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1. 发明申请

US20100129320A1 QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION 审中-公开
标题翻译：用于调制DNA甲基化的喹啉衍生物
公开(公告)号：US20100129320A1
公开(公告)日：2010-05-27
申请号：US12556510
申请日：2009-09-09
申请人： Pasit Phiasivongsa , Sanjeev G. Redkar , Swarna Gamage , Darby Brooke , William Denny , David J. Bearss , Hariprasad Vankayalapati
发明人： Pasit Phiasivongsa , Sanjeev G. Redkar , Swarna Gamage , Darby Brooke , William Denny , David J. Bearss , Hariprasad Vankayalapati
IPC分类号： A61K31/4725 , C07D401/12 , A61K31/506 , A61P35/02 , A61P7/00 , A61P35/00 , A61K38/20 , A61K38/21 , A61K31/706 , A61K39/395
CPC分类号： C07D401/12
摘要： Quinoline derivatives, particularly 4-anilinoquinoline derivatives, are provided. Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders.
摘要翻译：喹啉衍生物，特别是4-苯胺基喹啉衍生物。这样的喹啉衍生物可用于DNA甲基化的调节，例如通过选择性抑制DNA甲基转移酶DNMT1有效抑制C-5位上胞嘧啶的甲基化。提供了合成大量4-苯胺基喹啉衍生物和调节DNA甲基化的方法。还提供了用于配制和施用这些化合物或组合物以治疗诸如癌症和血液学疾病的病症的方法。

2. 发明授权

US3956471A Process of making calcium hypochlorite 失效
标题翻译：制造次氯酸钙的工艺
公开(公告)号：US3956471A
公开(公告)日：1976-05-11
申请号：US484932
申请日：1974-07-01
申请人： Brian James Pullman , William Denny Mant , Gordon Leigh Ross
发明人： Brian James Pullman , William Denny Mant , Gordon Leigh Ross
IPC分类号： C01B11/06
CPC分类号： C01B11/064
摘要： In the known process of preparing a slurry of calcium hypochlorite by reaction of chlorine with a slurry of calcium hydroxide and sodium hydroxide, we provide the improvement consisting of continuously pumping into a first stirred reactor an aqueous slurry of calcium hydroxide and sodium hydroxide optionally partially chlorinated and simultaneously passing chlorine gas into the reaction mixture at such a rate that the redox potential is in the range from 650-850 mV and allowing the contents of the first reactor to overflow continuously into a second stirred reactor and simultaneously passing chlorine gas into the second reactor at such a rate that the redox potential is in the range from 750-950 mV and allowing the contents of the second reactor to overflow and be removed as product; the temperature of the contents of the first and second reactor are independently maintained at a temperature in the range 15.degree. to 35.degree.C.
摘要翻译：在通过氯与氢氧化钙和氢氧化钠的浆料反应来制备次氯酸钙的浆料的已知方法中，我们提供了改进，其包括将第一搅拌反应器中的氢氧化钙和氢氧化钠的含水浆料任选地部分氯化同时使氯气进入反应混合物，使得氧化还原电位在650-850mV的范围内，并使第一反应器的内容物连续溢出到第二搅拌反应器中，同时使氯气进入第二反应器反应器以使得氧化还原电位在750-950mV范围内并允许第二反应器的内容物溢出并作为产物除去的速率; 第一和第二反应器的内容物的温度独立地保持在15℃至35℃的温度。

3. 发明授权

US2035702A Apparatus for measuring the axial force in a line of shafting 失效
标题翻译：用于测量轴系轴向力的装置
公开(公告)号：US2035702A
公开(公告)日：1936-03-31
申请号：US74874334
申请日：1934-10-17
申请人： WILLIAM DENNY & BROTHERS LTD
发明人： JAMES GUTHRIE WILLIAM
IPC分类号： G01L5/12
CPC分类号： G01L5/12

