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1. 发明申请

US20110190514A1 PYRONE ANALOG COMPOSITIONS AND METHODS 审中-公开
标题翻译：吡喃类似物组合物和方法
公开(公告)号：US20110190514A1
公开(公告)日：2011-08-04
申请号：US12877343
申请日：2010-09-08
申请人： Wendye Robbins , Ving Lee
发明人： Wendye Robbins , Ving Lee
IPC分类号： C07D311/30
CPC分类号： C07D311/30
摘要： Novel pyrone analogs are described which can enhance the effectiveness of a therapeutic agent when administered and/or reduce side effects caused by the administration of a therapeutic agent.
摘要翻译：描述了当施用和/或减少由施用治疗剂引起的副作用时可以增强治疗剂的有效性的新型吡喃酮类似物。

2. 发明申请

US20090082400A1 SOLUBLE PYRONE ANALOGS METHODS AND COMPOSITIONS 审中-公开
标题翻译：可溶性吡喃酮类似物的方法和组合物
公开(公告)号：US20090082400A1
公开(公告)日：2009-03-26
申请号：US12182979
申请日：2008-07-30
申请人： Ving LEE , Wendye Robbins
发明人： Ving LEE , Wendye Robbins
IPC分类号： A61K31/453 , A61K31/352 , A61P37/00 , A61P29/00
CPC分类号： A61K45/06 , A61K31/352 , A61K31/453 , A61K2300/00
摘要： Methods and compositions are described that comprise pyrone analogs such as flavonoids and cyclodextrins including quercetin and quercetin derivatives and sulfoalkyl ether cyclodextrins. In some cases the compounds of the invention are administered with a therapeutic agent such as an analgesic. In some cases, treatment with the compositions of the invention can result in the modulation of central nervous system and/or fetal effects of substances. Methods and compositions are described for the modulation of efflux transporter activity to increase the efflux of drugs and other compositions out of a physiological compartment and into an external environment. In particular, the methods and compositions disclosed herein provide for the increase of efflux transporter activity at blood-brain, blood-CSF and placental-maternal barriers to increase the efflux of drugs and other compositions from physiological compartments, including central nervous system and fetal compartments.
摘要翻译：描述了包含吡喃酮类似物如黄酮和包括槲皮素和槲皮素衍生物和磺基烷基醚环糊精的环糊精的方法和组合物。在一些情况下，本发明的化合物与治疗剂如镇痛剂一起施用。在一些情况下，用本发明的组合物进行治疗可导致中枢神经系统的调节和/或物质的胎儿作用。描述了调节流出物转运蛋白活性以增加药物和其它组合物从生理室外进入外部环境的方法和组合物。特别地，本文公开的方法和组合物提供在血脑，血液CSF和胎盘 - 母体屏障上的流出转运蛋白活性的增加，以增加药物和其它组合物从生理区域（包括中枢神经系统和胎儿隔室）的流出。

3. 发明授权

US07947733B2 Phosphorylated pyrone analogs and methods 失效
标题翻译：磷酸化吡喃酮类似物和方法
公开(公告)号：US07947733B2
公开(公告)日：2011-05-24
申请号：US12182992
申请日：2008-07-30
申请人： Wendye Robbins , Ving Lee
发明人： Wendye Robbins , Ving Lee
IPC分类号： A01N43/16 , A61K31/35 , C07D311/00
CPC分类号： C07F9/65522 , A61K31/665 , C07F9/65744
摘要： The invention relates to phosphorylated polyphenols, phosphorylated flavonoids, and phosphorylated pyrone analogs. Methods and compositions for the modulation of side effects of substances using such phosphorylated compounds are described. Methods and compositions are described for the modulation of blood-tissue barrier (BTB) transporter activity to increase the efflux of drugs and other compounds out of a physiological compartment and into an external environment. In particular, the methods and compositions disclosed herein provide lowered side effects when phosphorylated pyrone analogs are coadministered with therapeutic agents.
摘要翻译：本发明涉及磷酸化多酚，磷酸化黄酮和磷酸化吡喃酮类似物。描述了使用这种磷酸化化合物调节物质副作用的方法和组合物。描述了用于调节血液 - 组织屏障（BTB）转运蛋白活性以增加药物和其它化合物从生理区室外流入外部环境的方法和组合物。特别地，当磷酸化吡喃酮类似物与治疗剂共同施用时，本文公开的方法和组合物提供降低的副作用。

