N' - （2-甲氧基-5-甲基苯基）氨基甲酸酯和N-（9- 6-氨基己基）-9-氮杂双环[3.3.1]壬烷-3α-基）-N' - （2-甲氧基-5-甲基苯基）氨基甲酸酯显示出对于＆ 1受体。所公开的化合物中有生物素化和荧光类似物。这些化合物可以作为第二受体的探针。此外，一些公开的化合物可以通过胱天蛋白酶依赖性和半胱天冬酶非依赖性机制诱导凋亡细胞死亡，并且对于治疗肿瘤是有效的。这些化合物可用作化学治疗剂或化学敏化剂，用于治疗各种实体瘤。

4. 发明申请

US20080161343A1 Sigma 2 Receptor Ligands and Therapeutic Uses Therefor 有权
标题翻译： Sigma 2受体配体及其治疗用途
公开(公告)号：US20080161343A1
公开(公告)日：2008-07-03
申请号：US11776533
申请日：2007-07-11
申请人： Robert H. Mach , Zhude Tu , Wenhua Chu , Suwanna Vangveravong , Richard Hotchkiss , William Hawkins , Rebecca Aft
发明人： Robert H. Mach , Zhude Tu , Wenhua Chu , Suwanna Vangveravong , Richard Hotchkiss , William Hawkins , Rebecca Aft
IPC分类号： A61K31/439 , C07D453/02 , C12N5/06 , A61P35/00
CPC分类号： C07D451/14 , C07D451/02
摘要： A series of N-substituted 9-azabicyclo[3.3.1]nonan-3α-yl phenylcarbamate analogs are disclosed, as well as methods of their preparation. Their affinities for sigma (σ1 and σ2) receptors are described. Two new compounds, N-(9-(4-aminobutyl)-9-azabicyclo[3.3.1]nonan-3α-yl)-N′-(2-methoxy-5-methylphenyl)carbamate and N-(9-(6-aminohexyl)-9-azabicyclo[3.3.1]nonan-3α-yl)-N′-(2-methoxy-5-methylphenyl)carbamate, are shown to have a high affinity and selectivity for σ2 versus σ1 receptors. Among the disclosed compounds are biotinylated and fluorescent analogs. These compounds can serve as probes to the σ2 receptor. In addition, some disclosed compounds can induce apoptotic cell death by both caspase-dependent and caspase-independent mechanisms, and are effective for treatment of tumors. The compounds can be used as chemotherapeutics or chemosensitizers in the treatment of a wide variety of solid tumors.
摘要翻译：公开了一系列N-取代的9-氮杂双环[3.3.1]壬烷-3-基苯基氨基甲酸酯类似物及其制备方法。描述了它们对西格玛（sigma1和sigma2）受体的亲和力。两种新化合物N-（9-（4-氨基丁基）-9-氮杂双环[3.3.1]壬-3α-基）-N' - （2-甲氧基-5-甲基苯基）氨基甲酸酯和N-（9- 6-氨基己基）-9-氮杂双环[3.3.1]壬-3α-基）-N' - （2-甲氧基-5-甲基苯基）氨基甲酸酯显示出对sigma2与σ1受体的高亲和力和选择性。所公开的化合物中有生物素化和荧光类似物。这些化合物可以作为sigma2受体的探针。此外，一些公开的化合物可以通过胱天蛋白酶依赖性和半胱天冬酶非依赖性机制诱导凋亡细胞死亡，并且对于治疗肿瘤是有效的。这些化合物可用作化学治疗剂或化学敏化剂，用于治疗各种实体瘤。

5. 发明授权

US6140528A Intermediates to herbicidal isoxazole and 2-cyano-1,3-dione compounds 失效
标题翻译：中间体除草异恶唑和2-氰基-1,3-二酮化合物
公开(公告)号：US6140528A
公开(公告)日：2000-10-31
申请号：US444461
申请日：1999-11-22
申请人： David William Hawkins
发明人： David William Hawkins
IPC分类号： A01N37/34 , A01N41/12 , A01N43/80 , C07C381/00 , C07D261/08 , C07D261/18 , C07C255/49 , C07C255/57 , C07C323/09
CPC分类号： C07C381/00 , A01N41/12 , A01N43/80 , C07D261/08 , C07D261/18
摘要： The invention relates to intermediates to herbicidal compounds of formulae (Ia), (Ib) or (Ic): ##STR1##
摘要翻译：本发明涉及式（Ia），（Ib）或（Ic）的除草化合物的中间体：

6. 发明授权

US6114538A 4-Benzoylisoxazole intermediates to herbicides 失效
标题翻译： 4-苯甲酰异恶唑中间体除草剂
公开(公告)号：US6114538A
公开(公告)日：2000-09-05
申请号：US420783
申请日：1999-10-19
申请人： Angela Jacqueline Bailey , Michael Gingell , David William Hawkins
发明人： Angela Jacqueline Bailey , Michael Gingell , David William Hawkins
IPC分类号： A01N43/80 , A01N47/20 , C07C45/45 , C07C49/813 , C07C229/64 , C07C271/28 , C07D261/08 , C07D261/18 , C07D413/04
CPC分类号： C07D261/18 , A01N43/80 , A01N47/20 , C07C229/64 , C07C271/28 , C07C45/455 , C07C49/813 , C07D261/08
摘要： Compounds of the formula are useful as intermediates to new herbicidal 4-benzoylisoxazoles.
摘要翻译：式的化合物可用作新的除草4-苯甲酰基异恶唑的中间体。