4. 发明申请

US20090099106A1 QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION 失效
公开(公告)号：US20090099106A1
公开(公告)日：2009-04-16
申请号：US11959181
申请日：2007-12-18
申请人： Pasit Phiasivongsa , Sanjeev G. Redkar , Swarna Gamage , Darby Brooke , William Denny , David J. Bearss , Hariprasad Vankayalapati
发明人： Pasit Phiasivongsa , Sanjeev G. Redkar , Swarna Gamage , Darby Brooke , William Denny , David J. Bearss , Hariprasad Vankayalapati
IPC分类号： A61K31/47 , C07D401/02 , A61K31/4709 , C07D401/14 , A61P35/00 , A61K31/706 , A61K31/506 , C07D215/42
CPC分类号： C07D401/12
摘要： Quinoline derivatives, particularly 4-anilinoquinoline derivatives, are provided. Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders.

5. 发明申请

US20070032455A1 Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents 失效
标题翻译：新型硝基苯基芥末和硝基苯基氮丙啶醇及其相应的磷酸盐及其作为靶向细胞毒性剂的用途
公开(公告)号：US20070032455A1
公开(公告)日：2007-02-08
申请号：US10577078
申请日：2004-10-29
申请人： William Denny , Graham Atwell , Shangjin Yang , William Wilson , Adam Patterson , Nuala Helsby
发明人： William Denny , Graham Atwell , Shangjin Yang , William Wilson , Adam Patterson , Nuala Helsby
IPC分类号： A61K31/675 , C07F9/02 , A61K31/66
CPC分类号： C07F9/091 , C07C237/32 , C07C309/66 , C07C317/48 , C07D203/14
摘要： The present invention relates to a novel nitrophenyl mustard and nitrophenylaziridine alcohols, to their corresponding phosphates, to their use as targeted cytotoxic agents; as bioreductive drugs in hypoxic tumours, and to their use in cell ablation, including gene-directed enzyme-prodrug therapy (GDEPT) and antibody-directed enzymeprodrug therapy (ADEPT), in conjunction with nitroreductase enzymes.
摘要翻译：本发明涉及一种新的硝基苯基芥子和硝基苯基氮丙啶醇，以及它们相应的磷酸盐，用作靶向的细胞毒剂; 作为缺氧性肿瘤中的生物还原药物，以及其在细胞消融中的应用，包括基因定向酶前药治疗（GDEPT）和抗体定向酶法（ADEPT），与硝酸还原酶联用。

6. 发明授权

US2550752A Roll-stabilizing oscillating fin installation on ships 失效
标题翻译：在船上安装滚动稳定的振荡翅片
公开(公告)号：US2550752A
公开(公告)日：1951-05-01
申请号：US65296646
申请日：1946-03-08
申请人： WILLIAM DENNY AND BROTHERS LTD , BROWN BROTHERS AND COMPANY LTD
发明人： FOGGO ALLAN JAMES
IPC分类号： B63B39/06
CPC分类号： B63B39/06

7. 发明授权

US07790746B2 Quinoline derivatives for modulating DNA methylation 失效
标题翻译：用于调节DNA甲基化的喹啉衍生物
公开(公告)号：US07790746B2
公开(公告)日：2010-09-07
申请号：US11959181
申请日：2007-12-18
申请人： Pasit Phiasivongsa , Sanjeev G. Redkar , Swarna Gamage , Darby Brooke , William Denny , David J. Bearss , Hariprasad Vankayalapati
发明人： Pasit Phiasivongsa , Sanjeev G. Redkar , Swarna Gamage , Darby Brooke , William Denny , David J. Bearss , Hariprasad Vankayalapati
IPC分类号： A61K31/47
CPC分类号： C07D401/12
摘要： Quinoline derivatives, particularly 4-anilinoquinoline derivatives of formula (I), are provided: Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT 1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders.
摘要翻译：提供了喹啉衍生物，特别是式（I）的4-苯胺基喹啉衍生物：这样的喹啉衍生物可用于DNA甲基化的调节，例如有效抑制胞嘧啶在C-5位甲基化，例如通过选择性抑制 DNA甲基转移酶DNMT 1.提供了合成大量4-苯胺基喹啉衍生物和调节DNA甲基化的方法。还提供了用于配制和施用这些化合物或组合物以治疗诸如癌症和血液学疾病的病症的方法。