4. 发明申请

US20100297020A1 PHOSPHORYLATED AND PHOSPHONATED PYRONE ANALOGS FOR THERAPEUTIC TREATMENT 审中-公开
标题翻译：用于治疗疗法的磷酸化和磷化吡喃酮类似物
公开(公告)号：US20100297020A1
公开(公告)日：2010-11-25
申请号：US12757817
申请日：2010-04-09
申请人： May Dean-Ming Lee , Ving Lee , Wendye Robbins
发明人： May Dean-Ming Lee , Ving Lee , Wendye Robbins
IPC分类号： A61K49/00 , A61K31/665 , C07F9/40 , A61K31/7088 , A61K38/00 , A61P3/06 , A61P3/08 , A61P3/00 , A61P1/18
CPC分类号： A61K31/352 , A61K31/661 , A61K31/665 , A61K45/06 , A61K2300/00
摘要： Methods are described for the treatment and prevention of metabolic disorders or other diseases by administering a pyrone analog or a derivative thereof. Methods are also described for the treatment and prevention of metabolic disorders and other diseases by administering a pyrone analog, or a derivative thereof, in combination with one or more additional agents such as, for example, lipid lowering agents or glucose lowering agents. Methods are described for the modulation of lipid transporter activity to increase the efflux of lipid from a physiological compartment into an external environment. Methods disclosed herein may be used to assess treatment or prevention of a metabolic disorder following administration of a pyrone analog or a derivative thereof.
摘要翻译：描述了通过施用吡喃酮类似物或其衍生物来治疗和预防代谢紊乱或其它疾病的方法。还描述了通过给予吡喃酮类似物或其衍生物与一种或多种另外的试剂例如降脂药或葡萄糖降低剂组合来治疗和预防代谢紊乱和其它疾病的方法。描述了用于调节脂质转运蛋白活性以增加脂质从生理隔室进入外部环境的方法。在给予吡喃酮类似物或其衍生物后，本文公开的方法可用于评估代谢紊乱的治疗或预防。

5. 发明申请

US20090325906A1 Methods and compositions for therapeutic treatment 审中-公开
标题翻译：用于治疗性治疗的方法和组合物
公开(公告)号：US20090325906A1
公开(公告)日：2009-12-31
申请号：US12459178
申请日：2009-06-26
申请人： Wendye Robbins , Ving Lee
发明人： Wendye Robbins , Ving Lee
IPC分类号： A61K31/665 , A61K31/436 , A61K31/352
CPC分类号： A61K47/40 , A61K9/48 , A61K31/352 , A61K31/44 , A61K45/06 , A61K2300/00
摘要： Methods and compositions are described for the modulation of hyperglycemia and/or one or more symptoms of hyperglycemia. Methods and compositions are described for the modulation of efflux transporter activity to increase the efflux of calcineurin inhibitors out of a physiological compartment and into an external environment. In particular, the methods and compositions disclosed herein provide for the increase of efflux transporter activity to increase the efflux of calcineurin inhibitor from physiological compartments.
摘要翻译：描述了用于调节高血糖症和/或一种或多种高血糖症状的方法和组合物。描述了用于调节流出物转运蛋白活性以增加钙调神经磷酸酶抑制剂从生理室外流入外部环境的方法和组合物。特别地，本文公开的方法和组合物提供流出转运蛋白活性的增加以增加钙调神经磷酸酶抑制剂从生理区室的流出。

6. 发明申请

US20090088394A1 METHODS AND COMPOSITIONS FOR THERAPEUTIC TREATMENT 审中-公开
标题翻译：治疗方法和组合物
公开(公告)号：US20090088394A1
公开(公告)日：2009-04-02
申请号：US12204213
申请日：2008-09-04
申请人： Wendye Robbins
发明人： Wendye Robbins
IPC分类号： A61K31/7048 , A61K31/353 , A61P25/00
CPC分类号： A61K31/445 , A61K31/137 , A61K31/353 , A61K31/485 , A61K31/55 , A61K31/551 , A61K31/7024 , A61K31/7048 , A61K45/06 , A61K2300/00
摘要： Methods and compositions are described for the modulation of central nervous system and/or fetal effects of substances. Methods and compositions are described for the modulation of efflux transporter activity to increase the efflux of drugs and other compounds out of a physiological compartment and into an external environment. In particular, the methods and compositions disclosed herein provide for the increase of efflux transporter activity at blood-brain, blood-CSF and placental-maternal barriers to increase the efflux of drugs and other compounds from physiological compartments, including central nervous system and fetal compartments.
摘要翻译：描述了用于调节中枢神经系统和/或物质的胎儿作用的方法和组合物。描述了用于调节流出转运蛋白活性以增加药物和其它化合物从生理区域外部流入外部环境的方法和组合物。特别地，本文公开的方法和组合物提供了在血脑，血液CSF和胎盘 - 母体屏障上的流出转运蛋白活性的增加，以增加药物和其它化合物从生理区域（包括中枢神经系统和胎儿隔室）的流出。

7. 发明申请

US20110028437A1 PHOSPHORYLATED PYRONE ANALOGS AND METHODS 审中-公开
标题翻译：磷酸吡喃酮类似物和方法
公开(公告)号：US20110028437A1
公开(公告)日：2011-02-03
申请号：US12856291
申请日：2010-08-13
申请人： Wendye Robbins , Ving Lee
发明人： Wendye Robbins , Ving Lee
IPC分类号： A61K31/665 , A61P25/00 , A61P15/00 , A61P13/12 , A61P1/16 , A61P3/10
CPC分类号： A61K31/665 , C07F9/65522 , C07F9/65744
摘要： The invention relates to phosphorylated polyphenols, phosphorylated flavonoids, and phosphorylated pyrone analogs. Methods and compositions for the modulation of side effects of substances using such phosphorylated compounds are described. Methods and compositions are described for the modulation of blood-tissue barrier (BTB) transporter activity to increase the efflux of drugs and other compounds out of a physiological compartment and into an external environment. In particular, the methods and compositions disclosed herein provide lowered side effects when phosphorylated pyrone analogs are coadministered with therapeutic agents.
摘要翻译：本发明涉及磷酸化多酚，磷酸化黄酮和磷酸化吡喃酮类似物。描述了使用这种磷酸化化合物调节物质副作用的方法和组合物。描述了用于调节血液 - 组织屏障（BTB）转运蛋白活性以增加药物和其它化合物从生理区室外流入外部环境的方法和组合物。特别地，当磷酸化吡喃酮类似物与治疗剂共同施用时，本文公开的方法和组合物提供降低的副作用。