7. 发明授权

US07514561B2 Pesticidal 5-(acylamino) pyrazole derivatives 有权
标题翻译：杀虫剂5-（酰氨基）吡唑衍生物
公开(公告)号：US07514561B2
公开(公告)日：2009-04-07
申请号：US10537547
申请日：2003-11-12
申请人： Stefan Schnatterer , David William Hawkins , Daniela Jans , Michael Maier , Anke Kuhlmann , Erich Friedrich Sanwald , Maria-Theresia Thönessen , Karl Seeger
发明人： Stefan Schnatterer , David William Hawkins , Daniela Jans , Michael Maier , Anke Kuhlmann , Erich Friedrich Sanwald , Maria-Theresia Thönessen , Karl Seeger
IPC分类号： A61K31/4439 , A61K31/4152 , C07D231/28
CPC分类号： C07D401/12 , A01N43/56 , C07D231/44
摘要： Substituted-acylaminopyrazole derivatives of formula (I): or salts thereof, wherein the various symbols are as defined in the description, processes for their preparation, compositions thereof and methods for their use for the control of pests, such as arthropods (e.g. insects and arachnids) and helminths (including nematodes).
摘要翻译：式（I）的取代的酰基氨基吡唑衍生物或其盐，其中各种符号如说明书中所定义，其制备方法，组合物及其用于控制害虫的方法，例如节肢动物（例如昆虫和蛛形纲）和蠕虫（包括线虫）。

8. 发明申请

US20060206218A1 Flexible Function Blocks 有权
标题翻译：灵活的功能块
公开(公告)号：US20060206218A1
公开(公告)日：2006-09-14
申请号：US11420704
申请日：2006-05-26
申请人： David Glanzer , Stephen Mitschke , William Hawkins , Michael von Le Suire , Sergio Tateishi
发明人： David Glanzer , Stephen Mitschke , William Hawkins , Michael von Le Suire , Sergio Tateishi
IPC分类号： G05B11/01 , G05B19/42
CPC分类号： G05B15/02 , G05B19/042 , G05B19/056 , G05B2219/13101 , G05B2219/13127 , G05B2219/15068 , G05B2219/23256 , G05B2219/25085 , G05B2219/25428 , G05B2219/31118 , H04L67/125 , H04L67/325 , H04L69/08
摘要： A new and improved control system architecture using a combination of standard function blocks and new flexible function blocks eliminates the need for expensive and difficult to maintain custom control software and special I/O gateways for discrete/hybrid/batch and PLC applications. The end user builds application-specific flexible function blocks by configuring the number and type of inputs and outputs, and the block algorithm. Flexible function blocks and gateway flexible function block interconnect and interoperate with each other and with standard function blocks in a distributed control architecture.
摘要翻译：使用标准功能块和新的灵活功能块组合的新型改进的控制系统架构无需昂贵且难以维护的定制控制软件和独立/混合/批量和PLC应用的特殊I / O网关。最终用户通过配置输入和输出的数量和类型以及块算法来构建应用程序特定的灵活功能块。灵活的功能块和网关灵活的功能块互连，并在分布式控制架构中与标准功能块互通。

9. 发明授权

US5998653A 1-(substituted phenyl)-2,3-disubstituted propane-1,3-diones as intermediates to 4-benzoylisoxazoles 失效
标题翻译： 1-（取代苯基）-2,3-二取代的丙烷-1,3-二酮作为4-苯甲酰基异恶唑的中间体
公开(公告)号：US5998653A
公开(公告)日：1999-12-07
申请号：US858578
申请日：1997-05-19
申请人： Angela Jacqueline Bailey , Michael Gingell , David William Hawkins
发明人： Angela Jacqueline Bailey , Michael Gingell , David William Hawkins
IPC分类号： A01N43/80 , A01N47/20 , C07C45/45 , C07C49/813 , C07C229/64 , C07C271/28 , C07D261/08 , C07D261/18 , C07D413/04 , C07C271/08
CPC分类号： C07D261/18 , A01N43/80 , A01N47/20 , C07C229/64 , C07C271/28 , C07C45/455 , C07C49/813 , C07D261/08
摘要： Compounds of the formula ##STR1## are useful as intermediates to new herbicidal 4-benzoylisoxazoles.
摘要翻译：式的化合物可用作新的除草4-苯甲酰基异恶唑的中间体。

10. 发明授权

US2011459A Reenforced concrete pile 失效
标题翻译：钢筋混凝土桩
公开(公告)号：US2011459A
公开(公告)日：1935-08-13
申请号：US65019833
申请日：1933-01-04
申请人： SIDNEY SNOW FREDERICK , WILLIAM HAWKINS PERCIVAL
发明人： SIDNEY SNOW FREDERICK , WILLIAM HAWKINS PERCIVAL
IPC分类号： E02D5/52
CPC分类号： E02D5/523

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