8. 发明申请

US20080175814A1 QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION 审中-公开
标题翻译：用于调制DNA甲基化的喹啉衍生物
公开(公告)号：US20080175814A1
公开(公告)日：2008-07-24
申请号：US11871762
申请日：2007-10-12
申请人： Pasit Phiasivongsa , Sanjeev Redkar , Swarna Gamage , Darby Brooke , William Denny , David J. Bearss , Hariprasad Vankayalapati
发明人： Pasit Phiasivongsa , Sanjeev Redkar , Swarna Gamage , Darby Brooke , William Denny , David J. Bearss , Hariprasad Vankayalapati
IPC分类号： A61K38/20 , C07D215/00 , A61K31/47 , C07D239/02 , A61K38/21 , A61K38/16 , A61P35/00 , A61K39/395 , A61K31/506 , A61K31/53 , C12N5/00
CPC分类号： C07D401/12
摘要： Quinoline derivatives, particularly 4-anilinoquinoline derivatives, are provided. Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders.
摘要翻译：喹啉衍生物，特别是4-苯胺基喹啉衍生物。这样的喹啉衍生物可用于DNA甲基化的调节，例如通过选择性抑制DNA甲基转移酶DNMT1有效抑制C-5位上胞嘧啶的甲基化。提供了合成大量4-苯胺基喹啉衍生物和调节DNA甲基化的方法。还提供了用于配制和施用这些化合物或组合物以治疗诸如癌症和血液学疾病的病症的方法。

9. 发明申请

US20070191372A1 Dna-targeted benzotriazine 1,4-dioxides and their use in cancer therapy 审中-公开
标题翻译： Dna靶向的苯并三嗪1,4-二氧化物及其在癌症治疗中的应用
公开(公告)号：US20070191372A1
公开(公告)日：2007-08-16
申请号：US10528156
申请日：2003-09-17
申请人： J. Brown , William Denny , Michael Hay , Kevin Hicks , Swarnalatha Gamage , Frederik Pruijn , William Wilson
发明人： J. Brown , William Denny , Michael Hay , Kevin Hicks , Swarnalatha Gamage , Frederik Pruijn , William Wilson
IPC分类号： A61K31/53
CPC分类号： C07D253/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The present invention relates to DNA-targeted 1,2,4-benzotriazine-1,4-dioxides and related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.
摘要翻译：本发明涉及DNA靶向的1,2,4-苯并三嗪-1,4-二氧化物及其相关类似物及其制备方法，以及它们作为用于癌症治疗的缺氧选择性药物和放射增敏剂的用途，其单独或与辐射和/或其他抗癌药物。

10. 发明申请

US20050256191A1 Nitroaniline-based alkylating agents and their use as prodrugs 失效
标题翻译：基于硝基苯胺的烷基化剂及其作为前药的用途
公开(公告)号：US20050256191A1
公开(公告)日：2005-11-17
申请号：US10529772
申请日：2003-10-08
申请人： William Denny , Graham Atwell , Shangjin Yang , William Wilson
发明人： William Denny , Graham Atwell , Shangjin Yang , William Wilson
IPC分类号： A61P35/00 , C07C237/30 , C07C309/66 , C07C311/39 , C07D263/04 , C07D295/13 , C07D317/28 , C07C39/02 , A61K31/205
CPC分类号： C07D295/13 , C07C237/30 , C07C309/66 , C07C311/39 , C07D263/04 , C07D317/28
摘要： Nitroaniline-based unsymmetrical mustards of the general formula (I) are provided, together with methods of preparation and methods for their use as prodrugs for gene-dependent enzyme prodrug therapy (GDEPT) and cell ablation therapy in conjunction with nitroreductase enzymes as hypoxia selective cytotoxins and as anticancer agents.
摘要翻译：提供了通式（I）的基于硝基苯胺的不对称芥末，以及其制备方法和用作基因依赖性酶前体药物治疗（GDEPT）的前药的方法和与硝基还原酶作为缺氧选择性细胞毒素联合的细胞消除治疗并作为抗癌剂。

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