8. 发明申请

US20070087977A1 METHODS AND COMPOSITIONS FOR TREATING PAIN 审中-公开
标题翻译：用于治疗疼痛的方法和组合物
公开(公告)号：US20070087977A1
公开(公告)日：2007-04-19
申请号：US11553924
申请日：2006-10-27
申请人： Wendye Robbins
发明人： Wendye Robbins
IPC分类号： A61K31/7048 , A61K31/7008 , A61K31/573 , A61K31/551 , A61K31/485 , A61K31/55 , A61K31/445 , A61K31/353 , A61K31/195
CPC分类号： A61K31/195 , A61K31/353 , A61K31/445 , A61K31/485 , A61K31/55 , A61K31/551 , A61K31/573 , A61K31/7008 , A61K31/7048
摘要： Methods and compositions are described for the modulation of central nervous system and/or fetal effects of substances. Methods and compositions are described for the modulation of efflux transporter activity to increase the efflux of drugs and other compounds out of a physiological compartment and into an external environment. In particular, the methods and compositions disclosed herein provide for the increase of efflux transporter activity at blood-brain, blood-CSF and placental-maternal barriers to increase the efflux of drugs and other compounds from physiological compartments, including central nervous system and fetal compartments.
摘要翻译：描述了用于调节中枢神经系统和/或物质的胎儿作用的方法和组合物。描述了用于调节流出转运蛋白活性以增加药物和其它化合物从生理区域外部流入外部环境的方法和组合物。特别地，本文公开的方法和组合物提供了在血脑，血液CSF和胎盘 - 母体屏障上的流出转运蛋白活性的增加，以增加药物和其它化合物从生理区室（包括中枢神经系统和胎儿隔室）的流出。

9. 发明申请

US20060111308A1 Methods and compositions for therapeutic treatment 审中-公开
标题翻译：治疗方法和组合物
公开(公告)号：US20060111308A1
公开(公告)日：2006-05-25
申请号：US11281984
申请日：2005-11-16
申请人： Wendye Robbins
发明人： Wendye Robbins
IPC分类号： A61K31/7048 , A61K31/353
CPC分类号： A61K31/445 , A61K31/137 , A61K31/353 , A61K31/485 , A61K31/55 , A61K31/551 , A61K31/7024 , A61K31/7048 , A61K45/06 , A61K2300/00
摘要： Methods and compositions are described for the modulation of central nervous system and/or fetal effects of substances. Methods and compositions are described for the modulation of efflux transporter activity to increase the efflux of drugs and other compounds out of a physiological compartment and into an external environment. In particular, the methods and compositions disclosed herein provide for the increase of efflux transporter activity at blood-brain, blood-CSF and placental-maternal barriers to increase the efflux of drugs and other compounds from physiological compartments, including central nervous system and fetal compartments.
摘要翻译：描述了用于调节中枢神经系统和/或物质的胎儿作用的方法和组合物。描述了用于调节流出转运蛋白活性以增加药物和其它化合物从生理区域外部流入外部环境的方法和组合物。特别地，本文公开的方法和组合物提供了在血脑，血液CSF和胎盘 - 母体屏障上的流出转运蛋白活性的增加，以增加药物和其它化合物从生理区室（包括中枢神经系统和胎儿隔室）的流出。

10. 发明申请

US20100204089A1 PHOSPHORYLATED PYRONE ANALOGS AND METHODS 审中-公开
公开(公告)号：US20100204089A1
公开(公告)日：2010-08-12
申请号：US12765580
申请日：2010-04-22
申请人： Wendye Robbins , Ving Lee
发明人： Wendye Robbins , Ving Lee
IPC分类号： A61K31/665 , A61K38/13 , A61P25/00 , A61P11/00 , A61P3/10
CPC分类号： C07F9/65522 , A61K31/665 , C07F9/65744
摘要： The invention relates to phosphorylated polyphenols, phosphorylated flavonoids, and phosphorylated pyrone analogs. Methods and compositions for the modulation of side effects of substances using such phosphorylated compounds are described. Methods and compositions are described for the modulation of blood-tissue barrier (BTB) transporter activity to increase the efflux of drugs and other compounds out of a physiological compartment and into an external environment. In particular, the methods and compositions disclosed herein provide lowered side effects when phosphorylated pyrone analogs are coadministered with therapeutic agents.

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